Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

Molecular and Cellular Biology

Volumn 21, Issue 23, 2001, Pages 8225-8235

  De Ruiter, N D ^a   Burgering, B M T ^a   Bos, J L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN P27; RAL PROTEIN; RAS PROTEIN; THREONINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AFX; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G1 PHASE; CELL TRANSPORT; GENETIC TRANSCRIPTION; MOUSE; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

3T3 CELLS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL NUCLEUS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAL GTP-BINDING PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035171566     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.23.8225-8235.2001     Document Type: Article

References (38)

1. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
2. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
3. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
4. Inhibition of nuclear import by protein kinase B (AKT) regulates the subcellular distribution and activity of the Forkhead transcription factor AFX
5. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
6. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases
7. Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway
8. New developments in phospholipase D
9. Evidence for a Ras/Ral signaling cascade
10. Mutations in filamin 1 prevent migration of cerebral Cortical neurons in human periventricular heterotopia
11. Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells
12. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
13. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-κB
14. Involvement of Ral GTPase in v-Src-induced phospholipase D activation
15. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
16. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
17. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
18. Direct control of the Forkhead transcription factor AFX by protein kinase B
19. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts
20. RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1
21. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
22. Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression
23. The small GTPase RalA targets filamin to induce filopodia
24. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
25. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
26. Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation
27. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
28. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
29. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
30. Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IG-FBP-1) promoter enhances promoter function
31. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation
32. Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium
33. Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells
34. A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
35. Ras caught in another affair: The exchange factors for Ral
36. Stimulation of gene induction and cell growth by the Ras effector Rlf
37. Ras-dependent activation of the small GTPase Ral
38. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1