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Volumn 10, Issue 6, 1996, Pages 748-759

Progressive Cytoplasmic Tail Truncations of the Lutropin-Choriogonadotropin Receptor Prevent Agonist- or Phorbol Ester-Induced Phosphorylation, Impair Agonist- or Phorbol Ester-Induced Desensitization, and Enhance Agonist-Induced Receptor Down-Regulation

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; CYCLIC AMP; INOSITOL PHOSPHATE; LUTEINIZING HORMONE RECEPTOR; PHORBOL ESTER;

EID: 0029889283     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.10.6.8776735     Document Type: Article
Times cited : (40)

References (36)
  • 1
    • 0027219322 scopus 로고
    • Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line
    • Hipkin RW, Sánchez-Yagüe J, Ascoli M 1993 Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line. Mol Endocrinol 7:823-832
    • (1993) Mol Endocrinol , vol.7 , pp. 823-832
    • Hipkin, R.W.1    Sánchez-Yagüe, J.2    Ascoli, M.3
  • 2
    • 0028809315 scopus 로고
    • Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail
    • Hipkin RW, Wang Z, Ascoli M 1995 Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail. Mol Endocrinol 9:151-158
    • (1995) Mol Endocrinol , vol.9 , pp. 151-158
    • Hipkin, R.W.1    Wang, Z.2    Ascoli, M.3
  • 3
    • 0027405071 scopus 로고
    • Biochemical properties of the agonist-induced desensitization of the FSH- and LH/CG-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors
    • Sánchez-Yagüe J, Hipkin RW, Ascoli M 1993 Biochemical properties of the agonist-induced desensitization of the FSH- and LH/CG-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors. Endocrinology 132:1007-1016
    • (1993) Endocrinology , vol.132 , pp. 1007-1016
    • Sánchez-Yagüe, J.1    Hipkin, R.W.2    Ascoli, M.3
  • 6
    • 0028059202 scopus 로고
    • Truncations of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the α1B-adrenergic receptor
    • Lattion A-L, Diviani D, Cotecchia S 1994 Truncations of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the α1B-adrenergic receptor. J Biol Chem 269:22887-22893
    • (1994) J Biol Chem , vol.269 , pp. 22887-22893
    • Lattion, A.-L.1    Diviani, D.2    Cotecchia, S.3
  • 8
    • 0023841528 scopus 로고
    • Inactivation of photoexcited rhodopsin in retinal rods: The roles of rhodopsin kinase and 48-kDa protein (Arrestin)
    • Bennett N, Sitaramayya A 1988 Inactivation of photoexcited rhodopsin in retinal rods: The roles of rhodopsin kinase and 48-kDa protein (Arrestin). Biochemistry 27: 1710-1715
    • (1988) Biochemistry , vol.27 , pp. 1710-1715
    • Bennett, N.1    Sitaramayya, A.2
  • 9
    • 0028058914 scopus 로고
    • Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization
    • Takano T, Honda Z, Sakanaka C, Izumi T, Kameyama K, Haga K, Haga T, Kurokawa K, Shimizu T 1994 Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. J Biol Chem 269:22453-22458
    • (1994) J Biol Chem , vol.269 , pp. 22453-22458
    • Takano, T.1    Honda, Z.2    Sakanaka, C.3    Izumi, T.4    Kameyama, K.5    Haga, K.6    Haga, T.7    Kurokawa, K.8    Shimizu, T.9
  • 10
    • 0028809192 scopus 로고
    • Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2
    • Prossnitz ER, Kim CM, Benovic JL, Ye RD 1994 Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem 270:1130-1137
    • (1994) J Biol Chem , vol.270 , pp. 1130-1137
    • Prossnitz, E.R.1    Kim, C.M.2    Benovic, J.L.3    Ye, R.D.4
  • 11
    • 0028943362 scopus 로고
    • C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling
    • Alblas J, van Etten I, Khanum A, Moolenar WH 1995 C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. J Biol Chem 270:8944-8951
    • (1995) J Biol Chem , vol.270 , pp. 8944-8951
    • Alblas, J.1    Van Etten, I.2    Khanum, A.3    Moolenar, W.H.4
  • 12
    • 0026778801 scopus 로고
    • Truncation of the cytoplasmic tail of the lutropin choriogonadotropin receptor prevents agonist-induced uncoupling
    • Sánchez-Yagüe J, Rodríguez MC, Segaloff DL, Ascoli M 1992 Truncation of the cytoplasmic tail of the lutropin choriogonadotropin receptor prevents agonist-induced uncoupling. J Biol Chem 267:7217-7220
    • (1992) J Biol Chem , vol.267 , pp. 7217-7220
    • Sánchez-Yagüe, J.1    Rodríguez, M.C.2    Segaloff, D.L.3    Ascoli, M.4
  • 13
    • 0027492727 scopus 로고
    • A luteinizing hormone receptor with a severely truncated cytoplasmic tail (LHR-ct628) desensitizes to the same degree as the full length receptor
    • Zhu X, Gudermann T, Birnbaumer M, Birnbaumer L 1993 A luteinizing hormone receptor with a severely truncated cytoplasmic tail (LHR-ct628) desensitizes to the same degree as the full length receptor. J Biol Chem 268:1723-1728
    • (1993) J Biol Chem , vol.268 , pp. 1723-1728
    • Zhu, X.1    Gudermann, T.2    Birnbaumer, M.3    Birnbaumer, L.4
  • 14
    • 0019799010 scopus 로고
    • Mechanism of desensitization of adenylate cyclase by lutropin. Impaired introduction of GTP into the regulatory site
    • Ezra E, Salomon Y 1981 Mechanism of desensitization of adenylate cyclase by lutropin. Impaired introduction of GTP into the regulatory site. J Biol Chem 256:5377-5382
    • (1981) J Biol Chem , vol.256 , pp. 5377-5382
    • Ezra, E.1    Salomon, Y.2
  • 15
    • 0024418470 scopus 로고
    • Guanosine triphosphate fulfills a complete and specific nucleotide requirement for luteinizing hormone-induced desensitization of pig ovarian adenylyl cyclase
    • Ekstrom RC, Hunzicker-Dunn M 1989 Guanosine triphosphate fulfills a complete and specific nucleotide requirement for luteinizing hormone-induced desensitization of pig ovarian adenylyl cyclase. Endocrinology 125:2470-2474
    • (1989) Endocrinology , vol.125 , pp. 2470-2474
    • Ekstrom, R.C.1    Hunzicker-Dunn, M.2
  • 16
    • 0028099967 scopus 로고
    • Phosporylation-independent desensitization of the luteinizing hormone/ chorionic gonadotropin receptor in porcine follicular membranes
    • Lamm MLG, Hunzicker-Dunn M 1994 Phosporylation-independent desensitization of the luteinizing hormone/ chorionic gonadotropin receptor in porcine follicular membranes. Mol Endocrinol 8:1537-1546
    • (1994) Mol Endocrinol , vol.8 , pp. 1537-1546
    • Lamm, M.L.G.1    Hunzicker-Dunn, M.2
  • 17
    • 0021715897 scopus 로고
    • Cell-free lutropin-dependent desensitization of the lutropin-sensitive adenylate cyclase of pig ovarian follicles is dependent on ATP
    • Kuemmerle SC, Hunzicker-Dunn M 1984 Cell-free lutropin-dependent desensitization of the lutropin-sensitive adenylate cyclase of pig ovarian follicles is dependent on ATP. Biochem J 223:561-569
    • (1984) Biochem J , vol.223 , pp. 561-569
    • Kuemmerle, S.C.1    Hunzicker-Dunn, M.2
  • 19
    • 0027093726 scopus 로고
    • Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA
    • Hipkin RW, Sánchez-Yagüe J, Ascoli M 1992 Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA. Mol Endocrinol 6:2210-2218
    • (1992) Mol Endocrinol , vol.6 , pp. 2210-2218
    • Hipkin, R.W.1    Sánchez-Yagüe, J.2    Ascoli, M.3
  • 20
    • 0028785484 scopus 로고
    • Truncation of the C-terminal tail of the follitropin (FSH) receptor does not impair the agonist- or phorbol ester-induced receptor phosphorylation and uncoupling
    • Hipkin RW, Liu X, Ascoli M 1995 Truncation of the C-terminal tail of the follitropin (FSH) receptor does not impair the agonist- or phorbol ester-induced receptor phosphorylation and uncoupling. J Biol Chem 270: 26683-26689
    • (1995) J Biol Chem , vol.270 , pp. 26683-26689
    • Hipkin, R.W.1    Liu, X.2    Ascoli, M.3
  • 21
    • 0020356604 scopus 로고
    • Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits
    • Ascoli M 1982 Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits. J Biol Chem 257: 13306-13311
    • (1982) J Biol Chem , vol.257 , pp. 13306-13311
    • Ascoli, M.1
  • 22
    • 0019888624 scopus 로고
    • Removal of surface-bound human choriogonadotropin results in cessation of hormonal responses in cultured Leydig tumor cells
    • Segaloff DL, Ascoli M 1981 Removal of surface-bound human choriogonadotropin results in cessation of hormonal responses in cultured Leydig tumor cells. J Biol Chem 256:11420-11423
    • (1981) J Biol Chem , vol.256 , pp. 11420-11423
    • Segaloff, D.L.1    Ascoli, M.2
  • 23
    • 0022527455 scopus 로고
    • Gonadotropin-mediated desensitization in a murine Leydig tumor cell line does not alter the regulatory and catalytic components of adenylate cyclase
    • Rebois RV, Fishman PH 1986 Gonadotropin-mediated desensitization in a murine Leydig tumor cell line does not alter the regulatory and catalytic components of adenylate cyclase. Endocrinology 118:2340-2348
    • (1986) Endocrinology , vol.118 , pp. 2340-2348
    • Rebois, R.V.1    Fishman, P.H.2
  • 24
    • 0022363890 scopus 로고
    • Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line
    • Rebois RV, Patel J 1985 Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line. J Biol Chem 260:8026-8031
    • (1985) J Biol Chem , vol.260 , pp. 8026-8031
    • Rebois, R.V.1    Patel, J.2
  • 25
    • 0024380688 scopus 로고
    • Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells
    • Inoue Y, Rebois RV 1989 Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. J Biol Chem 264:8504-8508
    • (1989) J Biol Chem , vol.264 , pp. 8504-8508
    • Inoue, Y.1    Rebois, R.V.2
  • 26
    • 0026591515 scopus 로고
    • Effects of truncations of the cytoplasmic tail of the lutropin/choriogonadotropin receptor on receptor-mediated hormone internalization
    • Rodriguez MC, Xie Y-B, Wang H, Collison K, Segaloff DL 1992 Effects of truncations of the cytoplasmic tail of the lutropin/choriogonadotropin receptor on receptor-mediated hormone internalization. Mol Endocrinol 6:327-336
    • (1992) Mol Endocrinol , vol.6 , pp. 327-336
    • Rodriguez, M.C.1    Xie, Y.-B.2    Wang, H.3    Collison, K.4    Segaloff, D.L.5
  • 28
    • 0028245033 scopus 로고
    • Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells
    • Quintana J, Hipkin RW, Sánchez-Yagüe J, Ascoli M 1994 Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells. J Biol Chem 269:8772-8779
    • (1994) J Biol Chem , vol.269 , pp. 8772-8779
    • Quintana, J.1    Hipkin, R.W.2    Sánchez-Yagüe, J.3    Ascoli, M.4
  • 29
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 53: 304-308
    • (1976) Anal Biochem , vol.53 , pp. 304-308
    • Bradford, M.M.1
  • 30
    • 0023697534 scopus 로고
    • Characterization of an antiserum to the rat luteal luteinizing hormone/ chorionic gonadotropin receptor
    • Rosemblit N, Ascoli M, Segaloff DL 1988 Characterization of an antiserum to the rat luteal luteinizing hormone/ chorionic gonadotropin receptor. Endocrinology 123: 2284-2290
    • (1988) Endocrinology , vol.123 , pp. 2284-2290
    • Rosemblit, N.1    Ascoli, M.2    Segaloff, D.L.3
  • 31
    • 0023141666 scopus 로고
    • Immunoprecipitation of the lutropin/choriogonadotropin receptor from biosynthetically labeled Leydig tumor cells: A 92-kDa glycoprotein
    • Kim I-C, Ascoli M, Segaloff DL 1987 Immunoprecipitation of the lutropin/choriogonadotropin receptor from biosynthetically labeled Leydig tumor cells: a 92-kDa glycoprotein. J Biol Chem 262:470-477
    • (1987) J Biol Chem , vol.262 , pp. 470-477
    • Kim, I.-C.1    Ascoli, M.2    Segaloff, D.L.3
  • 32
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay and physiological dose-response curves
    • De Lean A, Munson PJ, Rodbard D 1978 Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay and physiological dose-response curves. Am J Physiol 235: E97-E102
    • (1978) Am J Physiol , vol.235
    • De Lean, A.1    Munson, P.J.2    Rodbard, D.3
  • 33
    • 0024533488 scopus 로고
    • The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin
    • Ascoli M, Pignataro OP, Segaloff DL 1989 The inositol phosphate/diacylglycerol pathway in MA-10 Leydig tumor cells. Activation by arginine vasopressin and lack of effect of epidermal growth factor and human choriogonadotropin. J Biol Chem 264:6674-6681
    • (1989) J Biol Chem , vol.264 , pp. 6674-6681
    • Ascoli, M.1    Pignataro, O.P.2    Segaloff, D.L.3
  • 34
    • 0027457240 scopus 로고
    • Mutation of a highly conserved acidic residue present in the second intracellular loop of G protein-coupled receptors does not impair hormone binding or signal transduction of the LH/CG receptor
    • Wang Z, Wang H, Ascoli M 1993 Mutation of a highly conserved acidic residue present in the second intracellular loop of G protein-coupled receptors does not impair hormone binding or signal transduction of the LH/CG receptor. Mol Endocrinol 7:85-93
    • (1993) Mol Endocrinol , vol.7 , pp. 85-93
    • Wang, Z.1    Wang, H.2    Ascoli, M.3
  • 35
    • 0019061918 scopus 로고
    • LIGAND: A versatile computerized approach for characterization of ligand-binding systems
    • Munson PJ, Rodbard D 1980 LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
    • (1980) Anal Biochem , vol.107 , pp. 220-239
    • Munson, P.J.1    Rodbard, D.2
  • 36
    • 0343053231 scopus 로고
    • Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells
    • Ascoli M, Puett D 1978 Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells. Proc Natl Acad Sci USA 75:99-102
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 99-102
    • Ascoli, M.1    Puett, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.