Expression of lethal mutations is suppressed in neoplastically transformed cells and after treatment of normal cells with carcinogens

Radiation Research

Volumn 145, Issue 6, 1996, Pages 714-721

  Mothersill, C ^a   Lyng, F ^a   O'Reilly, S ^a   Harney, J ^b   Seymour, C B ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CANCER; CHEMICAL CARCINOGENESIS; GENETIC STABILITY; HUMAN; HUMAN CELL; LETHAL MUTANT; ONCOGENE RAS; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CARCINOGENS; CELL LINE; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; COBALT RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; GENES, LETHAL; GENES, RAS; HUMANS; KERATINOCYTES; MICE; MICE, INBRED C3H; MUTAGENESIS; NITROSAMINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; URINARY TRACT;

EID: 0029951490     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579362     Document Type: Article

References (30)

1. B. A. Marder and W. F. Morgan, Delayed chromosomal instability induced by DNA damage. Mol. Cell Biol. 13, 6667-6677 (1993).
2. M. A. Kadhim, S. A. Lorimore, K. M. S. Townsend, D. T. Goodhead, V. J. Buckle and E. G. Wright, Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol., in press.
3. M. Durante, G. F. Grossi and T. C. Yang, Radiation-induced chromosomal instability in human mammary epithelial cells. Adv. Space Res. 18, (1/2)99-(1/2)108 (1996).
4. F. M. Lyng, S. O'Reilly, C. B. Seymour and C. E. Mothersill, Morphological evidence of radiation induced delayed apoptosis in the distant progeny of irradiated cells. Radiat. Environ. Biophys., in press.
5. C. B. Seymour, C. Mothersill and T. Alper, High yields of lethal mutations in somatic cells that survive ionizing radiation. Int. J. Radiat. Biol. 50, 167-179 (1986).
6. W. P. Chang and J. B. Little, Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation. Carcinogenesis 13, 923-928 (1992).
7. M. S. Mendonca, R. J. Antoniono and J. L. Redpath, Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells. Radiat. Res. 134, 209-216 (1993).
8. J. Z. Beer and I. Szumiel, Slow clones, reduced clonigenicity and intra-clonal recovery in X-irradiated L5178-S cell cultures. Radiat. Environ. Biophys. 33, 125-139 (1994).
9. A. Chatterjee, R. J. Hodgekiss and A. Rojas, The contribution of lethal mutations to excision assays for tumour cell survival. Acta Oncol. 34, 493-498 (1996).
10. C. B. Seymour and C. Mothersill, All colonies of CHO-K1 cells surviving γ-irradiation contain non-viable cells. Mutat. Res. 267, 19-30 (1992).
11. T. Stamato, R. Weinstein, B. Peters, J. Hu and A. Giaccia, Delayed mutation in Chinese hamster cells. Somat. Cell Mol. Genet. 13, 57-66 (1987).
12. C. B. Seymour and C. Mothersill, Lethal mutations, the survival curve shoulder and split-dose recovery. Int. J. Radiat. Biol. 56, 999-1010 (1989).
13. S. O'Reilly, C. Mothersill and C. B. Seymour, Post-irradiation expression of lethal mutations in an immortalised human keratinocyte cell line. Int. J. Radiat. Biol. 66, 77-83 (1994).
14. C. Mothersill, A. Cusack and C. B. Seymour, Enhanced proliferation of cells from human tissue explants following irradiation in the presence of environmental carcinogens. Radiat. Environ. Biophys. 28, 203-212 (1989).
15. F. M. Lyng, H. L. deFeijter-Rupp, T. Hayashi, J. Harney, D. M. Murphy, D. C. Cottell, J. E. Trosko and C. Mothersill, Nitrosamines. including one found in the urine of smokers, block intercellular communication in normal human urothelial cells in vitro. Cancer Epidemiol. Biomarkers Prevention, in press.
16. L. Pirisi, K. E. Creek, J. Doniger and J. A. DiPaolo, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papilloma virus type 16 DNA. Carcinogenesis 9, 1573-1579 (1988).
17. C. A. Reznikoff, D. W. Brankow and C. Heidelberger, Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to post-confluence inhibition of division. Cancer Res. 33, 3231-3238 (1973).
18. C. Mothersill, J. Harney, F. Lyng, D. Cottell and C. B. Seymour, Primary explants of normal human uroepithelium show an unusual response to low doses of cobalt-60 gamma rays. Radiat. Res. 142, 177-183 (1995).
19. T. T. Puck and P. I. Marcus, Action of X-rays on mammalian cells. J. Exp. Med. 103, 653-666 (1956).
20. J. F. R. Kerr and B. V. Harmon, Definition and incidence of apoptosis: an historical perspective. In Apoptosis: The Molecular Basis of Cell Death (L. D. Tomei and F. O. Cope, Eds.), pp. 5-29. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1991.
21. C. Mothersill and C. B. Seymour, The influence of lethal mutations on the quantification of radiation transformation frequencies. Int. J. Radiat. Biol. 51, 723-729 (1987).
22. B. A. Werness, A. J. Levine and P. M. Howley, Association of human papilloma virus type 16 and 18 E6 proteins with p53. Science 248, 76-79 (1990).
23. E. J. Hall, Radiobiology for the Radiologist, 4th ed. J. B. Lippincott, Philadelphia, 1994.
24. S. Neale and A. K. Solt, Factors affecting the induction of bacterial mutations by dimethylnitrosamine in mice. Chem. Biol. Interact. 31, 221-225 (1976).
25. D. P. Lane, A death in the life of p53. Nature 362, 786-787 (1993). [News; Comment]
26. W. J. Slichenmyer, W. J. Nelson, R. J. Slebbos and M. B. Kasten, Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53, 4164-4168 (1993).
27. A. J. Wagner, M. B. Small and N. Hay, Myc-mediated apoptosis is blocked by ectopic expression of bcl-2. Mol. Cell. Biol. 13, 2432-2440 (1993).
28. D. F. Spandau, Distinct conformations of p53 are observed at different stages of keratinocyte differentiation. Oncogene 9, 1861-1868 (1994).
29. J. C. Reed, Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6 (1994).
30. C. Mothersill, J. Harney and C. B. Seymour, Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human uroepithelium by radiation and N-nitrosodiethanolamine. Radiat. Res. 138, 93-98 (1994).