T-cell selection

Current Opinion in Immunology

Volumn 10, Issue 2, 1998, Pages 214-219

  Jameson, Stephen C ^a   Bevan, Michael J ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; MAJOR HISTOCOMPATIBILITY COMPLEX; REVIEW; T LYMPHOCYTE; THYMUS;

EID: 0031956761     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80251-3     Document Type: Article

References (46)

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14. + thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity. 6:1997;401-410.
15. + repertoire is different from that selected in normal animals.
16. + repertoire is different from that selected in normal animals.
17. + repertoire is different from that selected in normal animals.
18. + repertoire is different from that selected in normal animals.
19. a and thus express predominantly a single class I invariant peptide (CLIP) bound to class II MHC molecules.
20. of special interest Hogquist KA, Tomlinson AJ, Kieper WC, McGargill MA, Hart MC, Naylor S, Jameson SC. Identification of a naturally occurring ligand for thymic positive selection. Immunity. 6:1997;389-399 With [21], this represents the first identification of self peptides that induce positive selection of a known T-cell receptor (TCR). Fetal thymic organ culture of the transporter associated with antigen presentation (TAP)-deficient, TCR-transgenic mice was used to show that certain naturally presented self peptides from MHC class I could mediate positive selection.
21. of special interest Hu Q, Walker CRB, Girao C, Opferman JT, Sun J, Shabanowitz J, Hunt DF, Ashton-Rickardt PG. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes. Immunity. 7:1997;221-231 With [20], this represents the first identification of self peptides that induce positive selection of a known T-cell receptor (TCR). Fetal thymic organ culture of the transporter associated with antigen presentation (TAP)-deficient, TCR-transgenic mice was used to show that certain naturally presented self peptides from MHC class I could mediate positive selection.
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27. of special interest Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS. Peptide-induced positive selection fo TCR trangenic thymocytes in a coreceptor-independent manner. Immunity. 6:1997;643-653 With [26], the role of the CD8 co-receptor in determining lineage commitment was addressed. T-cell receptor (TCR)-transgenic thymocytes that express no CD8 molecules can be selected into the CD8 lineage by the addition of stronger agonist peptides.
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32. of special interest Dave VP, Cao Z, Browne C, Alarcon B, Fernandez-Miguel G, Lafaille J, de la Hera A, Tonegawa S, Kappes DJ. CD3° deficiency arrests development of the αβ but not the γδ T-cell lineage. EMBO J. 6:1997;1360-1370 This knockout reveals that the CD3δ chain is not absolutely required for early thymocyte development or for γδ T cell development, but it is needed for maturation of αβ T cells.
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35. of special interest Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE. Role of the multiple T cell receptor (TCR)-ζ chain signaling motifs in selection of the T cell repertoire. J Exp Med. 185:1997;893-900 This paper demonstrates a role for the ζ chain immunoreceptor tyrosine kinase activation motifs (ITAMs) in selection of particular TCRs (with examples of both class I and class II MHC restricted receptors).
36. of special interest Zerrahn J, Held W, Raulet DH. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell. 88:1997;627-636 With [37], these data indicate that MHC reactivity is inherent in T-cell receptors (TCRs) and its frequency is not drastically affected by positive or negative selection. The co-evolution of the MHC and TCR loci has determined that about 20% of non-selected, or germline TCRs interact with the MHC molecules of any one haplotype.
37. of special interest Merkenschlager M, Graf D, Lovatt M, Bommhardt U, Zamoyska R, Fisher A. How many thymocytes audition for selection? J Exp Med. 186:1997;1149-1158 With [36], these data indicate that MHC reactivity is inherent in T-cell receptors (TCRs) and its frequency is not drastically affected by positive or negative selection. The co-evolution of the MHC and TCR loci has determined that about 20% of non-selected, or germline TCRs interact with the MHC molecules of any one haplotype.
38. Jeme NK. The somatic regulation of immune generation. Eur J Immunol. 1:1971;1-9.
39. Blackman M, Yague J, Kubo R, Gay D, Coleclough C, Palmer E, Kappler J, Marrack P. The T cell repertoire may be biased in favor of MHC recognition. Cell. 47:1986;349-357.
40. Fink PJ, Bevan MJ. Positive selection of thymocytes. Adv Immunol. 59:1995;99-133.
41. of outstanding interest Tanchot C, Lemmonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 276:1997;2057-2062 A compelling series of experiments that demonstrates that survival of naive mature T cells requires exposure to the same MHC molecule that positively selected the T-cell receptor, and that naive and memory T cells differ in their MHC molecule requirements.
42. + T cells as shown by [41], requires exposure to MHC class II molecules in the periphery.
43. + T cells as shown by [41], requires exposure to MHC class II molecules in the periphery.
44. + T cells as shown by [41], requires exposure to MHC class II molecules in the periphery.
45. + T cells as shown by [41], requires exposure to MHC class II molecules in the periphery.
46. of special interest Kuo CT, Veselits ML, Leiden JM. LKLF: a transcriptional regulator of single-positive T-cell quiescence and survival. Science. 277:1997;1986-1990 This work demonstrates that LKLF is required for long-term survival of naive T cells. This Kruppel-like zinc-finger protein is expressed in resting peripheral T cells. In knockout animals, the T cells activate 'spontaneously' and undergo Fas-based death.