The C-terminal tail of the rat lutropin/choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex

Molecular Endocrinology

Volumn 14, Issue 6, 2000, Pages 926-936

  Kishi, M ^a   Ascoli, M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENDOSOME; HORMONE METABOLISM; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034463062     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.6.0475     Document Type: Article

References (41)

1. The lutropin/choriogonadotropin (LH/CG) receptor . . . 4 years later
2. Molecular tinkering of G proteincoupled receptor: An evolutionary success
3. The slow rate of internalization of deglycosylated hCG is not due to its inability to stimulate cAMP accumulation
4. Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis
5. Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the lutropin/choriogonadotropin receptor
6. Evidence that constitutively active luteinizing hormone/human chorionic gonadotropin receptors are rapidly internalized
7. Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone
8. Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin (LH/CG) receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization
9. Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin
10. The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain
11. A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex
12. Seven non-contiguous intracellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization, its sensitivity to non-visual arrestins
13. Pathways of internalization of the hCG/LH receptor: Immunoelectron microscopic studies in Leydig cells and transfected L cells
14. Internalization and recycling pathways of the thyrotropin receptor
15. Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits
16. Lutropin/choriogonadotropin down-regulates its receptor by both receptor mediated endocytosis and a cAMP-dependent reduction in receptor mRNA
17. Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor
18. Effects of truncations of the cytoplasmic tail of the lutropin/choriogonadotropin receptor on receptor-mediated hormone internalization
19. Truncation of the cytoplasmic tail of the lutropin choriogonadotropin receptor prevents agonist-induced uncoupling
20. Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells
21. The lutropin/choriogonadotropin (LH/CG) receptor is palmitoylated at intracellular cysteine residues
22. The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis
23. On the mechanisms involved in the regulation of the cell surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells
24. On the fates of receptorbound human ovine luteinizing hormone and human choriogonadotropin in cultured Leydig tumor cells. Demonstration of similar rates of internalization
25. Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity
26. The role of intermediate vesicles in the adsorptive endocytosis and transport of ligand to lysosomes by human fibroblasts
27. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
28. G protein-coupled receptor adaptation mechanisms
29. G-protein-coupled receptors: Turn-ons and turn-offs
30. Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization and enhance agonist-induced receptor down-regulation
31. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
32. 2-adrenergic receptor
33. Association of β-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictate the profile of receptor resensitization
34. Lutropin-choriogonadotropin receptor: An unusual member of the G protein-coupled receptor family
35. High-efficiency transformation of mammalian cells by plasmid DNA
36. pH and the recycling of transferrin during receptor-mediated endocytosis
37. Binding of apotransferrin to K562 cells: Explanation of the transferrin cycle
38. Receptor-mediated endocytosis of transferrin and the uptake of Fe in K562 cells: Identification of nonlysosomal acidic compartment
39. Enzymic, diagnosis of the genetic mucopolysaccharide storage disorders
40. Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells
41. Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail