Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

Nature Biotechnology

Volumn 17, Issue 3, 1999, Pages 253-258

  Biragyn, Arya ^c   Tani, Kenji ^a   Grimm, Michael C ^a   Weeks, Steven ^c   Kwak, Larry W ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Antigen presenting cell targeting; Chemokine fusion; Idiotypic vaccine; Interferon inducible protein 10; Monocyte chemotactic protein 3

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 3; TUMOR ANTIGEN;

ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CELLULAR IMMUNITY; CHEMOTAXIS; GENE FUSION; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TARGETING; RECEPTOR AFFINITY; RECEPTOR BINDING; TUMOR IMMUNITY; VACCINE PRODUCTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; BINDING, COMPETITIVE; CANCER VACCINES; CHEMOKINES; CHEMOKINES, CXC; CHEMOTAXIS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; GENE THERAPY; IMMUNOGLOBULIN VARIABLE REGION; INFLAMMATION; LYMPHOMA; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICROSCOPY, CONFOCAL; MONOCYTE CHEMOATTRACTANT PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 0032998424     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/6995     Document Type: Article

References (36)

1. Haelens, A. et al. Leukocyte migration and antivation by murine chemokines. Immunobiology 195, 499-521 (1996).
2. Rollins, B.J. Chemokines. Blood 90, 909-928 (1997).
3. Luster, A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338, 436-445 (1998).
4. Prado, G.N., Suzuki, H., Wilkinson, N., Cousins, B. & Navarro, J. Role of the C terminus of the interleukin 8 receptor in signal transduction and internalization. J. Biol. Chem. 271, 19186-19190 (1996).
5. Solari, R. et al. Receptor-mediated endocytosis of CC-chemokines. J. Biol. Chem. 272, 9617-9620 (1997).
6. Signoret, N. et al. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell. Biol. 139, 651-664 (1997).
7. Streiter, R.M. et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270, 27348-27357 (1995).
8. Ohmori, Y. & Hamilton, T.A. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem. Biophys. Res. Commun. 168, 1261-1267 (1990).
9. Luster, A.D. & Leder, P. IP-10, a -C-X-C-chemokine, elicits a potent thymus-dependent antitumor response in vivo. J. Exp. Med. 178, 1057-1065 (1993).
10. Thirion, S. et al. Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC. Biochem. Biophys. Res. Commun. 201, 493-499 (1994).
11. Gong, J.-H., Uguccioni, M., Dewald, B., Baggiolini, M. & Clark-Lewis, I. RANTES and MCP-3 antagonists bind multiple chemokine receptors. J. Biol. Chem. 271, 10521-10527 (1996).
12. Xu, L.L. et al. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors: binding and signaling of MCP3 through shared as well as unique receptors on monocytes and neutrophils. Eur. J. Immunol. 25, 2612-2617 (1995).
13. Stevenson, G.T. & Stevenson, F.K. Antibody to a molecularly-defined antigen confined to a tumor cell surface. Nature 254, 714-716 (1975).
14. Kaminski, M.S., Kitamura, K., Maloney, D.G. & Levy, R. Idiotype vaccination against murine B cell lymphoma, inhibition of tumor immunity by free idiotype protein. J. Immunol. 138, 1289-1296 (1987).
15. Kwak, L.W. et al. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N. Engl. J. Med. 327, 1209-1215 (1992).
16. Huston, J.S. et al. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 85, 5879-5883 (1988).
17. Huston, J.S. et al. Protein engineering of single-chain Fv analogs and fusion proteins. Methods Enzymol. 203, 46-98 (1991).
18. Bergman, Y. & Haimovich, J. Characterization of a carcinogen-induced murine B lymphocyte cell line of C3H/eB origin. Eur. J. Immunol. 7, 413-417 (1977).
19. Kim, K.J., Kanellopoulos-Langevin, C., Merwin, R.M., Sachs, D.H. & Asofsky, R. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122, 549-554 (1979).
20. Buchner, J., Pastan, I. & Brinkmann, U. A method for increasing the yield of property folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies. Anal. Biochem. 205, 263-270 (1992).
21. Boyle, J.S., Brady, J.L. & Lew, A.M. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature 392, 408-411 (1998).
22. Kwak, L.W. et al. Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor. Lancet 345, 1016-1020 (1995).
23. Tao, M.-H. & Levy, R. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 362, 755-758 (1993).
24. Syrengelas, A.D., Chen, T.T. & Levy, R. DNA immunization induces protective immunity against B-cell lymphoma. Nat Med 2, 1038-1041 (1996).
25. Stevenson, F.K. et al. Idiotypic DNA vaccines against B-cell lymphoma. Immunol. Rev. 145, 211-227 (1995).
26. King, C.Y. et al. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat. Med. 4, 1281-1286 (1998).
27. Cheng, L., Ziegelhoffer, P.R. & Yang, N.-S. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. Natl. Acad. Sci. USA 90, 4455-4459 (1993).
28. Liu, M.A. The immunologist's grail: vaccines that generate cellular immunity. Proc. Natl. Acad. Sci. USA 94, 10496-10498 (1997).
29. Feltquate, D.M., Heaney, S., Webster, R.G. & Robinson, H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 158, 2278-2284 (1997).
30. Wu, Y. & Kipps, T.J. Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes. J. Immunol. 159, 6037-6043 (1997).
31. Blasi, E., Matthieson, B.J. & Varesio, L. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 318, 667-670 (1985).
32. Falk, W., Goodwin, R.H. & Leonard, E.J. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33, 239-247 (1980).
33. Kwak, L.W., Young, H.A., Pennington, R.W. & Weeks, S.W. Vaccination with syngeneic. lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response. Proc. Natl. Acad. Sci. USA 93, 10972-10977 (1996).
34. Guide for the Care and Use of Laboratory Animals publication no. 86-23 (National Institutes of Health, Bethesda, Md, 1985).
35. Irvine, K.R., Rao, J.B., Rosenberg, S.A. & Restifo, N.P. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J. Immunol. 156, 238-245 (1996).
36. Kruisbeek, A.M. in Current Protocols in Immunology (eds. Coligan, J.E., Kruisbeck, A.M., Margulies, D.H., Shevach, E.M. & Strober, W.) 4.1.1-4.2.1 (Wiley & Sons, New York, 1994).