Role of the third intracellular loop for the activation of gonadotropin receptors

Molecular Endocrinology

Volumn 13, Issue 2, 1999, Pages 181-190

  Schulz, Angela ^a   Schöneberg, Torsten ^a   Paschke, Ralf ^b   Schultz, Günter ^a   Gudermann, Thomas ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; THYROTROPIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; GENE DELETION; LUTEINIZING HORMONE RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; TESTIS DISEASE; THYROID DISEASE; THYROTROPIN RELEASE;

ANIMALIA;

EID: 0032904550     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.2.0233     Document Type: Article

References (37)

1. 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636
2. 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem 267:1430-1433
3. 1B receptor subtype. J Biol Chem 269:27925-27931
4. 4. Cetani F, Tonacchera M, Vassart G 1996 Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors. FEBS Lett 378:27-31
5. 5. Robinson PR, Cohen GB, Zhukovsky EA, Oprian DD 1992 Constitutively active mutants of rhodopsin. Neuron 9:719-725
6. 6. Shenker A, Laue L, Kosugi S, Merendino JJ, Minegishi T, Cutler Jr GB 1993 A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365:652-654
7. 7. Parma J, Duprez L, van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G 1993 Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365:649-651
8. 8. Shenker A 1995 G protein-coupled receptor structure and function: the impact of disease-causing mutations. Baillieres Clin Endocrinol Metab 9:427-451
9. 9. Paschke R, Ludgate MN 1997 The thyrotropin receptor in thyroid diseases. N Engl J Med 337:1675-1681
10. 10. Strader CD, Fong TM, Graziano MP, Tota MR 1995 The family of G-protein-coupled receptors. FASEB J 9:745-754
11. 11. Lin Z, Shenker A, Pearlstein R 1997 A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations. Protein Eng 10:501-510
12. 12. Wonerow P, Schöneberg T, Schultz G, Gudermann T, Paschke R 1998 Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation. J Biol Chem 273:7900-7905
13. 2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells. J Biol Chem 267:4479-4488
14. 14. Kudo M, Osuga Y, Kobilka BK, Hsueh AJW 1996 Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. J Biol Chem 271:22470-22478
15. s alpha protein gene in 31 toxic thyroid nodules. J Clin Endocrinol Metab 82:3885-3891
16. i proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J Biol Chem 271:16764-16772
17. 17. Gromoll J, Simoni M, Nieschlag E 1996 An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. J Clin Endocrinol Metab 81:1367-1370
18. s. J Biol Chem 272:14586-14591
19. 19. Laue L, Chan WY, Hsueh AJ, Kudo M, Hsu SY, Wu SM, Blomberg L, Cutler Jr GB 1995 Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty. Proc Natl Acad Sci USA 92:1906-1910
20. 20. Russo D, Arturi F, Suarez HG, Schlumberger M, Du Villard JA, Crocetti U, Filetti S 1996 Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab 81:1548-1551
21. 21. Kosugi S, Mori T, Shenker A 1998 An anionic residue at position 564 is important for maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor. Mol Pharmacol 53:894-901
22. 22. Kosugi S, Kohn LD, Akamizu T, Mori T 1994 The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation. Mol Endocrinol 8:498-509
23. 23. Fernandez LM, Puett D 1997 Evidence for an important functional role of intracellular loop II of the lutropin receptor. Mol Cell Endocrinol 128:161-169
24. 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J 15:3566-3578
25. 25. Dhanwada KR, Vijapurkar U, Ascoli M 1996 Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis. Mol Endocrinol 10:544-554
26. 1 receptor. Eur J Pharmacol 288:251-257
27. 27. Franke RR, Sakmar TP, Graham RM, Khorana HG 1992 Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem 267:14767-14774
28. 28. Rosenthal, W, Antaramian, A, Gilbert, S, Birnbaumer, M 1993 Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase. J Biol Chem 268:13030-13033
29. 29. Acharya S, Karnik SS 1996 Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin. J Biol Chem 271:25406-25411
30. 30. Davis D, Liu X, Segaloff DL 1995 Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function. Mol Endocrinol 9:159-170
31. 31. Rozzell TG, Wang H, Liu X, Segaloff DL 1995 Intracellular retention of mutant gonadotropin receptors results in loss of hormone binding activity of the follitropin receptor but not of the lutropin/choriogonadotropin receptor. Mol Endocrinol 9:1727-1736
32. 32. Schöneberg T, Liu J, Wess J 1995 Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor. J Biol Chem 270:18000-18006
33. 33. Higuchi R 1989 Using PCR to engineer DNA. In: Ehrlich HA (ed) PCR Technology, Stockton Press, New York, pp 61-70
34. 34. Hitt M, Bett AJ, Addison CL, Prevec L, Graham FL 1995 Techniques for human adenovirus vector construction and characterization. In: Adolph KW (ed) Viral Gene Techniques. Academic Press, San Diego, CA, pp 13-30
35. 35. Schöneberg T, Yun J, Wenkert D, Wess J 1996 Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. EMBO J 15:1283-1291
36. 36. Berridge MJ 1983 Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J 212:849-858
37. 37. Munson PJ, Rodbard D 1980 Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239