Use of suppression subtractive hybridization for differential gene expression in stroke discovery of CD44 gene expression and localization in permanent focal stroke in rats

Stroke

Volumn 32, Issue 4, 2001, Pages 1020-1027

  Wang, Hugh ^a   Zhan, Yutian ^a   Xu, Lin ^a   Feuerstein, Giora Z ^a   Wang, Xinkang ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Cerebral ischemia; Cytokines; Gene expression; Inflammation

Indexed keywords

GLYCOPROTEIN; HERMES ANTIGEN; HYALURONAN SYNTHASE 2; HYALURONIC ACID; MESSENGER RNA; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN ISCHEMIA; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; DNA SEQUENCE; GENE EXPRESSION; HYBRIDIZATION; IMMUNOREACTIVITY; INFLAMMATORY DISEASE; MACROPHAGE; MALE; MICROGLIA; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; TISSUE REGENERATION;

EID: 0035068028     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.32.4.1020     Document Type: Article

References (36)

1. Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
2. The role of cytokines in the neuropathology of stroke and neurotrauma
3. Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity
4. The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion
5. A role for the cell adhesion molecule CD44 and sulfation in leukocyte-endothelial cell adhesion during an inflammatory response?
6. Differential expressions of CD44 variants in tumors affecting the central nervous system
7. Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells
8. CD44 and its interaction with extracellular matrix
9. TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation
10. CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
11. Signaling through CD44 is mediated by tyrosine kinases: Association with p561ck in T lymphocytes
12. Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells
13. CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP
14. Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques
15. Induction of CD44 expression in stab wounds of the brain: Long term persistence of CD44 expression
16. Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: A possible role in stroke
17. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
18. A rat model of focal embolic cerebral ischemia
19. Delayed expression of osteopontin after focal stroke in the rat
20. Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1beta mRNA in ischemic brain tolerance
21. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
22. Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats
23. Osteogenic protein 1 stimulates cells-associated matrix assembly by normal human articular chondrocytes: Up-regulation of hyaluronan synthase, CD44, and aggrecan
24. Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis
25. NeuN, a neuronal specific nuclear protein in vertebrates
26. CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease
27. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages
28. Stimulation of serglycin and CD44 mRNA expression in endothelial cells exposed to TNF-alpha and IL-1alpha
29. Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells
30. Hyaluronan in human cerebrospinal fluid
31. Hyaluronan-binding proteins in development, tissue homeostasis, and disease
32. CD44 positive macrophages take up hyaluronan during lung development
33. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat
34. Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke
35. Interaction between CD44 and osteopontin as a potential basis for metastasis formation
36. Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the "penumbra" following focal cerebral ischemia in the rat