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Volumn 25, Issue 4, 1999, Pages 343-357

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

Author keywords

Brain injury; Brain macrophages; Gliosis; GM CSF; IL 6 deficiency; Metallothionein I+II; Metallothionein III; Neurons

Indexed keywords

BLOOD BRAIN BARRIER; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IN SITU HYBRIDIZATION; INFLAMMATION; MACROPHAGE; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III; MONOCYTE; NERVE CELL; PATHOGENESIS;

EID: 0033557201     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(19990215)25:4<343::AID-GLIA4>3.0.CO;2-V     Document Type: Article
Times cited : (172)

References (70)
  • 1
    • 0030129558 scopus 로고    scopus 로고
    • Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds
    • Amat JA, Ishiguro H, Nakamura K, Norton WT. 1996. Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia 16:368-382.
    • (1996) Glia , vol.16 , pp. 368-382
    • Amat, J.A.1    Ishiguro, H.2    Nakamura, K.3    Norton, W.T.4
  • 2
    • 0026505309 scopus 로고
    • The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues
    • Andersson PB, Perry VH, Gordon S. 1992. The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues. Neuroscience 48:169-186.
    • (1992) Neuroscience , vol.48 , pp. 169-186
    • Andersson, P.B.1    Perry, V.H.2    Gordon, S.3
  • 3
    • 0029845691 scopus 로고    scopus 로고
    • The functional significance of brain metallothioneins
    • Aschner M. 1996. The functional significance of brain metallothioneins. FASEB J 10:1129-1136.
    • (1996) FASEB J , vol.10 , pp. 1129-1136
    • Aschner, M.1
  • 4
    • 0028012270 scopus 로고
    • Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
    • Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW. 1994. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856.
    • (1994) J Neurosci , vol.14 , pp. 846-856
    • Balasingam, V.1    Tejada-Berges, T.2    Wright, E.3    Bouckova, R.4    Yong, V.W.5
  • 5
    • 0030458608 scopus 로고    scopus 로고
    • Effect of stress on mouse and rat brain metallothionein I and III mRNA levels
    • Belloso E, Hernández J, Giralt M, Kille P, Hidalgo J. 1996. Effect of stress on mouse and rat brain metallothionein I and III mRNA levels. Neuroendocrinology 64:430-439.
    • (1996) Neuroendocrinology , vol.64 , pp. 430-439
    • Belloso, E.1    Hernández, J.2    Giralt, M.3    Kille, P.4    Hidalgo, J.5
  • 6
    • 0029776850 scopus 로고    scopus 로고
    • Production of monocyte chemotactic protein-1 by rat brain macrophages
    • Calvo CF, Yoshimura T, Gelman M, Mallat M. 1996. Production of monocyte chemotactic protein-1 by rat brain macrophages. Eur J Neurosci 8:1725-1734.
    • (1996) Eur J Neurosci , vol.8 , pp. 1725-1734
    • Calvo, C.F.1    Yoshimura, T.2    Gelman, M.3    Mallat, M.4
  • 8
    • 0032192504 scopus 로고    scopus 로고
    • Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6
    • Carrasco J, Hernández J, González B, Campbell IL, Hidalgo J. 1998. Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6. Exp Neurol 153:184-194.
    • (1998) Exp Neurol , vol.153 , pp. 184-194
    • Carrasco, J.1    Hernández, J.2    González, B.3    Campbell, I.L.4    Hidalgo, J.5
  • 9
    • 0030058649 scopus 로고    scopus 로고
    • Interleukin (IL.-6) gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: A study on IL-6-deficient mice
    • Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T. 1996. Interleukin (IL.-6) gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. J Exp Med 183:311-316.
    • (1996) J Exp Med , vol.183 , pp. 311-316
    • Chai, Z.1    Gatti, S.2    Toniatti, C.3    Poli, V.4    Bartfai, T.5
  • 10
    • 0028598750 scopus 로고
    • Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
    • Chiang CS, Stadler A, Samini A, Campbell I. 1994. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev Neurosci 16:212-221.
    • (1994) Dev Neurosci , vol.16 , pp. 212-221
    • Chiang, C.S.1    Stadler, A.2    Samini, A.3    Campbell, I.4
  • 11
    • 0029013734 scopus 로고
    • Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid induced seizures
    • Dalton T, Pazdernik TL, Wagner J, Samson F, Andrews GK. 1995. Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid induced seizures. Neurochem Int 27:59-71.
    • (1995) Neurochem Int , vol.27 , pp. 59-71
    • Dalton, T.1    Pazdernik, T.L.2    Wagner, J.3    Samson, F.4    Andrews, G.K.5
  • 12
    • 0025024263 scopus 로고
    • Endotoxin induction of murine metallothionein gene expression
    • De SK, McMaster MT, Andrews GK. 1990. Endotoxin induction of murine metallothionein gene expression. J Biol Chem 265:15267-15274.
    • (1990) J Biol Chem , vol.265 , pp. 15267-15274
    • De, S.K.1    McMaster, M.T.2    Andrews, G.K.3
  • 14
    • 0031016825 scopus 로고    scopus 로고
    • Disruption of the metallothionein-III gene in mice: Analysis of brain zinc, behavior and neuron vulnerability to metals, aging and seizures
    • Erickson JC, Hollopeter G, Thomas SA, Froelick GJ, Palmiter RD. 1997. Disruption of the metallothionein-III gene in mice: Analysis of brain zinc, behavior and neuron vulnerability to metals, aging and seizures. J Neurosci 17:1271-1281.
    • (1997) J Neurosci , vol.17 , pp. 1271-1281
    • Erickson, J.C.1    Hollopeter, G.2    Thomas, S.A.3    Froelick, G.J.4    Palmiter, R.D.5
  • 15
    • 0028263925 scopus 로고
    • Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)
    • Erickson JC, Sewell AK, Jensen LT, Winge DR, Palmiter RD. 1994. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res 649:297-304.
    • (1994) Brain Res , vol.649 , pp. 297-304
    • Erickson, J.C.1    Sewell, A.K.2    Jensen, L.T.3    Winge, D.R.4    Palmiter, R.D.5
  • 16
    • 0031852288 scopus 로고    scopus 로고
    • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induce autoimmune encephalomyelitis
    • Eugster H-P, Frei K, Kopf M, Lassmann H, Fontana A. 1998. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induce autoimmune encephalomyelitis. Eur J Immunol 28:2178-2187.
    • (1998) Eur J Immunol , vol.28 , pp. 2178-2187
    • Eugster, H.-P.1    Frei, K.2    Kopf, M.3    Lassmann, H.4    Fontana, A.5
  • 17
    • 17444437606 scopus 로고    scopus 로고
    • Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor
    • Faller P, Vasák M. 1997. Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor. Biochemistry 36:13341-13348.
    • (1997) Biochemistry , vol.36 , pp. 13341-13348
    • Faller, P.1    Vasák, M.2
  • 18
    • 0030459070 scopus 로고    scopus 로고
    • Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: A morphometrical study
    • Fujita H, Tanaka J, Toku K, Tateishi N, Suzuki Y, Matsuda S, Sakanaka M, Maeda N. 1996. Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study. Glia 18:269-281.
    • (1996) Glia , vol.18 , pp. 269-281
    • Fujita, H.1    Tanaka, J.2    Toku, K.3    Tateishi, N.4    Suzuki, Y.5    Matsuda, S.6    Sakanaka, M.7    Maeda, N.8
  • 19
    • 0028337327 scopus 로고
    • Regulation of metallothionein concentrations in rat brain: Effect of glucocorticoids, zinc, copper and endotoxin
    • Gasull T, Giralt M, Hernández J, Martinez P, Bremmer I, Hidalgo J. 1994. Regulation of metallothionein concentrations in rat brain: effect of glucocorticoids, zinc, copper and endotoxin. Am J Physiol 266:E760-E767.
    • (1994) Am J Physiol , vol.266
    • Gasull, T.1    Giralt, M.2    Hernández, J.3    Martinez, P.4    Bremmer, I.5    Hidalgo, J.6
  • 20
    • 0027443428 scopus 로고
    • Development of a competitive double antibody radioimmunoassay for rat metallothionein
    • Gasull T, Rebollo DV, Romero B, Hidalgo J. 1993. Development of a competitive double antibody radioimmunoassay for rat metallothionein. J Immunoassay 14:209-215.
    • (1993) J Immunoassay , vol.14 , pp. 209-215
    • Gasull, T.1    Rebollo, D.V.2    Romero, B.3    Hidalgo, J.4
  • 21
    • 0029847804 scopus 로고    scopus 로고
    • Molecular mechanisms of microglial activation. A. Implications for regeneration and neurogenerative diseases
    • Gebicke-Haerter PJ, Van Calker D, Nörenberg W, Illes P. 1996. Molecular mechanisms of microglial activation. A. Implications for regeneration and neurogenerative diseases. Neurochem Int 29: 1-12.
    • (1996) Neurochem Int , vol.29 , pp. 1-12
    • Gebicke-Haerter, P.J.1    Van Calker, D.2    Nörenberg, W.3    Illes, P.4
  • 22
    • 0002547748 scopus 로고
    • Colony-stimulating factors regulate programmed cell death of rat microglia/brain macrophages in vitro
    • Gehrmann J. 1995. Colony-stimulating factors regulate programmed cell death of rat microglia/brain macrophages in vitro. J Neuroimmunol 63: 55-61.
    • (1995) J Neuroimmunol , vol.63 , pp. 55-61
    • Gehrmann, J.1
  • 23
    • 0024211168 scopus 로고
    • Colony-stimulating factors as promoters of ameboid microglia
    • Giulian D, Ingemann JE. 1988. Colony-Stimulating factors as promoters of ameboid microglia. J Neurosci 8:4707-4717.
    • (1988) J Neurosci , vol.8 , pp. 4707-4717
    • Giulian, D.1    Ingemann, J.E.2
  • 24
    • 0024852196 scopus 로고
    • The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain
    • Giulian D, Chen J, Ingeman JE, George JK, Noponen M. 1989. The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J Neurosci 12:4416-4429.
    • (1989) J Neurosci , vol.12 , pp. 4416-4429
    • Giulian, D.1    Chen, J.2    Ingeman, J.E.3    George, J.K.4    Noponen, M.5
  • 25
    • 0028596581 scopus 로고
    • The impact of microglia-derived cytokines upon gliosis in the CNS
    • Giulian D, Li J, Li X, George J, Rutecki PA. 1994. The impact of microglia-derived cytokines upon gliosis in the CNS. Dev Neurosci 16:128-136.
    • (1994) Dev Neurosci , vol.16 , pp. 128-136
    • Giulian, D.1    Li, J.2    Li, X.3    George, J.4    Rutecki, P.A.5
  • 26
    • 0026024226 scopus 로고
    • Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures
    • Hama T, Kushima Y, Miyamoto M, Kubota M, Takei N, Hatanaka H. 1991. Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience 40:445-452.
    • (1991) Neuroscience , vol.40 , pp. 445-452
    • Hama, T.1    Kushima, Y.2    Miyamoto, M.3    Kubota, M.4    Takei, N.5    Hatanaka, H.6
  • 27
    • 0030984275 scopus 로고    scopus 로고
    • The pivotal role of interleukin 6 in formation and function of hematopoietically active murine long-term bone marrow cultures
    • Hauser SP, Kajkenova O, Lipschitz DA. 1997. The pivotal role of interleukin 6 in formation and function of hematopoietically active murine long-term bone marrow cultures. Stem Cells 15:125-132.
    • (1997) Stem Cells , vol.15 , pp. 125-132
    • Hauser, S.P.1    Kajkenova, O.2    Lipschitz, D.A.3
  • 28
    • 0025190892 scopus 로고
    • Lnterleukin-6 and the acute phase response
    • Heinrich P, Castell JV, Andus T. 1990. lnterleukin-6 and the acute phase response. J Biochem 265:621-636.
    • (1990) J Biochem , vol.265 , pp. 621-636
    • Heinrich, P.1    Castell, J.V.2    Andus, T.3
  • 29
    • 0031467403 scopus 로고    scopus 로고
    • IFN-γR+/+ mice show an enhanced liver and brain metallothionein I+II response to endotoxin but not to immobilization stress
    • Hernández J, Carrasco J, Arbones ML, Hidalgo J. 1997a. IFN-γR+/+ mice show an enhanced liver and brain metallothionein I+II response to endotoxin but not to immobilization stress. J Endotoxin Res 4:363-370.
    • (1997) J Endotoxin Res , vol.4 , pp. 363-370
    • Hernández, J.1    Carrasco, J.2    Arbones, M.L.3    Hidalgo, J.4
  • 30
    • 17044453671 scopus 로고    scopus 로고
    • Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice
    • Hernández J, Molinero A, Campbell IL, Hidalgo J. 1997b. Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice. Mol Brain Res 48:125-131.
    • (1997) Mol Brain Res , vol.48 , pp. 125-131
    • Hernández, J.1    Molinero, A.2    Campbell, I.L.3    Hidalgo, J.4
  • 31
    • 0025469698 scopus 로고
    • Liver, brain and heart metallothionein induction by stress
    • Hidalgo J, Borras M, Garvey JS, Armario A. 1990. Liver, brain and heart metallothionein induction by stress. J Neurochem 55:651-654.
    • (1990) J Neurochem , vol.55 , pp. 651-654
    • Hidalgo, J.1    Borras, M.2    Garvey, J.S.3    Armario, A.4
  • 32
    • 0031447258 scopus 로고    scopus 로고
    • Role of glucocorticoids on rat brain metallothionein-I and -III response to stress
    • Hidalgo J, Belloso E, Hernández J. Gasull T, Molinero A. 1997. Role of glucocorticoids on rat brain metallothionein-I and -III response to stress. Stress 1:231-240.
    • (1997) Stress , vol.1 , pp. 231-240
    • Hidalgo, J.1    Belloso, E.2    Hernández, J.3    Gasull, T.4    Molinero, A.5
  • 36
    • 0028800715 scopus 로고
    • Cytokines and the nervous system I: Expression and recognition
    • Hopkins SJ, Rothwell NJ. 1995. Cytokines and the nervous system I: expression and recognition. Trends Neurosci 18:83-88.
    • (1995) Trends Neurosci , vol.18 , pp. 83-88
    • Hopkins, S.J.1    Rothwell, N.J.2
  • 38
    • 0030601960 scopus 로고    scopus 로고
    • Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds: An immunocytochemical study using confocal laser scan microscope
    • Hozumi I, Inuzuka T, Ishiguro H, Hiraiwa M, Uchida Y, Tsuji S. 1996. Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds: an immunocytochemical study using confocal laser scan microscope. Brain Res 741:197-204.
    • (1996) Brain Res , vol.741 , pp. 197-204
    • Hozumi, I.1    Inuzuka, T.2    Ishiguro, H.3    Hiraiwa, M.4    Uchida, Y.5    Tsuji, S.6
  • 39
    • 0030050959 scopus 로고    scopus 로고
    • Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats
    • Inuzuka T, Hozumi I, Tamura A, Hiraiwa M, Tsuji S. 1996. Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats. Brain Res 709:151-131.
    • (1996) Brain Res , vol.709 , pp. 151-1131
    • Inuzuka, T.1    Hozumi, I.2    Tamura, A.3    Hiraiwa, M.4    Tsuji, S.5
  • 41
    • 0022362620 scopus 로고
    • Interleukin 1 regulates human metallothionein gene expression
    • Karin M, Imbra RJ, Heguy A, Wong G. 1985. Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol 5:2866-2869.
    • (1985) Mol Cell Biol , vol.5 , pp. 2866-2869
    • Karin, M.1    Imbra, R.J.2    Heguy, A.3    Wong, G.4
  • 42
    • 0027172593 scopus 로고
    • Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system
    • Kobayashi H, Uchida Y, Ihara Y, Nakajima K, Kohsaka S, Miyatake T, Tsuji S. 1993. Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system. Mol Brain Res. 19:188-194
    • (1993) Mol Brain Res. , vol.19 , pp. 188-194
    • Kobayashi, H.1    Uchida, Y.2    Ihara, Y.3    Nakajima, K.4    Kohsaka, S.5    Miyatake, T.6    Tsuji, S.7
  • 43
    • 0028343364 scopus 로고
    • Zinc toxicity in cultured cortical neurons: Involvement of N-methyl-D-aspartate receptors
    • Koh JY, Choi DW. 1994. Zinc toxicity in cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience 60: 1049-1057.
    • (1994) Neuroscience , vol.60 , pp. 1049-1057
    • Koh, J.Y.1    Choi, D.W.2
  • 45
    • 0030443169 scopus 로고    scopus 로고
    • Differential effects of macrophage- and granulocyte-macrophage colony-stimulating factors on cytokine gene expression during rat alveolar macrophage differentiation into multinucleated giant cells (MGC): Role for IL-6 in type 2 MGC formation
    • Lemaire I, Yang H, Lafont V, Dornand J, Commes T, Cantin MF. 1996. Differential effects of macrophage- and granulocyte-macrophage colony-stimulating factors on cytokine gene expression during rat alveolar macrophage differentiation into multinucleated giant cells (MGC): role for IL-6 in type 2 MGC formation. J Immunol 157:5118-5125.
    • (1996) J Immunol , vol.157 , pp. 5118-5125
    • Lemaire, I.1    Yang, H.2    Lafont, V.3    Dornand, J.4    Commes, T.5    Cantin, M.F.6
  • 46
    • 0030614992 scopus 로고    scopus 로고
    • IL-6 and TNFa expression in brains of twitcher, quaking and normal mice
    • LeVine SM, Brown DC. 1997. IL-6 and TNFa expression in brains of twitcher, quaking and normal mice. J Neuroimmunol 73:47-56.
    • (1997) J Neuroimmunol , vol.73 , pp. 47-56
    • LeVine, S.M.1    Brown, D.C.2
  • 47
    • 0025297592 scopus 로고
    • Production of hemopoietic colony-stimulating factors by astrocytes
    • Malipiero UV, Frei K, Fontana A. 1990. Production of hemopoietic colony-stimulating factors by astrocytes. J Immunol 144:3816-3821.
    • (1990) J Immunol , vol.144 , pp. 3816-3821
    • Malipiero, U.V.1    Frei, K.2    Fontana, A.3
  • 50
    • 0031921636 scopus 로고    scopus 로고
    • Interleukin-6 functions in autoimmune encephalomyelitis: A study in genetargeted mice
    • Mendel I, Katz A, Kozak N, Ben-Nun A, Revel M. 1998. Interleukin-6 functions in autoimmune encephalomyelitis: a study in genetargeted mice. Eur J Immunol 28:1727-1737.
    • (1998) Eur J Immunol , vol.28 , pp. 1727-1737
    • Mendel, I.1    Katz, A.2    Kozak, N.3    Ben-Nun, A.4    Revel, M.5
  • 51
    • 0029902728 scopus 로고    scopus 로고
    • Detection of plasma proteins in CNS: Conspicuous influence of tissue-processing parameters and the utilization of serum for blocking non-specific reactions
    • Moos T, Høyer PE. 1996. Detection of plasma proteins in CNS: conspicuous influence of tissue-processing parameters and the utilization of serum for blocking non-specific reactions. J Histochem Cytochem 44:591-603.
    • (1996) J Histochem Cytochem , vol.44 , pp. 591-603
    • Moos, T.1    Høyer, P.E.2
  • 52
    • 0028819715 scopus 로고
    • Constitutive expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient
    • Palmiter RD. 1995. Constitutive expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient. Toxicol Appl Pharmacol 135:139-146.
    • (1995) Toxicol Appl Pharmacol , vol.135 , pp. 139-146
    • Palmiter, R.D.1
  • 54
    • 0031558662 scopus 로고    scopus 로고
    • Increased astrocytic expression of metallothioneins I + II in brain stem of adult rats treated with 6-aminonicotinamide
    • Penkowa M, Hidalgo J, Moos T. 1997. Increased astrocytic expression of metallothioneins I + II in brain stem of adult rats treated with 6-aminonicotinamide. Brain Res 774:256-259.
    • (1997) Brain Res , vol.774 , pp. 256-259
    • Penkowa, M.1    Hidalgo, J.2    Moos, T.3
  • 55
    • 0029257277 scopus 로고
    • Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes
    • Penkowa M, Moos T. 1995. Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes. Glia 13:217-227.
    • (1995) Glia , vol.13 , pp. 217-227
    • Penkowa, M.1    Moos, T.2
  • 57
    • 0028568612 scopus 로고
    • Cytokines as mediators in the central nervous system
    • Pousset F. 1994. Cytokines as mediators in the central nervous system. Biomed Pharmacother 48:425-431.
    • (1994) Biomed Pharmacother , vol.48 , pp. 425-431
    • Pousset, F.1
  • 58
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet JL, Malhotra A, Gage FH. 1997. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577.
    • (1997) Trends Neurosci , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, A.2    Gage, F.H.3
  • 59
    • 0028869476 scopus 로고
    • Cytokines and the central nervous system. II. Actions and mechanisms of action
    • Rothwell NJ, Hopkins SJ. 1995. Cytokines and the central nervous system. II. Actions and mechanisms of action. Trends Neurosci 18:130-136.
    • (1995) Trends Neurosci , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 60
    • 0027533507 scopus 로고
    • Oxygen free radicals and metallothionein
    • Sato M, Bremner I. 1993. Oxygen free radicals and metallothionein. Free Radical Biol Med 14:325-337.
    • (1993) Free Radical Biol Med , vol.14 , pp. 325-337
    • Sato, M.1    Bremner, I.2
  • 61
    • 0025228503 scopus 로고
    • Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures
    • Schroeder JJ, Cousins RJ. 1990. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc Natl Acad Sci USA 87:3137-3141.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3137-3141
    • Schroeder, J.J.1    Cousins, R.J.2
  • 62
    • 0028932454 scopus 로고
    • Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties
    • Sewell AK, Jensen LT, Erickson JC, Palmiter RD, Winge DR. 1995. Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties. Biochemistry 34:4740-4747.
    • (1995) Biochemistry , vol.34 , pp. 4740-4747
    • Sewell, A.K.1    Jensen, L.T.2    Erickson, J.C.3    Palmiter, R.D.4    Winge, D.R.5
  • 64
    • 0027183521 scopus 로고
    • Origin of macrophages in central nervous tissue
    • Stevens A, Bähr M. 1993. Origin of macrophages in central nervous tissue. J Neurological Sci 118:117-122.
    • (1993) J Neurological Sci , vol.118 , pp. 117-122
    • Stevens, A.1    Bähr, M.2
  • 65
    • 0026781413 scopus 로고
    • Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons
    • Toulmond S, Vige X, Fage D, Benavides J. 1992. Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. Neurosci Lett 144:49-52.
    • (1992) Neurosci Lett , vol.144 , pp. 49-52
    • Toulmond, S.1    Vige, X.2    Fage, D.3    Benavides, J.4
  • 67
    • 0025768860 scopus 로고
    • The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
    • Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M. 1991. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 7:337-347.
    • (1991) Neuron , vol.7 , pp. 337-347
    • Uchida, Y.1    Takio, K.2    Titani, K.3    Ihara, Y.4    Tomonaga, M.5
  • 68
    • 0030828933 scopus 로고    scopus 로고
    • Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse
    • Vela JM, Hidalgo J, González B, Castellano B. 1997. Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse. Brain Res 767:345-355.
    • (1997) Brain Res , vol.767 , pp. 345-355
    • Vela, J.M.1    Hidalgo, J.2    González, B.3    Castellano, B.4
  • 69
    • 0028266972 scopus 로고
    • Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death
    • Yamada M, Hatanaka H. 1994. Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res 643:173-180.
    • (1994) Brain Res , vol.643 , pp. 173-180
    • Yamada, M.1    Hatanaka, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.