Coupling of termination, 3′ processing, and mRNA export

Molecular and Cellular Biology

Volumn 22, Issue 18, 2002, Pages 6441-6457

  Hammell, C M ^a   Gross, Stefan ^a   Zenklusen, Daniel ^a   Heath, Catherine V ^a   Stutz, Francoise ^a   Moore, Claire ^a   Cole, Charles N ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; GALACTOSE; MESSENGER RNA; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; RAFFINOSE; RNA POLYMERASE II;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FLOW CYTOMETRY; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; RNA CLEAVAGE; RNA PROCESSING; RNA TRANSCRIPTION; RNA TRANSPORT; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY; TWO HYBRID SYSTEM;

ALLELES; BIOLOGICAL TRANSPORT; CELL NUCLEUS; FLOW CYTOMETRY; FUNGAL PROTEINS; GENE DELETION; GREEN FLUORESCENT PROTEINS; KARYOPHERINS; LUMINESCENT PROTEINS; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; MUTATION; NUCLEAR PROTEINS; OPEN READING FRAMES; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINATION, GENETIC; RNA; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036723624     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.18.6441-6457.2002     Document Type: Article

References (93)

1. The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm
2. Kap104p: A karyopherin involved in the nuclear transport of messenger RNA binding proteins
3. Proteomic analysis of nucleoporin interacting proteins
4. Nuclear PRP20 protein is required for mRNA export
5. Isolation and characterization of RAT1: An essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA
6. Yeast Pab1 interacts with Rna15 and participates in the control of the poly(A) tail length in vitro
7. PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I
8. Coupling termination of transcription to messenger RNA maturation in yeast
9. Cellular localization of RNA14p and RNA15p, two yeast proteins involved in mRNA stability
10. Structure and regulation of the SSA4 HSP70 gene of Saccharomyces cerevisiae
11. Pre-mRNA processing factors are required for nuclear export
12. Deciphering the cellular pathway for transport of poly(A)-binding protein II
13. Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast
14. Regulation by HIV Rev depends upon recognition of splice sites
15. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling
16. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
17. Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA
18. Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery
19. A Ran-independent pathway for export of spliced mRNA
20. Choreographing mRNA biogenesis
21. Inefficient processing impairs release of RNA from the site of transcription
22. The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation
23. Replacement of the yeast TRP4 3′ untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail
24. Mature mRNA 3′ end formation stimulates RNA export from the nucleus
25. High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
26. Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
27. Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: Different functions for different segments of the CTD
28. Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure
29. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
30. A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes
31. Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p
32. Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor 1
33. Rna15 interaction with the a-rich yeast polyadenylation signal is an essential step in mRNA 3′-end formation
34. 3′-End-forming signals of yeast mRNA
35. 3′-End-forming signals of yeast mRNA
36. Monomethylated cap structures facilitate RNA export from the nucleus
37. Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export
38. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture
39. Quality control of mRNA 3′-end processing is linked to the nuclear exosome
40. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts
41. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
42. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
43. Role of polyadenylation in nucleocytoplasmic transport of mRNA
44. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
45. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
46. Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast
47. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
48. Leptomycin B inactivates CRM1/ exportin 1 by covalent modification at a cysteine residue in the central conserved region
49. Cse1p functions as the nuclear export receptor for importin alpha in yeast
50. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
51. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
52. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
53. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
54. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
55. Messenger RNAs are recruited for nuclear export during transcription
56. Splicing is required for rapid and efficient mRNA export in metazoans
57. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly
58. Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast
59. mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription
60. RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3′-end processing factor
61. The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3′-end formation
62. Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate: Sequence analysis reveals an RNA-binding domain in the RNA15 protein
63. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
64. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
65. mRNA splicing efficiency in yeast and the contribution of non-conserved sequences
66. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination
67. A multisubunit 3′ end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor
68. Integrating mRNA processing with transcription
69. Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae
70. Isolation of genes by complementation in yeast
71. Generating yeast transcriptional activators containing no yeast protein sequences
72. Saccharomyces cerevisiae mRNA 3′ end forming signals are also involved in transcription termination
73. Signals that produce 3′ termini in CYC1 mRNA of the yeast Saccharomyces cerevisiae
74. Distinct cis-acting signals enhance 3′ endpoint formation of CYC1 mRNA in the yeast Saccharomyces cerevisiae
75. Regulation of mRNA export in response to stress in Saccharomyces cerevisiae
76. Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
77. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
78. Getting started with yeast
79. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
80. Exportin 1 (Crm1p) is an essential nuclear export factor
81. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export
82. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p
83. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
84. TREX is a conserved complex coupling transcription with messenger RNA export
85. The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region
86. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
87. DNA sequence required for efficient transcription termination in yeast
88. Mutationally altered 3′ ends of yeast CYC1 mRNA affect transcript stability and translational efficiency
89. Nuclear export of mRNA
90. Formation of mRNA 3′ ends in eukaryotes: Mechanism, regulation, and interrelationships with other steps in mRNA synthesis
91. The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm
92. Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor
93. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans