Mutations of the Second Extracellular Loop of the Human Lutropin Receptor Emphasize the Importance of Receptor Activation and De-emphasize the Importance of Receptor Phosphorylation in Agonist-induced Internalization

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 7968-7973

  Li, Shenghua ^b   Liu, Xuebo ^b   Min, Le ^b   Ascoli, Mario ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; GENES; MUTAGENESIS; PROTEINS; SCANNING;

INTERNALIZATION; PHOSPHORYLATION; RECEPTORS;

GENETIC ENGINEERING;

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; LUTEINIZING HORMONE RECEPTOR; CHORIONIC GONADOTROPIN;

ARTICLE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; BIOSYNTHESIS; CELL LINE; CHEMISTRY; ENDOCYTOSIS; METABOLISM; MUTATION; PHOSPHORYLATION;

CELL LINE; CHORIONIC GONADOTROPIN; CYCLIC AMP; ENDOCYTOSIS; HUMANS; MUTATION; PHOSPHORYLATION; RECEPTORS, LH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035896538     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010482200     Document Type: Article

References (50)

1. Lefkowitz, R. J. (1998) J. Biol. Chem. 273, 18677-18680
2. Carman, C. V., and Benovic, J. L. (1998) Curr. Opin. Neurobiol. 8, 335-344
3. Bünemann, M., and Hosey, M. M. (1999) J. Physiol. 517, 5-23
4. Goodman, J., O. B., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) Nature 383, 447-450
5. Laporte, S. A., Oakley, R. H., Holt, J. A., Barak, L. S., and Caron, M. G. (2000) J. Biol. Chem. 275, 23120-23126
6. Warnock, D., and Schmid, S. (1996) BioEssays 18, 885-893
7. Bockaert, J., and Pin, J. P. (1999) EMBO J. 18, 1723-1729
8. Gether, U. (2000) Endocrine Rev. 21, 90-113
9. Segaloff, D. L., and Ascoli, M. (1993) Endocrine Rev. 14, 324-347
10. Simoni, M., J., G., and Nieschlag, E. (1997) Endocrine Rev. 18, 739-773
11. Rapoport, B., Chazenbalk, D., Jaume, J. C., and McLachlan, S. M. (1998) Endocrine Rev. 19, 673-716
12. Hsu, S. Y., and Hsueh, A. J. (2000) Mol. Endocrinol. 14, 594-604
13. Ascoli, M. (1984) J. Cell Biol. 99, 1242-1250
14. Ghinea, N., Vuhai, M. T., Groyer-Picard, M.-T., Houllier, A., Schoëvaërt, D., and Milgrom, E. (1992) J. Cell Biol. 118, 1347-1358
15. Lazari, M. F. M., Bertrand, J. E., Nakamura, K., Liu, X., Krupnick, J. G., Benovic, J. L., and Ascoli, M. (1998) J. Biol. Chem. 27 3, 18316-18324
16. Nakamura, K., Liu, X., and Ascoli, M. (2000) J. Biol. Chem. 275, 241-247
17. Min, L., and Ascoli, M. (2000) Mol. Endocrinol. 14, 1797-1810
18. Nakamura, K., Liu, X., and Ascoli, M. (1999) J. Biol. Chem. 274, 25426-25432
19. Baratti-Elbaz, C., Chinea, N., Lahuna, O., Loosfelt, H., Pichon, C., and Milgrom, E. (1999) Mol. Endocrinol. 13, 1751-1765
20. Minegishi, T., Nakamura, K., Takakura, Y., Miyamoto, K., Hasegawa, Y., Ibuki, Y., and Igarashi, M. (1990) Biochem. Biophys. Res. Commun. 172, 1049-1054
21. McFarland, K. C., Sprengel, R., Phillips, H. S., Kohler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L., and Seeburg, P. H. (1989) Science 245, 494-499
22. Fabritz, J., Ryan, S., and Ascoli, M. (1998) Biochemistry 37, 664-672
23. Krupnick, J. G., Santini, F., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1997) J. Biol. Chem. 272, 32507-32512
24. Damke, H., Baba, T., Warnock, D. E., and Schmid, S. L. (1994) J. Cell Biol. 127, 915-934
25. Lazari, M. F. M., Liu, X., Nakamura, K., Benovic, J. L., and Ascoli, M. (1999) Mol. Endocrinol. 13, 866-878
26. Nakamura, K., Lazari, M. F. M., Li, S., Korgaonkar, C., and Ascoli, M. (1999) Mol. Endocrinol. 13, 1295-1304
27. Chen, C., and Okayama, H. (1987) Mol. Cell. Biol. 7, 2745-2752
28. Nakamura, K., and Ascoli, M. (1999) Mol. Pharmacol. 56, 728-736
29. Wiley, H. S., and Cunningham, D. D. (1981) Cell 25, 433-440
30. Wiley, H. S., and Cunningham, D. D. (1982) J. Biol. Chem. 257, 4222-4229
31. Lloyd, C. E., and Ascoli, M. (1983) J. Cell Biol. 96, 521-526
32. Ascoli, M., and Segaloff, D. L. (1987) Endocrinology 120, 1161-1172
33. De Lean, A., Munson, P. J., and Rodbard, D. (1978) Am. J. Physiol. 235, E97-E102
34. Ascoli, M., and Puett, D. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 99-102
35. Kishi, M., and Ascoli, M. (2000) Mol. Endocrinol. 14, 926-936
36. Ryu, K., H., L., Kim, S., Beauchamp, J., Tung, C. S., Isaacs, N. W., Ji, I., and Ji, T. H. (1998) J. Biol. Chem. 273, 6285-6291
37. Gurevich, V. V., Richardson, R. M., Kim, C. M., Hosey, M. M., and Benovic, J. L. (1993) J. Biol. Chem. 268, 16879-16882
38. Gurevich, V. V., Dion, S. B., Onorato, J. J., Ptasienski, J., Kim, C. M., Sterne-Marr, R., Hosey, M. M., and Benovic, J. L. (1995) J. Biol. Chem. 270, 720-731
39. Kovoor, A., Celver, J., Abdryashitov, R. V., Chavkin, C., and Gurevich, V. V. (1999) J. Biol. Chem. 274, 6831-6834
40. Barak, L. S., Tiberi, M., Freedman, N. J., Kwatra, M. M., Lefkowitz, R. J., and Caron, M. G. (1994) J. Biol. Chem. 269, 2790-2795
41. Ferguson, S. S. G., Menard, L., Barak, L. S., Koch, W. J., Colapietro, A.-M., and Caron, M. G. (1995) J. Biol. Chem. 270, 24782-24789
42. Zhang, J., Ferguson, S. S. G., Barak, L. S., Bodduluri, S. R., Laporte, S. A., Law, P.-Y., and Caron, M. G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7157-7162
43. Keith, D. E., Murray, S. R., Zaki, P. A., Chu, P. C., Lissin, D. V., Kang, L., Evans, J. C., and von Zastrow, M. (1996) J. Biol. Chem. 271, 19021-19024
44. Hoelscher, S. R., Sairam, M. R., and Ascoli, M. (1991) Endocrinology 128, 2837-2843
45. Dhanwada, K. R., Vijapurkar, U., and Ascoli, M. (1996) Mol. Endocrinol. 10, 544-554
46. Min, K.-S., Liu, X., Fabritz, J., Jaquette, J., Abell, A. N., and Ascoli, M. (1998) J Biol. Chem. 273, 34911-34919
47. Martens, J. W. M., Verhoef-Post, M., Abelin, N., Ezabella, M., Toledo, S. P. A., Brunner, H. G., and Themmen, A. P. N. (1998) Mol. Endocrinol. 12, 775-784
48. Bradbury, F. A., and Menon, K. M. J. (1999) Biochemistry 38, 8703-8712
49. Nakamura, K., Krupnick, J. G., Benovic, J. L., and Ascoli, M. (1998) J. Biol. Chem. 273, 24346-24354
50. Malecz, N., Bambino, T., Bencsik, M., and Nissenson, R. A. (1998) Mol. Endocrinol. 12, 1846-1856