Stereological estimation of total microglia number in mouse hippocampus

Journal of Neuroscience Methods

Volumn 84, Issue 1-2, 1998, Pages 101-108

  Long, Jeffrey M ^a   Kalehua, Audrey N ^a   Muth, Nancy J ^b   Hengemihle, John M ^a   Jucker, Mathias ^c   Calhoun, Michael E ^c   Ingram, Donald K ^a   Mouton, Peter R ^a,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Essex Community College   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CA1; Dentate gyrus; Mac 1; Optical fractionator; Stereology

Indexed keywords

COMPLEMENT COMPONENT C3 RECEPTOR; RECEPTOR ANTIBODY;

AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CELL DENSITY; DEGENERATIVE DISEASE; DEMENTIA; DENTATE GYRUS; IMMUNOCYTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEREOLOGY;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CELL COUNT; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MACROPHAGE-1 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MICROSCOPY;

EID: 0032191756     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(98)00100-9     Document Type: Article

References (33)

1. Banati RB, Graeber MB Surveillance intervention and cytotoxicity: is there a protective role of microglia. Dev Neurosci. 16:1994;114-127.
2. Barron KD The microglia cell. A historical review. J Neurol Sci. 134:1995;57-68.
3. Benveniste EN Astrocyte-Microglia interactions. Murphy S Astrocytes: Pharmacology and Function. 1993;355-383 Academic Press, San Diego.
4. Bolender RP, Charleston JS Software for counting cells and estimation structure volumes with the optical disector and fractionator. Microsc Res Tech. 25:1993;314-324.
5. Calhoun ME, Jucker M, Martin LJ, Thinakaran G, Price DL, Mouton PR Comparative evaluation of synaptophysin-based methods for quantification of synapses. J Cytol. 25:1996;821-828.
6. Chiang CS, Stalder A, Samimi A, Campbell IL Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev Neurosci. 16:1994;212-221.
7. Coggeshall RE, Lekan HA Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol. 364:1996;6-15.
8. Eikelenboom P, Veerhuis R The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurbiol Aging. 17:1996;673-680.
9. Fattori E, Lazzaro D, Musiani P, Modesti A, Alonzi T, Ciliberto G IL-6 expression in meurons of transgenic mice causes reactive astrocytosis and increase in ramified microglia cells but no neuronal damage. Eur J Neurosci. 7:1995;2441-2449.
10. Franklin KBJ, Paxinos G The Mouse Brain in Stereotaxic Coordinates. 1997;Academic Press, New York.
11. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guild T, Hagoplan S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberbug I, Little S, Masilah E, McCounlouge L, Montoya-Zavals M, Mucke L, Paganni L, Penniman E, Power M, Schenk D, Seubert P, Synder B, Soriano F, Tan H, Vitale J, Wasdsworth S, Wolozin B, Zhao B Alzheimer-type neuropathology in transgenic mice overexpressing V717F B-amyloid precursor protein. Nature. 373:1995;523-527.
12. Gundersen HJG Stereology of arbitrary particles: A review of unbiase number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc. 143:1986;3-45.
13. Gundersen HJG, Jensen EB The efficiency of systematic sampling in stereology and its prediction. J Mirosc. 147:1987;229-263.
14. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, West MJ The new stereological tools: disectors, fractionator, nucleator and point sampled intercepts and their used in pathological research and diagnosis. APMIS. 96:1988;875-881.
15. Hsu SM, Raine L, Fanger H Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 4:1981;577-580.
16. Htain WW, Leong SK, Ling EA A comparative Mac-1 immunocytochemical and lectin histochemical study of microglia cells in the normal and athymic mice. Glia. 12:1994;44-51.
17. Lawson LJ, Perry VH, Dri P, Gordon S Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 39:1990;151-170.
18. Mackenzie IRA, Hao C, Munoz DG Role of microglia in senile plaque formation. Neurobiol Aging. 16:1995;797-804.
19. McGeer PL, McGeer EG The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev. 21:1995;195-218.
20. Mouton PR, Price DL, Walker LC Empirical assessment of synpase numbers in the primate cortex. J Neurosci Meth. 75:1997;114-117.
21. Mrak RE, Sheng JG, Griffin WS Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol. 26:1995;816-823.
22. Pakkenberg B, Gundersen HJG Total number of neurons and glia cells in human brain nuclei estimated by the disector and fractionator. J Microsc. 150:1988;1-20.
23. Perry VH, Gordon S Macrophages and the nervous system. Int Rev Cytol. 125:1991;203-244.
24. Perry VH, Matyszak MK, Fearn S Altered antigen expression of microglia in the aged rodent cns. Glia. 7:1993;60-67.
25. Reeves RH, Yao J, Crowley MR, Bucks S, Zhang X, Yarowsky P, Gearhart JD, Hilt DC Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc Natl Acad Sci USA. 91:1994;5359-5363.
26. Roberts N, Cruz-Orive LM, Reid NMK, Brodie DA, Bourne M, Edwards RHT Unbiased estimation of human body composition by the cavalieri method using magnetic resonance imaging. J Microsc. 171:1993;239-253.
27. Sterio DC The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc. 134:1984;127-136.
28. Streit WJ, Graeber MB, Kreutzberg GW Functional plasticity of microglia: a review. Glia. 1:1988;301-307.
29. Sturrock RR A comparative quantitative and morphological study of aging in the mouse neostriatum, indusium griseum and anterior commissure. Neuropathol Appl Neurobiol. 6:1980;51-68.
30. Subbiah P, Mouton P, Fedor H, McArthur JC, Glass JD Stereological analysis of cerebral atrophy in human immunodeficiency virus-associated dementia. J Neuropathol Exp Neurol. 55:1996;1032-1037.
31. West MJ New stereological methods for counting neurons. Neurobiol Aging. 14:1993;275-285.
32. West MJ, Slomianka L, Gundersen HJG Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec. 231:1991;482-497.
33. West MJ, Østergaard K, Andreassen Finsen B Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method. J Comp Neurol. 370:1996;11-22.