E protein function in lymphocyte development

Annual Review of Immunology

Volumn 20, Issue , 2002, Pages 301-322

  Quong, Melanie W ^a   Romanow, William J ^a   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

B lymphocyte; E2A; Helix loop helix (HLH); Id; Thymocyte

Indexed keywords

HELIX LOOP HELIX PROTEIN; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; PALINDROMIC DNA; PROTEIN E; PROTEIN E12; PROTEIN E2 2; PROTEIN E47; PROTEIN HEB; RAS PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; GENE ACTIVATION; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELL; HUMAN; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; B-LYMPHOCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HELIX-LOOP-HELIX MOTIFS; HUMANS; LYMPHOCYTES; MICE; NEOPLASMS; NERVE TISSUE PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TCF TRANSCRIPTION FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0036217915     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.20.092501.162048     Document Type: Review

References (124)

1. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
2. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo
3. Two distinct transcription factors that bind the immunoglobulin enhancer μE5/κE2 motif
4. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
5. A T-cell-specific transcriptional enhancer element 3′ of Cα in the human T-cell receptor α locus
6. Expression of the mouse pre-T cell receptor α gene is controlled by an upstream region containing a transcriptional enhancer
7. Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain gene
8. Immunoglobulin gene transcription
9. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
10. Transcription factor regulation of B lineage commitment
11. Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
12. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
13. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
14. The E2A gene product contains two separable and functionally distinct transcription activation domains
15. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells
16. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex
17. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers
18. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
19. The helix-loop-helix motif: Structure and function
20. B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-1ike subunits
21. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
22. B-cell-specific DNA binding by an EA7 homodimer
23. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
24. The regulation and function of the Id proteins in lymphocyte development
25. The protein Id-a negative regulator of helix-loop-helix DNA binding proteins
26. An Id-related helix-loop-helix protein encoded by a growth-factor inducible gene
27. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types
28. Extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins
29. The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein
30. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3
31. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
32. E2A proteins: Essential regulators at multiple stages of B-cell development
33. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
34. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2
35. Regulation of RAG expression in developing lymphocytes
36. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
37. The helix-loop-helix gene E2A is required for B cell formation
38. Failure of B-cell differentiation in mice lacking the transcription factor EBF
39. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
40. Constitutive expression of the Id1 gene impairs mouse B cell development
41. Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3
42. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
43. Both E12 and E47 allow commitment to the B cell lineage
44. Functional replacement of the mouse E2A gene with a human HEB cDNA
45. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
46. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
47. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
48. EA7 activates the Ig-heavy chain and TdT loci in non-B cells
49. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
50. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
51. Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter
52. Early B-cell development in the mouse: Insights from mutations introduced by gene targeting
53. Signaling through the B cell antigen receptor in developing B cells
54. B cell development pathways
55. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
56. RAG-1-deficient mice have no mature B and T lymphocytes
57. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
58. A critical role of lambda 5 protein in B cell development
59. Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition
60. The immunoglobulin (Ig) α and Ig β cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice
61. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes
62. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
63. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β
64. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
65. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
66. Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells
67. Immunoglobulin class switching
68. Germinal centers
69. Distinctive characteristics of germinal center B cells
70. Hypermutation in antibody affinity maturation
71. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
72. Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching
73. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene
74. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation
75. Regulation of thymocyte development from immature progenitors
76. Early αβ T cell development in the thymus of normal and genetically altered mice
77. Positive selection of thymocytes bearing alpha beta T cell receptors
78. Signaling checkpoints during the development of T lymphocytes
79. Natural killer cell differentiation: Insights from knockout and transgenic mouse models and in vitro systems
80. Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse
81. Early stages in the development of human T, natural killer and thymic dendritic cells
82. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2
83. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
84. Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
85. Early thymocyte development is regulated by modulation of E2A protein activity
86. Positive and negative regulation of V(D)J recombination by the E2A proteins
87. Induction of a diverse T cell receptor γ/δ repertoire by the helix-loop-helix proteins E2A and HEB in nonlymphoid cells
88. Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells
89. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
90. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB
91. Branching out to gain control: How the pre-TCR is linked to multiple functions
92. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-T α chain expression
93. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis
94. Positive selection of lymphocytes
95. Selective events in T cell development
96. T-cell selection
97. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
98. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
99. Selective requirement for MAP kinase activation in thymocyte differentiation
100. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
101. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
102. The influence of the MAPK pathway on T cell lineage commitment
103. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
104. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
105. Deficient T cell fate specification in mice with an induced inactivation of Notch1
106. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
107. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
108. Notch inhibition of E47 supports the existence of a novel signaling pathway
109. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas
110. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells
111. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
112. Overexpression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages
113. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
114. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
115. Thymic tumorigenesis induced by overexpression of p561ck
116. Genomic organization and expression of Tp1-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: Activation by provirus insertion
117. Tumor progression locus 2 (Tp1-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation
118. Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase
119. Cot proto-oncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells
120. The helix-loop-helix protein Id2 is overexpressed in human pancreatic cancer
121. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis
122. Modulation of the immune response and tumor growth by activated Ras
123. Serine/threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity
124. Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases