Dietary restriction increases the number of newly generated neural cells, and BDNF expression, in the dentate gyrus of rats

Journal of Molecular Neuroscience

Volumn 15, Issue 2, 2000, Pages 99-108

  Lee, J ^a,b   Duan, W ^a   Long, J M ^a   Ingram, D K ^a   Mattson, M P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aging; Alzheimer's disease; Bromodeoxyuridine; Caloric restriction; Hippocampus; Stem cells; Stereology

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BROXURIDINE; DNA;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CALORIC RESTRICTION; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; DIET RESTRICTION; DNA SYNTHESIS; HIPPOCAMPUS; LEARNING; MALE; MEMORY; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; STEM CELL; STEREOLOGY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; BROMODEOXYURIDINE; CELL DIVISION; CEREBRAL CORTEX; DENTATE GYRUS; ENERGY INTAKE; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0034489693     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:15:2:99     Document Type: Article

References (40)

1. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain
2. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults
3. Regulation of neurogenesis by growth factors and neurotransmitters
4. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults
5. Marked age-dependent neuro-protection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury
6. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease
7. Food restriction and brain aging
8. Multipotent progenitor cells in the adult dentate gyrus
9. Mammalian neural stem cells
10. Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats
11. The efficiency of systematic sampling in stereology and its prediction
12. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
13. Dietary restriction: Effects on radial maze learning and lipofuscin pigment deposition in the hippocampus and frontal cortex
14. Dietary restriction benefits learning and motor performance of aged mice
15. More hippocampal neurons in adult mice living in an enriched environment
16. Early induction of mRNA for calbindin-D28k and BDNF but not NT-3 in rat hippocampus after kainic acid treatment
17. 2-deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Involvement of stress proteins
18. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
19. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma
20. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
21. Dietary lipids and antioxidants in Parkinson's disease: A population-based, case-control study
22. Stereological estimation of total microglia number in mouse hippocampus
23. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
24. Neuroblasts of the postnatal mammalian forebrain: Their phenotype and fate
25. 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
26. Impact of dietary restriction on brain aging and neurodegenerative disorders: Emerging findings from experimental and epidemiological studies
27. Reduced risk of Alzheimer's disease among individuals with low calorie intake
28. Essential role for TrkB receptors in hippocampus-mediated learning
29. Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory
30. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
31. In situ hybridization approaches to the study of the nervous system
32. Oxidative stress, caloric restriction, and aging
33. The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes
34. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
35. The beneficial effects of dietary restriction: Reduced oxidative damage and enhanced apoptosis
36. New stereologial methods for counting neurons
37. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
38. Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism
39. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation