Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects of X rays and alpha particles

Radiation Research

Volumn 148, Issue 4, 1997, Pages 299-307

  Little, John B ^a   Nagasawa, Hatsumi ^a   Pfenning, Tracy ^a   Vetrovs, Helen ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; ANIMAL CELL; CELL CLONING; CHO CELL; CONTROLLED STUDY; GENE MUTATION; GENE STRUCTURE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION MUTAGENESIS; REVIEW; X IRRADIATION;

ALPHA PARTICLES; ANIMALS; CHO CELLS; CLONE CELLS; COLONY-FORMING UNITS ASSAY; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG RESISTANCE; GENES; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENESIS; MUTAGENICITY TESTS; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; SEQUENCE DELETION; TIME FACTORS; X-RAYS;

EID: 0030752597     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579514     Document Type: Review

References (48)

1. E. Fearson and B. Vogelstein, A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
2. L. A. Loeb, Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075-3079 (1991).
3. R. Fishel, M. K. Lescoe, M. R. S. Rao, N. G. Copeland, N. A. Jenkins, J. Garber, M. Kane and R. Kolodner, The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027-1038 (1993).
4. R. Parsons, G-M. Li, M. J. Longley, W. Fang, N. Papadopoulos, J. Jen, A. de la Chapelle, K. W. Kinzler, B. Vogelstein and P. Modrich, Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75, 1227-1236 (1993).
5. J. B. Little, L. Gorgojo and H. Vetrovs, Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 19, 1425-1429 (1990).
6. W. P. Chang and J. B. Little, Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: Association with delayed reproductive death phenotype. Mutat. Res. 270, 191-199 (1992).
7. C-Y. Li, D. W. Yandell and J. B. Little, Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. Mol. Carcinogen. 5, 270-277 (1992).
8. M. A. Kadhim, D. A. MacDonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden and E. G. Wright, Transmission of chromosomal aberrations and genomic instability after plutonium alpha-particle irradiation. Nature 355, 738-740 (1992).
9. K. Holmberg, S. Falr, A. Johansson and B. Lambert, Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutat. Res. 286, 321-330 (1993).
10. B. A. Marder and W. F. Morgan, Delayed chromosomal instability induced by DNA damage. Mol. Cell. Biol. 13, 6667-6677 (1993).
11. M. B. Martins, L. Sabatier, M. Ricoul, A. Pinton and B. Dutrillaux, Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts? Mutat. Res. 285, 229-237 (1993).
12. M. A. Kadhim, S. A. Lorimore, K. M. Townsend, D. T. Goodhead, V. J. Buckle and E. G. Wright. Radiation-induced genomic instability delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int. J. Radiat. Biol. 67, 287-293 (1995).
13. L. Sabatier, B. Dutrillaux and M. B. Martin, Chromosomal instability. Nature 357, 548 (1992). [Scientific Correspondence]
14. L. Sabatier, J. Lebeau and B. Dutrillaux, Chromosomal instability and alterations of telomeric repeats in irradiated human fibroblasts. Int. J. Radiat. Biol. 66, 611-613 (1994).
15. S. Pampfer and C. Streffer, Increased chromosome aberration levels in cells from mouse fetuses after zygote X-irradiation. Int. J. Radiat. Biol. 55, 85-92 (1989).
16. G. E. Watson, S. A. Lorimore and E. G. Wright. Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells. Int. J. Radiat. Biol. 69, 175-182 (1996).
17. A. R. Kennedy, M. Fox, G. Murphy and J. B. Little, Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells. Proc. Natl. Acad. Sci. USA 77, 7262-7266 (1980).
18. A. R. Kennedy and J. B. Little, Evidence that a second event in X-ray-induced oncogenic transformation in vitro occurs during cellular proliferation. Radiat. Res. 99, 228-248 (1984).
19. M. S. Mendonca, R. J. Antoniono and J. L. Redpath, Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells. Radiat. Res. 134, 209-216 (1993).
20. M. S. Mendonca, C. L. Fasching, E. S. Srivatsan, E. J. Stanbridge and J. L. Redpath, Loss of a putative tumor suppressor locus after gamma-ray-induced neoplastic transformation of HeLa x skin fibroblast human cell hybrids. Radiat. Res. 143, 34-44 (1995).
21. C. B. Seymour, C. Mothersill and T. Alper, High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radiat. Biol. 50, 167-179 (1986).
22. W. P. Chang and J. B. Little, Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol. 60, 483-496 (1991).
23. C. S. Selvanayagam, C. M. Davis, M. N. Cornforth and R. L. Ullrich, Latent expression of p53 mutations and radiation-induced mammary cancer. Cancer Res. 55, 3310-3317 (1995).
24. N. F. Metting, A. M. Koehler, H. Nagasawa, J. M. Nelson and J. B. Little, Design of a benchtop alpha particle irradiator. Health Phys. 68, 710-715 (1995).
25. L. Gorgojo and J. B. Little, Expression of lethal mutations in progeny of irradiated mammalian cells. Int. J. Radiat. Biol. 55, 619-630 (1989).
26. J. B. Little, J-M. Frenial and J. Coppey, Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation. Teratogen. Carcinogen. Mutagen. 8, 287-292 (1988).
27. Y. Kinashi, H. Nagasawa and J. B. Little, Molecular structural analysis of 417 HPRT mutations induced by restriction endonucleases in Chinese hamster ovary (CHO) cells. Mutat. Res. 326, 83-92 (1995).
28. B. J. F. Rossiter, J. C. Fuscoe, D. M. Muzny, M. Fox and C. T. Caskey, The Chinese hamster hprt gene: Restriction map, sequence analysis, and multiplex PCR deletion screen. Genomics 9, 247-256 (1991).
29. H. Nagasawa and J. B. Little, Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells. Proc. Natl. Acad. Sci. USA 76, 1943-1947 (1979).
30. J. Thacker, The nature of mutants induced by ionizing radiation in cultured hamster cells. III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that we majority have deletions of all or part of the hprt gene. Mutat. Res. 160, 267-275 (1986).
31. D. W. Yandell, T. P. Dryja and J. B. Little, Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations. Somat. Cell Mol. Genet. 12, 255-263 (1986).
32. T. L. Morgan, E. W. Fleck, K. A. Poston, B. A. Denovan, C. N. Newman, B. J. F. Rossiter and J. H. Miller, Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells. Mutat. Res. 232, 171-182 (1990).
33. G. L. Chan and J. B. Little, Induction of ouabain-resistant mutations in C3H 10T1/2 mouse cells by ultraviolet light. Proc. Natl. Acad. Sci. USA 75, 3363-3366 (1978).
34. C. F. Arlett, D. Turnbull, S. A. Harcourt, A. R. Lehmann and C. M. Colella, A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells. Mutat. Res. 33, 261-178 (1975).
35. L. Manti, M. Jamali, K. M. Prise, B. D. Michael and K-R. Trott, Genomic instability in Chinese hamster cells after exposure to X rays or alpha particles of different mean linear energy transfer. Radiat. Res. 147, 22-28 (1997).
36. M. Jamali and K. R. Trott, Persistent increase in the rates of apoptosis and dicentric chromosomes in surviving V79 cells after X-irradiation. Int. J. Radiat. Biol. 70, 705-709 (1996).
37. S. O'Reilly, C. Mothersill and C. B. Seymour, Postirradiation expression of lethal mutations in an immortalized human keratinocyte cell line. Int. J. Radiat. Biol. 66, 77-83 (1994).
38. K. Harper, S. A. Lorimore and E. G. Wright, Delayed appearance of radiation-induced mutations at the hprt locus in murine haemopoietic cells. Exp. Hematol. 16, 263-269 (1997).
39. A. J. Grosovsky, K. K. Parks, C. R. Giver and S. L. Nelson, Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability. Mol. Cell. Biol. 16, 6252-6262 (1996).
40. W. F. Morgan, J. P. Day, M. I. Kaplan, E. M. McGhee and C. L. Limoli, Genomic instability induced by ionizing radiation. Radiat. Res. 146, 247-258 (1996).
41. J. P. Murnane, Role of induced genetic instability in the mutagenic effects of chemicals and radiation. Mutat. Res. 367, 11-23 (1996).
42. W. F. Morgan and J. P. Murnane, A role for genomic instability in cellular radioresistance? Cancer Metastasis Rev. 14, 49-58 (1995).
43. S. M. Clutton, K. M. S. Townsend, C. Walker, J. D. Ansell and E. G. Wright, Radiation induced genomic instability and persisting oxidative stress in primary bone marrow cultures. Carcinogenesis 17, 1633-1639 (1996).
44. M. A. Kadhim, C. A. Walker, M. A. Plumb and E. G. Wright, No association between p53 status and α-particle-induced chromosomal instability in human lymphoblastoid cells. Int. J. Radiat. Biol. 69, 167-174 (1996).
45. B. Paquette and J. B. Little, Genomic rearrangements in mouse C3H/10T1/2 cells transformed by x-rays, UV-C, and 3-methylcholanthrene, detected by a DNA fingerprint assay. Cancer Res. 52, 5788-5793 (1992).
46. B. Paquette and J. B. Little, In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H/10T1/2 cells transformed in vitro by X-rays. Cancer Res. 54, 3173-3178 (1994).
47. G. E. Watson, S. A. Lorimore, S. M. Clutton, M. A. Kadhim and E. G. Wright, Genetic factors influencing alpha-particle-induced chromosomal instability. Int. J. Radiat. Biol., in press.
48. B. Ponnaiya, M. N. Cornforth and R. L. Ullrich, Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiat. Res. 147, 121-125 (1997).