The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 1177-1187

  Zhao, Jian ^a,b   Jin, Shao Bo ^b   Björkroth, Birgitta ^a   Wieslander, Lars ^b   Daneholt, Bertil ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Dbp5; Pre mRNP; RNA export; RNA helicase

Indexed keywords

MESSENGER RNA; PROTEIN CT DBP5; PROTEIN DBP5; RIBONUCLEOPROTEIN; RNA HELICASE; UNCLASSIFIED DRUG;

ARTICLE; BALBIANI RING; CHIRONOMUS TENTANS; COMPLEX FORMATION; CYTOPLASM; FLY; GENE; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEAR PORE; NUCLEOTIDE SEQUENCE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN RNA BINDING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RNA TRANSPORT; TRANSCRIPTION REGULATION;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CHIRONOMIDAE; CHROMOSOMES; CYTOPLASM; DEAD-BOX RNA HELICASES; GALACTOSE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAT; HUMANS; INSECT PROTEINS; LARVA; MOLECULAR SEQUENCE DATA; NUCLEAR PORE; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; RIBONUCLEOPROTEINS; RNA HELICASES; RNA, MESSENGER; RNA-BINDING PROTEINS; SALIVARY GLANDS; SALIVARY PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STRESS; TRANSCRIPTION, GENETIC;

ARACHNIDA; CHIRONOMUS TENTANS; DIPTERA; HEXAPODA;

EID: 0036500482     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.1177     Document Type: Article

References (42)

1. A protein of the SR family of splicing factors binds extensively to exonic Balbiani ring pre-mRNA and accompanies the RNA from the gene to the nuclear pore
2. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
3. Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription
4. Demonstration of a dynamic, transcription-dependent organization of pre-mRNA splicing factors in polytene nuclei
5. mRNA export: The long and winding road
6. A look at messenger RNP moving through the nuclear pore
7. hnRNP proteins and the biogenesis of mRNA
8. Transport between the cell nucleus and the cytoplasm
9. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
10. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular structure
11. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Glelp and suppresses the mRNA export defect of xpol-1 cells
12. The DExH protein NPH-II is a processive and directional motor for unwinding RNA
13. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
14. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
15. Assembly and disassembly of spliceosomes along a specific pre-messenger RNP fiber
16. hnRNP complexes: Composition, structure and function
17. The spliceosome deposits multiple proteins 20-24 nucleotides-upstream of mRNA exon-exon junctions
18. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and non-sense-mediated mRNA decay
19. + RNA export
20. The protein family of RNA helicases
21. Splicing is required for rapid and efficient mRNA export in metazoans
22. Nucleocytoplasmic transport: The soluble phase
23. Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscopy tomography
24. Transport of proteins and RNAs in and out of the nucleus
25. Nucleocytoplasmic transport: Signals, mechanics and regulation
26. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
27. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
28. Transcription of heat shock gene loci versus non-heat shock loci in Chironomus tentans polytene chromosomes: Evidence for heat-induced formation of novel putative ribonucleoprotein particles (hsRNPs) in the major heat shock puffs
29. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
30. + RNA and nuclear pores
31. Visualization of the formation and transport of a specific hnRNP particle
32. Three-dimensional structure of a specific pre-messenger RNP particle established by electron microscope tomography
33. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
34. The RNA export factor Glelp is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Riplp, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p
35. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
36. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
37. The hrp23 protein in the Balbiani ring pre-mRNP particles is released just before or at the binding of the particles to the nuclear pore complex
38. + RNA export
39. A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
40. A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export
41. Nuclear export of mRNA
42. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans