Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 22, 2002, Pages 14398-14403

  Kato Stankiewicz, Juran ^a   Hakimi, Irina ^b   Zhi, Gang ^b   Zhang, Jie ^b,f   Serebriiskii, Ilya ^c   Guo, Lea ^a   Edamatsu, Hironori ^a,g   Koide, Hiroshi ^d   Menon, Sanjay ^b   Eckl, Robert ^e   Sakamuri, Sukumar ^b   Lu, Yingchun ^b   Chen, Quin Zene ^b   Agarwal, Seema ^b   Baumbach, William R ^b   Golemis, Erica A ^c   Tamanoi, Fuyuhiko ^a   Khazak, Vladimir ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Morphochem Inc   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d KANAZAWA UNIVERSITY   (Japan)

^e Biovertis AG   (Germany)

^f PFIZER INC   (United States)

^g KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL CYCLE; CELL INVASION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

3T3 CELLS; ANIMALS; CHO CELLS; CRICETINAE; GENE LIBRARY; HUMANS; LUCIFERASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; SERUM RESPONSE ELEMENT; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFORMATION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037195142     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.222222699     Document Type: Article

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