Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis

Molecular Endocrinology

Volumn 10, Issue 5, 1996, Pages 544-554

  Dhanwada, Kavita R ^a   Vijapurkar, Ulka ^a   Ascoli, Mario ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; ENDOCYTOSIS; GENE MUTATION; HALF LIFE TIME; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ARGININE; ASPARAGINE; ASPARTIC ACID; CELL LINE; CHORIONIC GONADOTROPIN; CYCLIC AMP; EMBRYO; ENDOCYTOSIS; HISTIDINE; HUMANS; KIDNEY; MUTAGENESIS; PROTEIN CONFORMATION; RECEPTORS, LH; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0029923845     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.5.544     Document Type: Article

References (53)

1. Brown MS, Goldstein JL 1986 A receptor mediated pathway for cholesterol homeostasis. Science 232:34-47
2. Steinman RM, Mellman IS, Muller WA, Cohn ZA 1983 Endocytosis and the recycling of plasma membrane. J Cell Biol 96:1-27
3. Brown MS, Anderson RGW, Goldstein JL 1983 Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell 32:663-667
4. Sorkin A, Waters CM 1993 Endocytosis of growth factor receptors. Bioessays 15:375-382
5. 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J Biol Chem 267:3530-3538
6. Ascoli M 1982 Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits. J Biol Chem 257: 13306-13311
7. Ascoli M 1984 Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin. J Cell Biol 99:1242-1250
8. Ascoli M, Segaloff DL 1987 On the fates of receptor-bound human ovine luteinizing hormone and human choriogonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization. Endocrinology 120:1161-1172
9. Ghinea N, Vuhai MT, Groyer-Picard M-T, Houllier A, Schoëvaërt D, Milgrom E 1992 Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L cells. J Cell Biol 118:1347-1358
10. Lloyd CE, Ascoli M 1983 On the mechanisms involved in the regulation of the cell surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells. J Cell Biol 96:521-526
11. Wang H, Segaloff DL, Ascoli M 1991 Lutropin/choriogonadotropin down-regulates its receptor by both receptor mediated endocytosis and a cAMP-dependent reduction in receptor mRNA. J Biol Chem 266:780-785
12. Ascoli M 1979 Inhibition of the degradation of receptor-bound human choriogonadotropin by leupeptin. Biochim Biophys Acta 586:608-614
13. Ascoli M, Puett D 1978 Inhibition of the degradation of receptor-bound human choriogonadotropin by lysosomotropic agents, protease inhibitors, and metabolic inhibitors. J Biol Chem 253:7832-7838
14. Segaloff DL, Ascoli M 1981 Removal of surface-bound human choriogonadotropin results in cessation of hormonal responses in cultured Leydig tumor cells. J Biol Chem 256:11420-11423
15. Freeman DA, Ascoli M 1981 Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis. Proc Natl Acad Sci USA 78:6309-6313
16. Freeman DA, Ascoli M 1982 Desensitization of steroido-genesis in cultured Leydig tumor cells: role of cholesterol. Proc Natl Acad Sci USA 79:7796-7800
17. Sairam MR 1989 Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J 3:1915-1926
18. Hoelscher SR, Sairam MR, Ascoli M 1991 The slow rate of internalization of deglycosylated hCG is not due to its inability to stimulate cAMP accumulation. Endocrinology 128:2837-2843
19. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC 1992 Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 11:1-20
20. Ceresa BP, Limbird LE 1994 Mutation of an aspartate residue highly conserved among G-protein coupled receptors results in non-reciprocal disruption of α2-adrenergic receptor-G protein interactions. J Biol Chem 269: 29557-29564
21. Quintana J, Wang H, Ascoli M 1993 The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors. Mol Endocrinol 7:767-775
22. 383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production. J Biol Chem 266:14953-14957
23. Franke RR, Sakmar TP, Graham RM, Khorana HG 1992 Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem 267:14767-14774
24. Sung C-H, Davenport CM, Hennessey JC, Maumenee IH, Jacobson SG, Heckenlively JR, Nowakowski R, Fishman G, Gouras P, Nathans J 1991 Rhodopsin mutations in autosomal dominant retinitis pigmentosa. Proc Natl Acad Sci USA 88:6481-6485
25. Rosenthal W, Antaramian A, Gilbert S, Birnbaumer M 1993 Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase. J Biol Chem 268:13030-13033
26. Benya RV, Akeson M, Mrozinski J, Jensen RT, Battey JF 1994 Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes. Mol Pharmacol 46:495-501
27. Whaley BS, Yuan N, Birnbaumer L, Clark RB, Barber R 1994 Differential expression of the β-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation. Mol Pharmacol 45:481-489
28. Samama P, Cotecchia S, Costa T, Lefkowitz RJ 1993 A mutation-induced activated state of the β2-adrenergic receptor. J Biol Chem 268:4625-4636
29. +2 mobilization. J Biol Chem 267: 4479-4488
30. Hipkin RW, Sánchez-Yagüe J, Ascoli M 1993 Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line. Mol Endocrinol 7:823-832
31. Hipkin RW, Wang Z, Ascoli M 1995 Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail. Mol Endocrinol 9:151-158
32. Zhu X, Gilbert S, Birnbaumer M, Birnbaumer L 1994 Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density. Mol Pharmacol 46:460-469
33. Wiley HS, Cunningham DD 1982 The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. J Biol Chem 257:4222-4229
34. 671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor. J Biol Chem 265:12820-12827
35. Wiley HS, Cunningham DD 1981 A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands. Cell 25:433-440
36. Lutz W, Londowski JM, Sanders M, Salisbury J, Kumar R 1992 A vasopressin analog that binds but does not activate V1 or V2 vasopressin receptors is not internalized into cells that express V1 or V2 receptors. J Biol Chem 267:1109-1115
37. von Zastrow M, Kobilka BK 1994 Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization. J Biol Chem 269:18448-18452
38. Cheung AH, Dixon RAF, Hill WS, Sigal IS, Strader CD 1990 Separation of the structural requirements for agonist-promoted activation and sequestration of the β-adrenergic receptor. Mol Pharmacol 37:775-779
39. Tseng M-J, Detjen K, Struk V, Logsdon CD 1995 Carboxyl-terminal domains determine internalization and recycling characteristics of bombesin receptor chimeras. J Biol Chem 270:18858-18864
40. Hunyady L, Baukal AJ, Balla T, Catt KJ 1994 Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction. J Biol Chem 269:24798-24804
41. Zanolari B, Raths S, Singer-Krüger B, Riezman H 1992 Yeast pheromone receptor endocytosis and hyperphosphorylation are independent of G protein-mediated signal transduction. Cell 71:755-763
42. Wise A, Lee TW, MacEwan DJ, Milligan G 1995 Degradation of G11α/Gqα is accelerated by agonist occupancy of α1A/D and α1C adrenergic receptors. J Biol Chem 270:17196-17203
43. Chun M, Liyanage UK, Lisanti MP, Lodish HF 1994 Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin. Proc Natl Acad Sci USA 91:11728-11732
44. a receptors. J Biol Chem 270:10855-10860
45. Li S, Okamoto T, Chun M, Sargiacomo M, Casanova JE, Hansen SH, Nishimoto I, Lisanti MP 1995 Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem 270:15693-15701
46. s class of heterotrimeric G proteins. Nature 362:456-458
47. Colombo MI, Mayorga LS, Nishimoto I, Ross EM, Stahl PD 1994 Gs regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis. J Biol Chem 269:14919-14923
48. Hansen SH, Casanova JE 1994 Gsa stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A. J Cell Biol 126:677-687
49. Nussenzveig DR, Heinflink M, Gershengorn MC 1993 Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C. Mol Endocrinol 7:1105-1111
50. Ezra E, Salomon Y 1980 Mechanism of desensitization of adenylate cyclase by lutropin. GTP-dependent uncoupling of the receptor. J Biol Chem 255:653-658
51. Chen C, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
52. Wang Z, Wang H, Ascoli M 1993 Mutation of a highly conserved acidic residue present in the second intracellular loop of G protein-coupled receptors does not impair hormone binding or signal transduction of the LH/CG receptor. Mol Endocrinol 7:85-93
53. Ascoli M, Puett D 1978 Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells. Proc Natl Acad Sci USA 75:99-102