Replacement of the yeast TRP4 3′ untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail

RNA

Volumn 8, Issue 3, 2002, Pages 336-344

  Düvel, Katrin ^a   Valerius, Oliver ^a   Mangus, David A ^a   Jacobson, Allan ^a   Braus, Gerhard H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

3 ; General control; Hammerhead ribozyme; MRNA processing; Poly(A) tail; Saccharomyces cerevisiae; Untranslated region

Indexed keywords

MESSENGER RNA; POLYADENYLIC ACID; RIBOZYME;

ALLELE; ARTICLE; BIOSYNTHESIS; CELL GROWTH; ENZYME ACTIVITY; GENETIC REGULATION; GROWTH RATE; MESSENGER RNA SYNTHESIS; NONHUMAN; POLYSOME; PRIORITY JOURNAL; RNA PROCESSING; RNA STABILITY; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; UNTRANSLATED REGION;

3' UNTRANSLATED REGIONS; ACTIVE TRANSPORT, CELL NUCLEUS; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; BINDING SITES; CELL DIVISION; GENE EXPRESSION; PLASMIDS; POLY A; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, CATALYTIC; RNA, FUNGAL; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; TRYPTOPHAN;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036230021     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838202021039     Document Type: Article

References (51)

1. Ribonuclease P
2. The structure, function and application of the hammerhead ribozyme
3. Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation
4. Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast
5. Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae
6. Self-splicing of group I introns
7. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: Different deadenylation kinetics and uncoupling from translation
8. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of yeast cell cycle
9. A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation
10. Kinetics of hairpin ribozyme cleavage in yeast
11. A single point mutation in the yeast TRP4 gene affects efficiency of mRNA 3′ end processing and alters selection of the poly(A) site
12. Mature mRNA 3′ end formation stimulates RNA export from the nucleus
13. Uncoupling of mRNA 3′ cleavage and polyadenylation by expression of a hammerhead ribozyme in yeast
14. Sequence requirements of the bidirectional yeast TRP4 mRNA 3′ end formation signal
15. A complex unidirectional signal element mediates GCN4 mRNA 3′ end formation in yeast
16. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
17. Regulation of the TRP4 gene of Saccharomyces cerevisiae at the transcriptional level and functional analysis of its promoter
18. The TRP4 gene of Saccharomyces cerevisiae: Isolation and structural analysis
19. The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency
20. Visualizing mRNA expression in plant protoplasts: Factors influencing efficient mRNA uptake and translation
21. Life with 6000 Genes
22. Control of translation initiation in animals
23. Redundant 3′ end-forming signals for the yeast CYC1 mRNA
24. Chemical analysis of microbial cells
25. Quality control of mRNA 3′-end processing is linked to the nuclear exosome
26. Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome
27. Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae
28. Poly(A) metabolism and translation: The closed loop model
29. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
30. A comparison of mammalian and yeast pre-mRNA 3′ end processing
31. Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast
32. Linking mRNA turnover and translation: Assessing the polyribosomal association of mRNA decay factors and degradative intermediates
33. Permeabilization of microorganisms by Triton X-100
34. Nuclear export of the small ribosomal sub-unit requires the ran-GTPase cycle and certain nucleoporins
35. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′-3′ digestion of the transcript
36. mRNA poly(A) tail: A 3′ enhancer of translational initiation
37. Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MATα 1 gene are involved in promoting rapid mRNA decay in yeast
38. Dual function of the messenger RNA cap structure in poly (A)-tail-promoted translation in yeast
39. Poly (A)-tail-promoted translation in yeast: Implications for translational control
40. Efficient translation of poly (A)-deficient mRNAs in Saccharomyces cerevisiae
41. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae
42. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
43. Transfer RNA biogenesis: A visa to leave the nucleus
44. Small catalytic RNAs
45. Ribozymes: The characteristics and properties of catalytic RNAs
46. A common function for mRNA 5′ and 3′ ends in translation initiation in yeast
47. Association of the yeast poly(A) tail binding protein with translation initiation factor elF-4G
48. Nuclear export receptors: From importin to exportin
49. 3′-End processing of pre-mRNA in eukaryotes
50. Formation of mRNA 3′ ends in eukaryotes: Mechanism, regulation, and interrelationships with other steps in mRNA synthesis