The lutropin/choriogonadotropin receptor, a 2002 perspective

Endocrine Reviews

Volumn 23, Issue 2, 2002, Pages 141-174

  Ascoli, Mario ^a   Fanelli, Francesca ^b   Segaloff, Deborah L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; PROGESTERONE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; CONTROLLED STUDY; FEMALE GENITAL SYSTEM; FIRST TRIMESTER PREGNANCY; HORMONAL REGULATION; HORMONE ACTION; HORMONE BINDING; HORMONE STRUCTURE; HUMAN; LEYDIG CELL; NONHUMAN; OVULATION; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036217072     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/edrv.23.2.0462     Document Type: Review

References (293)

1. On the structure of the luteinizing hormone/chorionic gonadotropin receptor
2. Lutropin-choriogonadotropin receptor: An unusual member of the G protein-coupled receptor family
3. Cloning and sequencing of porcine LH-hCG receptor cDNA: Variants lacking transmembrane domain
4. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
5. Molecular tinkering of G protein-coupled receptor: An evolutionary success
6. Cloning and sequencing of human LH/hCG receptor cDNA
7. Expression of human luteinizing hormone (LH) receptor: Interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species
8. The lutropin/choriogonadotropin (LH/CG) receptor . . . 4 years later
9. hCG-receptor binding and transmembrane signaling
10. Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor
11. The luteinizing hormone receptor
12. G protein-coupled receptors. I. Diversity of receptor-ligand interactions
13. The orientation of the lutropin/choriogonadotropin receptor as revealed by site-specific antibodies
14. Roles of transmembrane prolines and proline-induced kinks of the lutropin/choriogonadotropin receptor
15. Purification, characterization, and aminoterminal sequence of rat ovarian receptor for luteinizing hormone/human choriogonadotropin
16. Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA
17. Variant forms of the pig lutropin/choriogonadotropin receptor
18. Basolateral localization and transcytosis of gonadotropin and thyrotropin receptors expressed in Madin-Darby canine kidney cells
19. Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor
20. Mutations of the second extracellular loop of the human lutropin receptor emphasize the importance of receptor activation and de-emphasize the importance of receptor phosphorylation in agonist-induced internalization
21. Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity
22. Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells
23. Deletions of portions of the extracellular loops of the lutropin/choriogonadotropin receptor decrease the binding affinity for ovine luteinizing hormone, but not for human choriogonadotropin, by preventing the formation of mature cell surface receptor
24. The six N-linked carbohydraes of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding or signal transduction
25. Posttranslational processing in the Golgi plays a critical role in the trafficking of the luteinizing hormone/human chorionic gonadotropin receptor to the cell surface
26. The lutropin/choriogonadotropin (LH/CG) receptor is palmitoylated at intracellular cysteine residues
27. Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the lutropin/choriogonadotropin receptor
28. p38JAB1 Binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation
29. Association of gonadotropin receptor precursors with the protein folding chaperone calnexin
30. Monoclonal antibodies against luteinizing hormone receptor. Immunochemical characterization of the receptor
31. Posttranslational modifications of the lutropin receptor: Mass spectrometric analysis
32. Functional glycosylation sites of the rat luteinizing hormone receptor required for ligand binding
33. Deglycosylation of the human luteinizing hormone receptor does not affect ligand binding and signal transduction
34. N-linked oligosacharides are not required for hormone binding of the lutropin receptor in a Leydig tumor cell line and rat granulosa cells
35. Site specificity of the chorionic gonadotropin N-linked oligosacharides in signal transduction
36. Role of carbohydrates in glycoprotein hormone signal transduction
37. Setting the standards: Quality control in the secretory pathway
38. Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones
39. Hormone interactions to Leu-rich repeats in the gonadotropin receptors. I. Analysis of leu-rich repeats of human luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor
40. Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling
41. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven transmembrane region
42. The leucine-rich repeat: A versatile binding motif
43. Structural diversity of leucine-rich repeat proteins
44. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
45. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions
46. Modeling of the three dimensional structure of proteins with the typical leucine rich repeats
47. Crystal structure of human chorionic gonadotropin
48. Purification and structural analysis of a soluble human chorionogonadotropin hormone-receptor complex
49. High-level expression of a functional single-chain human chorionic gonadotropin-luteinizing hormone receptor ectodomain complex in insect cells
50. The follicle-stimulating hormone receptor: Biochemistry, molecular biology, physiology and pathophysiology
51. The thyrotropin (TSH) hormone receptor: Interaction with TSH and autoantibodies
52. Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function
53. Characterization of two fly LGR (leucine-rich repeat containing, G protein-coupled receptor) proteins homologous to vertebrate glycoprotein hormone receptors: Constitutive activation of wild-type fly LGR1 but not LGR2 in transfected mammalian cells
54. Discovering new hormones, receptors, and signaling mediators in the genomic era
55. A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction
56. The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively actived in mammalian cells
57. Molecular cloning of a novel, putative G protein-coupled receptor from sea anemones structurally related to members of the FSH, TSH and LH/CG receptor family from mammals
58. Molecular cloning, genomic organization, and developmental regulation of a novel receptor from drosophila melanogaster structurally related to members of the thyroid-stimulating hormone, follicle stimulating hormone, luteinizing hormone/choriogonadotropin receptor family from mammals
59. A model of the lutropin/choriogonadotropin receptor: Insights into the structural and functional effects of constitutively activating mutations
60. Theoretical study on mutation-induced activation of the luteinizing hormone receptor
61. Arrangement of rhodopsin transmembrane α-helices
62. An α-carbon template for the transmembrane helices in the rhodopsin family of G protein-coupled receptors
63. Crystal structure of rhodopsin: A G protein-coupled receptor
64. Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness
65. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
66. G protein-coupled receptor kinases as modulators of G protein signalling
67. G protein-coupled receptor kinases
68. Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line
69. Phosphorylation-independent desensitization of the luteinizing hormone/chorionic gonadotropin receptor in porcine follicular membranes
70. Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail
71. Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization and enhance agonist-induced receptor down-regulation
72. Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone
73. Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin (LH/CG) receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization
74. Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21
75. Structure of the human luteinizing hormone choriogonadotropin receptor gene: Unusal promoter and 5′ non-coding regions
76. Structure of the luteinizing hormone receptor gene and multiple exons of the coding sequence
77. Structural organization of the rat luteinizing hormone (LH) receptor gene
78. Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes a G protein modulation and a potential second hormone binding site
79. The 5′ flanking region of the rat lutropin/choriogonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by cAMP
80. A novel human luteinizing hormone receptor gene
81. Multiple luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid transcripts
82. Promoter and regulatory regions of the rat luteinizing hormone receptor gene
83. Molecular cloning of a novel luteinizing-hormone/human chorionic gonadotropin-receptor cDNA
84. 3′ Untranslated region-mediated regulation of luteinizing hormone/human chorionic gonadotropin receptor expression
85. Expression of LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript
86. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity
87. Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity
88. Expression of luteinizing hormone/human chorionic gonadotropin (LH/HCG) receptor mRNA in the human ovary
89. Functional expression of recombinant human luteinizing hormone/human choriogonadotropin receptor
90. Cloning and functional expression of the luteinizing hormone receptor complementary deoxyribonucleic acid from the marmoset monkey testis: Absence of sequences encoding exon 10 in other species
91. The unique exon 10 of the human luteinizing hormone receptor is necessary for expression of the receptor protein at the plasma membrane in the human luteinizing hormone receptor, but deleterious when inserted in the human follicle-stimulating hormone receptor
92. Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone (LH) receptor: Differential action of human chorionic gonadotropin and LH
93. Evidences for an allelic variant of the human LC/CG receptor rather than a gene duplication: Functional comparison of wild-type and variant receptors
94. Inactivation of the luteinizing hormone/chorionic gonadotropin receptor by an insertional mutation in Leydig cell hypoplasia
95. Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty
96. Naturally occurring mutations of the luteinizing-hormone receptor: Lessons learned about reproductive physiology and G protein-coupled receptors
97. A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia
98. Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene
99. Testicular and ovarian resistance to luteinzing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene
100. Compounds heterozygous mutations of the luteinizing hormone receptor gene in leydig cell hypoplasia
101. A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: Correlation between receptor activity and phenotype
102. A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor
103. Comparison of immunocytochemical and molecular features with the phenotype in a case of incomplete male pseudohermaphroditism associated with a mutation of the luteinizing hormone receptor
104. An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female
105. A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters
106. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
107. Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precoious puberty
108. Characterization of heterogenous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty
109. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male precocious puberty
110. A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty
111. A case of male-limited precocious puberty caused by a point mutation in the second transmembrane domain of the luteinizing hormone choriogonadotropin receptor gene
112. Identification of constitutively activating mutation of the luteinizing hormone receptor in a family with male limited gonadotropin independent precocious puberty (testotoxicosis)
113. A new point mutation in the luteinizing hormone receptor gene in familial and sporadic male limited precocious puberty: Genotype does not always correlate with phenotype
114. A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty
115. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor
116. Severe testotoxicosis phenotype associated with Asp578→Tyr mutation of the lutropin/choriogonadotropin receptor gene
117. A mutation in the first transmembrane domain of the lutropin receptor causes male precocious puberty
118. A limited repertoire of mutations of the luteinizing hormone (LH) receptor gene in familial and sporadic patients with male LH-independent precocious puberty
119. A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty
120. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty
121. A novel luteinizing hormone receptor mutation in a patient with familial male-limited precocious puberty: Effect of the size of a critical amino acid on receptor activity
122. Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region
123. The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation
124. Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain
125. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281→isoleucine) in the extracellular domain of the thyrotropin receptor
126. Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor
127. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice
128. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene
129. Expression and localization of luteinizing hormone receptor in the female mouse reproductive tract
130. Evidence for the presence of luteinizing hormone/human chorionic gonadotropin-binding sites in the porcine uterus
131. Estrous cycle-related changes of high affinity luteinizing hormone-chorionic gonadotropin binding sites in the rat uterus
132. Uterine luteinizing hormone/human chorionic gonadotropin-binding sites in the early pregnant rat uterus: Evidence for total occupancy in the periimplantation period
133. Identification of LH/hCG receptors in rabbit uterus
134. The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua
135. Functional relevance of luteinizing hormone receptor in mouse uterus
136. Cycle dependent LH/hCG receptor gene expression in porcine nongonadal reproductive tissues
137. Human chorionic gonadotropin binding sites in the human endometrium
138. Messenger ribonucleic acid for the gonadal luteinizing hormone hormone/human chorionic gonadotropin receptor is not present in human endomedtrium
139. The expression of human chorionic gonadotropin luteinizing hormone receptors in human endometrial and myometrial blood vessels
140. A paradigm shift on the targets of luteinizing hormone/human chorionic gonadotropin actions in the body
141. The begining of a new era in reproductive biology and medicine: Expression of low levels of functional luteinizing hormone hormone/human chorionic gonadotropin receptors in nongonadal tissues
142. Luteinizing hormone/human chorionic gonadotropin receptors in breast cancer
143. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: Regulation by tissue specific splicing
144. Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome
145. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome
146. Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice
147. Suppression of gonadotropins inhibits gonadal tumorogenesis in mice transgenic for the mouse inhibin-α subunit promoter/simian viruse 40 T-antigen fusion gene
148. Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin α-subunit promoter/simian virus 40 T-antigen fusion gene
149. Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex
150. Diversity and selectivity of receptor-G protein interaction
151. Heptahelical receptor signaling: Beyond the G protein paradigm
152. Signaling at zero G: G protein-independent functions for 7-TM receptors
153. 2+ mobilization
154. 2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3′,5′-cyclic adenosine monophosphate formation: Evidence for parallel activation of two signaling pathways
155. The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2
156. The luteinizing hormone/chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals
157. 578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor
158. The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: Analysis using chimeric human LH/follicle-stimulating hormone receptors
159. An anionic residue at position 564 is important for maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor
160. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C
161. sα and pertussis toxin-catalyzed ADP-ribosylation of Giα*
162. Luteinizing hormone/choriogonadotropin receptor-mediated activation of heterotrimeric guanine nucleotide binding proteins in ovarian follicular membranes
163. The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin
164. Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line
165. Immortalized Leydig cell lines as models for studying Leydig cell physiology
166. Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density
167. MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): A novel experimental paradigm to study the functional properties of the hLHR
168. Role of the third intracellular loop for the activation of gonadotropin receptors
169. G protein-coupled receptor cross-talk: The fine-tuning of multiple receptor-signalling pathways
170. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
171. Novel molecular mediators in the pathway connecting G protein-coupled receptors to MAP kinase cascades
172. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
173. cAMP and βγ subunits of hetertrimeric G proteins stimulated the mitogen-activated protein kinase pathway in COS-7 cells
174. Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity
175. Leutropin/β-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface
176. Derivation of functional antagonists using N-terminal extracellular domain of gonadotropin and thyrotropin receptors
177. Hormone binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the LH/CG receptor expressed in mammalian cells
178. The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain
179. Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not the lutropin/choriogonadotropin receptor
180. An improved method for the solubilization of stable gonadotropin receptors
181. The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. I. Mutational analysis
182. Mutational analysis of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucine rich repeats 1-6 are involved in hormone binding
183. Co-evolution of ligand-receptor pairs
184. Identification of hormone-binding regions of the luteinizing hormone/human chorionic gonadotropin receptor using synthetic peptides
185. The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. II. Photoaffinity labeling
186. Requirement of cysteine residues in exons 1-6 of the extracellular domain of the luteinizing formine receptor for gonadotropin binding
187. Hormone interactions to Leu-rich repeats in the gonadotropin receptors. II. Analysis of leu-rich repeat 4 of human luteinizing hormone/chorionic gonadotropin receptor
188. Human chorionic gonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis
189. Modulation of high affinity hormone binding. Human choriogonadotropin binding to the exodomain of the receptor is influenced by exoloop 2 of the receptor
190. 383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production
191. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors
192. + modulates the affinity of the lutropin/choriogonadotropin (LH/CG) receptor
193. A mutation-induced activated state of the β2-adrenergic receptor
194. Evidence for the direct involvement of transmembrane region 6 of the lutropin/choriogonadotropin receptor in activating Gs
195. Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop
196. G protein-coupled receptors. II. Mechanisms of agonist activation
197. s and increase agonist affinity
198. Structural basis of β-adrenergic receptor function
199. o by mastoparan, related amphiphilic peptides and hydrophobic amines
200. G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide
201. Positive charges in a putative amphiphilic helix in the carboxyl-terminal region of the third intracellular loop of the luteinizing hormone/chorionic gonadotropin receptor are not required for hormone-stimulated cAMP production but are necessary for expression of the receptor at the plasma membrane
202. Arrestin-rhodopsin interaction: Multi-site binding delineated by peptide inhibition
203. Theoretical study on the electrostatically driven step of receptor-G protein recognition
204. Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis
205. Mutation of a highly conserved acidic residue present in the second intracellular loop of G protein-coupled receptors does not impair hormone binding or signal transduction of the LH/CG receptor
206. Identification of amino acid residues in transmembrane helices VI and VII of the lutropin/choriogonadotropin receptor involved in signaling
207. Functional role of transmembrane helix 7 in the activation of the heptahelical lutropin receptor
208. Rhodopsin activation blocked by metal ion-binding sites linking transmembrane helices C and F
209. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
210. Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs
211. 1B-adrenergic receptor by all amino acid substitutions at a single site
212. Amino acid side chains that define muscarinic receptor/G protein coupling. Studies of the third intracellular loop
213. Constitutive activity of glucagon receptor mutants
214. Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor
215. Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III
216. Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling
217. 583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling
218. Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor
219. 397 is important for receptor activation
220. Receptor activation of and signal generation by the lutropin/choriogonadotropin receptor
221. Glycoprotein hormones: Structure and function
222. Structure of LH and hCG
223. The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: Studies using chimeric human and fly receptors
224. Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation
225. The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: Implications for hormone-receptor interaction of antagonist design
226. Deletions in the third intracellular loop of the thyrotropin receptor
227. Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization
228. In situ hybridization of luteinizing hormone/human chorionic gonadotropin receptor messenger ribonucleic acid during hormone-induced down-regulation and the subsequent recovery in rat corpus luteum
229. Evidence that human chorionic gonadotropin/luteinizing hormone receptor-down regulation involves decreased levels of receptor messenger ribonucleic acid
230. Gonadotropin-induced up- and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinization
231. Cellular localization and hormonal regulation of follicle-stimulating hormone and luteinizing hormone receptor messenger RNAs in the rat ovary
232. Hormonal regulation of LH receptor mRNA and expression in the rat ovary
233. Epidermal growth factor, a phorbol ester and cAMP decrease the transcription of the LH/CG receptor gene in MA-10 Leydig tumor cells
234. Characterization of the functional properties and nuclear binding proteins of the rat luteinizing hormone/chorionic gonadotropin receptor promoter in Leydig cells
235. Lutropin/choriogonadotropin down-regulates its receptor by both receptor mediated endocytosis and a cAMP-dependent reduction in receptor mRNA
236. Loss of lutropin/human choriogonadotropin receptor messenger ribonucleic acid during ligand-induced down-regulation occurs post transcriptionally
237. Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frame
238. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulation
239. Characterization of diverse functional elements in the upstream Sp1 domain of the rat luteinizing hormone receptor gene promoter
240. Transcriptional protein binding domains governing basal expression of the rat luteinizing hormone receptor gene
241. Multiple elements and protein factors coordinate the basal and cyclic adenosine 3′,5′-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells
242. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor
243. The human luteinizing hormone receptor gene promoter: Activation by Sp1 and Sp3 and inhibitory regulation
244. EAR2 and EAR3/COUP-TF1 regulate transcription of the rat LH receptor
245. Promoter function of different lengths of the murine luteinizing hormone receptor gene 5′-flanking region in transfected gonadal cells and in transgenic mice
246. Regulation of function of the murine luteinizing hormone receptor promoter by cis- and trans-acting elements in mouse Leydig tumor cells
247. A role for increased lutropin/choriogonadotropin receptor (LHR) gene transcription in the follitropin-stimulated induction of the LHR in granulosa cells
248. A novel cyclic adenosine 3′,5′-monophosphate-responsive element involved in the transcriptional regulation of the lutropin receptor gene in granulosa cells
249. Regulation of peptide hormone receptors and gonadal steroidogenesis
250. Sources of cholesterol used for steroid biosynthesis in cultured Leydig tumor cells
251. Structure, function and regulation of steroidogenic enzymes in the Leydig cell
252. Regulatory mechanisms that modulate signaling by G protein-coupled receptors
253. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
254. Desensitization of G protein-coupled receptors
255. β-Arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of β-arrestin1-dependent targeting of c-Src in receptor endocytosis
256. β-Arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
257. The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization
258. Desensitization of the luteinizing hormone/choriogonadotropin receptor in ovarian follicular membranes is inhibited by catalytically inactive ARNO+
259. The effect of protein kinases on desensitization of the porcine follicular membrane luteinizing hormone/chorionic gonadotropin-sensitive adenylyly cyclase
260. Homologous desensitization of ovarian luteinizing hormone/human chorionic gonadotropin-responsive adenylyl cyclase is dependent upon GTP
261. Guanosine triphosphate fulfills a complete and specific nucleotide requirement for luteinizing hormone-induced desensitization of pig ovarian adenylyl cyclase
262. Reversal of the desensitized state of pig ovarian follicular human choriogonadotropin-sensitive adenylylcyclase by guanosine 5′-O-(2-thiodiphosphate)
263. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes
264. β-Arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor
265. Activation of the luteinizing hormone/choriogonadotropin hormone receptor promotes ADP ribosylation factor 6 activation in porcine ovarian follicular membranes
266. β Arrestin-mediated ARF6 activation and β2-adrenergic receptor endocytosis
267. Truncation of the cytoplasmic tail of the lutropin choriogonadotropin receptor prevents agonist-induced uncoupling
268. Biochemical properties of the agonist-induced desensitization of the FSH- and LH/ CG-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors
269. The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation
270. Seven non-contiguous intracellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization and its sensitivity to non-visual arrestins
271. Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat lutropin receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway
272. Pathways of internalization of the hCG/LH receptor: Immunoelectron microscopic studies in Leydig cells and transfected L cells
273. Internalization and recycling pathways of the thyrotropin receptor
274. Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin
275. The C-terminal tail of the rat lutropin/choriogonadotropin receptor independently modulates hCG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex
276. A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex
277. On the mechanisms involved in the regulation of the cell surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells
278. The slow rate of internalization of deglycosylated hCG is not due to its inability to stimulate cAMP accumulation
279. Evidence that constitutively active luteinizing hormone/human chorionic gonadotropin receptors are rapidly internalized
280. Endocytosis
281. Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits
282. Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor
283. G-protein-coupled receptors: Turnons and turn-offs
284. G-protein-coupled receptor adaptation mechanisms
285. Intracellular targeting and trafficking of thrombin receptors
286. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
287. a receptors
288. Regulation and intracellular trafficking pathways of the endothelin receptors
289. Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor
290. Identification of ionizable amino acid residues on the extracellular domain of the lutropin receptor involved in ligand binding
291. The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis
292. A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands
293. On the fates of receptor-bound human ovine luteinizing hormone and human choriogonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization