Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of P53 mutant cell lines

International Journal of Radiation Oncology Biology Physics

Volumn 45, Issue 3, 1999, Pages 743-751

  Dibiase, Steven J ^a   Guan, Jun ^a   Curran Jr , Walter J ^a   Iliakis, George ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apoptosis; DNA repair; p53; Radiosensitivity

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; MUTANT; MUTATION; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; WESTERN BLOTTING;

NON-PROGRAMMATIC;

APOPTOSIS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; DNA REPAIR; HUMANS; MUTATION; OSTEOSARCOMA; RADIATION TOLERANCE; RADIOBIOLOGY; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032851826     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00229-1     Document Type: Article

References (44)

1. Brahme S.A. Optimized radiation therapy based on radiological objectives. Semin Radiat Oncol. 9:1999;35-47.
2. Bates S., Vousden K.H. Mechanisms of p53-mediated apoptosis. Cell Mol Life Sci. 55:1999;28-37.
3. Amundson S.A., Myers T.G., Fornace A.J. Jr. Roles for p53 in growth arrest and apoptosis Putting on the brakes after genotoxic stress . Oncogene. 17:1998;3287-3299.
4. Ding H.F., Fisher D.E. Mechanisms of p53-mediated apoptosis. Crit Rev Oncol. 9:1998;83-98.
5. Sherr C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12:1998;2984-2991.
6. Giaccia A.J., Kastan M.B. The complexity of p53 modulation Emerging patterns from divergent signals . Genes Dev. 12:1998;2973-2983.
7. Prives C. Signaling to p53 Breaking the MDM2-p53 circuit . Cell. 2:1998;5-8.
8. Bray S.E., Schorl C., Hall P.A. The challenge of p53 Linking biochemistry, biology, and patient management . Stem Cells. 16:1998;248-260.
9. Kirsch D.G., Kastan M.B. Tumor-suppressor p53 Implications for tumor development and prognosis . J Clin Oncol. 16:1998;3158-3168.
10. Kastan M.B., Onyekwere O., Sidransky D., et al. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
11. Hartwell L.H., Weinert T.A. Checkpoints Controls that ensure the order of cell cycle events . Science. 246:1989;629-634.
12. Lee J.M., Bernstein A. p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci USA. 90:1993;5742-5746.
13. McIlwrath A.J., Vasey P.A., Ross G.M., et al. Cell cycle arrests and radiosensitivity of human tumor cell lines Dependence on wild-type p53 for radiosensitivity . Cancer Res. 54:1994;3718-3722.
14. Bristow R.G., Jang A., Peacock J., et al. Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras. Oncogene. 9:1994;1527-1536.
15. Yount G.L., Haas-Kogan D.A., Vidair C.A., et al. Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res. 56:1996;500-506.
16. Slichenmyer W.J., Nelson W.G., Slebos R.J., et al. Loss of p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53:1993;4164-4168.
17. Brown J.M., Wouters B.G. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59:1999;1391-1399.
18. Servomaa K., Kiuru A., Grenman R., et al. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Prolif. 29:1996;219-230.
19. Rowan S., Ludwig R.L., Haupt Y., et al. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J. 15:1996;827-838.
20. Bargonetti J., Manfredi J.J., Chen X., et al. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev. 7:1993;2565-2574.
21. Hollstein M., Sidransky D., Vogelstein B., et al. p53 mutations in human cancers. Science. 253:1991;49-53.
22. Iliakis G. The role of DNA double strand breaks in ionizing radiation induced killing of eukaryotic cells. Bioessays. 13:1991;641-648.
23. Ward J.F. Biochemistry of DNA lesions. Radiat Res. 104:1985;S103-S111.
24. Jeggo P.A. Indentification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res. 150:(Suppl.):1998;S80-S91.
25. McMillan T.J., Peacock J.H. Molecular determinants of radiosensitivity in mammalian cells. Int J Radiat Biol. 65:1994;49-55.
26. Frankenberg-Schwager M. Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiother Oncol. 14:1989;307-320.
27. Schwartz J.L., Rotmensch J., Giovanazzi S., et al. Faster repair of DNA double-strand breaks in radioresistant human tumor cells. Int J Radiat Oncol Biol Phys. 15:1988;907-912.
28. Kelland L.R., Edwards S.M., Steel G.G. Induction and rejoining of DNA double-strand breaks in human cervix carcinoma cell lines of differing radiosensitivity. Radiat Res. 116:1988;526-538.
29. Giaccia A.J., Schwartz J., Shieh J., et al. The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity. Radiother Oncol. 24:1992;231-238.
30. Strasser A., Harris A.W., Jacks T., et al. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79:1994;329-339.
31. Friedlander P., Haupt Y., Prives C., et al. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol. 16:1996;4961-4971.
32. Haupt Y., Rowan S., Shaulian E., et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9:1995;2170-2183.
33. McKenna W.G., Weiss M.C., Endlich B., et al. Synergistic effectof the v-myc oncogene with h-ras on radioresistance. Cancer Res. 50:1990;97-102.
34. Metzger L., Iliakis G. Kinetics of DNA double strand breaks throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. Int J Radiat Biol. 59:1991;1325-1339.
35. Stamato T.D., Denko N. Asymmetric field inversion gel electrophoresis A new method for detecting DNA double-strand breaks in mammalian cells . Radiat Res. 121:1990;196-205.
36. Cheong N., Perrault R., Iliakis G. In vitro rejoining of DNA double strand breaks A comparison of genomic-DNA with plasmid-DNA-based assays . Int J Radiat Biol. 73:1998;481-493.
37. Iliakis G., Metzger L., Muschel R.J., et al. Induction and repair of DNA double strand breaks in radiation resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc. Cancer Res. 50:1990;6575-6579.
38. McCloskey D.E., Kaufmann S.H., Prestigiacomo L.J., et al. Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells. Clin Cancer Res. 2:1996;847-854.
39. Kagawa K., Inoue T., Tokino T., et al. Overexpression of GML promotes radiation-induced cell cycle arrest and apoptosis. Biochem Biophys Res Commun. 24:1997;481-485.
40. Yamagishi N., Miyakoshi J., Takebe H. Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells. Carcinogenesis. 18:1997;695-700.
41. Cariello N.F., Cui L., Beroud C., et al. Database and software for the analysis of mutations in the human p53 gene. Cancer Res. 54:1994;4454-4460.
42. Powell S., McMillan T.J. Clonal variation of DNA repair in a human glioma cell line. Radiother Oncol. 1991;225-232.
43. Debenham P.G., Webb M.B., Jones N.J., et al. Molecular studies on the nature of the repair defect in ataxia-telangiectasia and their implications for cellular radiobiology. J Cell Sci Suppl. 6:1987;177-184.
44. Stapper N.J., Stuschke M., Sak A., et al. Radiation-induced apoptosis in human sarcoma and glioma cell lines. Int J Cancer. 62:1995;58-62.