메뉴 건너뛰기




Volumn 9, Issue 2, 1997, Pages 263-275

Early αβ T cell development in the thymus of normal and genetically altered mice

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 0030890694     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80146-X     Document Type: Article
Times cited : (218)

References (81)
  • 1
    • 0028872616 scopus 로고
    • Development and selection of T cells: Facts and puzzles
    • of special interest. Comprehensive and up-to-date review covering all aspects of T-cell development.
    • Kisielow P, von Boehmer H. Development and selection of T cells: facts and puzzles. of special interest Adv Immunol. 58:1995;87-209 Comprehensive and up-to-date review covering all aspects of T-cell development.
    • (1995) Adv Immunol , vol.58 , pp. 87-209
    • Kisielow, P.1    Von Boehmer, H.2
  • 2
    • 0030963615 scopus 로고    scopus 로고
    • Structure and function of the pre-T cell receptor
    • Latest review on the structural and functional analysis of the pre-TCR. It also provides a chronicle of the experiments that have led to the identification of the pre-TCR and pTα of outstanding interest
    • Von Boehmer H, Fehling HJ. Structure and function of the pre-T cell receptor. of outstanding interest Annu Rev Immunol. 15:1997; Latest review on the structural and functional analysis of the pre-TCR. It also provides a chronicle of the experiments that have led to the identification of the pre-TCR and pTα.
    • (1997) Annu Rev Immunol , vol.15
    • Von Boehmer, H.1    Fehling, H.J.2
  • 3
    • 0029022214 scopus 로고
    • Pathways from hematopoietic stem cells to thymocytes
    • of special interest. Review focussing on prethymic and fetal T-cell development. Discusses in detail the identification and purification of a T-lineage-committed precursor population in murine fetal blood.
    • Rodewald H-R. Pathways from hematopoietic stem cells to thymocytes. of special interest Curr Opin Immunol. 7:1995;176-187 Review focussing on prethymic and fetal T-cell development. Discusses in detail the identification and purification of a T-lineage-committed precursor population in murine fetal blood.
    • (1995) Curr Opin Immunol , vol.7 , pp. 176-187
    • Rodewald, H.-R.1
  • 4
    • 0028281866 scopus 로고
    • Early stages in human and mouse T-cell development
    • Spits H. Early stages in human and mouse T-cell development. Curr Opin Immunol. 6:1994;212-221.
    • (1994) Curr Opin Immunol , vol.6 , pp. 212-221
    • Spits, H.1
  • 5
    • 0029962079 scopus 로고    scopus 로고
    • Early T lymphocyte progenitors
    • of outstanding interest. Comprehensive and up-to-date review on the biology of early T lymphocyte progenitors in mouse and man, including potential prethymic precursor populations in the adult and fetal stage.
    • Shortman K, Wu L. Early T lymphocyte progenitors. of outstanding interest Annu Rev Immunol. 14:1996;29-47 Comprehensive and up-to-date review on the biology of early T lymphocyte progenitors in mouse and man, including potential prethymic precursor populations in the adult and fetal stage.
    • (1996) Annu Rev Immunol , vol.14 , pp. 29-47
    • Shortman, K.1    Wu, L.2
  • 6
    • 0027153201 scopus 로고
    • - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
    • - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol. 150:1993;4244-4252.
    • (1993) J Immunol , vol.150 , pp. 4244-4252
    • Godfrey, D.I.1    Kennedy, J.2    Suda, T.3    Zlotnik, A.4
  • 7
    • 0026085993 scopus 로고
    • CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus
    • Wu L, Scollay R, Egerton M, Pearse M, Sprangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature. 349:1991;71-74.
    • (1991) Nature , vol.349 , pp. 71-74
    • Wu, L.1    Scollay, R.2    Egerton, M.3    Pearse, M.4    Sprangrude, G.J.5    Shortman, K.6
  • 8
    • 0029921899 scopus 로고    scopus 로고
    • CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells
    • Ismaili J, Antica M, Wu L. CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. Eur J Immunol. 26:1996;731-737.
    • (1996) Eur J Immunol , vol.26 , pp. 731-737
    • Ismaili, J.1    Antica, M.2    Wu, L.3
  • 10
    • 0027205082 scopus 로고
    • Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population
    • Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature. 362:1993;761-763.
    • (1993) Nature , vol.362 , pp. 761-763
    • Ardavin, C.1    Wu, L.2    Li, C.-L.3    Shortman, K.4
  • 11
    • 0029787979 scopus 로고    scopus 로고
    • Thymic dendritic cell precursors: Relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny
    • + triple negatives are not yet fully committed to the T-cell lineage as they can give rise to a particular type of dendritic cell that is characterized by high-level expression of CD8α.
    • + triple negatives are not yet fully committed to the T-cell lineage as they can give rise to a particular type of dendritic cell that is characterized by high-level expression of CD8α.
    • (1996) J Exp Med , vol.184 , pp. 903-911
    • Wu, L.1    Li, C.-L.2    Shortman, K.3
  • 13
    • 0029024913 scopus 로고
    • T cell receptor gene recombination patterns and mechanisms: Cell death, rescue, and T cell production
    • of special interest. A very thorough analysis of the onset of TCRα and TCRβ gene rearrangements in different thymocyte subpopulations by quantitative Southern blotting.
    • Petrie HT, Livak F, Burtrum D, Mazel S. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. of special interest J Exp Med. 182:1995;121-127 A very thorough analysis of the onset of TCRα and TCRβ gene rearrangements in different thymocyte subpopulations by quantitative Southern blotting.
    • (1995) J Exp Med , vol.182 , pp. 121-127
    • Petrie, H.T.1    Livak, F.2    Burtrum, D.3    Mazel, S.4
  • 14
    • 0029097045 scopus 로고
    • T-cell lineage commitment and cytokine responses of thymic progenitors
    • Moore TA, Zlotnik A. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood. 86:1995;1850-1860.
    • (1995) Blood , vol.86 , pp. 1850-1860
    • Moore, T.A.1    Zlotnik, A.2
  • 15
    • 0029072262 scopus 로고
    • +) thymocytes in normal and genetically modified mice
    • +) thymocytes in normal and genetically modified mice. J Immunol. 154:1995;5103-5113.
    • (1995) J Immunol , vol.154 , pp. 5103-5113
    • Pénit, C.1    Lucas, B.2    Vasseur, F.3
  • 16
    • 0028426281 scopus 로고
    • T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice
    • Dudley EC, Petri HT, Shah LM, Owen MJ, Hayday AC. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:1994;83-93.
    • (1994) Immunity , vol.1 , pp. 83-93
    • Dudley, E.C.1    Petri, H.T.2    Shah, L.M.3    Owen, M.J.4    Hayday, A.C.5
  • 17
    • 0029311234 scopus 로고
    • αβ and γδ T cells can share a late common precursor
    • of special interest. This paper reports on the frequency of productive versus nonproductive TCRγ and δ rearrangement in αβ thymocytes of normal and TCRδ-deficient mice and on the frequency of productive versus nonproductive TCRβ rearrangements in γδ T cells. The findings make important predictions about the mechanism of αβ/γδ lineage commitment and about the developmental stage at which the two lineages diverge. The data also show that γ, δ and β rearrangements do occur in either lineage.
    • Dudley EC, Girardi M, Owen MJ, Hayday AC. αβ and γδ T cells can share a late common precursor. of special interest Curr Biol. 5:1995;659-669 This paper reports on the frequency of productive versus nonproductive TCRγ and δ rearrangement in αβ thymocytes of normal and TCRδ-deficient mice and on the frequency of productive versus nonproductive TCRβ rearrangements in γδ T cells. The findings make important predictions about the mechanism of αβ/γδ lineage commitment and about the developmental stage at which the two lineages diverge. The data also show that γ, δ and β rearrangements do occur in either lineage.
    • (1995) Curr Biol , vol.5 , pp. 659-669
    • Dudley, E.C.1    Girardi, M.2    Owen, M.J.3    Hayday, A.C.4
  • 18
    • 0030019723 scopus 로고    scopus 로고
    • T cell receptor δ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: Implications for αβ/γδ lineage commitment
    • of special interest. This paper defines the developmental stage at which the TCRα locus is activated and also demonstrates expression of full-length TCRδ message in thymocytes belonging to the αβ lineage. It clearly shows that TCRδ rearrangements do occur in αβ T cells.
    • Wilson A, De Villartay J-P, MacDonald R. T cell receptor δ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: implications for αβ/γδ lineage commitment. of special interest Immunity. 4:1996;37-45 This paper defines the developmental stage at which the TCRα locus is activated and also demonstrates expression of full-length TCRδ message in thymocytes belonging to the αβ lineage. It clearly shows that TCRδ rearrangements do occur in αβ T cells.
    • (1996) Immunity , vol.4 , pp. 37-45
    • Wilson, A.1    De Villartay, J.-P.2    MacDonald, R.3
  • 19
    • 0027168220 scopus 로고
    • Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development
    • Malick CA, Dudley EC, Viney JL, Owen MJ, Hayday AC. Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell. 73:1993;513-519.
    • (1993) Cell , vol.73 , pp. 513-519
    • Malick, C.A.1    Dudley, E.C.2    Viney, J.L.3    Owen, M.J.4    Hayday, A.C.5
  • 22
    • 0029924217 scopus 로고    scopus 로고
    • Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
    • + triple-negative population can be sorted into two subsets representing cells immediately before and after β-selection. The study also demonstrates that productive TCRβ rearrangement is tightly associated with the induction of massive cellular proliferation.
    • + triple-negative population can be sorted into two subsets representing cells immediately before and after β-selection. The study also demonstrates that productive TCRβ rearrangement is tightly associated with the induction of massive cellular proliferation.
    • (1996) Genes Dev , vol.10 , pp. 948-962
    • Hoffman, E.S.1    Passoni, L.2    Crompton, T.3    Leu, T.M.J.4    Schatz, D.G.5    Koff, A.6    Owen, M.J.7    Hayday, A.C.8
  • 23
    • 0027491232 scopus 로고
    • Control points in early T-cell development
    • Godfrey DI, Zlotnik A. Control points in early T-cell development. Immunol Today. 14:1993;547-553.
    • (1993) Immunol Today , vol.14 , pp. 547-553
    • Godfrey, D.I.1    Zlotnik, A.2
  • 24
    • 0028960511 scopus 로고
    • Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation
    • Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation. Cell. 80:1995;813-823.
    • (1995) Cell , vol.80 , pp. 813-823
    • Blunt, T.1    Finnie, N.J.2    Taccioli, G.E.3    Smith, G.C.M.4    Demengeot, J.5    Gottlieb, T.M.6    Mizuta, R.7    Varghese, A.J.8
  • 26
    • 0025231503 scopus 로고
    • Developmental biology of T cells in T cell receptor transgenic mice
    • Von Boehmer H. Developmental biology of T cells in T cell receptor transgenic mice. Annu Rev Immunol. 8:1990;531-551.
    • (1990) Annu Rev Immunol , vol.8 , pp. 531-551
    • Von Boehmer, H.1
  • 30
    • 0027375004 scopus 로고
    • A novel difsulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
    • Groettrup M, Ungewiss K, Azogui O, Palacios R, Owen MJ, Hayday AC, von Boehmer H. A novel difsulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell. 75:1993;283-294.
    • (1993) Cell , vol.75 , pp. 283-294
    • Groettrup, M.1    Ungewiss, K.2    Azogui, O.3    Palacios, R.4    Owen, M.J.5    Hayday, A.C.6    Von Boehmer, H.7
  • 31
    • 0027230682 scopus 로고
    • T cell receptor β chain dimers on immature thymocytes from normal mice
    • Groettrup M, von Boehmer H. T cell receptor β chain dimers on immature thymocytes from normal mice. Eur J Immunol. 23:1993;1393-1396.
    • (1993) Eur J Immunol , vol.23 , pp. 1393-1396
    • Groettrup, M.1    Von Boehmer, H.2
  • 33
  • 34
    • 0029947128 scopus 로고    scopus 로고
    • Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes
    • of special interest. A detailed, up-to-date review with an emphasis on the biochemistry of T cell and B cell receptors.
    • Borst J, Jacobs H, Brouns G. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. of special interest Curr Opin Immunol. 8:1996;181-190 A detailed, up-to-date review with an emphasis on the biochemistry of T cell and B cell receptors.
    • (1996) Curr Opin Immunol , vol.8 , pp. 181-190
    • Borst, J.1    Jacobs, H.2    Brouns, G.3
  • 35
    • 0029584385 scopus 로고
    • Early T cell development in CD3-deficient mice
    • of special interest. A detailed review of early T cell development with particular focus on the effects of genetic inactivation of certain CD3 components. This review summarizes the findings from several independently generated CD3ζ/η knockout mice
    • Tanaka Y, Ardouin L, Gillet A, Lin SY, Magnan A, Malissen B, Malissen M. Early T cell development in CD3-deficient mice. of special interest Immunol Rev. 148:1995;171-199 A detailed review of early T cell development with particular focus on the effects of genetic inactivation of certain CD3 components. This review summarizes the findings from several independently generated CD3ζ/η knockout mice.
    • (1995) Immunol Rev , vol.148 , pp. 171-199
    • Tanaka, Y.1    Ardouin, L.2    Gillet, A.3    Lin, S.Y.4    Magnan, A.5    Malissen, B.6    Malissen, M.7
  • 36
    • 0029000949 scopus 로고
    • Intra- And extra-thymic expression of the pre-T cell receptor α gene
    • of special interest. A sensitive PCR analysis of the expression pattern of pTα inside and outside of the thymus. The paper reports the detection of pTα transcripts in immature thymic subpopulations, in liver and intestine, which are known as sites of extrathymic T lymphopoiesis, and in the adult bone marrow as well as in a T-lineage-committed precursor population from fetal blood.
    • Bruno L, Rocha B, Rolink A, von Boehmer H, Rodewald HR. Intra- and extra-thymic expression of the pre-T cell receptor α gene. of special interest Eur J Immunol. 25:1995;1877-1882 A sensitive PCR analysis of the expression pattern of pTα inside and outside of the thymus. The paper reports the detection of pTα transcripts in immature thymic subpopulations, in liver and intestine, which are known as sites of extrathymic T lymphopoiesis, and in the adult bone marrow as well as in a T-lineage-committed precursor population from fetal blood.
    • (1995) Eur J Immunol , vol.25 , pp. 1877-1882
    • Bruno, L.1    Rocha, B.2    Rolink, A.3    Von Boehmer, H.4    Rodewald, H.R.5
  • 38
    • 0029065488 scopus 로고
    • Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells
    • of outstanding interest. This paper reports the phenotype of the pTα knockout mouse and establishes the crucial role of pTα in early αβ T cell development.
    • Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. of outstanding interest Nature. 375:1995;795-798 This paper reports the phenotype of the pTα knockout mouse and establishes the crucial role of pTα in early αβ T cell development.
    • (1995) Nature , vol.375 , pp. 795-798
    • Fehling, H.J.1    Krotkova, A.2    Saint-Ruf, C.3    Von Boehmer, H.4
  • 42
    • 0029094319 scopus 로고
    • Altered T cell development in mice with a targeted mutation of the CD3ε gene
    • - stage, but no defects at earlier stages. Rearrangements at the TCRγ, δ and β loci are not impaired. The findings provide important information about the developmental stage at which the CD3 complex becomes involved in early T cell development.
    • - stage, but no defects at earlier stages. Rearrangements at the TCRγ, δ and β loci are not impaired. The findings provide important information about the developmental stage at which the CD3 complex becomes involved in early T cell development.
    • (1995) EMBO J , vol.14 , pp. 4641-4653
    • Malissen, M.1    Gillet, A.2    Ardouin, L.3    Bouvier, G.4    Trucy, J.5    Ferrier, P.6    Vivier, E.7    Malissen, B.8
  • 46
    • 0028467163 scopus 로고
    • An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
    • Mombaerts P, Anderson SJ, Perlmutter RM, Mak TW, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1:1994;261-267.
    • (1994) Immunity , vol.1 , pp. 261-267
    • Mombaerts, P.1    Anderson, S.J.2    Perlmutter, R.M.3    Mak, T.W.4    Tonegawa, S.5
  • 47
    • 0030022930 scopus 로고    scopus 로고
    • + thymocytes
    • of special interest. This paper shows that in mice RAG-1-deficient embryonic stem cells, when carrying an activated ras transgene, can give rise to DP thymocytes which are derived by complementation of RAG-2-deficient blastocysts. This can be seen as a strong indication that ras is involved in the pre-TCR signal transduction pathway.
    • + thymocytes. of special interest Proc Natl Acad Sci USA. 93:1996;4683-4687 This paper shows that in mice RAG-1-deficient embryonic stem cells, when carrying an activated ras transgene, can give rise to DP thymocytes which are derived by complementation of RAG-2-deficient blastocysts. This can be seen as a strong indication that ras is involved in the pre-TCR signal transduction pathway.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4683-4687
    • Swat, W.1    Shinkai, Y.2    Cheng, H.-L.3    Davidson, L.4    Alt, F.W.5
  • 48
    • 0028926511 scopus 로고
    • The regulation and function of p21(ras) during T-cell activation and growth
    • Pastor MI, Reif K, Cantrell D. The regulation and function of p21(ras) during T-cell activation and growth. Immunol Today. 16:1995;159-164.
    • (1995) Immunol Today , vol.16 , pp. 159-164
    • Pastor, M.I.1    Reif, K.2    Cantrell, D.3
  • 49
    • 0030602798 scopus 로고    scopus 로고
    • The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
    • of special interest. The paper reports the successful use of retrovirus-mediated gene transfer in order to introduce mutated MAP kinase kinase (MAPKK) genes into thymocytes developing in fetal thymic organ culture. The study shows that the introduction of a dominant-negative form of MAPKK can severely inhibit the generation of DP thymocytes in TCRα-deficient and anti-CD3-stimulated RAG-deficient thymic organ cultures, suggesting an involvement of the MAP kinase cascade in pre-TCR signalling.
    • Crompton T, Gilmour KC, Owen MJ. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. of special interest Cell. 86:1996;243-251 The paper reports the successful use of retrovirus-mediated gene transfer in order to introduce mutated MAP kinase kinase (MAPKK) genes into thymocytes developing in fetal thymic organ culture. The study shows that the introduction of a dominant-negative form of MAPKK can severely inhibit the generation of DP thymocytes in TCRα-deficient and anti-CD3-stimulated RAG-deficient thymic organ cultures, suggesting an involvement of the MAP kinase cascade in pre-TCR signalling.
    • (1996) Cell , vol.86 , pp. 243-251
    • Crompton, T.1    Gilmour, K.C.2    Owen, M.J.3
  • 50
    • 0028859281 scopus 로고
    • Selective requirement for MAP kinase activation in thymocyte differentiation
    • of special interest. This paper shows that expression of a catalytically inactive form of MAPK kinase in thymocytes does not impair the generation of double-positive thymocytes, negative selection or TCR-induced proliferation, but does inhibit positive selection.
    • Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. Selective requirement for MAP kinase activation in thymocyte differentiation. of special interest Nature. 373:1995;620-623 This paper shows that expression of a catalytically inactive form of MAPK kinase in thymocytes does not impair the generation of double-positive thymocytes, negative selection or TCR-induced proliferation, but does inhibit positive selection.
    • (1995) Nature , vol.373 , pp. 620-623
    • Alberola-Ila, J.1    Forbush, K.A.2    Seger, R.3    Krebs, E.G.4    Perlmutter, R.M.5
  • 51
    • 0029556980 scopus 로고
    • Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene
    • of special interest. This paper reports the cDNA sequence of human pTα and reveals that there is no sequence conservation between the cytoplasmic portions of human and mouse pTα.
    • Del Porto P, Bruno L, Mattei M-G, Von Boehmer H, Saint-Ruf C. Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene. of special interest Proc Natl Acad Sci USA. 92:1995;12105-12109 This paper reports the cDNA sequence of human pTα and reveals that there is no sequence conservation between the cytoplasmic portions of human and mouse pTα.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12105-12109
    • Del Porto, P.1    Bruno, L.2    Mattei, M.-G.3    Von Boehmer, H.4    Saint-Ruf, C.5
  • 52
    • 0027489782 scopus 로고
    • Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε
    • Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε Proc Natl Acad Sci USA. 90:1993;11401-11405.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11401-11405
    • Levelt, C.N.1    Mombaerts, P.2    Iglesias, A.3    Tonegawa, S.4    Eichmann, K.5
  • 53
    • 0028203979 scopus 로고
    • CD3 components at the surface of pre-T cells can mediate pre-T cell development in vivo
    • Jacobs H, Vandeputte D, Tolkamp L, De Vries E, Borst J, Berns A. CD3 components at the surface of pre-T cells can mediate pre-T cell development in vivo. Eur J Immunol. 24:1994;934-939.
    • (1994) Eur J Immunol , vol.24 , pp. 934-939
    • Jacobs, H.1    Vandeputte, D.2    Tolkamp, L.3    De Vries, E.4    Borst, J.5    Berns, A.6
  • 54
    • 0028174201 scopus 로고
    • -/- mice in the absence of TCRβ chain expression
    • -/- mice in the absence of TCRβ chain expression. Int Immunol. 6:1994;995-1001.
    • (1994) Int Immunol , vol.6 , pp. 995-1001
    • Shinkai, Y.1    Alt, F.W.2
  • 56
    • 0028102350 scopus 로고
    • Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes
    • Wiest DL, Kearse K, Shores EW, Singer A. Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J Exp Med. 180:1994;1375-1382.
    • (1994) J Exp Med , vol.180 , pp. 1375-1382
    • Wiest, D.L.1    Kearse, K.2    Shores, E.W.3    Singer, A.4
  • 57
    • 0030025256 scopus 로고    scopus 로고
    • Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway
    • - stage. The generation of γδ T cells is not impaired. The authors suggest that cAMP pathways may interfere with pre-TCR signalling.
    • - stage. The generation of γδ T cells is not impaired. The authors suggest that cAMP pathways may interfere with pre-TCR signalling.
    • (1996) EMBO J , vol.15 , pp. 528-537
    • Lalli, E.1    Sassone-Corsi, P.2    Ceredig, R.3
  • 58
    • 0029892252 scopus 로고    scopus 로고
    • Function of the pre-T-cell receptor α chain in T-cell development and allelic exclusion at the T-cell receptor β locus
    • -/- embryonic stem cell complementation. The data obtained with this assay and also with a complementation assay using pTα-deficient embryonic stem cells which carry a functional TCRβ transgene indicate that allelic exclusion of endogenous TCRβ is largely intact, despite the absence of pTα.
    • -/- embryonic stem cell complementation. The data obtained with this assay and also with a complementation assay using pTα-deficient embryonic stem cells which carry a functional TCRβ transgene indicate that allelic exclusion of endogenous TCRβ is largely intact, despite the absence of pTα.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2169-2173
    • Xu, Y.1    Davidson, L.2    Alt, F.W.3    Baltimore, D.4
  • 59
    • 0025355746 scopus 로고
    • T-cell specific rearrangement of T-cell receptor β transgenes in mice
    • Van Meerwijk JPM, Blüthmann H, Steinmetz M. T-cell specific rearrangement of T-cell receptor β transgenes in mice. EMBO J. 9:1990;1057-1062.
    • (1990) EMBO J , vol.9 , pp. 1057-1062
    • Van Meerwijk, J.P.M.1    Blüthmann, H.2    Steinmetz, M.3
  • 60
    • 0029004406 scopus 로고
    • lck deficient mice: Allelic exclusion of the TCRβ locus is incomplete but thymocyte development is not restored by TCRβ or TCRαβ transgenes
    • of special interest. Analysis of TCRβ- and TCRαβ-transgenic, Ick-deficient mice. The data show that functional TCRβ-transgenes cannot rescue T cell development in the absence of Ick. Surprisingly, TCRβ allelic exclusion seems to be still 90% efficient, suggesting that the threshold for signalling allelic exclusion is much lower than that for signalling expansion and progression to the DP stage.
    • lck deficient mice: allelic exclusion of the TCRβ locus is incomplete but thymocyte development is not restored by TCRβ or TCRαβ transgenes. of special interest Eur J Immunol. 25:1995;1312-1318 Analysis of TCRβ- and TCRαβ-transgenic, Ick-deficient mice. The data show that functional TCRβ-transgenes cannot rescue T cell development in the absence of Ick. Surprisingly, TCRβ allelic exclusion seems to be still 90% efficient, suggesting that the threshold for signalling allelic exclusion is much lower than that for signalling expansion and progression to the DP stage.
    • (1995) Eur J Immunol , vol.25 , pp. 1312-1318
    • Wallace, V.A.1    Kawai, K.2    Levelt, C.N.3    Kishihara, K.4    Molina, T.5    Timms, E.6    Pircher, H.7    Penninger, J.8    Ohashi, P.9    Eichmann, K.10    Mak, T.W.11
  • 61
    • 0029886467 scopus 로고    scopus 로고
    • Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development
    • Löffert D, Ehlich A, Müller W, Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:1996;133-144.
    • (1996) Immunity , vol.4 , pp. 133-144
    • Löffert, D.1    Ehlich, A.2    Müller, W.3    Rajewsky, K.4
  • 63
    • 0030294283 scopus 로고    scopus 로고
    • Fyn can partially substitute for Ick in T lymphocyte development
    • fyn completely restores the generation of double-positive thymocytes and γδ T cells in Ick-deficient mice.
    • fyn completely restores the generation of double-positive thymocytes and γδ T cells in Ick-deficient mice.
    • (1996) Immunity , vol.5 , pp. 417-428
    • Groves, T.1    Smiley, P.2    Cooke, M.P.3    Forbush, K.4    Perlmutter, R.M.5    Guidos, C.J.6
  • 64
    • 0027328795 scopus 로고
    • γδ T cells promote CD4 and CD8 expression by SCID thymocytes
    • Lynch F, Shevach EM. γδ T cells promote CD4 and CD8 expression by SCID thymocytes. Int Immunol. 5:1993;991-995.
    • (1993) Int Immunol , vol.5 , pp. 991-995
    • Lynch, F.1    Shevach, E.M.2
  • 65
    • 0025257379 scopus 로고
    • T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway
    • Shores EW, Sharrow SO, Uppenkamp I, Singer A. T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway. Eur J Immunol. 20:1990;69-77.
    • (1990) Eur J Immunol , vol.20 , pp. 69-77
    • Shores, E.W.1    Sharrow, S.O.2    Uppenkamp, I.3    Singer, A.4
  • 66
    • 0031050713 scopus 로고    scopus 로고
    • T cell receptor α gene rearrangement and transcription in adult thymic γδ cells
    • Mertsching E, Wilson A, MacDonald HR, Ceredig R. T cell receptor α gene rearrangement and transcription in adult thymic γδ cells. Eur J Immunol. 27:1997;389-396.
    • (1997) Eur J Immunol , vol.27 , pp. 389-396
    • Mertsching, E.1    Wilson, A.2    MacDonald, H.R.3    Ceredig, R.4
  • 68
    • 0029880454 scopus 로고    scopus 로고
    • + stage of thymocyte differentiation in the absence of T cell receptor rearrangement
    • + thymocytes can unfold their differentiation program upon extension of their life span.
    • + thymocytes can unfold their differentiation program upon extension of their life span.
    • (1996) J Exp Med , vol.183 , pp. 1923-1928
    • Jiang, D.1    Lenardo, M.J.2    Zúniga-Pflücker, J.C.3
  • 69
    • 0030022628 scopus 로고    scopus 로고
    • A role for CD81 in early T cell development
    • - thymocytes (reaggregation culture). The data strongly suggest that CD81 (or an associated molecule that is also functional in fibroblasts, but only in the presence of CD81) is an important stimulator of early αβ T cell development.
    • - thymocytes (reaggregation culture). The data strongly suggest that CD81 (or an associated molecule that is also functional in fibroblasts, but only in the presence of CD81) is an important stimulator of early αβ T cell development.
    • (1996) Science , vol.271 , pp. 198-200
    • Boismenu, R.1    Rhein, M.2    Fischer, W.H.3    Havran, W.L.4
  • 70
    • 43949157634 scopus 로고
    • The ins and outs of the transmembrane 4 superfamily
    • Wright MD, Tomlinson MG. The ins and outs of the transmembrane 4 superfamily. Immunol Today. 15:1994;588-594.
    • (1994) Immunol Today , vol.15 , pp. 588-594
    • Wright, M.D.1    Tomlinson, M.G.2
  • 71
    • 0029788213 scopus 로고    scopus 로고
    • CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development
    • of special interest. This paper provides evidence for a role of the TNF-receptor-like molecule CD27 in early T cell development. Injection of a CD27-specific monoclonal antibody into RAG-deficient mice blocked the anti-CD3-induced developmental progression of triple-negative thymocytes, and anti-CD27 treatment of TCRα-deficient mice resulted in a marked reduction of the total number of thymocytes.
    • Gravestein LA, van Ewijk W, Ossendorp F, Borst J. CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development. of special interest J Exp Med. 184:1996;675-685 This paper provides evidence for a role of the TNF-receptor-like molecule CD27 in early T cell development. Injection of a CD27-specific monoclonal antibody into RAG-deficient mice blocked the anti-CD3-induced developmental progression of triple-negative thymocytes, and anti-CD27 treatment of TCRα-deficient mice resulted in a marked reduction of the total number of thymocytes.
    • (1996) J Exp Med , vol.184 , pp. 675-685
    • Gravestein, L.A.1    Van Ewijk, W.2    Ossendorp, F.3    Borst, J.4
  • 72
    • 0026670892 scopus 로고
    • Phenotypic and functional characterization of c-kit expression during intra-thymic T cell development
    • Godfrey DI, Zlotnik A, Suda T. Phenotypic and functional characterization of c-kit expression during intra-thymic T cell development. J Immunol. 149:1992;2281-2285.
    • (1992) J Immunol , vol.149 , pp. 2281-2285
    • Godfrey, D.I.1    Zlotnik, A.2    Suda, T.3
  • 74
    • 0030978529 scopus 로고    scopus 로고
    • Pre-thymocyte expansion byc-kit and the common cytokine receptor γ chain is essential for repertoire formation
    • in press
    • Rodewald HR, Ogawa M, Haller C, Waskow C, DiSanto JP. Pre-thymocyte expansion byc-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity. 1997;. in press.
    • (1997) Immunity
    • Rodewald, H.R.1    Ogawa, M.2    Haller, C.3    Waskow, C.4    Disanto, J.P.5
  • 75
    • 0029051162 scopus 로고
    • Cytokine production and requirements during T-cell development
    • of special interest. A review which provides a comprehensive list of known thymic cytokines, their cellular origin and their effect on defined thymocyte subpopulations, as well as a short description of the phenotypes of relevant knock out mouse mutants.
    • Zlotnik A, Moore TA. Cytokine production and requirements during T-cell development. of special interest Curr Opin Immunol. 7:1995;206-213 A review which provides a comprehensive list of known thymic cytokines, their cellular origin and their effect on defined thymocyte subpopulations, as well as a short description of the phenotypes of relevant knock out mouse mutants.
    • (1995) Curr Opin Immunol , vol.7 , pp. 206-213
    • Zlotnik, A.1    Moore, T.A.2
  • 76
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • of special interest. Reports the phenotype of IL-7 knockout mice which are highly lymphopenic in the peripheral blood and lymphoid organs. Regarding T cell development, the number of thymocytes is reduced approximately 20-fold. Interestingly, all thymic subsets, as defined by CD4 and CD8 expression, are affected to a similar extent, suggesting that IL-7 acts as a proliferation and maintenance factor for thymocytes, but not as a differentiation factor.
    • Von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SEG, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. of special interest J Exp Med. 181:1995;1519-1526 Reports the phenotype of IL-7 knockout mice which are highly lymphopenic in the peripheral blood and lymphoid organs. Regarding T cell development, the number of thymocytes is reduced approximately 20-fold. Interestingly, all thymic subsets, as defined by CD4 and CD8 expression, are affected to a similar extent, suggesting that IL-7 acts as a proliferation and maintenance factor for thymocytes, but not as a differentiation factor.
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • Von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.G.5    Murray, R.6
  • 78
    • 0028925778 scopus 로고
    • Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
    • of special interest. Reports the phenotype of mice with a targeted disruption of the common cytokine receptor gamma chain gene. The phenotype is virtually identical to that of IL-7 knockout (see annotation to [76]) suggesting that the defect is mainly due to a lack of IL-7-mediated signaling.
    • Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russel SM, Drago J, Noguchi M, Grinberg A, Bloom ET, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. of special interest Immunity. 2:1995;223-238 Reports the phenotype of mice with a targeted disruption of the common cytokine receptor gamma chain gene. The phenotype is virtually identical to that of IL-7 knockout (see annotation to [76]) suggesting that the defect is mainly due to a lack of IL-7-mediated signaling.
    • (1995) Immunity , vol.2 , pp. 223-238
    • Cao, X.1    Shores, E.W.2    Hu-Li, J.3    Anver, M.R.4    Kelsall, B.L.5    Russel, S.M.6    Drago, J.7    Noguchi, M.8    Grinberg, A.9    Bloom, E.T.10
  • 79
    • 0028878330 scopus 로고
    • Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
    • of special interest. See annotation to [78].
    • DiSanto JP, Müller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. of special interest Proc Natl Acad Sci USA. 92:1995;377-381 See annotation to [78].
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 377-381
    • Disanto, J.P.1    Müller, W.2    Guy-Grand, D.3    Fischer, A.4    Rajewsky, K.5
  • 80
    • 0029962080 scopus 로고    scopus 로고
    • Interleukin-2 receptor gamma chain: Its role in multiple cytokine receptor complexes and T cell development in XSCID
    • Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T. Interleukin-2 receptor gamma chain: its role in multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol. 14:1996;179-205.
    • (1996) Annu Rev Immunol , vol.14 , pp. 179-205
    • Sugamura, K.1    Asao, H.2    Kondo, M.3    Tanaka, N.4    Ishii, N.5    Ohbo, K.6    Nakamura, M.7    Takeshita, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.