HCG-receptor binding and transmembrane signaling

Molecular and Cellular Endocrinology

Volumn 125, Issue 1-2, 1996, Pages 55-64

  Puett, David ^a   Bhowmick, Neil ^a   Fernandez, Lizette M ^a   Huang, Jianing ^a   Wu, Chengbin ^a   Narayan, Prema ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Human choriogonadotropin (hCG); Luteinizing hormone (LH); Signaling receptor for LH and hCG

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; FOLLITROPIN RECEPTOR; MUTANT PROTEIN; PROTEIN SUBUNIT;

CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CHORIONIC GONADOTROPIN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, LH; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030596020     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(96)03954-8     Document Type: Conference Paper

References (61)

1. [1] Pierce, J.G. and Parsons, T.F. (1981) Glycoprotein hormones: structure and function. Annu. Rev. Biochem. 50, 465-495.
2. [2] Matzuk, M.M. and Hsueh, A.J.W. et al. (1990) The biological role of the carboxyl terminal extension of human choriogonadotropin β subunit. Endocrinology 126, 376-383.
3. [3] McFarland, K.C. and Sprengel, R. et al. (1989) Lutropin-choriogonadotropin receptor: an unusual member of the G-protein coupled receptor family. Science 245, 494-499.
4. [4] Braun, T. and Schofield, P.R. et al. (1991) Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. EMBO. J. 10, 1885-1890.
5. [5] Ji, I. and Ji, T.H. (1991) Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site. Endocrinology 128, 2648-2650.
6. [6] Moyle, W.R. and Bernad, M.P. et al. (1991) Lutropin/-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface. J. Biol. Chem. 266, 10807-10812.
7. [7] Tsai-Morris, C.H. and Buczko, E. et al. (1990) Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity. J. Biol. Chem. 265, 19385-19388.
8. [8] Xie, Y.-B. and Wang, H. et al. (1990) Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J. Biol. Chem. 265, 21411-21414.
9. [9] Segaloff, D.L. and Ascoli, M. (1993) The lutropin/choriogonadotropin receptor...4 years later. Endocr. Rev. 14, 324-347.
10. [10] Birken, S. and Kolkz, M.A.G. et al. (1987) Structural and functional studies of the tryptic core of the human chorionic gonadotropin β-subunit. Endocrinology 121, 657-666.
11. [11] Bousfield, G.R. and Ward, D.N. (1988) Selective proteolysis of ovine lutropin or its β-subunit by endoproteinase Arg-C. J. Biol. Chem. 263, 12602-12607.
12. [12] Keutmann, H.T. and Charlesworth, M.C. et al. (1987) A receptor-binding region in human choriogonadotropin/lutropin β-subunit. Proc. Natl. Acad. Sci. USA 84, 2038-2042.
13. [13] Keutmann, H.T. and Mason, K.A. et al. (1989) Role of the β 93-100 determinant loop sequence in receptor binding and biological activity of human luteinizing hormone and chorionic gonadotropin. Mol. Endocrinol. 3, 526-531.
14. [14] Puett, D. and Huang, J. et al. (1994) Delineation of subunit and receptor contact sites by site-directed mutagenesis of hCGβ. In: Glycoprotein Hormones: Structure, function and clinical implications (Lustbader, J.W. and Puett, D. et al., eds.), pp. 122-134, Serono Symposia, Springer-Verlag, NY.
15. [15] Salesse, R. and Bidart, J.-M. et al. (1990) Peptide mapping of intersubunit and receptor interactions of human choriogonadotropin. Mol. Cell Endocrinol. 68, 113-119.
16. [16] Moyle, W.R. and Campbell, R.K. et al. (1994) Co-evolution of ligand-receptor pairs. Nature 368, 251-255.
17. [17] Moyle, W.R. and Campbell, R.K. et al. (1995) Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones. J. Biol. Chem. 270, 20020-20032.
18. [18] Dias, J.A. (1992) Progress and approaches in mapping the surfaces of human follicle-stimulating hormone. Trends Endocrinol. Metab. 3, 24-29.
19. [19] Keutmann, H.T. (1992) Receptor-binding regions in human glycoprotein hormones. Mol. Cell Endocrinol. 86, C1-C6.
20. [20] Roche, P.C. and Ryan, R.J. et al. (1992) Identification of hormone-binding regions of the luteinizing hormone/human chorionic gonadotropin receptor using synthetic peptides. Endocrinology 131, 268-274.
21. [21] Ryan, R.J. and Keutmann, H.T. et al. (1987) Structure-function relationships of gonadotropins. Rec. Prog. Horm. Res. 43, 383-429.
22. [22] Fernandez, L.M. and Puett, D. (1996) Identification of amino acid residues in transmembrane helices VI and VII of the lutropin/choriogonadotropin receptor involved in signaling. Biochemistry 35, 3986-3993.
23. [23] Fernandez, L.M. and Puett, D. (1996) Lys-583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling. J. Biol. Chem. 271, 925-930.
24. [24] Huang, J. and Puett, D, (1995) Identification of two amino acid residues on the extracellular domain of the lutropin/choriogonadotropin receptor important in signaling. J. Biol. Chem. 270, 30023-30028.
25. [25] Xia, H. and Puett, D. (1994) Identification of conserved amino acid residues in the β subunit of human choriogonadotropin important in holoprotein formation. J. Biol. Chem. 269, 17944-17953.
26. [26] Chen, F. and Wang, Y. et al. (1992) The carboxyl-terminal region of the glycoprotein hormone α-subunit: contributions to receptor binding and signaling in human chorionic gonadotropin. Mol. Endocrinol. 6, 914-919.
27. [27] Xia, H. and Chen, F. et al. (1994) A region in the human glycoprotein hormone α-subunit important in holoprotein formation and receptor binding. Endocrinology 134, 1768-1770.
28. [28] Chaney, W.C. and Howard, D.R. et al. (1986) High-frequency transfection of CHO cells using polybrene. Som. Cell. Mol. Genet. 12, 237-244.
29. [29] Chen, F. and Puett, D. (1991) Delineation via site-directed mutagenesis of the carboxyl-terminal region of human choriogonadotropin β required for subunit assembly and biological activity. J. Biol. Chem. 266, 6904-6908.
30. [30] El-Deiry, S. and Kaetzel, D. et al. (1989) Site-directed mutagenesis of the human chorionic gonadotropin β-subunit: bioactivity of a heterologous hormone, bovine a-human des-( 122-145)β. Mol. Endocrinol. 3, 1523-1528.
31. [31] Xia, H. and Huang, J. et al. (1993) Lysines 2 and 104 of the human choriogonadotropin β-subunit influence receptor binding. J. Mol. Endocrinol. 10, 337-343.
32. [32] Ascoli, M. (1981) Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108, 88-95.
33. [33] Chen, F. and Puett, D. (1991) Contributions of arginines-43 and -94 of human choriogonadotropin β to receptor binding and activation as determined by oligonucleotide-based mutagenesis. Biochemistry 30, 10171-10175.
34. [34] Narayan, P. and Wu, C. et al. (1995) Functional expression of yoked human chorionic gonadotropin in baculovirus-infected insect cells. Mol. Endocrinol. 9, 1720-1726.
35. [35] Xia, H. and Fernandez, L.M. et al. (1993) Replacement of the invariant tyrosine in the CAGY region of the human choriogonadotropin β-subunit. Mol. Cell Endocrinol. 92, R1-R5.
36. [36] Chen, F. and Wang, Y. et al. (1991) Role of the invariant Asp-99 of human choriogonadotropin β in receptor binding and biological activity. J. Biol. Chem. 266, 19357-19361.
37. [37] Huang, J. and Puett, D. (1994) On the role of the invariant glutamine at position 54 in the human choriogonadotropin β-subunit. Mol. Cell. Biochem. 136, 183-186.
38. [38] Huang, J. and Ujihara, M. et al. (1993) Mutagenesis of the determinant loop region of human choriogonadotropin β. Mol. Cell. Endocrinol. 90, 211-218.
39. [39] Lapthorn, A.J. and Harris, D.C. et al. (1994) Crystal structure of human chorionic gonadotropin. Nature 369, 455-461.
40. [40] Wu, H. and Lustbader, J.W. et al. (1994) Structure of human chorionic gonadotropin at 2,6 Å resolution from MAD analysis of the selenomethionyl protein. Structure 2, 545-558.
41. [41] Liu, C. and Roth, K.E. et al. (1993) Site-directed alanine mutagenesis of Phe-33, Arg-35, and Arg-42-Ser-43-Lys-44 in the human gonadotropin α-subunit. J. Biol. Chem. 268, 21613-21617.
42. [42] Yoo, J. and Zeng, H. et al. (1993) COOH-terminal amino acids of the α subunit play common and different roles in human choriogonadotropin and follitropin. J. Biol. Chem. 268, 13034-13042.
43. [43] Zeng, H. and Ji, I. et al. (1995) Lys-91 and His-90 of the α-subunit are crucial for receptor-binding and hormone action of follicle-stimulating hormone (FSH) and play hormone-specific roles in FSH and human chorionic gonadotropin. Endocrinology 136, 2984-2953.
44. [44] Campbell, R.K. and Dean-Emig, D.M. et al. (1991) Conversion of human choriogonadotropin into a follitropin by protein engineering. Proc. Natl. Acad. Sci. USA 88, 760-764.
45. [45] Furuhashi, M. and Ando, H. et al. (1994) Mutagenesis of cysteine residues in the human gonadotropin α subunit. J. Biol. Chem. 269, 25543-25548.
46. [46] Suganuma, N. and Matzuk, M.M. et al. (1989) Elimination of disulfide bonds affects assembly and secretion of the human chorionic gonadotropin β subunit. J. Biol. Chem. 264, 19302-19307.
47. [47] Huang, J. and Chen, F. et al. (1993) Amino-carboxy-terminus deletion mutants of human choriogonadotropin β. J. Biol. Chem. 268, 9311-9315.
48. [48] Bielenska, M. and Pixley, M.R. et al. (1990) Site-directed mutagenesis identify two receptor binding domains in the human chorionic gonadotropin alpha subunit. J. Cell Biol. 111: 330a.
49. [49] Jianing, X. and Dreano, M. et al. (1995) Structural predictions for the ligand binding region of glycoprotein hormone receptors and the nature of hormone receptor interactions. Structure 3, 1341-1353.
50. [50] Stein, S.A. and Oates, E.L. et al. (1994) Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. Mol. Endocrinol. 8, 129-138.
51. [51] Hipkin, R.W. and Sanchez-Yague, J. et al. (1992) Identification of characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA. Mol. Endocrinol. 6, 2210-2218.
52. [52] Kajava, A.V. and Vassart, G. et al. (1995) Modeling of the three-dimensional structure of proteins with the typical leucinerich repeats. Structure 3, 867-877.
53. [53] Bhowmick, N. and Huang, J. et al. (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Mol. Endocrinol. 10, 1147-1159.
54. [54] Kobe, B. and Deisenhofer, J. (1993) Crystal structure of porcine ribonuctease inhibitor, a protein with leucine-rich repeats. Nature 366, 751-756.
55. [55] Sugahara, T. and Pixley, M.R. et al. (1995) Biosynthesis of a biologically active single peptide chain containing the human common α and chorionic gonadotropin β subunits in tandem. Proc. Natl. Acad. Sci. USA 92, 2041-2045.
56. [56] Matzuk, M.M. and Boime, I. (1989) Mutagenesis and gene transfer define site-specific roles of the gonadotropin oligosaccharides. Biol. Reprod. 40, 48-53.
57. [57] Amir, S.M. and Kasagi, K. et al. (1987) The role of subunit sialic acid in the thyrotropic and gonadotropic activities of human chorionic gonadotropin. Endocrinology 121, 160-166.
58. [58] Gu, W.-X. and Du, G.-G. et al. (1995) The thyrotropin (TSH) receptor transmembrane domain mutation (Pro-556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding. Endocrinology 136, 3146-3153.
59. [59] Ryu, K.-S. and Gilchrist, R.L. et al. (1996) Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor. J. Biol. Chem. 271, 7301-7304.
60. [60] Shi, Y. and Zou, M. et al. (1995) Thyrotropin internalization is directed by a highly conserved motif in the seventh transmembrane region of its receptor. Endocrine 3, 409-414.
61. [61] Laue, L. and Wu, S.M. et al. (1995) Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig cell hypoplasia. Mol. Endocrinol. 10, 987-997.