Structural comparison of Ntn-hydrolases

Protein Science

Volumn 9, Issue 12, 2000, Pages 2329-2337

  Oinonen, C ^a   Rouvinen, J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Aspartylglucosaminidase; Glutamine amidotransferase; Glycosylasparaginase; Ntn fold; Ntn hydrolase; Penicillin acylase; Proteasome; fold

Indexed keywords

AMIDASE; GLUTAMINASE; HYDROLASE; N4 (BETA N ACETYLGLUCOSAMINYL)ASPARAGINASE; PROTEASOME;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CATALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0034495297     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.12.2329     Document Type: Article

References (28)

1. A sting in the (N-terminal) tail
2. Crystal structure of heat shock locus V (HsIV) from Escherichia coli
3. A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-Ala-esterase from Ochrobactrum anthropi
4. A protein catalytic framework with an N-terminal nucleophile is capable of self-activation
5. Sequence and structural features of the T-fold, an original tunnelling building unit
6. Penicillin acylase has a single-amino-acid catalytic centre
7. Structure of 20S proteasome from yeast at 2.4 Å resolution
8. Activation of glycosylasparaginase: Formation of active N-terminal threonine by intramolecular autoproteolysis
9. Crystal structures of Flavobaeterium glycosylasparaginase. An N-terminal nucleophile hydrolase activated by intramolecular proteolysis
10. Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: Evidence from the 1.8 Å crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase
11. Improved methods for building protein models in electron density maps and the location of errors in these models
12. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
13. Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution
14. Crystal structure of penicillin G acylase from the Bro1 mutant strain of Providencia rettgeri
15. A visual protein crystallographic software system for X11/Xview
16. Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli
17. Three-dimensional structure of human lysosomal aspartylglucosaminidase
18. A simulation of the catalytic mechanism of aspartylglucosaminidase using ab initio quantum mechanics and molecular dynamics
19. Ab initio quantum mechanical model calculations on the catalytic mechanism of aspartylglucosaminidase (AGA): A serine protease-like mechanism with an N-terminal threonine and substrateassisted catalysis
20. Multiple protein sequence alignment from tertiary structure comparison: Assignment of global and residue confidence levels
21. Autocatalytic processing of the 20S proteasome
22. Structure of the allosteric regulatory enzyme of purine biosynthesis
23. Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members
24. Functional analyses of active site residues of human lysosomal aspartylglucosaminidase: Implications for catalytic mechanism and autocatalytic activation
25. Structural insights into the mechanism of intramolecular proteolysis
26. Crystal structure of glycosylasparaginase from Flavobacterium meningosepticum
27. Critical elements in proteasome assembly