Extracellular signaling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability

Radiation Research

Volumn 156, Issue 5 II, 2001, Pages 618-627

  Barcellos Hoff, M H ^a   Brooks, A L ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; CARCINOGENESIS; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL REGENERATION; CONFERENCE PAPER; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENETIC STABILITY; HOMEOSTASIS; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION HAZARD; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

EID: 0034763554     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2001)156[0618:esttma]2.0.co;2     Document Type: Conference Paper

References (107)

1. The influence of extracellular matrix on gene expression: Is structure the message?
2. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues
3. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles
4. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells
5. Induction of stress genes by low doses of gamma rays
6. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
7. The complexity of radiation stress responses: Analysis by informatics and functional genomics approaches
8. Clastogenic effects of defined numbers of 3.2 MeV alpha particles on individual CHO-K1 cells
9. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei
10. Studies of bystander effects in human fibroblasts using a charged particle microbeam
11. Genetic steps in colorectal cancer
12. Role of chromosome translocations in human neoplasia
13. Transmission of chromosomal instability after plutonium alpha-particle irradiation
14. Dose- and time-response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line
15. Chromosomal instability and its relationship to other end points of genomic instability
16. Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells
17. An illustrative comparison of the event-size distributions for gamma-rays and alpha-particles in the whole mammalian cell nucleus
18. Induction of a bystander mutagenic effect of alpha particles in mammalian cells
19. Radiation-induced genomic instability: A paradigm breaking phenomenon and its relevance to environmentally induced cancer
20. A matter of life and cell death
21. Stem cells: A new lease on life
22. Functional differentiation and alveolar morphogenesis of primary mammary epithelial cells cultures on reconstituted basement membrane
23. Effects of inhibition of basement membrane collagen deposition on rat mammary gland development
24. Glycosaminoglycans in the basal lamina and extracellular matrix of the developing mouse mammary duct
25. Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for a intact basement membrane for tissue-specific gene expression
26. The differentiated state of normal and malignant cells or how to define a "normal" cell in culture
27. Re-expression of the alpha 2 beta 1 integrin abrogates malignant phenotype of breast carcinoma cells
28. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
29. Interferon-alpha restores normal beta 1 integrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia
30. How does the extracellular matrix direct gene expression?
31. Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells
32. Elimination of transformed cells by normal cells: A novel concept for the control of carcinogenesis
33. How can tumor cells escape intercellular induction of apoptosis?
34. Inhibition of carcinogen-altered rat tracheal epithelial cell proliferation by normal epithelial cells in vivo
35. Dynamics of neoplastic development in carcinogen-exposed tracheal mucosa
36. The rate of progression of radiation-transformed mammary epithelial cells is enhanced after low-dose-rate neutron irradiation
37. Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion
38. Breast cancer: Induction of differentiation by embryonic tissue
39. Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth
40. The possible role of abnormal fibroblasts in the pathogenesis of breast cancer
41. Hypothesis: Persistent expression of fetal phenotypic characteristics by fibroblasts is associated with an increased susceptibility to neoplastic disease
42. Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels
43. Phenotypic heterogeneity in breast fibroblasts: Functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma
44. Fibroblasts from relatives of hereditary breast cancer patients display fetal-like behavior in vitro
45. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia
46. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
47. The tumor promoting effect of wounding: A possible role for TGFβ induced fibrotic stroma
48. Role of host and tumor calcium in metastases
49. Wounding and its role in RSV-mediated tumor formation
50. Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice
51. Mediation of wound-related Rous sarcoma virus tumorigenesis and TGF-β
52. Tumorigenic conversion of immortal human keratinocytes through stromal cell activation
53. Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and premalignant phenotype in mammary epithelial cells
54. Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development
55. Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation
56. Detection of ductal dysplasia in mammary outgrowths derived from carcinogen-treated virgin female BALB/c mice
57. Quantitative and molecular comparison of initiation frequency of mammary carcinogenesis by radiation and chemical carcinogens
58. Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme
59. Accelerated mammary cancer development by fetal salivary mesenchyme isografted to adult mouse mammary epithelium
60. Matrix metalloproteinases as emerging targets in anticancer therapy; status and prospects
61. Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
62. Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents
63. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland
64. Transforming growth factor-β activation in irradiated murine mammary gland
65. Latent transforming growth factor-β activation in situ: Quantitative and functional evidence following low dose irradiation
66. Molecular and cell biology of TGF-beta
67. TGF-β1 and radiation fibrosis: A master switch and a specific therapeutic target?
68. Multiple changes in gene expression are associated with normal cell-induced modulation of the neoplastic phenotype
69. The potential influence of radiation-induced microenvironments in neoplastic progression
70. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
71. Stromal cell involvement in leukemogenesis and carcinogenesis
72. Epithelial-stromal interactions in normal and chemical carcinogen-treated adult bladder
73. N-Nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations
74. Radiation carcinogenesis
75. Radiation-induced clastogenic plasma factors
76. Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: Protective effects of antioxidant plant phenols, vitamins and oligoelements
77. No evidence for radiation-induced clastogenic factors after in vivo or in vitro exposure of human blood
78. Partial volume rat lung irradiation: An evaluation of early DNA damage
79. Participation of gap-junctional cell communication on the adaptive response in human cells induced by low dose of X-rays
80. 2 particle number and size on the frequency and distribution of chromosome aberrations in the liver of the Chinese hamster
81. 2 particles in the Chinese hamster
82. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model
83. Cytokines in context
84. Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells
85. 1 arrest by cell-substratum interactions
86. Altruistic cell suicide in relation to radiation hormesis
87. Transforming growth factor-beta: Possible roles in carcinogenesis
88. TGF-β signaling in growth control, cancer, and heritable disorders
89. Skin wound healing: Transforming growth factor antagonists decrease scarring and improve quality
90. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
91. Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy
92. Reversal of in vivo drug resistance by the transforming growth factor-beta inhibitor decorin
93. Three distinct roles for TGF-beta during intercellular induction of apoptosis: A review
94. Ex vivo tumor cell lines are resistant to intercellular induction of apoptosis and independent of exogenous survival factors
95. Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
96. Mammary tumor suppression by transforming growth factor β1 transgene expression
97. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
98. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
99. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
100. Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
101. An overview of epithelio-mesenchymal transformation
102. 1 arrest, p53, and Rb
103. Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes
104. Microdosimetry near the trajectory of high-energy heavy ions