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Volumn 89, Issue 1, 1999, Pages 14-22

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1

Author keywords

Experimental therapeutics; Neurofibromatosis type 1; Ras

Indexed keywords

ALLELE; ARTICLE; GENE EXPRESSION; HUMAN; NEUROFIBROMATOSIS; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 0033605482     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990326)89:1<14::AID-AJMG5>3.0.CO;2-4     Document Type: Article
Times cited : (118)

References (103)
  • 1
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B α
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B α. Curr Biol 7:261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 3
    • 0025201012 scopus 로고
    • The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
    • Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851-859.
    • (1990) Cell , vol.63 , pp. 851-859
    • Ballester, R.1    Marchuk, D.2    Boguski, M.3    Saulino, A.4    Letcher, R.5    Wigler, M.6    Collins, F.7
  • 5
    • 0022137480 scopus 로고
    • Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
    • Bar-Sagi D, Feramisco JR. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42:841-848.
    • (1985) Cell , vol.42 , pp. 841-848
    • Bar-Sagi, D.1    Feramisco, J.R.2
  • 6
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. 1992. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 356:713-715.
    • (1992) Nature , vol.356 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 7
    • 0029126877 scopus 로고
    • Neurofibromatosis type 1 and Ras-mediated signaling: Filling in the GAPs
    • Bernards A. 1995. Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs. Biochim Biophys Acta 1242:43-59.
    • (1995) Biochim Biophys Acta , vol.1242 , pp. 43-59
    • Bernards, A.1
  • 8
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski M, McCormick F. 1993. Proteins regulating Ras and its relatives. Nature 366:643-653.
    • (1993) Nature , vol.366 , pp. 643-653
    • Boguski, M.1    McCormick, F.2
  • 10
    • 0025010979 scopus 로고
    • The GTPase superfamily: A conserved switch for diverse cell functions
    • Bourne HR, Sanders DA, McCormick F. 1990. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348:125-132.
    • (1990) Nature , vol.348 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 11
    • 0026627960 scopus 로고
    • Identification of murine homologues of the Drosophila son of sevenless gene: Potential activators of ras
    • Bowtell D, Fu P, Simon M, Senior P. 1992. Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Acad Acad Sci U S A 89:6511-6515.
    • (1992) Proc Acad Acad Sci U S A , vol.89 , pp. 6511-6515
    • Bowtell, D.1    Fu, P.2    Simon, M.3    Senior, P.4
  • 14
    • 0025152970 scopus 로고
    • Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway
    • Buchberg A, Cleveland L, Jenkins N, et al. 1990. Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway. Nature 347:291-294.
    • (1990) Nature , vol.347 , pp. 291-294
    • Buchberg, A.1    Cleveland, L.2    Jenkins, N.3
  • 15
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
    • Buday L, Downward J. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611-620.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 16
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey PJ, Seabra MC. 1996. Protein prenyltransferases. J Biol Chem 271: 5289-5292.
    • (1996) J Biol Chem , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 18
    • 0026768072 scopus 로고
    • Isolation of multiple mouse cDNAs with coding homology to saccharomyces cerevisiae CDC25: Identification of a region related to Bcr, Vav, Dbl and CDC24
    • Cen H, Papageorge AG, Zippel R, Lowy DR, Zhang K. 1992. Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24. EMBO J 11:4007-4015.
    • (1992) EMBO J , vol.11 , pp. 4007-4015
    • Cen, H.1    Papageorge, A.G.2    Zippel, R.3    Lowy, D.R.4    Zhang, K.5
  • 19
    • 0026735063 scopus 로고
    • Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
    • Clarke S. 1992. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu Rev Biochem 61:355-386.
    • (1992) Annu Rev Biochem , vol.61 , pp. 355-386
    • Clarke, S.1
  • 20
    • 0027494347 scopus 로고
    • Protein methylation
    • Clarke S. 1993. Protein methylation. Curr Opin Cell Biol 5:977-983.
    • (1993) Curr Opin Cell Biol , vol.5 , pp. 977-983
    • Clarke, S.1
  • 21
    • 0000081175 scopus 로고
    • Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases
    • Published erratum appears in Proc Natl Acad Sci U S A 1988;85(20):7556
    • Clarke S, Vogel JP, Deschenes RJ, Stock J. 1988. Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci U S A 85:4643-4647. (Published erratum appears in Proc Natl Acad Sci U S A 1988;85(20):7556.)
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4643-4647
    • Clarke, S.1    Vogel, J.P.2    Deschenes, R.J.3    Stock, J.4
  • 22
    • 0029160585 scopus 로고
    • Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene
    • Colman SD, Williams CA, Wallace MR. 1995. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene. Nature Genet 11:90-92.
    • (1995) Nature Genet , vol.11 , pp. 90-92
    • Colman, S.D.1    Williams, C.A.2    Wallace, M.R.3
  • 23
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply ras?
    • Cox AD, Der CJ. 1997. Farnesyltransferase inhibitors and cancer treatment: targeting simply ras? Biochim Biophys Acta 1333:F51-F71.
    • (1997) Biochim Biophys Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 24
    • 0027304607 scopus 로고
    • Extracellular signals and reversible protein phosphorylation: What to Mek of it all
    • Crews CM, Erikson RL. 1993. Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell 74:215-217.
    • (1993) Cell , vol.74 , pp. 215-217
    • Crews, C.M.1    Erikson, R.L.2
  • 27
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
    • Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC. 1998. RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science 280:1082-1086.
    • (1998) Science , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorff, D.A.2    Chan, E.Y.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 28
    • 0027910431 scopus 로고
    • Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
    • Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45-51.
    • (1993) Nature , vol.363 , pp. 45-51
    • Egan, S.E.1    Giddings, B.W.2    Brooks, M.W.3    Buday, L.4    Sizeland, A.M.5    Weinberg, R.A.6
  • 29
    • 0030280090 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukemia: Molecular understanding and prospects for therapy
    • Emanuel PD, Shannon KM, Castleberry RP. 1996. Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. Mol Med Today 2:468-475.
    • (1996) Mol Med Today , vol.2 , pp. 468-475
    • Emanuel, P.D.1    Shannon, K.M.2    Castleberry, R.P.3
  • 30
    • 0031026133 scopus 로고    scopus 로고
    • Cloning and characterization of Ras-GR.F2, a novel guanine nucleotide exchange factor for Ras
    • Fam NP, Fan WT, Wang Z, Zhang LJ, Chen H, Moran MF. 1997. Cloning and characterization of Ras-GR.F2, a novel guanine nucleotide exchange factor for Ras. Mol Cell Biol 17:1396-1406.
    • (1997) Mol Cell Biol , vol.17 , pp. 1396-1406
    • Fam, N.P.1    Fan, W.T.2    Wang, Z.3    Zhang, L.J.4    Chen, H.5    Moran, M.F.6
  • 33
    • 0030296550 scopus 로고    scopus 로고
    • Evidence for a Ras/Ral signaling cascade
    • Feig LA, Urano T, Cantor S. 1996. Evidence for a Ras/Ral signaling cascade. Trends Biochem Sci 21:438-441.
    • (1996) Trends Biochem Sci , vol.21 , pp. 438-441
    • Feig, L.A.1    Urano, T.2    Cantor, S.3
  • 34
    • 0025829655 scopus 로고
    • Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product
    • Finegold AA, Johnson DI, Farnsworth CC, Gelb MH, Judd SR, Glomset JA, Tamanoi F. 1991. Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product. Proc Natl Acad Sci U S A H8:4448-4452.
    • (1991) Proc Natl Acad Sci U S A , vol.H8 , pp. 4448-4452
    • Finegold, A.A.1    Johnson, D.I.2    Farnsworth, C.C.3    Gelb, M.H.4    Judd, S.R.5    Glomset, J.A.6    Tamanoi, F.7
  • 35
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PM. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.M.8
  • 36
    • 0030962347 scopus 로고    scopus 로고
    • The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
    • Gibbs JB, Oliff A. 1997. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu Rev Pharmacol Toxicol 37:143-166.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 143-166
    • Gibbs, J.B.1    Oliff, A.2
  • 37
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs JB, Oliff A, Kohl NE. 1994. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77:175-178.
    • (1994) Cell , vol.77 , pp. 175-178
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3
  • 40
    • 0031007708 scopus 로고    scopus 로고
    • Requirement of drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides
    • Guo HF, The I, Hannan F, Bernards A, Zhong Y. 1997. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276: 795-798.
    • (1997) Science , vol.276 , pp. 795-798
    • Guo, H.F.1    The, I.2    Hannan, F.3    Bernards, A.4    Zhong, Y.5
  • 41
    • 0031470405 scopus 로고    scopus 로고
    • Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice
    • Iversen P, Lewis I, Turczynowicz S, Hasle H, Niemeyer C., Schmiegelow K, Bastiras S, Biondi A, Hughes TP, Lopez AF. 1997. Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Blood 90:4910-4917.
    • (1997) Blood , vol.90 , pp. 4910-4917
    • Iversen, P.1    Lewis, I.2    Turczynowicz, S.3    Hasle, H.4    Niemeyer, C.5    Schmiegelow, K.6    Bastiras, S.7    Biondi, A.8    Hughes, T.P.9    Lopez, A.F.10
  • 42
    • 0029796382 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis in JMML cells by the granulocyte-macrophage colony-stimulating factor analogue E21R
    • Iversen P, Rodwell RL, Pitcher L, Taylor KM, Lopez AF. 1996. Inhibition of proliferation and induction of apoptosis in JMML cells by the granulocyte-macrophage colony-stimulating factor analogue E21R. Blood 88:2634-2639.
    • (1996) Blood , vol.88 , pp. 2634-2639
    • Iversen, P.1    Rodwell, R.L.2    Pitcher, L.3    Taylor, K.M.4    Lopez, A.F.5
  • 44
    • 0027211048 scopus 로고
    • Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP-Ras
    • Johnson MR, Look AT, DeClue JE, Valentine MB, Lowy DR. 1993. Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP-Ras. Proc Natl Acad Sci U S A 90:5539-5545.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5539-5545
    • Johnson, M.R.1    Look, A.T.2    DeClue, J.E.3    Valentine, M.B.4    Lowy, D.R.5
  • 46
    • 0033605596 scopus 로고    scopus 로고
    • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells
    • Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ, Young SG. 1999. Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem 274: 8383-8390.
    • (1999) J Biol Chem , vol.274 , pp. 8383-8390
    • Kim, E.1    Ambroziak, P.2    Otto, J.C.3    Taylor, B.4    Ashby, M.5    Shannon, K.6    Casey, P.J.7    Young, S.G.8
  • 51
    • 0030045594 scopus 로고    scopus 로고
    • Nf1 deficiency causes Ras-mediated granulocyte-macrophage colony stimulating factor hypersensitivity and chronic myeloid leukemia
    • Largaespada DA, Brannan CI, Jenkins NA, Copeland NG. 1996. Nf1 deficiency causes Ras-mediated granulocyte-macrophage colony stimulating factor hypersensitivity and chronic myeloid leukemia. Nature Genet 12:137-143.
    • (1996) Nature Genet , vol.12 , pp. 137-143
    • Largaespada, D.A.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4
  • 52
    • 0028272507 scopus 로고
    • Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
    • Leevers S, Peterson H, Marshall C. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411-414.
    • (1994) Nature , vol.369 , pp. 411-414
    • Leevers, S.1    Peterson, H.2    Marshall, C.3
  • 53
    • 0027468594 scopus 로고
    • Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis
    • Legius E, Marchuk DA, Collins FS, Glover TW. 1993. Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nature Genet 3:122-126.
    • (1993) Nature Genet , vol.3 , pp. 122-126
    • Legius, E.1    Marchuk, D.A.2    Collins, F.S.3    Glover, T.W.4
  • 57
    • 26744472779 scopus 로고    scopus 로고
    • Effects of farneysl transferase inhibitor (FT1) L744,832 in a RAS-activated murine myeloid leukemia model
    • Mahgoub N, Taylor B, Le Beau M, Gratiot M, Carlson K, Jackts T, Shannon KM. 1997. Effects of farneysl transferase inhibitor (FT1) L744,832 in a RAS-activated murine myeloid leukemia model. Blood 90(suppl 1): 497a.
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Mahgoub, N.1    Taylor, B.2    Le Beau, M.3    Gratiot, M.4    Carlson, K.5    Jackts, T.6    Shannon, K.M.7
  • 58
    • 0032521211 scopus 로고    scopus 로고
    • Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
    • Mangues R, Corral T, Kohl NE, Symmans, WF, Lu S, Malumbresm M, Gibbs JB. Oliff A, Pellicer A. 1998. Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res 58: 1253-1259.
    • (1998) Cancer Res , vol.58 , pp. 1253-1259
    • Mangues, R.1    Corral, T.2    Kohl, N.E.3    Symmans, W.F.4    Lu, S.5    Malumbresm, M.6    Gibbs, J.B.7    Oliff, A.8    Pellicer, A.9
  • 60
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall C. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.1
  • 61
    • 0026523616 scopus 로고
    • Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator
    • Martegani E, Vanoni M, Zippel R, Coccetti P, Brambilla R, Ferrari C, Sturani E, Alberghina L. 1992. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J 11:2151-2157.
    • (1992) EMBO J , vol.11 , pp. 2151-2157
    • Martegani, E.1    Vanoni, M.2    Zippel, R.3    Coccetti, P.4    Brambilla, R.5    Ferrari, C.6    Sturani, E.7    Alberghina, L.8
  • 62
    • 0029664925 scopus 로고    scopus 로고
    • Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein β γ subunits
    • Mattingly RR, Macara IG. 1996. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein β γ subunits. Nature 382:268-272.
    • (1996) Nature , vol.382 , pp. 268-272
    • Mattingly, R.R.1    Macara, I.G.2
  • 63
    • 0027337519 scopus 로고
    • Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase
    • Moodie SA, Willumsen BM, Weber MJ, Wolfman A. 1993. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658-1661.
    • (1993) Science , vol.260 , pp. 1658-1661
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 65
    • 0022347122 scopus 로고
    • Sarcoma viruses carrying the ras oncogene activate differentiation-associated properties of a neuronal cell line
    • Noda M, Ko M, Ogura A. 1985. Sarcoma viruses carrying the ras oncogene activate differentiation-associated properties of a neuronal cell line. Nature 318:73-75.
    • (1985) Nature , vol.318 , pp. 73-75
    • Noda, M.1    Ko, M.2    Ogura, A.3
  • 66
  • 67
    • 0023155907 scopus 로고
    • CDC25: A component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae
    • Robinson LC, Gibbs JB, Marshall MS. Sigal IS, Tatchell K. 1987. CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 235:1218-1221.
    • (1987) Science , vol.235 , pp. 1218-1221
    • Robinson, L.C.1    Gibbs, J.B.2    Marshall, M.S.3    Sigal, I.S.4    Tatchell, K.5
  • 70
    • 0027294981 scopus 로고
    • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
    • Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D. 1993. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363:83-85.
    • (1993) Nature , vol.363 , pp. 83-85
    • Rozakis-Adcock, M.1    Fernley, R.2    Wade, J.3    Pawson, T.4    Bowtell, D.5
  • 74
    • 0032530150 scopus 로고    scopus 로고
    • Endoplasmic reticulum membrane localization of Rcelp and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage
    • Schmidt WK, Tam A, Fujimura-Kamada K, Michaelis S. 1998. Endoplasmic reticulum membrane localization of Rcelp and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage. Proc Natl Acad Sci USA 95:11175-11180.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11175-11180
    • Schmidt, W.K.1    Tam, A.2    Fujimura-Kamada, K.3    Michaelis, S.4
  • 75
    • 0030871667 scopus 로고    scopus 로고
    • High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
    • Sewing A, Wiseman B, Lloyd AC, Land H. 1997. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 17:5588-5597.
    • (1997) Mol Cell Biol , vol.17 , pp. 5588-5597
    • Sewing, A.1    Wiseman, B.2    Lloyd, A.C.3    Land, H.4
  • 76
    • 0027979146 scopus 로고
    • Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders
    • Shannon KM, O'Connell P, Martin GA, Paderanga D, Olson K, Dinndorf P, McCormick F. 1994. Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med 330:597-601.
    • (1994) N Engl J Med , vol.330 , pp. 597-601
    • Shannon, K.M.1    O'Connell, P.2    Martin, G.A.3    Paderanga, D.4    Olson, K.5    Dinndorf, P.6    McCormick, F.7
  • 77
    • 0026659515 scopus 로고
    • Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
    • Shou C, Farnsworth CL, Neel BG, Feig LA. 1992. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature 358:351-354.
    • (1992) Nature , vol.358 , pp. 351-354
    • Shou, C.1    Farnsworth, C.L.2    Neel, B.G.3    Feig, L.A.4
  • 78
    • 0030947237 scopus 로고    scopus 로고
    • Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders
    • Side L, Taylor B, Cayouette M, Connor E, Thompson P, Luce M, Shannon K. 1997. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med 336: 1713-1720.
    • (1997) N Engl J Med , vol.336 , pp. 1713-1720
    • Side, L.1    Taylor, B.2    Cayouette, M.3    Connor, E.4    Thompson, P.5    Luce, M.6    Shannon, K.7
  • 80
    • 0025997867 scopus 로고
    • Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
    • Simon MA, Bowtell DDL, Dodson GS, Laverty TR, Rubin GM. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67:701-716.
    • (1991) Cell , vol.67 , pp. 701-716
    • Simon, M.A.1    Bowtell, D.D.L.2    Dodson, G.S.3    Laverty, T.R.4    Rubin, G.M.5
  • 81
    • 0024957180 scopus 로고
    • Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis: Loss of heterozygosity for chromosome 17
    • Skuse GR, Kosciolek BA, Rowley PT. 1989. Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis: loss of heterozygosity for chromosome 17. Genes Chromosom Cancer 1:36-11.
    • (1989) Genes Chromosom Cancer , vol.1 , pp. 36-111
    • Skuse, G.R.1    Kosciolek, B.A.2    Rowley, P.T.3
  • 82
    • 0028241533 scopus 로고
    • Activation of Raf as a result of recruitment to the plasma membrane
    • Stokoe D, MacDonald S, Cadwallader K, Symons M, Hancock J. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1466.
    • (1994) Science , vol.264 , pp. 1463-1466
    • Stokoe, D.1    MacDonald, S.2    Cadwallader, K.3    Symons, M.4    Hancock, J.5
  • 88
    • 0032541321 scopus 로고    scopus 로고
    • Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
    • Venkatachalam S, Shi YP, Jones SN, Vogel H, Bradley A, Pinkel D, Donehower LA. 1998. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J 17:4657-4667.
    • (1998) EMBO J , vol.17 , pp. 4657-4667
    • Venkatachalam, S.1    Shi, Y.P.2    Jones, S.N.3    Vogel, H.4    Bradley, A.5    Pinkel, D.6    Donehower, L.A.7
  • 90
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
    • (1994) J Biol Chem , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 91
    • 0029120950 scopus 로고
    • Loss of neurofibromin results in neurotropin-independent survival of embryonic sensory and sympathetic neurons
    • Vogel KS, Brannan CI, Jenkins NA, Copeland NG, Parada L. 1995. Loss of neurofibromin results in neurotropin-independent survival of embryonic sensory and sympathetic neurons. Cell 82:733-742.
    • (1995) Cell , vol.82 , pp. 733-742
    • Vogel, K.S.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4    Parada, L.5
  • 92
    • 0027250250 scopus 로고
    • Mammalian Ras interacts directly with the serine/threonine kinase Raf
    • Vojtek AB, Hollenberg SM, Cooper JA. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214.
    • (1993) Cell , vol.74 , pp. 205-214
    • Vojtek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 93
    • 0025297599 scopus 로고
    • Type 1 neurofibromatosis gene: Identification of a large transcript disrupted in three NF1 patients
    • Wallace M, Marchuk D, Andersen L, et al. 1990. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 249:181-186.
    • (1990) Science , vol.249 , pp. 181-186
    • Wallace, M.1    Marchuk, D.2    Andersen, L.3
  • 94
    • 0027200883 scopus 로고
    • Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
    • Warne PH, Viciana PR, Downward J. 1993. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 364:352-355.
    • (1993) Nature , vol.364 , pp. 352-355
    • Warne, P.H.1    Viciana, P.R.2    Downward, J.3
  • 97
    • 0031687777 scopus 로고    scopus 로고
    • Signal transduction via Ras
    • Wittinghofer A. 1998. Signal transduction via Ras. Biol Chem 379:933-937.
    • (1998) Biol Chem , vol.379 , pp. 933-937
    • Wittinghofer, A.1
  • 100
    • 0029154458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors block the neurofibromatosis type 1 (NF1) malignant phenotype
    • Yan N, Ricca C, Fletcher J, Glover T, Seizinger BR, Manne V. 1996. Farnesyltransferase inhibitors block the neurofibromatosis type 1 (NF1) malignant phenotype. Cancer Res 55:3569-3575.
    • (1996) Cancer Res , vol.55 , pp. 3569-3575
    • Yan, N.1    Ricca, C.2    Fletcher, J.3    Glover, T.4    Seizinger, B.R.5    Manne, V.6
  • 101
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R, Cooper GM. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 103
    • 0032101134 scopus 로고    scopus 로고
    • Nf1 regulates hematopoietic progenitor cell growth and Ras signaling in response to multiple cytokines
    • Zhang Y, Vik TA, Ryder JW, Srour, EF, Jacks T, Shannon K, Clapp DW. 1998. Nf1 regulates hematopoietic progenitor cell growth and Ras signaling in response to multiple cytokines. J Exp Med 187:1893-1902.
    • (1998) J Exp Med , vol.187 , pp. 1893-1902
    • Zhang, Y.1    Vik, T.A.2    Ryder, J.W.3    Srour, E.F.4    Jacks, T.5    Shannon, K.6    Clapp, D.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.