Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain

American Journal of Pathology

Volumn 148, Issue 6, 1996, Pages 1797-1806

  Cribbs, David H ^a   Chen, Lian Sheng ^b   Bende, Steven M ^c   LaFerla, Frank M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BRAIN PROTEIN; DIGOXIGENIN; MESSENGER RNA; PRESENILIN 1;

ADOLESCENT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EARLY DIAGNOSIS; EMBRYO; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE DEGENERATION; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ISOLATION;

ALZHEIMER DISEASE; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BRAIN; CELLS, CULTURED; CEREBRAL CORTEX; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; MICE; NEURONS; PRESENILIN-1; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0029982341     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Selkoe D: The molecular pathology of Alzheimer's disease. Neuron 1991, 6:487-498
2. Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J: Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991, 349:704-706
3. Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J, Mullan M: Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature 1991, 353:844-846
4. Murrell J, Farlow M, Ghetti B, Benson MD: A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991, 254:97-99
5. Saunders AM, Strittmatter WJ, Schmechel D, St. George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi, BL, Gusella JF, Crapper-MacLachlan DR, Alberts, MJ, Hulette C, Crain B, Goldgaber D, Roses AD: Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993, 43:1467-1472
6. Rebeck GW, Reiter JS, Strickland DK, Hyman BT: Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 1993, 11: 575-585
7. Kamboh MI, Sanghera DK, Ferrell RE, DeKosky ST: APOE4-associated Alzheimer's disease risk is modified by a 1-antichymotrypsin polymorphism: Nature Genetics 1995, 10:486-488
8. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, DaSilva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995, 375:754-760
9. Alzheimer's disease collaborative group: The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nature Genetics 1995, 11:219-222
10. Levy-Lahad E, Wijsman ES, Nemens E, Anderson L, Goddard KAB, Weber JL, Bird TD, Schellenberg GD: A familial Alzheimer's disease locus on chromosome 1. Science 1995, 269:970-973
11. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, Mar L, Sorbi S, Nacmias B, Piacentini S, Amaducci L, Chumakov I, Cohen D, Lannfelt L, Fraser PE, Rommens JM, St. George-Hyslop PH: Familial Alzheimer's disease in kindreds with rnissense mutations in a gene on chromosome 1 related to Alzheimer's disease type 3 gene. Nature 1995, 376:775-778
12. Sorbi S, Nacmias B, Forleo P, Piacentini S, Sherrington R, Rogaev E, St: George Hyslop P, Amaducci L: Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease. Lancet 1995, 346:439-440
13. Tanahashi H, Mitsunaga Y, Takahashi K, Tasaki H, Watanabe S, Tabira T: Missense mutation of S182 gene in Japanese familial Alzheimer's disease. Lancet 1995, 346:440
14. Van Broeckhoven C: Presenilins and Alzheimer disease. Nature Genetics 1995, 11:230-232
15. Wisniewski T, Palha JA, Ghiso J, Frangione B: S182 protein in Alzheimer's disease neuritic plaques. Lancet 1995, 346:1366
16. Scheuner D, Bird T, Citron M, Lannfelt L, Schellenberg G. Selkoe D, Viitanen, Younkin SG: Fibroblasts from carriers of familial AD linked to chromosome 14 show increased Aβ production. Soc Neurosci Abstr 1995, 21:1500
17. Feinberg AP, Vogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983, 132:6-13
18. Cox KH, DeLeon DV, Angerer LM, Angerer RC: Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Biol 1984, 101:485-502
19. McCarthy KD, de Vellis J: Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980, 85:890-902
20. Pike CJ, Cummings BJ, Monzavi R, Cotman CW: β-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. Neuroscience 1994, 63:517-531
21. Brewer GJ, Cotman CW: Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res 1989, 494:65-74
22. Chomczynski P, Sacchi N: Single-step method of isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal Biochem 1987, 162:156-159
23. Rentrop M, Knapp B, Winter H, Schweizer J: Amino-alkysilane-treated glass slides as support for in situ hybridization of keratin cDNAs to frozen tissue section under varying fixation and pretreatment conditions. Histochem J 1986, 18:271-276
24. Panoskaltsis-Mortari A, Bucy RP: In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts. BioTechniques 1995, 18:300-307
25. Tanzi, RE, Gusella JF, Watkins PC, Bruns GAP, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL: Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 1987, 235:880-884
26. Neve RL, Finch EA, Dawes LR: Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1988, 1:669-677
27. Mita S, Schon, EA, Herbert J: Widespread expression of amyloid β-protein precursor gene in rat brain. Am J Pathol 1989, 134:1253-1261
28. Slunt HH, Thinakaran G, Lee MK, Sisodia SS: Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction. Amyloid: Int J Exp Clin Invest 1995, 2:188-190
29. Levitan D, Greenwald I: Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 1995, 377:351-354
30. Dewji NN, Singer SJ: Genetic clues to Alzheimer's disease. Science 1996, 271:159-160
31. Loo DT, Copani AG, Pike CJ, Whittemore ER, Walenecicz AJ, Cotman CW: Apoptosis is induced in culture central nervous system neurons. Proc Natl Acad Sci USA 1993, 90:7951-7955
32. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild C, Jay G: The Alzheimer's Aβ peptide induces neurodegeneration and apoptosis in transgenic mice. Nature Genetics 1995, 9:21-30
33. Su JH, Anderson AJ, Cummings BJ, Cotman CW: Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994, 5:2529-2533
34. Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM: Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 1995, 89:35-41
35. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 1996, 271:521-525