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+ triple negatives are not yet fully committed to the T-cell lineage as they can give rise to a particular type of dendritic cell that is characterized by high-level expression of CD8α.
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T cell receptor gene recombination patterns and mechanisms: Cell death, rescue, and T cell production
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of special interest. A very thorough analysis of the onset of TCRα and TCRβ gene rearrangements in different thymocyte subpopulations by quantitative Southern blotting.
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Petrie HT, Livak F, Burtrum D, Mazel S. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. of special interest J Exp Med. 182:1995;121-127 A very thorough analysis of the onset of TCRα and TCRβ gene rearrangements in different thymocyte subpopulations by quantitative Southern blotting.
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Hayday, A.C.5
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0029311234
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αβ and γδ T cells can share a late common precursor
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of special interest. This paper reports on the frequency of productive versus nonproductive TCRγ and δ rearrangement in αβ thymocytes of normal and TCRδ-deficient mice and on the frequency of productive versus nonproductive TCRβ rearrangements in γδ T cells. The findings make important predictions about the mechanism of αβ/γδ lineage commitment and about the developmental stage at which the two lineages diverge. The data also show that γ, δ and β rearrangements do occur in either lineage.
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Dudley EC, Girardi M, Owen MJ, Hayday AC. αβ and γδ T cells can share a late common precursor. of special interest Curr Biol. 5:1995;659-669 This paper reports on the frequency of productive versus nonproductive TCRγ and δ rearrangement in αβ thymocytes of normal and TCRδ-deficient mice and on the frequency of productive versus nonproductive TCRβ rearrangements in γδ T cells. The findings make important predictions about the mechanism of αβ/γδ lineage commitment and about the developmental stage at which the two lineages diverge. The data also show that γ, δ and β rearrangements do occur in either lineage.
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Dudley, E.C.1
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Owen, M.J.3
Hayday, A.C.4
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18
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0030019723
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T cell receptor δ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: Implications for αβ/γδ lineage commitment
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of special interest. This paper defines the developmental stage at which the TCRα locus is activated and also demonstrates expression of full-length TCRδ message in thymocytes belonging to the αβ lineage. It clearly shows that TCRδ rearrangements do occur in αβ T cells.
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Wilson A, De Villartay J-P, MacDonald R. T cell receptor δ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: implications for αβ/γδ lineage commitment. of special interest Immunity. 4:1996;37-45 This paper defines the developmental stage at which the TCRα locus is activated and also demonstrates expression of full-length TCRδ message in thymocytes belonging to the αβ lineage. It clearly shows that TCRδ rearrangements do occur in αβ T cells.
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Wilson, A.1
De Villartay, J.-P.2
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20
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In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogeneous β genes
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Early expression of a T cell receptor transgene suppresses rearrangement of the Vγ4 gene segment
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Von Boehmer H, Bonneville M, Ishida I, Ryser S, Lincoln G, Smith RT, Kishi H, Scott B, Kisielow P, Tonegawa S. Early expression of a T cell receptor transgene suppresses rearrangement of the Vγ4 gene segment. Proc Natl Acad Sci USA. 85:1988;9759-9772.
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Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
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+ triple-negative population can be sorted into two subsets representing cells immediately before and after β-selection. The study also demonstrates that productive TCRβ rearrangement is tightly associated with the induction of massive cellular proliferation.
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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation
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25
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Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
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A novel difsulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
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Groettrup M, Ungewiss K, Azogui O, Palacios R, Owen MJ, Hayday AC, von Boehmer H. A novel difsulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell. 75:1993;283-294.
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Groettrup, M.1
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Palacios, R.4
Owen, M.J.5
Hayday, A.C.6
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Groettrup, M.1
Von Boehmer, H.2
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Analysis and expression of a cloned pre-T cell receptor gene
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Saint-Ruf C, Ungewiss K, Groettrup M, Bruno L, Fehling HJ, von Boehmer H. Analysis and expression of a cloned pre-T cell receptor gene. Science. 266:1994;1208-1212.
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Science
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Saint-Ruf, C.1
Ungewiss, K.2
Groettrup, M.3
Bruno, L.4
Fehling, H.J.5
Von Boehmer, H.6
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33
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Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene
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Fehling HJ, Laplace C, Mattei M-G, Saint-Ruf C, Von Boehmer H. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene. Immunogenetics. 42:1995;275-281.
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Fehling, H.J.1
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Saint-Ruf, C.4
Von Boehmer, H.5
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34
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0029947128
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Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes
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of special interest. A detailed, up-to-date review with an emphasis on the biochemistry of T cell and B cell receptors.
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Borst J, Jacobs H, Brouns G. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. of special interest Curr Opin Immunol. 8:1996;181-190 A detailed, up-to-date review with an emphasis on the biochemistry of T cell and B cell receptors.
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Curr Opin Immunol
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Borst, J.1
Jacobs, H.2
Brouns, G.3
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35
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0029584385
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Early T cell development in CD3-deficient mice
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of special interest. A detailed review of early T cell development with particular focus on the effects of genetic inactivation of certain CD3 components. This review summarizes the findings from several independently generated CD3ζ/η knockout mice
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Tanaka Y, Ardouin L, Gillet A, Lin SY, Magnan A, Malissen B, Malissen M. Early T cell development in CD3-deficient mice. of special interest Immunol Rev. 148:1995;171-199 A detailed review of early T cell development with particular focus on the effects of genetic inactivation of certain CD3 components. This review summarizes the findings from several independently generated CD3ζ/η knockout mice.
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Immunol Rev
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Tanaka, Y.1
Ardouin, L.2
Gillet, A.3
Lin, S.Y.4
Magnan, A.5
Malissen, B.6
Malissen, M.7
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36
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0029000949
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Intra- And extra-thymic expression of the pre-T cell receptor α gene
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of special interest. A sensitive PCR analysis of the expression pattern of pTα inside and outside of the thymus. The paper reports the detection of pTα transcripts in immature thymic subpopulations, in liver and intestine, which are known as sites of extrathymic T lymphopoiesis, and in the adult bone marrow as well as in a T-lineage-committed precursor population from fetal blood.
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Bruno L, Rocha B, Rolink A, von Boehmer H, Rodewald HR. Intra- and extra-thymic expression of the pre-T cell receptor α gene. of special interest Eur J Immunol. 25:1995;1877-1882 A sensitive PCR analysis of the expression pattern of pTα inside and outside of the thymus. The paper reports the detection of pTα transcripts in immature thymic subpopulations, in liver and intestine, which are known as sites of extrathymic T lymphopoiesis, and in the adult bone marrow as well as in a T-lineage-committed precursor population from fetal blood.
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Eur J Immunol
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Bruno, L.1
Rocha, B.2
Rolink, A.3
Von Boehmer, H.4
Rodewald, H.R.5
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Oncogenic potential of a pre-T cell receptor lacking the TCRβ variable domain
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Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells
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Fehling, H.J.1
Krotkova, A.2
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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
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0029094319
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Altered T cell development in mice with a targeted mutation of the CD3ε gene
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- stage, but no defects at earlier stages. Rearrangements at the TCRγ, δ and β loci are not impaired. The findings provide important information about the developmental stage at which the CD3 complex becomes involved in early T cell development.
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- stage, but no defects at earlier stages. Rearrangements at the TCRγ, δ and β loci are not impaired. The findings provide important information about the developmental stage at which the CD3 complex becomes involved in early T cell development.
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EMBO J
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Malissen, M.1
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Bouvier, G.4
Trucy, J.5
Ferrier, P.6
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Ick
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Ick. Nature. 357:1992;161-164.
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Nature
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Molina, T.J.1
Kishihara, K.2
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Timms, E.6
Wakeham, A.7
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46
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0028467163
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An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
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Mombaerts P, Anderson SJ, Perlmutter RM, Mak TW, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1:1994;261-267.
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Immunity
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Mombaerts, P.1
Anderson, S.J.2
Perlmutter, R.M.3
Mak, T.W.4
Tonegawa, S.5
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47
-
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0030022930
-
+ thymocytes
-
of special interest. This paper shows that in mice RAG-1-deficient embryonic stem cells, when carrying an activated ras transgene, can give rise to DP thymocytes which are derived by complementation of RAG-2-deficient blastocysts. This can be seen as a strong indication that ras is involved in the pre-TCR signal transduction pathway.
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+ thymocytes. of special interest Proc Natl Acad Sci USA. 93:1996;4683-4687 This paper shows that in mice RAG-1-deficient embryonic stem cells, when carrying an activated ras transgene, can give rise to DP thymocytes which are derived by complementation of RAG-2-deficient blastocysts. This can be seen as a strong indication that ras is involved in the pre-TCR signal transduction pathway.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4683-4687
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Swat, W.1
Shinkai, Y.2
Cheng, H.-L.3
Davidson, L.4
Alt, F.W.5
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48
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0028926511
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The regulation and function of p21(ras) during T-cell activation and growth
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Pastor MI, Reif K, Cantrell D. The regulation and function of p21(ras) during T-cell activation and growth. Immunol Today. 16:1995;159-164.
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Immunol Today
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, pp. 159-164
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Pastor, M.I.1
Reif, K.2
Cantrell, D.3
-
49
-
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0030602798
-
The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
-
of special interest. The paper reports the successful use of retrovirus-mediated gene transfer in order to introduce mutated MAP kinase kinase (MAPKK) genes into thymocytes developing in fetal thymic organ culture. The study shows that the introduction of a dominant-negative form of MAPKK can severely inhibit the generation of DP thymocytes in TCRα-deficient and anti-CD3-stimulated RAG-deficient thymic organ cultures, suggesting an involvement of the MAP kinase cascade in pre-TCR signalling.
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Crompton T, Gilmour KC, Owen MJ. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. of special interest Cell. 86:1996;243-251 The paper reports the successful use of retrovirus-mediated gene transfer in order to introduce mutated MAP kinase kinase (MAPKK) genes into thymocytes developing in fetal thymic organ culture. The study shows that the introduction of a dominant-negative form of MAPKK can severely inhibit the generation of DP thymocytes in TCRα-deficient and anti-CD3-stimulated RAG-deficient thymic organ cultures, suggesting an involvement of the MAP kinase cascade in pre-TCR signalling.
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(1996)
Cell
, vol.86
, pp. 243-251
-
-
Crompton, T.1
Gilmour, K.C.2
Owen, M.J.3
-
50
-
-
0028859281
-
Selective requirement for MAP kinase activation in thymocyte differentiation
-
of special interest. This paper shows that expression of a catalytically inactive form of MAPK kinase in thymocytes does not impair the generation of double-positive thymocytes, negative selection or TCR-induced proliferation, but does inhibit positive selection.
-
Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. Selective requirement for MAP kinase activation in thymocyte differentiation. of special interest Nature. 373:1995;620-623 This paper shows that expression of a catalytically inactive form of MAPK kinase in thymocytes does not impair the generation of double-positive thymocytes, negative selection or TCR-induced proliferation, but does inhibit positive selection.
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(1995)
Nature
, vol.373
, pp. 620-623
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-
Alberola-Ila, J.1
Forbush, K.A.2
Seger, R.3
Krebs, E.G.4
Perlmutter, R.M.5
-
51
-
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0029556980
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Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene
-
of special interest. This paper reports the cDNA sequence of human pTα and reveals that there is no sequence conservation between the cytoplasmic portions of human and mouse pTα.
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Del Porto P, Bruno L, Mattei M-G, Von Boehmer H, Saint-Ruf C. Cloning and comparative analysis of the human pre-T-cell receptor α-chain gene. of special interest Proc Natl Acad Sci USA. 92:1995;12105-12109 This paper reports the cDNA sequence of human pTα and reveals that there is no sequence conservation between the cytoplasmic portions of human and mouse pTα.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 12105-12109
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Del Porto, P.1
Bruno, L.2
Mattei, M.-G.3
Von Boehmer, H.4
Saint-Ruf, C.5
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52
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0027489782
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Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε
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Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε Proc Natl Acad Sci USA. 90:1993;11401-11405.
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Proc Natl Acad Sci USA
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, pp. 11401-11405
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Levelt, C.N.1
Mombaerts, P.2
Iglesias, A.3
Tonegawa, S.4
Eichmann, K.5
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53
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0028203979
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CD3 components at the surface of pre-T cells can mediate pre-T cell development in vivo
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Jacobs H, Vandeputte D, Tolkamp L, De Vries E, Borst J, Berns A. CD3 components at the surface of pre-T cells can mediate pre-T cell development in vivo. Eur J Immunol. 24:1994;934-939.
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Eur J Immunol
, vol.24
, pp. 934-939
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Jacobs, H.1
Vandeputte, D.2
Tolkamp, L.3
De Vries, E.4
Borst, J.5
Berns, A.6
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54
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0028174201
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-/- mice in the absence of TCRβ chain expression
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-/- mice in the absence of TCRβ chain expression. Int Immunol. 6:1994;995-1001.
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(1994)
Int Immunol
, vol.6
, pp. 995-1001
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Shinkai, Y.1
Alt, F.W.2
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55
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0029145881
-
lck and CD3ζ in early thymic selection
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-/- mice is markedly dependent on the presence of Ick, but not on the presence of CD3ζ.
-
-/- mice is markedly dependent on the presence of Ick, but not on the presence of CD3ζ.
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(1995)
Immunity
, vol.3
, pp. 215-222
-
-
Levelt, C.N.1
Mombaerts, P.2
Wang, B.3
Kohler, H.4
Tonegawa, S.5
Eichmann, K.6
Terhorst, C.7
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56
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0028102350
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Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes
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Wiest DL, Kearse K, Shores EW, Singer A. Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J Exp Med. 180:1994;1375-1382.
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J Exp Med
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Wiest, D.L.1
Kearse, K.2
Shores, E.W.3
Singer, A.4
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57
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0030025256
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Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway
-
- stage. The generation of γδ T cells is not impaired. The authors suggest that cAMP pathways may interfere with pre-TCR signalling.
-
- stage. The generation of γδ T cells is not impaired. The authors suggest that cAMP pathways may interfere with pre-TCR signalling.
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EMBO J
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Lalli, E.1
Sassone-Corsi, P.2
Ceredig, R.3
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58
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0029892252
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Function of the pre-T-cell receptor α chain in T-cell development and allelic exclusion at the T-cell receptor β locus
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-/- embryonic stem cell complementation. The data obtained with this assay and also with a complementation assay using pTα-deficient embryonic stem cells which carry a functional TCRβ transgene indicate that allelic exclusion of endogenous TCRβ is largely intact, despite the absence of pTα.
-
-/- embryonic stem cell complementation. The data obtained with this assay and also with a complementation assay using pTα-deficient embryonic stem cells which carry a functional TCRβ transgene indicate that allelic exclusion of endogenous TCRβ is largely intact, despite the absence of pTα.
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(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2169-2173
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Xu, Y.1
Davidson, L.2
Alt, F.W.3
Baltimore, D.4
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59
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0025355746
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T-cell specific rearrangement of T-cell receptor β transgenes in mice
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Van Meerwijk JPM, Blüthmann H, Steinmetz M. T-cell specific rearrangement of T-cell receptor β transgenes in mice. EMBO J. 9:1990;1057-1062.
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EMBO J
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Van Meerwijk, J.P.M.1
Blüthmann, H.2
Steinmetz, M.3
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60
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0029004406
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lck deficient mice: Allelic exclusion of the TCRβ locus is incomplete but thymocyte development is not restored by TCRβ or TCRαβ transgenes
-
of special interest. Analysis of TCRβ- and TCRαβ-transgenic, Ick-deficient mice. The data show that functional TCRβ-transgenes cannot rescue T cell development in the absence of Ick. Surprisingly, TCRβ allelic exclusion seems to be still 90% efficient, suggesting that the threshold for signalling allelic exclusion is much lower than that for signalling expansion and progression to the DP stage.
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lck deficient mice: allelic exclusion of the TCRβ locus is incomplete but thymocyte development is not restored by TCRβ or TCRαβ transgenes. of special interest Eur J Immunol. 25:1995;1312-1318 Analysis of TCRβ- and TCRαβ-transgenic, Ick-deficient mice. The data show that functional TCRβ-transgenes cannot rescue T cell development in the absence of Ick. Surprisingly, TCRβ allelic exclusion seems to be still 90% efficient, suggesting that the threshold for signalling allelic exclusion is much lower than that for signalling expansion and progression to the DP stage.
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(1995)
Eur J Immunol
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, pp. 1312-1318
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Wallace, V.A.1
Kawai, K.2
Levelt, C.N.3
Kishihara, K.4
Molina, T.5
Timms, E.6
Pircher, H.7
Penninger, J.8
Ohashi, P.9
Eichmann, K.10
Mak, T.W.11
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61
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0029886467
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Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development
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Löffert D, Ehlich A, Müller W, Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:1996;133-144.
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Immunity
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Löffert, D.1
Ehlich, A.2
Müller, W.3
Rajewsky, K.4
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64
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0027328795
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γδ T cells promote CD4 and CD8 expression by SCID thymocytes
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Lynch F, Shevach EM. γδ T cells promote CD4 and CD8 expression by SCID thymocytes. Int Immunol. 5:1993;991-995.
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Int Immunol
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Lynch, F.1
Shevach, E.M.2
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65
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0025257379
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T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway
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Shores EW, Sharrow SO, Uppenkamp I, Singer A. T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway. Eur J Immunol. 20:1990;69-77.
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Eur J Immunol
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Shores, E.W.1
Sharrow, S.O.2
Uppenkamp, I.3
Singer, A.4
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66
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0031050713
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T cell receptor α gene rearrangement and transcription in adult thymic γδ cells
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Mertsching E, Wilson A, MacDonald HR, Ceredig R. T cell receptor α gene rearrangement and transcription in adult thymic γδ cells. Eur J Immunol. 27:1997;389-396.
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Eur J Immunol
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Mertsching, E.1
Wilson, A.2
MacDonald, H.R.3
Ceredig, R.4
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68
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0029880454
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+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement
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+ thymocytes can unfold their differentiation program upon extension of their life span.
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+ thymocytes can unfold their differentiation program upon extension of their life span.
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(1996)
J Exp Med
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Jiang, D.1
Lenardo, M.J.2
Zúniga-Pflücker, J.C.3
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69
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0030022628
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A role for CD81 in early T cell development
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- thymocytes (reaggregation culture). The data strongly suggest that CD81 (or an associated molecule that is also functional in fibroblasts, but only in the presence of CD81) is an important stimulator of early αβ T cell development.
-
- thymocytes (reaggregation culture). The data strongly suggest that CD81 (or an associated molecule that is also functional in fibroblasts, but only in the presence of CD81) is an important stimulator of early αβ T cell development.
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Science
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Boismenu, R.1
Rhein, M.2
Fischer, W.H.3
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43949157634
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The ins and outs of the transmembrane 4 superfamily
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Wright MD, Tomlinson MG. The ins and outs of the transmembrane 4 superfamily. Immunol Today. 15:1994;588-594.
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Immunol Today
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Wright, M.D.1
Tomlinson, M.G.2
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71
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0029788213
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CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development
-
of special interest. This paper provides evidence for a role of the TNF-receptor-like molecule CD27 in early T cell development. Injection of a CD27-specific monoclonal antibody into RAG-deficient mice blocked the anti-CD3-induced developmental progression of triple-negative thymocytes, and anti-CD27 treatment of TCRα-deficient mice resulted in a marked reduction of the total number of thymocytes.
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Gravestein LA, van Ewijk W, Ossendorp F, Borst J. CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development. of special interest J Exp Med. 184:1996;675-685 This paper provides evidence for a role of the TNF-receptor-like molecule CD27 in early T cell development. Injection of a CD27-specific monoclonal antibody into RAG-deficient mice blocked the anti-CD3-induced developmental progression of triple-negative thymocytes, and anti-CD27 treatment of TCRα-deficient mice resulted in a marked reduction of the total number of thymocytes.
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(1996)
J Exp Med
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Gravestein, L.A.1
Van Ewijk, W.2
Ossendorp, F.3
Borst, J.4
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72
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0026670892
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Phenotypic and functional characterization of c-kit expression during intra-thymic T cell development
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Godfrey DI, Zlotnik A, Suda T. Phenotypic and functional characterization of c-kit expression during intra-thymic T cell development. J Immunol. 149:1992;2281-2285.
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J Immunol
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Godfrey, D.I.1
Zlotnik, A.2
Suda, T.3
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74
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0030978529
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Pre-thymocyte expansion byc-kit and the common cytokine receptor γ chain is essential for repertoire formation
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in press
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Rodewald HR, Ogawa M, Haller C, Waskow C, DiSanto JP. Pre-thymocyte expansion byc-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity. 1997;. in press.
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Immunity
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Rodewald, H.R.1
Ogawa, M.2
Haller, C.3
Waskow, C.4
Disanto, J.P.5
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75
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0029051162
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Cytokine production and requirements during T-cell development
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of special interest. A review which provides a comprehensive list of known thymic cytokines, their cellular origin and their effect on defined thymocyte subpopulations, as well as a short description of the phenotypes of relevant knock out mouse mutants.
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Zlotnik A, Moore TA. Cytokine production and requirements during T-cell development. of special interest Curr Opin Immunol. 7:1995;206-213 A review which provides a comprehensive list of known thymic cytokines, their cellular origin and their effect on defined thymocyte subpopulations, as well as a short description of the phenotypes of relevant knock out mouse mutants.
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(1995)
Curr Opin Immunol
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Zlotnik, A.1
Moore, T.A.2
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76
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0028929565
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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
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of special interest. Reports the phenotype of IL-7 knockout mice which are highly lymphopenic in the peripheral blood and lymphoid organs. Regarding T cell development, the number of thymocytes is reduced approximately 20-fold. Interestingly, all thymic subsets, as defined by CD4 and CD8 expression, are affected to a similar extent, suggesting that IL-7 acts as a proliferation and maintenance factor for thymocytes, but not as a differentiation factor.
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Von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SEG, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. of special interest J Exp Med. 181:1995;1519-1526 Reports the phenotype of IL-7 knockout mice which are highly lymphopenic in the peripheral blood and lymphoid organs. Regarding T cell development, the number of thymocytes is reduced approximately 20-fold. Interestingly, all thymic subsets, as defined by CD4 and CD8 expression, are affected to a similar extent, suggesting that IL-7 acts as a proliferation and maintenance factor for thymocytes, but not as a differentiation factor.
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(1995)
J Exp Med
, vol.181
, pp. 1519-1526
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Von Freeden-Jeffry, U.1
Vieira, P.2
Lucian, L.A.3
McNeil, T.4
Burdach, S.E.G.5
Murray, R.6
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77
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0027988545
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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
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Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med. 180:1994;1955-1960.
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J Exp Med
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Peschon, J.J.1
Morrissey, P.J.2
Grabstein, K.H.3
Ramsdell, F.J.4
Maraskovsky, E.5
Gliniak, B.C.6
Park, L.S.7
Ziegler, S.F.8
Williams, D.E.9
Ware, C.B.10
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78
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0028925778
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Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
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of special interest. Reports the phenotype of mice with a targeted disruption of the common cytokine receptor gamma chain gene. The phenotype is virtually identical to that of IL-7 knockout (see annotation to [76]) suggesting that the defect is mainly due to a lack of IL-7-mediated signaling.
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Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russel SM, Drago J, Noguchi M, Grinberg A, Bloom ET, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. of special interest Immunity. 2:1995;223-238 Reports the phenotype of mice with a targeted disruption of the common cytokine receptor gamma chain gene. The phenotype is virtually identical to that of IL-7 knockout (see annotation to [76]) suggesting that the defect is mainly due to a lack of IL-7-mediated signaling.
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(1995)
Immunity
, vol.2
, pp. 223-238
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Cao, X.1
Shores, E.W.2
Hu-Li, J.3
Anver, M.R.4
Kelsall, B.L.5
Russel, S.M.6
Drago, J.7
Noguchi, M.8
Grinberg, A.9
Bloom, E.T.10
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79
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0028878330
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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
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of special interest. See annotation to [78].
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DiSanto JP, Müller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. of special interest Proc Natl Acad Sci USA. 92:1995;377-381 See annotation to [78].
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Proc Natl Acad Sci USA
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Disanto, J.P.1
Müller, W.2
Guy-Grand, D.3
Fischer, A.4
Rajewsky, K.5
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80
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0029962080
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Interleukin-2 receptor gamma chain: Its role in multiple cytokine receptor complexes and T cell development in XSCID
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Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T. Interleukin-2 receptor gamma chain: its role in multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol. 14:1996;179-205.
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Sugamura, K.1
Asao, H.2
Kondo, M.3
Tanaka, N.4
Ishii, N.5
Ohbo, K.6
Nakamura, M.7
Takeshita, T.8
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