A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4342-4345

  Okayasu, Ryuichi ^a,b   Suetomi, Katsutoshi ^b   Yu, Yongjia ^b   Silver, Andy ^c   Bedford, Joel S ^b   Cox, Roger ^c   Ullrich, Robert L ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; DNA REPAIR; ENZYME ACTIVITY; FEMALE; GENETIC VARIABILITY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION RESPONSE; RADIOSENSITIVITY;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; BLOTTING, WESTERN; CATALYSIS; CELLS, CULTURED; DIMERIZATION; DISEASE SUSCEPTIBILITY; DNA; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; KIDNEY; KINETICS; MALE; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, SCID; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; SPECIES SPECIFICITY;

EID: 0034662649     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Double strand break repair
2. Identification of genes involved in repair of DNA double strand breaks in mammalian cells
3. BRCA1, BRCA2, and Rad 51 operate in a common DNA damage response pathway
4. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
5. The response of twenty seven inbred strains of mice to daily doses of whole body x-irradiation
6. Extrapolation of the relative risk of radiogenic neoplasms across mouse strains and to man
7. Genetic variation in the acute lethal response of four inbred mouse strains to whole body X-irradiation
8. Contributions to survival made by body cells of genetically differentiated strains of mice following X-irradiations
9. 1 offspring
10. The effect of dose rate on mode of acute radiation death of C57BL/6 and BALB/c mice
11. Strain-dependent susceptibility to radiation-induced mammary cancer is a result of difference in epithelial cell sensitivity to transformation
12. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white
13. Radiation-induced instability and its relation to radiation carcinogenesis
14. Latent expression of p53 mutations and radiation-induced mammary cancer
15. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mice
16. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
17. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice
18. Minisatellite instability in severe combined immunodeficiency mouse cells
19. The neoplastic transformation of SCID cells by radiation
20. An ionizing radiation-sensitive mutant of CHO cells: Irs-20. I. Isolation and initial characterization
21. Molecular and biochemical characterization of DNA-dependent protein kinase-defective rodent mutant irs-20
22. Wortmannin inhibits repair of DNA double strand break repair in irradiated normal human cells
23. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis
24. DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
25. Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity
26. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double strand break repair
27. Defective DNA-dependent protein kinase activity is linked V(D)J recombination and DNA repair defect associated with murine scid mutation
28. Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: Association with aging and longevity
29. Chromosomal radiosensitivity during G2 phase and susceptibility to plasmacytoma induction in mice
30. Genetic dissection of susceptibility to radiation-induced apoptosis of thymocytes and mapping of Rapop1, a novel susceptibility gene
31. DNA double strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice
32. Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
33. DNA-PK, the DNA-activated protein kinase is differentially expressed in normal and malignant human tissues