Elevated breast cancer risk in irradiated balb/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene

Cancer Research

Volumn 61, Issue 5, 2001, Pages 1820-1824

  Yu, Yongjia ^a   Okayasu, Ryuichi ^b   Weil, Michael M ^c   Silver, Andy ^d   McCarthy, Maureen ^a   Zabriskie, Ryan ^a   Long, Scott ^c   Cox, Roger ^d   Ullrich, Robert L ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; LEUCINE ZIPPER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; BREAST CELL; CANCER RISK; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; ENZYME ACTIVE SITE; FEMALE; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; RADIOSENSITIVITY; RAT STRAIN; SIGNAL TRANSDUCTION;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CRICETINAE; CROSSES, GENETIC; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEOPLASMS, RADIATION-INDUCED; NUCLEAR PROTEINS; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035266285     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Ionizing radiation: Levels and effects
2. Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. I. Background
3. Breast cancer: Genetic predisposition and exposure to radiation
4. Genetic predisposition to cancer
5. Deficient DNA repair capacity, a predisposing factor in breast cancer
6. Heritability of cellular radiosensitivity: A marker of low-penetrance predisposition genes in breast cancer?
7. The response of twenty seven inbred strains of mice to daily doses of whole body x-irradiation
8. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse
9. Extrapolation of the relative risk of radiogenic neoplasms across mouse strains and to man
10. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of difference in epithelial cell sensitivity to transformation
11. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white
12. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c mice exposed in vivo to y-radiation and/or 7,12-dimethylbenz[a]anthracene
13. Radiation-induced instability and its relation to radiation carcinogenesis
14. Radiation-induced cytogenetic instability in vivo
15. The DNA-dependent protein kinase
16. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
17. A comprehensive large-insert yeast artificial chromosome library for physical mapping of the mouse genome
18. Genealogies of mouse inbred strains
19. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mice
20. DNA-PK, the DNA-activated protein kinase is differentially expressed in normal and malignant human tissues