Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice

Molecular Endocrinology

Volumn 15, Issue 1, 2001, Pages 172-183

  Zhang, Fu Ping ^a   Poutanen, Matti ^a   Wilbertz, Johannes ^b   Huhtaniemi, Ilpo ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GONADOTROPIN; LUTEINIZING HORMONE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC RECOMBINATION; GERM CELL; HORMONE SYNTHESIS; KNOCKOUT MOUSE; MALE; MEIOSIS; MOUSE; NONHUMAN; ORGAN WEIGHT; OVARY FOLLICLE DEVELOPMENT; PATHOGENESIS; PHENOTYPE; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PSEUDOHERMAPHRODITISM; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT; TESTIS;

ANIMALIA;

EID: 0035133266     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.1.0582     Document Type: Article

References (46)

1. Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function
2. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
3. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
4. The effect of a null mutation in the FSH receptor gene on mouse reproduction
5. Male hypogonadism due to a mutation in the gene for the β-subunit of follicle-stimulating hormone
6. Follitropin (FSH) deficiency in an infertile male due to FSHβ gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations
7. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility
8. Hypogonadism caused by a single amino acid substitution in the β subunit of luteinizing hormone
9. Fetal testis - A very special endocrine organ
10. Development of luteinizing hormone action in the perinatal rat ovary
11. The beginning of a new era in reproductive biology and medicine: Expression of low levels of functional luteinizing hormone/human chorionic gonadotropin receptors in non-gonadal tissues
12. Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex
13. Long-term testosterone treatment prevents gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α subunit promoter/simian virus 40 T-antigen fusion gene
14. The lutropin/choriogonadotropin receptor... 4 years later
15. Variant forms of the pig lutropin/choriogonadotropin receptor
16. Studies on sex differentiation in mammals
17. Functional maturation of the pituitarygonadal axis in the neonatal female rat
18. Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
19. Targeted disruption of the pituitary glycoprotein hormone α-subunit produces hypogonadal and hypothyroid mice
20. Gonadotropin-independent regulation of steroidogenesis in the rat fetal testis
21. Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
22. Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function
23. The effects of recombinant FSH on testosterone-induced spermatogenesis in gonadotrophin-deficient (hpg) mice
24. Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice
25. Hormonal regulation of spermatogenesis in the hypophysectomized rat: Cell viability after hormonal replacement in adults after intermediate periods of hypophysectomy
26. Experimental cryptorchidism in the adult mouse. II. A hormonal study
27. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism
28. Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats
29. The role of the testicular factor INSL3 in establishing the gonadal position
30. Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 α-hydroxylase/C17-20 lyase in Leydig cells
31. Studies of the onset of Leydig precursor cell differentiation in the prepubertal rat testis
32. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary
33. HCG binding and stimulation of testosterone biosynthesis in the human fetal testis
34. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors
35. Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin α-subunit promoter/simian virus T-antigen fusion gene: Characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines
36. Lutropin-choriogonadotropin receptor: An unusual member of the G protein-coupled receptor family
37. Ontogeny of luteinizing hormone receptor gene expression in the rat testis
38. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
39. Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells
40. Rat cholesterol side-chain cleavage cytochrome P-450 (P-450-scc) gene
41. Isolation, characterization, and chromosomal mapping of mouse P450 17-α-hydroxylase/C17-20 lyase
42. Receptors for gonadotropic hormones
43. Effect of postnatal treatment with a gonadotropin-releasing hormone antagonist on sexual maturation of male rats
44. A supersensitive immunofluorometric assay for rat luteinizing hormone
45. Development of time-resolved immunofluorometric assays for rat follicle-stimulating hormone and luteinizing hormone and application on sera of cycling rats
46. A rapid and sensitive method for the quantitation of microgram qualities of protein utilizing the principle of protein-dye binding