Transcription factor regulation of B lineage commitment

Current Opinion in Immunology

Volumn 13, Issue 2, 2001, Pages 180-185

  Kee, B L ^a   Murre, C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; HEMATOPOIETIC CELL; HUMAN; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROLYMPHOCYTE; REVIEW;

EID: 0035314004     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00202-8     Document Type: Review

References (54)

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4. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
5. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
6. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
7. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
8. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
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10. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD and myc proteins
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13. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
14. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
15. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
16. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
17. The role of E-proteins in B- and T-lymphocyte development
18. E2A proteins: Essential regulators at multiple stages of B-cell development
19. Both E12 and E47 allow commitment to the B cell lineage
20. Functional replacement of the mouse E2A gene with a human HEB cDNA
21. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
22. E47 activates the Ig-heavy chain and TdT loci in non-B cells
23. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain transcription and rearrangement in a pre-T-cell line
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26. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
27. The characterization of the Olf-1/EBF-like HLH transcription factor family: Implications in olfactory gene regulation and neuronal development
28. Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression
29. Failure of B-cell differentiation in mice lacking the transcription factor EBF
30. Purification of early-B-cell factor and characterization of its DNA-binding specificity
31. EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains
32. A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation
33. The B29 (immunoglobulin β-chain) gene is a genetic target for early B-cell factor
34. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
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36. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax-5/BSAP
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39. Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis
40. Dependence of BSAP repressor and activator functions on BSAP concentration
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42. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
43. Independent regulation of the two Pax5 alleles during B-cell development
44. Hypothesis: Genes which function in a stochastic lineage commitment process are subject to monoallelic expression
45. LEF-1, a gene encoding a lymphoid-specific protein, with an HMG domain, regulates T-cell receptor α enhancer function
46. Assembly and function of a TCRa enhancer complex is dependent on LEF-1 induced DNA bending and multiple protein-protein interactions
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48. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
49. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
50. Wnt signaling and cancer
51. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
52. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
53. Lymphopenia in IL-7 gene deleted mice identifies IL-7 as a nonredundant cytokine
54. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates