Historical and current highlights in radiation biology: Has anything important been learned by irradiating cells?

Radiation Research

Volumn 158, Issue 3, 2002, Pages 251-291

  Bedford, Joel S ^a   Dewey, William C ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEIC ACID;

CARCINOGENESIS; CELL CYCLE; CELL IRRADIATION; CLINICAL RESEARCH; CYTOGENETICS; DNA REPAIR; GENETIC REGULATION; HUMAN; IRRADIATION; MOLECULAR BIOLOGY; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PHENOMENOLOGY; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION RESPONSE; RADIOBIOLOGY; RADIOSENSITIVITY; REVIEW; ANIMAL; ART; ARTICLE; CELL; GENE; GENETICS; HEALTH CARE ORGANIZATION; HISTORY; MICROBIAL GENETICS; NON-PROGRAMMATIC; RADIATION EXPOSURE; RADIATION INJURY;

ANIMALIA;

NON-PROGRAMMATIC;

ANIMALS; CELLS; DNA; GENES; GENETICS, MICROBIAL; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; NEOPLASMS, RADIATION-INDUCED; PORTRAITS; RADIATION GENETICS; RADIATION INJURIES, EXPERIMENTAL; RADIOBIOLOGY; SOCIETIES, SCIENTIFIC;

EID: 0036715867     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)158[0251:HACHIR]2.0.CO;2     Document Type: Review

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110. Relationship between the recovery from sublethal x-ray damage and the rejoining of chromosome breaks in normal human fibroblasts
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113. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts
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123. The relationship of DNA and chromosome damage to survival of synchronized x-irradiated L 5178Y cells. I. Initial damage
124. Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay
125. DNA double strand breaks in Ehrlich ascites tumour cells at low doses of x-rays. II. Can cell death be attributed to double strand breaks?
126. Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells
127. 0 cells immediately after exposure to gamma-rays
128. Ionizing radiation induces two forms of interphase 1 chromosome breaks in Chinese hamster ovary cells that rejoin with different kinetics and show different sensitivity to treatment in hypertonic medium or beta-araA
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130. Effects of X-irradiation on cell cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia
131. The accurate estimation of chromatid breakage and its relevance to a new interpretation of chromatid aberrations induced by ionizing radiations
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133. New Giemsa method for the differential staining of sister chromatids
134. The induction of chromatid deletions in accord with the breakage- and-reunion hypothesis
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155. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
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158. Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries
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160. Chromosomal radiosensitivity at intrachromosomal telomeric sites
161. COFISH reveals inversions associated with isochromosome formation
162. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
163. Analysis of naturally occurring and radiation-induced breakpoint locations in human chromosomes 1, 2 and 4
164. Noninvolvement of the X chromosome in radiation-induced chromosome translocations in the human lymphoblastoid cell line TK 6
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166. The theory of dual radiation action
167. Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization
168. Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting
169. A proposed system for scoring structural aberrations detected by chromosome painting
170. Radiation-induced damage and the formation of chromosomal aberrations
171. Nomenclature systems for FISHpainted chromosome aberrations
172. FISH "painting" patterns resulting from complex exchanges
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174. Random breakage and reunion chromosome aberration formation model; an interaction-distance version based on chromatin geometry
175. Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles
176. 238Pu alpha-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes
177. Ultrasoft 1.5 keV aluminum K X rays are efficient producers of complex chromosome exchange aberrations as revealed by fluorescence in situ hybridization
178. The induction of chromosome exchange aberrations by carbon ultrasoft X-rays in V 79 hamster cells
179. Testing the notion of the one-hit exchange
180. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine
181. A new pathway for DNA repair in Escherichia coli
182. The adaptive response in radiobiology: Evolving insights and implications
183. Possible causes of variability of the adaptive response in human lymphocytes
184. 3H]-thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves induction of a chromosomal repair mechanism
185. Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA
186. The adaptive response to very low doses of ionizing radiation
187. Induction of the adaptive response by X-rays is dependent on radiation intensity
188. Evidence for induced radioresistance from survival and other end points: An introduction
189. Adaptive response of human lymphocytes to low level radiation from radioisotopes or X-rays
190. L cells
191. Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays
192. Cytogenetic adaptive response of cultured fish cells to low doses of X-rays
193. Combined application of MH and TEM for conditioning treatment simultaneously triggers two protective functions against induction of chromatid aberrations in Vicia faba root tip meristem cells
194. Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells
195. The dose response relation in radiation-induced cancer
196. Further observations on induction of tumors in mice with radioactive thymidine
197. Cell retention and incidence of carcinoma in several portions of the gastrointestinal tract
198. Radiation biology and cancer
199. Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere-like sequences and chromosome 2 fragile sites
200. The role of DNA repeats and associated secondary structures in genomic instability and neoplasia
201. Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12
202. Murine radiation myeloid leukaemogenesis: A possible role for radiation sensitive sites on chromosome 2
203. Induction of mammary neoplasms in the Sprague-Dawley rat by 430-keV neutrons and X-rays
204. Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons
205. Myeloid leukemia in male RFM mice following irradiation with fission spectrum neutrons or gamma rays
206. Radiation carcinogenesis: Time-dose relationships
207. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation
208. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white
209. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse
210. Radiation-induced instability and its relation to radiation carcinogenesis
211. Radiation induced cytogenetic instability in vivo
212. Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene
213. Problems in experimental tumorigenesis of the pituitary gland, gonads, adrenal cortices and mammary glands: A review
214. A quantitative dose-response study of lymphoid tumor development in irradiated C 57 black mice
215. Radiation-induced lymphoid tumors of mice
216. Establishment and characterization of a cloned line of C 3H mouse embryo cells sensitive to postconfluence inhibition of division
217. Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro
218. Transformation of mammalian cells in vitro by low doses of X-rays
219. X-radiation-induced transformation in a C3H mouse embryo-derived cell line
220. Transformation of mouse C3H10T1/2 cells by single and fractionated doses of x rays and fission-spectrum neutrons
221. Relationship between x-ray exposure and malignant transformation of C3H 10T1/2 cells
222. Malignant transformation in cultured hamster embryo cells produced by X-rays, 460-keV monoenergetic neutrons and heavy ions
223. The inverse dose-rate effect for oncogenic transformation by neutrons and charged particles: A plausible interpretation consistent with the published data
224. Oncogenic transformation by charged particles of defined LET
225. 60Co gamma rays
226. 60Co gamma rays reduces neoplastic transformation in vitro
227. Timing of the steps in transformation of C3H 10T1/2 cells by X-irradiation
228. Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation
229. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
230. In vitro radiation-induced neoplastic progression of low-grade uroepithelial tumors
231. The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line
232. The influence of interstitial telomeric sequences on chromosome instability in human cells
233. Comments on "Telomere-mediated chromosome healing"
234. Role of induced genetic instability in the mutagenic effects of chemicals and radiation
235. Strand-specific postreplicative processing of mammalian telomeres
236. On some biological effects of radiation. The Mackenzie Davidson Memorial Lecture
237. Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC 3H mice
238. Dynamics of neoplastic development in carcinogen-exposed tracheal mucosa
239. Detection of ductal dysplasia in mammary outgrowths derived from carcinogen-treated virgin female BALB/c mice
240. Morphological and histological characteristics of mammary dysplasias occurring in cell dissociation-derived murine mammary outgrowths
241. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c mice exposed in vivo to gamma-radiation and/or 7,12-dimethylbenz[a]anthracene
242. Induction of chromosomal instability in human mammary cells by neutrons and gamma rays
243. Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion
244. Modification of expression of the malignant phenotype in radiation-initiated cells
245. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues
246. Latency and activation in the control of TGF-β
247. Transforming growth factorβ and breast cancer: Mammary gland development
248. It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
249. Extracellular signaling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability
250. Genetic effects of X-rays in maize
251. Über mehrpolige mitosen als mittel zur. Analyse des zellkerns
252. Frameshift mutagenesis in Salmonella
253. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
254. An interesting state of affairs in genetic toxicology
255. Molecular cytogenetics: Rosetta stone for understanding cancer-twenty-ninth G. H. A. Clowes Memorial Award Lecture
256. A minute chromosome in human granulocytic leukemia
257. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescent and Giemsa staining
258. Chromosome translocations and human cancer
259. Chromosome translocations and human cancer
260. Role of chromosome translocations in human neoplasia
261. Mutation and cancer: Statistical study of retinoblastoma
262. Retinoblastoma and subband deletion of chromosome 13
263. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
264. Loss of heterozygosity in stages of malignancy
265. A genetic model for colorectal tumorigenesis
266. Many gene changes found in cancer
267. Comparative painting of mammalian chromosomes
268. Conservation of chromosome 1 in turtles over 66 million years
269. Genetic constitutions of host and pathogen in mouse typhoid
270. The clonal evolution of tumor cell populations
271. Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation
272. Transmission of chromosomal instability after plutonium α-particle irradiation
273. Radiation-induced genomic instability: Delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells
274. Chromosomal instability and its relationship to other end points of genomic instability
275. Radiationinduced genomic instability: Delayed mutagenic and cytogenetic effects of X rays and alpha particles
276. Delayed chromosomal instability induced by DNA damage
277. Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts?
278. A role for genomic instability in cellular radioresistance?
279. Genomic instability induced by ionizing radiation
280. Expression of lethal mutations is suppressed in neoplastically transformed cells and after treatment of normal cells with carcinogens
281. Role of induced genetic instability in the mutagenic effects of chemicals and radiation
282. Induction of chromosomal instability in human mammary cells by neutrons and gamma rays
283. Chromosomal instability and alterations of telomeric repeats in irradiated human fibroblasts
284. Delayed mutation in Chinese hamster cells
285. 137CS gamma rays or HZE-Fe ions
286. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability
287. 224Ra alpha particles
288. α-particle-induced chromosomal instability in human bone marrow cells
289. No evidence for chromosomal instability in radiation workers with in vivo exposure to plutonium
290. Effect of visible light on the recovery of Streptomyces griseus conidia from ultra-violet irradiation injury
291. Photoreactivation of transforming DNA by an enzyme from baker's yeast
292. Photoreactivation of ultravioletinduced chromosomal aberrations
293. DNA repair in bacteria and mammalian cells
294. The disappearance of thymine dimers from DNA: An error-correcting mechanism
295. Release of ultraviolet lightinduced thymine dimers from DNA in E. coli K-12
296. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues
297. A mammalian endonuclease specific for apurinic sites in double-stranded deoxyribonucleic acid. II. Further studies on the substrate specificity
298. A mammalian endonuclease specific for apurinic sites in double-stranded deoxyribonucleic acid. I. Purification and general properties
299. Controlling the efficiency of excision repair
300. DNA mismatch correction
301. Mismatch repair and genetic stability in human cells
302. Mechanisms of DNA-mismatch correction
303. The human mutator gene homolog MSH 2 and its association with hereditary nonpolyposis colon cancer
304. Reconstruction in vivo of irradiated Escherichia coli deoxyribonucleic acid; The rejoining of broken pieces
305. Rejoining of x-ray induced breaks in the DNA of leukaemia cells
306. DNA-strand breaks and rejoining following exposure of synchronized Chinese hamster cells to ionizing radiations
307. Effects of hyperthermia on repair of radiation-induced DNA strand breaks
308. DNA double-strand breaks measured in individual cells subjected to gel electrophoresis
309. The role of DNA single- and double-strand breaks in cell killing by ionizing radiation
310. Visualization of DNA loops in nucleoids from HeLa cells: Assays for DNA damage and repair
311. DNA repair in a Fanconi's anemia fibroblast cell strain
312. Comet assay in human biomonitoring studies: Reliability, validation, and applications
313. Biochemistry of DNA lesions
314. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation and reparability
315. The complexity of DNA damage: Relevance to biological consequences
316. CHEF electrophoresis, a sensitive technique for the determination of DNA doublestrand breaks
317. An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules
318. Measurement of radiation-induced DNA double strand breaks by pulsed-field gel electrophoresis
319. Two methods for assaying DNA double-strand break repair in mammalian cells by asymmetric field inversion gel electrophoresis
320. Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells
321. Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines
322. An ionizing radiation-sensitive mutant of CHO cells: irs-20. III. Chromosome aberrations, DNA breaks and mitotic delay
323. DNA double strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual NotI fragments by hybridization
324. DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method
325. Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts
326. Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts
327. The repair of double-strand breaks in DNA: A model involving recombination
328. The double-strand-break repair model for recombination
329. Transcriptional activation functions in BRCA 2
330. Emerging roles of BRCA 1 in transcriptional regulation and DNA repair
331. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
332. Impairment of V(D)J recombination in double-strand break repair mutants
333. VDJ recombination
334. Defective repair replications of DNA in xeroderma pigmentosum
335. Xeroderma pigmentosum: A human disease in which an initial stage of DNA repair is defective
336. A summary of mutations in the UV-sensitive disorders: Xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy
337. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre 11 relocalization
338. Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum
339. Genes required for ionizing radiation resistance in yeast
340. Ataxia telangiectasia: A human mutation with abnormal radiation sensitivity
341. Ataxia-telangiectasia: Chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
342. Networking cellular responses to DNA damage
343. The genetic defect in ataxia-telangiectasia
344. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
345. The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p 53 induction
346. Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line
347. Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs
348. Hypersensitivity to ionizing radiation, in vitro, in a new chromosomal breakage disorder, the Nijmegen breakage syndrome
349. The mammalian Mre11-Rad50-nbs1 protein complex: Integration of functions in the cellular DNA-damage response
350. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
351. Isolation of a cell cycle-dependent gamma-ray sensitive Chinese hamster ovary cell
352. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V (D)J recombination
353. X-ray-sensitive mutants of Chinese hamster ovary cell line, isolation and cross sensitivity to other DNA damaging agents
354. Studies on mammalian mutants defective in rejoining double-strand breaks in DNA
355. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
356. An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization
357. Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20
358. An ionizing radiation-sensitive mutant of CHO cells: irs-20. II. Dose-rate effects and cellular recovery processes
359. Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD 52 epistasis group
360. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
361. The Rad 51 paralog Rad51B promotes homologous recombinational repair
362. Radiobiologic principles
363. Radiation biology: The conceptual and practical impact on radiation therapy
364. Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells
365. Interpretation de quelques resultats de la radiotherapie et essai de fixation d'une technique rationnelle
366. Action of radiation on mammalian cells. III. Relationship between reproductive death and induction of chromosome anomalies by X-irradiation of euploid human cells in vitro
367. Chromosomal aberrations and mortality of x-irradiated mammalian cells: Emphasis on repair
368. Radiation-induced cellular reproductive death and chromosome aberrations
369. Uber einige wirkungen von strahlen, II
370. Uber einige wirkungen von strahlen, I
371. Low voltage electron beam irradiation of normal and 5-bromouridine deoxyriboside-treated L-P59 mouse fibroblast cells in vitro
372. The relative radiosensitivity of the nucleus and cytoplasm of Chinese hamster fibroblasts
373. Radionuclide toxicity in cultured mammalian cells. Elucidation of the primary site for radiation-induced division delay
374. The nucleus is the target for radiation-induced chromosomal instability
375. A direct measure of the radiation sensitivity of normal mouse bone marrow cells
376. The dose-survival relationship for irradiation of epithelial cells of mouse skin
377. Dose-survival characteristics of epithelial cells of mouse intestinal mucosa
378. Method of constructing a doseresponse curve for normal cells in situ
379. A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells
380. Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system
381. Evidence for recovery from X-ray damage in Chlamydomonas
382. X-ray damage and recovery in mammalian cells in culture
383. Radiation response of mammalian cells grown in culture. I. Repair of x-ray damage in surviving Chinese hamster cells
384. Survival of HeLa cells cultured in vitro and exposed to protracted gamma radiation
385. Dose-rate: Its effect on the survival of HeLa cells irradiated with gamma rays
386. Dose-rate effects in synchronous mammalian cells in culture
387. 1/2 cells
388. Dose fractionation effects in plateau phase cultures of C3H 10T1/ 2 cells
389. Effect of dose fractionation on early and late skin responses to gamma-rays and neutrons
390. Lethal and sublethal cellular injury in multifraction irradiation
391. Response of mouse jejunal crypt cells to low dose rate irradiation with Californium neutrons or radium gamma-rays
392. Radiosensitivity and fractionation response of crypt cells of mouse jejunum
393. Neutron therapy and specific ionization. Janeway Memorial Lecture
394. Beitrage zur biologie der strahlenwirkung
395. Zur kenntnis der bedingungen der biologischen wirkung der roentgenstrahlen
396. Action of radium on cancer cells: Some factors affecting susceptibility of cancer cells to radium
397. Influence of oxygen tension on x-ray-induced chromosomal damage in Ehrlich ascites tumor cells irradiated in vitro and in vivo
398. A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated in vivo
399. Histological structure of some human lung cancers and possible implications for radiotherapy
400. Hypoxic cell radiosensitizers: The end of an era?
401. Keynote address: Hypoxic cell radiosensitizers: Where next?
402. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
403. The exceptionally small size of the scrapie agent
404. Synthesis of deoxyribonucleic acid in normal and irradiated cells and its relation to chromosome breakage
405. X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells
406. Interaction of heat with radiation and chemotherapy
407. The effect of hypoxia on the growth and radiation response of mammalian cells in culture
408. Dose-rate effects in synchronous mammalian cells in culture. II. A comparison of the life cycle of HeLa cells during continuous irradiation or multiple-dose fractionation
409. The cell cycle dependence of thermotolerance: I. CHO cells heated at 42°C
410. Effect of X-rays on time of first cleavage in arabica eggs
411. Effect of gamma-rays on mitosis in vitro
412. Influence of X-rays on cell division. Part I
413. Effects of X-rays on chick tissue in culture
414. Effects of beta-rays upon division and growth of cancer cells
415. Action of radiation on mammalian cells, IV. Reversible mitotic lag in the S3 HeLa cell produced by low doses of X-rays
416. Radiation-induced division delay in synchronized Chinese hamster ovary cells in monolayer culture
417. Use of the mitotic selection procedure for cell cycle analysis: Emphasis on radiation-induced mitotic delay
418. Variations in several responses of HeLa cells to X-irradiation during the division cycle
419. Time, cells and X rays
420. Delayed initiation of DNA synthesis in irradiated human diploid cells
421. Participation of p 53 protein in the cellular response to DNA damage
422. Wildtype p 53 is a cell cycle checkpoint determinant following irradiation
423. Checkpoints: Controls that ensure the order of cell cycle events
424. Cell cycle control and cancer
425. 1 phase arrest and p 53 function in human tumor cells
426. + human tumor cells synchronized by mitotic selection
427. Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p 53 mutant cell lines
428. Electronic separation of biological cells by volume
429. The LLNL high-speed sorter: Design features, operational characteristics, and biological utility
430. Flow karyotyping and sorting of human chromosomes
431. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization
432. Cytogenetic analysis by in situ hybridization with fluorescently labeled nucleic acid probes
433. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
434. Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival
435. Relationship between chromosome damage and cell death
436. 1 arrest and long-term induction of Cip 1 in normal human fibroblasts
437. Effect of radiation on DNA synthesis in mammalian cells
438. Deficient DNA synthesis and mitotic death in x-irradiated HeLa cells
439. Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro
440. Combined hyperthermia and radiation suggest and alternative to heavy particle therapy for reduced oxygen enhancement ratios
441. Rationale for use of hyperthermia in cancer therapy
442. Effect of pH on hyperthermic cell survival
443. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials
444. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost ± hyperthermia for glioblastoma multiforme
445. Modulation of thermal induction of hsp 70 expression by Ku autoantigen or its individual subunits
446. Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
447. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
448. Radiation-induced apoptosis: Relevance to radiotherapy
449. DNA damage can induce apoptosis in proliferating lymphoid cells via p53- independent mechanisms inhibitable by Bcl-2
450. Characterization of radiation-induced apoptosis in rodent cell lines
451. Radiation-induced signal transduction and stress response
452. Computerized video time-lapse microscopy studies of ionizing radiationinduced rapid-interphase and mitosis-related apoptosis in lymphoid cells
453. Using computerized video time lapse for quantifying cell death of X-irradiated rat embryo cells transfected with c-myc or c-Ha-ras
454. Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behavior of sister cells
455. DNA damage enables p73
456. Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis
457. Bax-induced caspase activation and apoptosis via cytochrome C release from mitochondria is inhibitable by Bcl-xL
458. Apoptosis. An endonuclease at last
459. Apoptosis, p 53 and tumor cell sensitivity to anticancer agents
460. Molecular Biology to Radiation Oncology: A Model for Translational Research? Opportunities in basic and translational research