Transforming growth factor-β and breast cancer: Mammary gland development

Breast Cancer Research

Volumn 2, Issue 2, 2000, Pages 92-99

  Barcellos Hoff, M H ^a   Ewan, K B R ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Activation; Latent; Mammary; Proliferation; Transforming growth factor (TGF) 1

Indexed keywords

CYTOKINE; DIMER; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; BREAST CANCER; BREAST DEVELOPMENT; BREAST EPITHELIUM; CELL PROLIFERATION; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE ACTIVITY; HUMAN; HUMAN TISSUE; MOLECULAR WEIGHT; MORPHOGENESIS; PHYSIOLOGY; PROTEIN SECRETION; REVIEW; SPATIAL ORIENTATION; TISSUE; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

NON-PROGRAMMATIC;

ANIMALS; BREAST; BREAST NEOPLASMS; CELL DIVISION; FEMALE; HUMANS; MICE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0034469054     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr40     Document Type: Review

References (58)

1. Regulation of mammary growth and function by TGF-β
2. Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells
3. Roles for transforming growth factors-β in the genesis, prevention and treatment of breast cancer
4. Reversible inhibition of mammary gland growth by transforming growth factor-β
5. TGF-β1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization
6. Postnatal development of the rodent mammary gland
7. Conversion of a high molecular weight latent beta-TGF from chicken embryo fibroblasts into a low molecular weight active beta-TGF under acidic conditions
8. 1 gene
9. Identification and activation of latent transforming growth factor-β
10. The extracellular regulation of growth factor action
11. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1
12. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
13. Localization of basic fibroblast growth factor and transforming growth factor β1 in the human mammary gland
14. Comparative genomic hybridization analysis of lobular carcinoma in situ and a typical lobular hyperplasia and potential roles for gains and losses of genetic material in breast neoplasia
15. Immunohistochemical demonstration of growth factors, TGF-alpha, TGF-beta, IGF-I and neu oncogene product in benign and malignant human breast tissues
16. TGF-β induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects
17. Multiple forms of TGF-beta 1 in breast tissues: A biologically active form of the small latent complex of TGF-beta 1
18. Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in co-culture
19. Urokinase-type-plasminogen-activator (uPA) production by human breast (myo) fibroblasts in vitro: Influence of transforming growth factor-beta(1) [TGF beta(1)] compared with factor(s) released by human epithelial-carcinoma cells
20. Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast
21. Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mamary gland development
22. Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1
23. Latency and activation in the regulation of TGF-β
24. Transforming growth factor-β activation in irradiated murine mammary gland
25. Immunohistochemical detection of active TGF-β in situ using engineered tissue
26. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland
27. Latent transforming growth factor-β activation in situ: Quantitative and functional evidence following low dose irradiation
28. Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation
29. Autocrine secretion of TGF-beta 1 and TGF-beta 2 by pre-adipocytes and adipocytes: A potent negative regulator of adipocyte differentiation and proliferation of mammary carcinoma cells
30. Differential response of fetal and adult fibroblasts to cytokines: Cell migration and hyaluronan synthesis
31. Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-β in vascular smooth muscle cells
32. Loss of growth inhibitory activity of TGF-β toward normal human mammary epithelial cells growth within collagen gel matrix
33. Effect of transforming growth factor-β1 on proliferation and death of rat prostatic cells
34. Coordinated regulation of apoptosis and cell proliferation by transforming growth factor β1 in cultured uterine epithelial cells
35. Apoptotic cell death and tissue remodeling during mouse mammary gland involution
36. The regulatory role of transforming growth factor-beta in activation of milk mononuclear cells
37. Growth regulatory activities of endothelial extracellular matrix mediation by transforming growth factor-β
38. Changes in the extracellular matrix of the normal human breast during the menstrual cycle
39. Epithelium-dependent extracellular matrix synthesis in transforming growth factor-β1-growth-inhibited mouse mammary gland
40. Extracellular cellular matrix regulates expression of the TGF-β1 gene
41. Extracellular matrix regulates ovarian hormone-dependent proliferation of mouse mammary epithelial cells
42. Induction of transforming growth factor β1 in human breast cancer in vivo following tamoxifen treatment
43. Transforming growth factor β mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium
44. TGFβ suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels
45. Stimulation and inhibition of human mammary epithelial cell duct morphogenesis in vitro
46. TGF-β1 induces morphogenesis of branching cords by cloned mammary epithelial cells at subpicomolar concentrations
47. TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
48. Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
49. The role of TGF-β in patterning and growth of the mammary ductal tree
50. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor
51. TGF-β and functional differentiation
52. Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation
53. Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
54. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
55. Maternal rescue of transforming growth factor-β1 null mice
56. Dominant-negative interference of the transforming growth factor-beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice
57. Overexpression of a kinase-deficient transforming growth factor-β type II receptor in mouse mammary stroma results in increased epithelial branching
58. Transforming growth factor-β in breast cancer: A working hypothesis