Role of induced genetic instability in the mutagenic effects of chemicals and radiation

Mutation Research - Genetic Toxicology

Volumn 367, Issue 1, 1996, Pages 11-23

  Murnane, John P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CHEMICAL AGENT;

CANCER; CHROMOSOME REARRANGEMENT; DNA DAMAGE; GENETIC DISORDER; GENETIC STABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; POINT MUTATION; PRIORITY JOURNAL; RADIATION; REVIEW;

EID: 0030042134     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90017-8     Document Type: Article

References (160)

1. Alper, T., C. Mothersill and C.B. Seymour (1988) Lethal mutations attributable to misrepair of Q-lesions, Int. J. Radiat. Biol., 54, 525-530.
2. Alvarez, L., J.W. Evans, R. Wilks, J.N. Lucas, J.M. Brown and A.J. Giaccia (1993) Chromosomal radiosensitivity at intrachromosomal telomeric sites, Genes Chrom. Cancer, 8, 8-14.
3. Antequera, F., J. Boyes and A. Bird (1990) High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines, Cell, 62, 503-514.
4. Ashley, T. and D.C. Ward (1993) A 'hot spot' of recombination coincides with an interstitial telomeric sequence in the Armenian hamster, Cytogenet. Cell Genet., 62, 169-171.
5. Bakalkin, G., T. Yakovleva, G. Selivanova, K.P. Magnusson, L. Szekely, E. Kiseleva, G. Klein, L. Terenius and K.G. Wiman (1994) p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer, Proc. Natl. Acad. Sci. USA, 91, 413-417.
6. Barnes, D.E., A.E. Tomkinson, A.R. Lehmann, A.D.B. Webster and T. Lindahl (1992) Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents, Cell, 69, 495-503.
7. Baylin, S.B., M. Makos, J.J. Wu, R.-W.C. Yen, A. de Bustros, P. Vertino and B.D. Nelkin (1991) Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression, Cancer Cells, 3, 383-390.
8. Bender, M.A., R.J. Preston, R.C. Leonard, B.E. Pyatt and P.C. Gooch (1989) Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of age range, Mutation Res., 212, 149-154.
9. Benn, P.A. (1976) Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos, Am. J. Hum. Genet., 28, 465-473.
10. Bischoff, F.Z., S.O. Yim, S. Pathak, G. Grant, M.J. Siciliano, B.C. Giovanella, L.C. Strong and M.A. Tainsky (1990) Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuplotdy and immortalization, Cancer Res., 50, 7979-7984.
11. Bootsma, D., G. Weeda, W. Vermeulen, H. van Vuuren, C. Troelstra, P. van der Spek and J. Hoeijmakers (1995) Nucleotide excision repair syndromes: molecular basis and clinical symptoms, Phil. Trans. R. Soc. London (B), 347, 75-81.
12. Bouffler, S., A. Silver, D. Papworth, J. Coates and R. Cox (1993) Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere-like sequences and chromosome 2 fragile sites, Genes Chrom. Cancer, 6, 98-106.
13. Brown, W.M., K.E. Buckton, A.O. Langlands and G.E. Woodcock (1967) The identification of lymphocyte clones, with chromosome structural aberrations, in irradiated men and women, Int. J. Radiat. Biol, 13, 155-169.
14. Caldecott, K.W., C.K. McKeown, J.D. Tucker, S. Ljungquist and L.H. Thompson (1994) An interaction between the mammalian DNA repair protein XRCCl and DNA ligase III, Mol. Cell. Biol., 14, 68-76.
15. Carrano, A.V., J. Minkler and D. Piluso (1975) On the fate of stable chromosomal aberrations, Mutation Res., 30, 153-156.
16. Cedar, H. (1988) DNA methylation and gene activity, Cell, 53, 3-4.
17. Chang, W.P. and J.B. Little (1991) Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol., 60, 483-496.
18. Chang, W.P. and B.J. Little (1992a) Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation, Carcinogenesis, 13, 923-928.
19. Chang, W.P. and J.B. Little (1992b) Evidence that DNA doublestrand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells, Radiat. Res., 131, 53-59.
20. Chang, W.P. and J.B. Little (1992c) Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype, Mutation Res., 270, 191-199.
21. Cheng, K.C. and L.A. Loeb (1993) Genomic instability and tumor progression: mechanistic considerations, Adv. Cancer Res., 60, 121-156.
22. Clarke, A.R., C.A. Purdie, D.J. Harrison, R.G. Morris. C.C. Bird, M.L. Hooper and A.H. Wyllie (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways, Nature, 362, 849-852.
23. Conrad, M.N., J.H. Wright, A.J. Wolf and V.A. Zakian (1990) RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability, Cell, 63, 739-750.
24. Cornforth, M.N. and J.S. Bedford (1985) On the nature of a defect in cells from individuals with ataxia-telangiectasia, Science, 227, 1589-1591.
25. Counter, C.M., A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley and S. Bacchetti (1992) Telomere short-ening associated with chromosome instability is arrested in immortal cells which express telomerase activity, EMBO J., 11, 1921-1929.
26. Cox, R., W.K. Masson, R.R. Weichselbaum, J. Nove and J.B. Little (1981) The repair of potentially lethal damage in X-irradiated cultures of normal and ataxia telangiectasia human fibroblasts, Int. J. Radiat. Biol., 39, 357-365.
27. de Lange, T., L. Shiue, R.M. Myers, D.R. Cox, S.L. Naylor, A.M. Killery and H.E. Varmus (1990) Structure and variability of human chromosome ends, Mol. Cell. Biol., 10, 518-527.
28. CIP1/WAF1 undergo normal development, but are defective in Gl checkpoint control, Cell, 82, 675-684.
29. 1 arrest and long-term induction of Cip1 in normal human fibroblasts, Genes Dev., 8, 2540-2551.
30. dos Santos, C.C., H. Gavish and M. Buchwald (1994) Fanconi anemia revisited: old ideas and new advances, Stem Cells, 12, 142-153.
31. Dracopoli, N.C., A.N. Houghton and L.J. Old (1985) Loss of polymorphic restriction fragments in malignant melanoma: Implications for tumor heterogeneity, Proc. Natl. Acad. Sci. USA, 82, 1470-1474.
32. Dutta, A., J.M. Ruppert, J.C. Aster and E. Winchester (1993) Inhibition of DNA replication factor RPA by p53, Nature, 365, 79-82.
33. Elkind, M.M. and M. Sutton (1959) X-ray damage and recovery in mammalian cells in culture, Nature, 184, 1293-1295.
34. Elkind, MM., A. Han and K. Voltz (1963) Radiation response of mammalian cells grown in culture. IV. Dose dependence of division delay and post-irradiation growth of surviving and non-surviving Chinese hamster cells, J. Natl. Cancer Inst., 30, 705-711.
35. Fishel, R., M.K. Lescoe, M.R.S. Rao, N.G. Copeland, N.A. Jenkins, J. Garber, M. Kane and R. Kolodner (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer [published erratum appears in Cell, 77, 167], Cell, 75, 1027-1038.
36. Gatti, R.A., E. Boder, H.V. Vinters, R.S. Sparkes, A. Norman and K. Lange (1991) Ataxia-telangiectasia: An interdisciplinary approach to pathogenesis, Medicine, 70, 99-117.
37. Goh, G. (1975) Total-body irradiation and human chromosomes, IV. cytogenetic follow-up studies 8 and 10 1/2 years after total-body irradiation, Radiat. Res., 62, 364-373.
38. Gorgojo, L. and J.B. Little (1989) Expression of lethal mutations in progeny of irradiated mammalian cells, Int. J. Radiat. Biol., 55, 619-630.
39. Greenwell, P.W., S.L. Kronmal, S.E. Porter, J. Gassenhuber, B. Obermaier and T.D. Petes (1995) TEL1, a gene involved in controlling telomere length in Saccharomyces cerevisiae, is homologous to the human ataxia telangiectasia (ATM) gene, Cell, in press.
40. Griffiths, S.D., S.J. Marsden, E.G. Wright, M.F. Greaves and D.T. Goodhead (1994) Lethality and mutagenesis of B lymphocyte progenitor cells following exposure to α-particles and X-rays, Int. J. Radiat. Biol., 66, 197-205.
41. Harley, C.B., A.B. Futcher and C.W. Greider (1990) Telomeres shorten during ageing of human fibroblasts, Nature, 345, 458-460.
42. Hartwell, L. (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells, Cell, 71, 543-546.
43. Hastie, N.D. and R.C. Allshire (1989) Human telomeres: fusion and interstitial sites, Trends Genet., 5, 326-331.
44. Hastie, N.D., M. Dempster, M.G. Dunlop, A.M. Thompson, D.K. Green and R.C. Allshire (1990) Telomere reduction in human colorectal carcinoma and with ageing, Nature, 346, 866-868.
45. Heartlein, M.W., J.H.M. Knoll and S.A. Latt (1988) Chromosome instability associated with human alphoid DNA transfected into the Chinese hamster genome, Mol. Cell. Biol., 8, 3611-3618.
46. Heim, R.A., N.J. Lench and M. Swift (1992) Heterozygous manifestations in our autosomal recessive human cancer-prone syndromes: ataxia telangiectasia, xeroderma pigmentosum, Fanconi anemia, and Bloom syndrome, Mutation Res., 284, 25-36.
47. Herman, J.G., F. Latif, Y. Weng, M.I. Lerman, B. Zbar, S. Liu, D. Samid, D.-S.R. Duan, J.R. Gnarra, W.M. Linehan and S.B. Baylin (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma, Proc. Natl. Acad. Sci. USA, 91, 9700-9704.
48. Hoehn, H. and G.M. Martin (1973) Clonal variants of constitutive heterochromatin of human fibroblasts after recovery from mitomycin treatment, Chromosoma, 43, 203-210.
49. Hoffschir, F., M. Ricoul, N. Lemieux, S. Estrade, R. Cassingena and B. Dutrillaux (1992) Jumping translocations originate clonal rearrangements in SV40-transformed human fibroblasts, Int. J. Cancer, 52, 130-136.
50. Holbrook, N.J. and A.J. Fornace, Jr. (1991) Response to adversity: molecular control of gene activation following genotoxic stress, New Biologist, 3, 825-833.
51. Hollstein, M., D. Sidransky, B. Vogelstein and C.C. Harris (1991) p53 mutations in human cancers, Science, 253, 49-53.
52. Holmberg, K., S. Fait, A. Johansson and B. Lambert (1993) Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures, Mutation Res., 286, 321-330.
53. Issa, J.-P.J., P.M. Vertino, J. Wu, S. Sazawal, P. Celano, B.D. Nelkin, S.R. Hamilton and S.B. Baylin (1993) Increased cytosine DNA-methyltransferase activity during colon cancer progression, J. Natl. Cancer Inst., 85, 1235-1240.
54. Issa, J.-P. J., S.B. Baylin and S.A. Belinsky (1995) Methylation of the estrogen receptor CpG island distinguishes spontaneous and plutonium-induced tumors from NNK-induced lung tumors in rodents, Proc. Am. Assoc. Cancer Res., 36, 537.
55. Jones, P.A. and J.D. Buckley (1990) The role of DNA methylation in cancer, Adv. Cancer Res., 54, 1-23.
56. Jones, P.A., M.J. Wolkowicz, W.M. Rideout, III, F.A. Gonzales, C.M. Marziasz, G.A. Coetzee and S.J. Tapscott (1990) De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines, Proc. Natl. Acad. Sci. USA, 87, 6117-6121.
57. Kadhim, M.A., D.A. MacDonald, D.T. Goodhead, S.A. Lorimore, S.J. Marsden and E.G. Wright (1992) Transmission of chromosomal instability after plutonium alpha-particle irradiation, Nature, 355, 738-740.
58. Kadhim, M.A., S.A. Lorimore, M.D. Hepburn, D.T. Goodhead, V.J. Buckle and E.G. Wright (1994) α-particle-induced chromosomal instability in human bone marrow cells, Lancet, 344, 987-988.
59. Kadhim, M.A., S.A. Lorimore, K.M. Townsend, D.T. Goodhead, V.J. Buckle and E.G. Wright (1995) Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells, Int. J. Radiat. Biol., 67, 287-293.
60. Karin, M. (1994) Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors, Curr. Opin. Cell Biol., 6, 415-424.
61. Kastan, M.B., O. Onyekwere, D. Sidransky, B. Vogelstein and R.W. Craig (1991) Participation of p53 protein in the cellular response to DNA damage, Cancer Res., 51, 6304-6311.
62. Kastan, M.B., Q. Zhan, W.S. el-Deiry, F. Carrier, T. Jacks, W.V. Walsh, B.S. Plunkett, B. Vogelstein and A.J. Fornace, Jr. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia, Cell, 71, 587-597.
63. Kastan, M.B., C.E. Canman and C.J. Leonard (1995) p53, cell cycle control and apoptosis: Implications for cancer, Cancer Metast. Rev., 14, 3-15.
64. Kautiainen, T.L. and P.A. Jones (1986) DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture, J. Biol. Chem., 261, 1594-1598.
65. Kennedy, A.R. and J.B. Little (1984) Evidence that a second event in X-ray-induced oncogenic transformation in vitro occurs during cellular proliferation, Radial. Res., 99, 228-248.
66. Keshet, I., J. Yisraeli and H. Cedar (1985) Effect of regional DNA methylation on gene expression, Proc. Natl. Acad. Sci. USA, 82, 2560-2564.
67. Kim, N.W., M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L.C. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich and J.W. Shay (1994) Specific association of human telomerase activity with immortal cells and cancer, Science, 266, 2011-2015.
68. Kojis, T.L., R.A. Gatti and R.S. Sparkes (1991) The cytogenetics of ataxia telangiectasia, Cancer Genet. Cytogenet., 56, 143-156.
69. 1-3 repeats, Genes Dev., 7, 2345-2356.
70. Kronenberg, A. (1994) Radiation-induced genomic instability, Int. J. Radiat. Biol., 66, 603-609.
71. Kyrion, G., K.A. Boakye and A.J. Lustig (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae, Mol. Cell. Biol., 12, 5159-5173.
72. Laird, P.W., L. Jackson-Grusby, A. Fazeli, S.L. Dickinson, W.E. Jung, E. Li, R.A. Weinberg and R. Jaenisch (1995) Suppression of intestinal neoplasia by DNA hypomethylation, Cell, 81, 197-205.
73. Lane, D.P. (1992) Cancer. p53, guardian of the genome, Nature. 358, 15-16.
74. Lane, D.P. (1993) Cancer. A death in the life of p53, Nature, 362, 786-787.
75. Leach, F.S., N.C. Nicolaides, N. Papadopoulos, B. Liu, J. Jen, R. Parsons, P. Peltomaki, P. Sistonen, L.A. Aaltonen, M. Nystrom-Lahti, X.-Y. Guan, J. Zhang, P.S. Meltzer, J.-W. Yu, F.-T. Kao, D.J. Chen, K.M. Cerosaletti, R.E.K. Fournier, S. Todd. T. Lewis, R.S. Leach, S.L. Naylor, J. Weissenbach, J.-P. Mecklin, H. Jarvinen, G.M. Petersen, S.R. Hamilton, J. Green, J. Jass, P. Watson, H.T. Lynch, J.W. Trent, A. de la Chapelle, K.W. Kinzler and B. Vogelstein (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer, Cell, 75, 1215-1225.
76. Lee, C.L.Y., S.H.S. Lee and O.P. Kamra (1979) Studies on isolated cloned populations from irradiated human embryonic cell cultures, Cytogenet. Cell Genet., 24, 150-159.
77. Lee, J.M., J.L.A. Abrahamson, R. Kandel, L.A. Donehower and A. Bernstein (1994) Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53-deficient mice, Oncogene, 9, 3731-3736.
78. Lee, S., B. Elenbaas, A. Levine and J. Griffith (1995a) p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches, Cell, 81, 1013-1020.
79. Lee, Y.-W., C.B. Klein, B. Kargacin, K. Salnikow, J. Kitahara, K. Dowjat, A. Zhitkovich, N.T. Christie and M. Costa (1995b) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens, Mol. Cell. Biol., 15, 2547-2557.
80. Lewis, J. and A. Bird (1991) DNA methylation and chromatin structure, FEBS Lett., 285, 155-159.
81. Li, R. and M.R. Botchan (1993) The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication, Cell, 73, 1207-1221.
82. Li, X.-M., P.H. Yen and L.J. Shapiro (1992) Characterization of a low copy repetitive element S232 involved in the generation of frequent deletions of the distal short arm of the human X chromosome, Nucleic Acids Res., 20, 1117-1122.
83. Little, J.B. (1994) Failla Memorial Lecture. Changing views of cellular radiosensitivity, Radiat. Res., 140, 299-311.
84. Little, J.B. and H. Nagasawa (1985) Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxiatelangiectasia fibroblasts. Radiat. Res., 101, 81-93.
85. Little, J.B., L. Gorgojo and H. Vetrovs (1990) Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells, Int. J. Radiat. Oncol. Biol. Phys., 19, 1425-1429.
86. Livingstone, L.R., A. White, J. Sprouse, E. Livanos, T. Jacks and T.D. Tlsty (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53, Cell, 70, 923-935.
87. Lowe, S.W., E.M. Schmitt, S.W. Smith, B.A. Osborne and T. Jacks (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes, Nature, 362, 847-849.
88. Lundblad, V. and J.W. Szostak (1989) A mutant with a defect in telomerase elongation leads to senescence in yeast, Cell, 57, 633-643.
89. Lustig, A.J. and T.D. Petes (1986) Identification of yeast mutants with altered telomere structure, Proc. Natl. Acad. Sci. USA, 83, 1398-1402.
90. Ma, C., S. Martin, B. Trask and J.L. Hamlin (1993) Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells, Genes Dev., 7, 605-620.
91. Malkin, D., F.P. Li, L.C. Strong, J.F. Fraumeni, Jr., C.E. Nelson, D.H. Kim, J. Kassel, M.A. Gryka, F.Z. Bischoff, M.A. Tainsky and S.H. Friend (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms, Science, 250, 1233-1238.
92. Marder, B.A. and W.F. Morgan (1993) Delayed chromosomal instability induced by DNA damage, Mol. Cell. Biol., 13, 6667-6677.
93. Marin, G. and M.A. Bender (1963) Radiation-induced mammalian cell death: lapse-time cinemicrographic observations, Exp. Cell Res., 43, 413-423.
94. Martins, M.B., L. Sabatier, M. Ricoul, A. Pinton and B. Dutrillaux (1993) Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts?, Mutation Res., 285, 229-237.
95. Matsumura, T., J.L. Hunter, M. Farooq and R. Holliday (1989a) Maintenance of DNA methylation level in SV40-infected human fibroblasts during their in vitro limited proliferative life span, Exp. Cell Res., 184, 148-157.
96. Matsumura, T., F. Malik and R. Holliday (1989b) Levels of DNA methylation in diploid and SV40 transformed human fibroblasts, Exp. Gerontol., 24, 477-481.
97. McClintock, B. (1941) The stability of broken ends of chromosomes in Zea mays, Genetics, 41, 234-282.
98. Meltzer, P.S., X.-Y. Guan and J.M. Trent (1993) Telomere capture stabilizes chromosome breakage, Nature Genet., 4, 252-255.
99. Mendonca, M.S., W. Kurohara, R. Antoniono and J.L. Redpath (1989) Plating efficiency as a function of time postirradiation: evidence for the delayed expression of lethal mutations, Radiat. Res., 119, 387-393.
100. Mendonca, M.S., R.J. Antoniono and J.L. Redpath (1993) Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells, Radiat. Res., 134, 209-216.
101. Meuth, M. (1989) Illegitimate recombination in mammalian cells, in: D.E. Berg and M.M. Howe (Eds.), Mobile DNA, Amer. Soc. Microbiol., Washington, D.C., pp. 833-860.
102. Meyn, M.S., L. Strasfeld and C. Allen (1994) Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia, Int. J. Radiat. Biol., 66 (Suppl.), S141-S149.
103. Minkler, J.L., D. Piluso, J.W. Gofman and R.K. Tandy (1971) A long-term effect of radiation on chromosomes of cultured human fibroblasts, Mutation Res., 13, 67-75.
104. Modrich, P. (1994) Mismatch repair, genetic stability, and cancer, Science, 266, 1959-1960.
105. Morgan, W.F. and J.P. Murnane (1995) A role for genomic instability in cellular radioresistance?, Cancer Metast. Rev., 14, 49-58.
106. Murnane, J.P. (1990) The role of recombinational hotspots in genome instability in mammalian cells, BioEssays, 12, 577-581.
107. Murnane, J.P. (1995) Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective, Cancer Metast. Rev., 14, 17-29.
108. Murnane, J.P., L. Sabatier, B.A. Marder and W.F. Morgan (1994) Telomere dynamics in an immortal human cell line, EMBO J., 13, 4953-4962.
109. Nagasawa, H. and J.B. Little (1983) Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts, Mutation Res., 109, 297-308.
110. Nagasawa, H., S.A. Latt, M.E. Lalande and J.B. Little (1985) Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts, Mutation Res., 148, 71-82.
111. Nias, A.H.W., C.W. Gilbert, L.G. Lajtha and C.S. Lange (1965) Clone-size analysis in the study of cell growth following single or during continuous irradiation, Int. J. Radiat. Biol., 9, 275-290.
112. Nicotera, T.M. (1991) Molecular and biochemical aspects of Bloom's syndrome, Cancer Genet. Cytogenet., 53, 1-13.
113. Nilsson, P., C. Mehle, K. Remes and G. Roos (1994) Telomerase activity in vivo in human malignant hematopoietic cells, Oncogene, 9, 3043-3048.
114. Oberosler, P., P. Hloch, U. Ramsperger and H. Stahl (1993) p53-catalyzed annealing of complementary single-stranded nucleic acids, EMBO J., 12, 2389-2396.
115. Ohtani-Fujita, N., T. Fujita, A. Aoike, N.E. Osifchin, P.D. Robbins and T. Sakai (1993) CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene, Oncogene, 8, 1063-1067.
116. Painter, R.B. and B.R. Young (1980) Radiosensitivity in ataxiatelangiectasia: a new explanation, Proc. Natl. Acad. Sci. USA, 77, 7315-7317.
117. Pandita, T.K. and W.N. Hittelman (1992a) The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia, Radiat. Res., 131, 214-223.
118. Pandita, T.K. and W.N. Hittelman (1992b) Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells, Radiat. Res., 130, 94-103.
119. Paquette, B. and J.B. Little (1992) Genomic rearrangements in mouse C3H/10T1/2 cells transformed by X-rays, UV-C, and 3-methylcholanthrene, detected by a DNA fingerprint assay, Cancer Res., 52, 5788-5793.
120. Puck, T.T. and P.I. Marcus (1956) Action of x-rays on mammalian cells, J. Exp. Med., 103, 653-666.
121. Radman, M., I. Matic, J.A. Halliday and F. Taddei (1995) Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans, Phil. Trans. Royal Soc. London (B), 347, 97-103.
122. Ray, F.A., J. Meyne and P.M. Kraemer (1992) SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts, Mutation Res. 284, 265-273.
123. Sabatier, L., B. Dutrillaux and M.B. Martin (1992) Chromosomal instability (Scientific Correspondence), Nature, 357, 548.
124. Sabatier, L., J. Lebeau and B. Dutrillaux (1994) Chromosomal instability and alterations of telomeric repeats in irradiated human fibroblasts, Int. J. Radiat. Biol., 66, 611-613.
125. Sager, R., I.K. Gadi, L. Stephens and C.T. Grabowy (1985) Gene amplification: An example of accelerated evolution in tumorigenic cells, Proc. Natl. Acad. Sci. USA, 82, 7015-7019.
126. Sakai, T., J. Toguchida, N. Ohtani, D.W. Yandell, J.M. Rapaport and T.P. Dryja (1991) Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene, Am. J. Hum. Genet., 48, 880-888.
127. Saltman, D., R. Morgan, M.L. Cleary and T. de Lange (1993) Telomeric structure in cells with chromosome end associations, Chromosoma, 102, 121-128.
128. Sandell, L.L. and V.A. Zakian (1993) Loss of a yeast telomere: arrest, recovery, and chromosome loss, Cell, 75, 729-739.
129. Savitsky, K., A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D.A. Tagle, S. Smith. T. Uziel, S. Sfez, M. Ashkenazi, I. Pecker, M. Frydman, R. Harnik, S.R. Patanjali, A. Simmons, G.A. Clines, A. Sartiel, R.A. Gatti, L. Chessa, O. Sanal, M.F. Lavin, N.G.J. Jaspers, A.M.R. Taylor, C.F. Arlett, T. Miki, S.M. Weissman, M. Lovett, F.S. Collins and Y. Shiloh (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase, Science, 268, 1749-1753.
130. Seymour, C.B., C. Mothersill and T. Alper (1986) High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation, Int. J. Radiat. Biol., 50, 167-179.
131. Silver, A. and R. Cox (1993) Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice, Proc. Natl. Acad. Sci. USA, 90, 1407-1410.
132. Sinclair, W.K. (1964) X-ray-induced heritable damage (small-colony formation) in cultured mammalian cells, Radiat. Res., 21, 584-611.
133. Smith, P.J. and M.C. Paterson (1983) Effect of aphidicolin on de novo DNA synthesis, DNA repair and cytotoxicity in γ-irradiated human fibroblasts: implications for the enhanced radiosensitivity in ataxia telangiectasia, Biochim. Biophys. Acta, 739, 17-26.
134. Smith, K.A., P.A. Gorman, M.B. Stark, R.P. Groves and G.R. Stark (1990) Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells, Cell, 63, 1219-1227.
135. Smith, K.A., M.B. Stark, P.A. Gorman and G.R. Stark (1992) Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells, Proc. Natl. Acad. Sci. USA, 89, 5427-5431.
136. Srivastava, S., Z.Q. Zou, K. Pirollo, W. Blattner and E.H. Chang (1990) Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome, Nature, 348, 747-749.
137. Stamato, T., R. Weinstein, B. Peters, J. Hu, B. Doherty and A. Giaccia (1987) Delayed mutation in Chinese hamster cells, Somat. Cell Mol. Genet., 13, 57-65.
138. Strathdee, C.A., H. Gavish, W.R. Shannon and M. Buchwald (1992) Cloning of cDNAs for Fanconi's anaemia by functional complementation [published erratum appears in Nature], 358, 434, Nature, 356, 763-767.
139. Tainsky, M.A., F.Z. Bischoff and L.C. Strong (1995) Genomic instability due to germline p53 mutations drives preneoplastic progression toward cancer in human cells., Cancer Metastasis Rev., 14, 43-48.
140. Thompson, L.H. and H.D. Suit (1969) Proliferation kinetics of x-irradiated mouse L cells studied with time-lapse photography. II. Int. J. Radiat. Biol., 15, 347-362.
141. Tlsty, T.D., B.H. Margolin and K. Lum (1989) Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis, Proc. Natl. Acad. Sci. USA, 86, 9441-9445.
142. Todd, P. (1968) Defective mammalian cells isolated from X-irradiated cultures, Mutation Res., 5, 173-183.
143. Toledo, F., D. Roscouet, G. Buttin and M. Debatisse (1992a) Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification, EMBO J., 11, 2665-2673.
144. Toledo, F., K.A. Smith, G. Buttin and M. Debatisse (1992b) The evolution of the amplified adenylate deaminase 2 domains in Chinese hamster cells suggests the sequential operation of different mechanisms of DNA amplification, Mutation Res., 276, 261-273.
145. Trott, K.R. and O. Hug (1970) Intraclonal recovery of division probability in pedigrees of single x-irradiated mammalian cells, Int. J. Radiat. Biol., 17, 483-486.
146. Vertino, P.M., J.-P. Issa, O.M. Pereira-Smith and S.B. Baylin (1994) stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts, Cell Growth Differ., 5, 1395-1402.
147. Visfeldt, J. (1966) Clone formation in tissue culture. Experience from long-term cultures of irradiated human skin, Acta Pathol. Microbiol. Scand., 68, 305-312.
148. Wahls, W.P., L.J. Wallace and P.D. Moore (1990) Hypervariable minisatellite DNA is a hotspot for homologous recombination in human cells, Cell, 60, 95-103.
149. Wang, X.W., K. Forrester, H. Yeh, M.A. Feitelson, J.R. Gu and C.C. Harris (1994) Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3, Proc. Natl. Acad. Sci. USA, 91, 2230-2234.
150. Weichselbaum, R.R., J. Nove and J.B. Little (1978) Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum, Nature, 271, 261-262.
151. Weichselbaum, R.R., D. Hallahan, Z. Fuks and D. Kufe (1994) Radiation induction of immediate early genes: effectors of the radiation-stress response, Int. J. Radiat. Biol., 30, 229-234.
152. Westra, A. and G.W. Barendsen (1966) Proliferation characteristics of cultured mammalian cells after irradiation with sparsely and densely ionizing radiations, Int. J. Radiat. Biol., 11, 477-485.
153. White, M.A., M. Dominska and T.D. Petes (1993) Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in saccharomyces cerevisiae, Proc. Natl. Acad. Sci. USA, 90, 6621-6625.
154. n, Nature, 346, 868-871.
155. Wilson, V.L. and P.A. Jones (1983) DNA methylation decreases in aging but not in immortal cells, Science, 220, 1055-1057.
156. Wilson, V.L., R.A. Smith, S. Ma and R.G. Cutler (1987) Genomic 5-methyldeoxycytidine decreases with age, J. Biol. Chem., 262, 9948-9951.
157. Wright, E.G. (1995) Alpha-particle-induced genomic instability in haemopoietic cells, Proceedings of the 43rd Annual Meeting of the Radiation Research Society, San Jose, CA.
158. Wu, J., J.-P. Issa, J. Herman, D.E. Bassett, Jr., B.D. Nelkin and S.B. Baylin (1993) Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells, Proc. Natl. Acad. Sci. USA. 90, 8891-8895.
159. Yin, Y., M.A. Tainsky, F.Z. Bischoff, L.C. Strong and G.M. Wahl (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles, Cell, 70, 937-948.
160. Yu, G.-L., J.D. Bradley, L.D. Attardi and E.H. Blackburn (1990) In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs, Nature, 344, 126-132.