Positive selection of thymocytes bearing αβ T cell receptors

Current Opinion in Immunology

Volumn 9, Issue 2, 1997, Pages 250-255

  Marrack, Philippa ^a   Kappler, John ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PEPTIDE; PROTEIN; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR;

CELL MATURATION; CELL SELECTION; PROTEIN EXPRESSION; SHORT SURVEY; THYMOCYTE;

EID: 0030966756     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80144-6     Document Type: Article

References (52)

1. Bevan MJ. In a radiation chimaera host H-2 antigens determine the immune responsiveness of donor cytotoxic cells. Nature. 269:1977;417-418.
2. Zinkernagel RM, Callahan GN, Althage A, Cooper S, Klein PA, Klein J. On the thymus in the differentiation of 'H-2 self-recognition' by T cells: Evidence for dual recognition? J Exp Med. 147:1978;882-896.
3. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell. 49:1987;273-278.
4. a-encoded antigens. J Exp Med. 167:1988;2005-2015.
5. + thymocytes. Nature. 333:1988;742-747.
6. Hogquist KA, Jameson CS, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell. 76:1994;17-27.
7. Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S. Evidence for a differential avidity model of T cell selection in the thymus. Cell. 76:1994;651-663.
8. Sebzda E, Wallace VA, Mayer J, Yeung RSM, Mak TW, Ohashi PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science. 263:1994;1615-1618.
9. Robey E, Ramsdell F, Kioussis D, Sha W, Loh D, Axel R, Fowlkes BJ. The level of CD8 expression can determine the outcome of thymic selection. Cell. 69:1992;1089-1096.
10. + helper T cells in class II major histocompatibility complex mutant mice. J Exp Med. 79:1994;1997-2004.
11. Alam SM, Travers PJ, Wung JL, Nasholds W, Redpath S, Jameson SC, Gascoigne NR. T-cell-receptor affinity and thymocyte positive selection. of outstanding interest Nature. 381:1996;616-620 This nice paper is the first to measure the actual affinities involved in the reaction between TCRs and ligands which can positively select thymocytes or activate mature T cells bearing these TCRs. The paper should be read with the caveat that these phenomena are probably not controlled by affinity alone. The avidity with which the cells interact, which will be affected by ligand and TCR concentration and interactions between other surface molecules, is probably the crucial factor.
12. + T cells by TCR ligation without aggregation even in the absence of MHC. Nature. 371:1994;67-70.
13. Ignatowicz L, Kappler J, Parker DC, Marrack P. The responses of mature T cells are not necessarily antagonized by their positively selecting peptide. of special interest J Immunol. 157:1996;1827-1831 This paper took advantage of the production of mice in which all MHC class II proteins were bound to a single peptide. Therefore all the class II-restricted T cells in the mouse must have been positively selected on that combination. Nevertheless their responses as mature cells were not antagonized by the selecting ligand.
14. Williams O, Tanaka Y, Bix M, Murdjeva M, Littman DR, Kioussis D. Inhibition of thymocyte negative selection by T cell receptor antagonist peptides. Eur J Immunol. 26:1996;532-538.
15. Singer GG, Abbas AK. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity. 1:1994;365-375.
16. Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, et al. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. of special interest Cell. 84:1996;551-562 This paper suggests the identity of one of the cofactors acting in thymocyte deletion. It is also one of the first to assign a function to CD30, a protein associated with Hodgkin's disease.
17. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J Exp Med. 179:1994;709-713.
18. Hoffmann MW, Heath WR, Ruschmeyer D, Miller JF. Deletion of high-avidity T cells by thymic epithelium. Proc Natl Acad Sci USA. 92:1996;9851-9855.
19. Laufer TM, DeKoming J, Markowitz JS, Lo D, Glimcher LH. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymus cortex. of special interest Nature. 383:1996;81-85 This group has created some new mice strains which are important resources in dissection of the roles of different kinds of antigen presenting cells in thymocyte maturation.
20. Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. of outstanding interest Science. 274:1996;209-219 This paper is the first to report the structure of an intact TCR and its binding to an MHC-peptide ligand. Essential reading.
21. Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. of outstanding interest Nature. 384:1996;134-141 This paper is the second to report the structure of an intact TCR and its binding to an MHC-peptide ligand. Essential reading.
22. Schumacher TN, Ploegh HL. Are MHC-bound peptides a nuisance for positive selection? Immunity. 1:1994;721-723.
23. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med. 177:1993;1469-1473.
24. + T cells in the thymus. Cell. 73:1993;1041-1049.
25. + T cells appear in these mice, demonstrating that one MHC-peptide combination can positively select many thymocytes. Most of the selected cells react with the same MHC class II protein bound to the many self peptides which can engage it in normal mice. Thus most of the T cells which are positively selected by the single MHC-peptide combination would normally be clonally deleted in wild type mice.
26. Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N, Ploegh H, Benoist C, Mathis D. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. of outstanding interest Cell. 84:1996;531-541 See annotation [25].
27. Martin WD, Hicks GG, Mendiratta SK, Leva HI, Ruley HE, Van Kaer L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation and T cell repertoire selection. of outstanding interest Cell. 84:1996;543-550 See annotation [25].
28. Fung-Leung WP, Surh CD, Liljedahl M, Pang J, Leturcq D, Peterson PA, Webb SR, Karlsson L. Antigen presentation and T cell development in H2-M-deficient mice. of outstanding interest Science. 271:1996;1278-1281 See annotation [25].
29. Pawelowski TJ, Singleton MD, Loh DY, Berg R, Staerz UD. Permissive recognition during positive selection. of special interest Eur J Immunol. 26:1996;851-857 This controversial paper shows that many peptides which are not necessarily of related sequence can positively select thymocytes bearing a particular TCR.
30. Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D. Another view of the selective model of thymocyte selection. Cell. 73:1993;225-236.
31. Crump AL, Grusby MJ, Glimcher LH, Cantor H. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci USA. 90:1993;10739-10743.
32. Davis CB, Killeen N, Crooks MEC, Raulet D, Littman DR. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 73:1993;237-247.
33. Corbella P, Moskophidis D, Spanopoulou E, Mamalaki C, Tolaini M, Itano A, Lans D, Baltimore D, Robey E, Kioussis D. Functional commitment to helper T-cell lineage precedes positive selection and is independent of T-cell receptor MHC specificity. Immunity. 1:1994;269-276.
34. + T lymphocytes. Eur J Immunol. 23:1993;2834-2840.
35. Itano A, Cado D, Chan FK, Robey E. A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. Immunity. 1:1994;287-290.
36. Itano A, Salmon P, Kioussis D, Toliani M, Corbella P, Robey E. The cytoplasmic domain of CD4 promotes the development of CD4 lineage cells. J Exp Med. 183:1996;731-741.
37. Killeen N, Littman DR. Helper T-cell development in the absence of CD4-p56Ick association. Nature. 364:1993;729-732.
38. + is a default pathway.
39. + lineages: a new perspective on thymic commitment and selection. Immunity. 2:1995;413-425.
40. hi thymocytes. J Exp Med. 181:1995;1643-1651.
41. Locksley RM, Reiner SL, Hatam F, Littman D, Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science. 261:1993;1449-1450.
42. Dalloul AH, Ngo K, Fung-Leung WP. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol. 26:1996;213-218.
43. Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. of outstanding interest Nature. 384:1996;577-581 An important paper which is the first to suggest that CD8 may affect the three-dimensional structure of the loops of TCRs which bind MHC and peptide.
44. Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D, Weinmaster G, Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. of outstanding interest Cell. 87:1996;483-492 This paper introduces an entirely new idea that thymocyte decisions can be affected by fate determining proteins such as Notch.
45. +, double positive stage. J Exp Med. 184:1996;1619-1630.
46. Cheng L, Dejbakhsh-Jones S, Liblau R, Zeng D, Strober S. Different patterns of TCR transgene expression in single-positive and double-negative T cells. Evidence for separate pathways of T cell maturation. J Immunol. 156:1996;3591-3601.
47. Dejbakhsh-Jones S, Jerabek L, Weissman IL, Strober S. Extrathymic maturation of alpha beta T cells from hemopoetic stem cells. J Immunol. 155:1995;3338-3344.
48. Lynch S, Kelleher D, McManus R, O'Farrelly C. RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. Eur J Immunol. 25:1995;1143-1147.
49. Fuller B, LeFrancois L. Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes. of outstanding interest J Immunol. 155:1995;2808-2811 A demonstration that T cell positive selection may occur at sites outside the thymus.
50. Fung-Leung WP, Kishihara K, Gray D, The HS, Lau CY, Mak TW. Intestinal T cells in CD8 alpha knock out mice and T cell receptor transgenic mice. Adv Exp Med Biol. 137:1995;121-124.
51. + intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J Exp Med. 173:1991;483-486.
52. Rocha B, Von Boehmer H, Guy-Grand D. Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut. Proc Natl Acad Sci USA. 89:1992;5336-5340.