Integration of calcium and Ras signalling

Nature Reviews Molecular Cell Biology

Volumn 3, Issue 5, 2002, Pages 339-348

  Cullen, Peter J ^a   Lockyer, Peter J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GUANOSINE TRIPHOSPHATASE; PHOSPHOLIPASE C; RAS PROTEIN;

BIOSENSOR; CALCIUM SIGNALING; ENZYME ACTIVATION; ENZYME INACTIVATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

CALCIUM; MAP KINASE SIGNALING SYSTEM; NEURONS; RAS GTPASE-ACTIVATING PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RAS-GRF1; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEINS;

EID: 0036274818     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm808     Document Type: Review

References (98)

1. 2+ signalling
2. 2+ signals
3. 2+ entry
4. 2+ signalling
5. 2+-independent pathways. Stimulation by thapsigargin and EGF
6. 2+, serum, plasma, and folic acid in the control of proliferation of normal and Rous Sarcoma Virus-infected chicken fibroblasts
7. 2+ requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells
8. 2+ signalling and cell proliferation
9. Members of the src and ras oncogene families supplant the EGF requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program
10. 2+ influx stimulate MEK and MAP kinase via activation of Ras
11. Increasing complexity of Ras signalling
12. Ras and Rap1: Two highly related small GTPases with distinct function
13. The Ras branch of small GTPases: Ras family members don't fall far from the tree
14. Understanding Ras: "It ain't over 'til it's over"
15. The many faces of Ras: Recognition of small GTP-binding proteins
16. RAFTK/Pyk2-mediated cellular signalling
17. 2+induced regulation of ion-channel and MAP kinase functions
18. A role for Pyk2 and Src in linking G-proteincoupled receptors with MAP kinase activation
19. Molecular cloning of cDNAs encoding a guanine-nucleotidereleasing factor for p21 Ras
20. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevislae RAS activator
21. Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevislae
22. 2+ activation of Ras mediated by neuronal exchange factor Ras-GRF
23. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
24. The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium
25. 2+ requires an intact DH domain
26. 2+-dependent activation of Raf
27. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways
28. Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2
29. Signal-dependent membrane targeting by pleckstrin homology (PH) domains
30. Maintenance of Cdc42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF Evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by Cdc42-GTP
31. 2+-dependent routes to Ras: Mechanisms for neuronal survival, differentiation, and plasticity?
32. A role for the Ras signalling pathway in synaptic transmission and long-term memory
33. Imprinted gene in postnatal growth role
34. Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine nucleotide releasing factor 1 (Ras-GRF1)
35. 2+ signaling, is expressed in pancreatic β cells and brain
36. 2+- and diacylglycerol-binding motifs
37. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
38. Regulation of RasGRP via a phorbol ester-responsive C1 domain
39. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
40. Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras 3
41. CaIDAG-GEFIII activation of Ras, R-Ras, and Rap1
42. Phorbol esters modulate the Ras exchange factor RasGRP3
43. 2+ in the EGF activation of MAP kinases
44. 2+ inhibits epidermal growth factor-induced activation of p21 ras in human primary keratinocytes
45. Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation
46. 2+dependent membrane phospholipid-binding domain in p120 Ras GTPase-activating protein
47. 2+-dependent phospholipid-binding (CaLB) domain within p120 Gap, a GTPase-activating protein for p21 Ras
48. 2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and p120GAP
49. Investigating the role played by protein-lipid and protein-protein interactions in the membrane association of the p120GAP CaLB domain
50. z
51. IP4BP
52. Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling
53. 2+-dependent inactivation of the Ras-MAPK pathway
54. 4-binding protein as a member of the GAP1 family
55. IP4BP domain directing plasma membrane targeting
56. IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association
57. 2+ signalling
58. 2+ compartmentalization in dendritic spines
59. 2+ regulation of neuronal gene expression
60. 2+ microdomain near NMDA receptors: On switch for ERK-dependent synapse-to-nucleus communication
61. 2+ channel-calmodulin complex through the MAP kinase pathway
62. 2+ channel
63. 2+ responses
64. 2+ signal transmission between the endoplasmic reticulum and mitochondria
65. 2+ entry requires localization in cholesterol-rich domains
66. 2+-sensitive adenylyl cyclase in an excitable cell
67. 2+ channels In hippocampal neurons
68. 2+ concentration in the endoplasmic reticulum of intact cells
69. 2+ based on green fluorescent proteins and calmodulin
70. 2+ transient specifies the magnitude of transcriptional responses
71. Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive MAPK pathway
72. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
73. 2+ response amplitude and duration
74. 2+ oscillations increase the efficiency and specificity of gene expression
75. 2+ spike frequency can optimize gene expression
76. MAPK-regulated transcription: A continously variable gene switch?
77. 2+ signals
78. 2+ oscillations
79. Spatio-temporal images of growth-factor-induced activation of Ras and Rap
80. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
81. γ12 and stimulates the Ras-MAPK pathway
82. Regulation of a novel human phospholipase C. PLCε, through membrane targeting by Ras
83. Smrcka a novel Ras effector
84. Ras effectors: Buying shares in Ras plc
85. Activation of phospholipase Cε by heterotrimeric G protein βγ-subunits
86. 2+ signalling pathway mediated by cAMP and a Rap GTPase
87. Mm exchange factor by muscarinic receptors and G-protein βγ subunits
88. Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors
89. Mm/GRF1, a guanine nucleotide exchange factor for Ras
90. Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G-protein mediated signals
91. Mm
92. Mm following phosphorylation by the non-receptor tyrosine kinase Src
93. Ras signalling on the endoplasmic reticulum and the Golgi
94. Endomembrane trafficking of Ras: The CAAX motif targets proteins to the ER and Golgi
95. RasGRP4 is a novel ras activator isolated from acute myeloid leukaemia
96. A synaptic Ras-GTPase-activating protein (p135 SynGAP) inhibited by CaM kinase II
97. The extended protein kinase C superfamily