Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling

Endocrinology

Volumn 140, Issue 4, 1999, Pages 1775-1782

  Alvarez, Carlos A ^a   Narayan, Prema ^a   Huang, Jianing ^a   Puett, David ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; COMPLEMENTARY DNA; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; IODINE 125; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033054119     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.4.6624     Document Type: Article

References (27)

1. 1. Wess J 1997 G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB J 11:346-354
2. 2. Gudermann T, Schoneberg T, Schultz G 1997 Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci 20:399-427
3. 3. Segaloff DL, Ascoli M 1993 The lutropin/choriogonadotropin receptor . . . 4 years later. Endocr Rev 14:324-347
4. 4. Tsai-Morris CH, Buczko E, Wang W, Dufau ML 1990 Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity. J Biol Chem 265:19385-19388
5. 5. Xie Y-B, Wang H, Segaloff DL 1990 Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J Biol Chem 265:21411-21414
6. 6. Braun T, Schofield PR, Sprengel R 1991 Amino-terminal leucine-rich repeats determine hormone selectivity. EMBO J 10:1885-1890
7. 7. Ji I, Ji TH 1991 Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site. Endocrinology 128:2648-2650
8. 8. Moyle WR, Bernard MP, Myers RV, Marko OM, Strader CD 1991 Lutropin/ β-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface. J Biol Chem 266:10807-10812
9. 9. Ji I, Ji TH 1991 Human choriogonadotropin binds to a lutropin receptor with essentially no N-terminal extension and stimulates cAMP synthesis. J Biol Chem 266:13076-13079
10. 10. Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R 1996 Electron-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol 259:393-421
11. 11. Gouaux E 1998 It's not just a phase: crystallization and X-ray structure determination of bacteriorhodopsin in lipidic cubic phases. Structure 6:5-10
12. 12. Unger VM, Hargrave PA, Baldwin JM, Schertler GFX 1997 Arrangement of rhodopsin transmembrane α-helices. Nature 389:203-211
13. 13. Baldwin JM 1993 The probable arrangement of the helices in G protein-coupled receptors. EMBO J 12:1693-1703
14. 14. Bourne HR 1997 How receptors talk to trimeric G proteins. Curr Opin Cell Biol 9:134-142
15. 15. Hamm HE 1998 The many faces of G protein signaling. J Biol Chem 273: 669-672
16. 16. Dufau ML 1998 The luteinizing hormone receptor. Annu Rev Physiol 60:461-496
17. i proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J Biol Chem 271: 16764-16772
18. 18. Huang J, Puett D 1995 Identification of two amino acid residues on the extracellular domain of the lutropin/choriogonadotropin receptor important in signaling. J Biol Chem 270:30023-30028
19. 19. Deng WP, Nickoloff JA 1992 Site-specific mutagenesis of virtually any plasmid by eliminating a unique site. Anal Biochem 200:81-88
20. 20. Sanger F, Nicklen S, Coulson AR 1977 DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
21. 21. Thomas DM, Segaloff DL 1994 Hormone-binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor expressed in mammalian cells. Endocrinology 135:1902-1912
22. 22. Roche PC, Bergert ER, Ryan RJ 1985 A simple and rapid method using polyethyleneimine-treated filters for assay of solubilized LH/hCG receptors. Endocrinology 117:790-792
23. 23. Stavrou SS, Zhu YS, Cai LQ, Katz MD, Herrera C, Defillo-Ricart M, Imperato-McGinley J 1998 A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. J Clin Endocrinol Metab 83:2091-2098
24. 24. Moyle WR, Campbell RK, Rao SNV, Ayad NG, Bernard MP, Han Y, Wang Y 1995 Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones. J Biol Chem 270:20020-20032
25. 25. Kajava AV, Vassart G, Wodak S 1995 Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 3:867-877
26. 26. Jiang X, Dreano M, Buckler DR, Cheng S, Ythier A, Wu H, Hendrickson WA, Tayar NE 1995 Structural predictions for the ligand binding region of glycoprotein hormone receptors and the nature of hormone receptor interactions. Structure 3:1341-1353
27. 27. Bhowmick N, Huang J, Puett D, Isaacs NW, Lapthorn AJ 1996 Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Mol Endocrinol 10:1147-1159