Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor

Molecular Endocrinology

Volumn 14, Issue 11, 2000, Pages 1797-1810

  Min, L ^a   Ascoli, M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; RETINA S ANTIGEN;

ARTICLE; CONFORMATIONAL TRANSITION; GENE MUTATION; GENE OVEREXPRESSION; HORMONE TRANSPORT; HUMAN; INTERNALIZATION; LEYDIG CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0033645593     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.11.0555     Document Type: Article

References (50)

1. Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor expressed in a stably transfected cell line
2. Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormone
3. Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin (LH/CG) receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization
4. Pathways of internalization of the hCG/LH receptor: Immunoelectron microscopic studies in Leydig cells and transfected L cells
5. A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex
6. Seven non-contiguous intracellular residues of the lutropin/choriogonadotropin receptor dictate the rate of agonist-induced internalization, its sensitivity to non-visual arrestins
7. Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis
8. Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the lutropin/choriogonadotropin receptor
9. Evidence that constitutively active luteinizing hormone/human chorionic gonadotropin receptors are rapidly internalized
10. Desensitization of G protein-coupled receptors
11. G protein-coupled receptor kinases
12. Human chorionic gonadotropin- and phorbol ester stimulated phosphorylation of the LH/CG receptor maps to serines 635, 639, 645 and 652 in the C-terminal cytoplasmic tail
13. Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization and enhance agonist-induced receptor down-regulation
14. A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty
15. Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty
16. Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor
17. 578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor
18. A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: Correlation between receptor activity and phenotype
19. Mutation of an aspartate residue highly conserved among G-protein coupled receptors results in non-reciprocal disruption of α2-adrenergic receptor-G protein interactions
20. Critical role of a conserved intramembrane tyrosine residue in angiotensin II receptor activation
21. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors
22. Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal and activation- and phosphorylation-independent but arrestin-dependent pathway for internalization
23. The lutropin/choriogonadotropin (LH/CG) receptor ... 4 Years later
24. Constitutively active α-1b adrenergic receptor mutants display different phosphorylation and internalization features
25. Agonist-induced phosphorylation of the angiotensin II (AT1A) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state
26. The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain
27. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
28. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
29. G protein-coupled receptor adaptation mechanisms
30. G-protein-coupled receptors: Turn-ons and turn-offs
31. Modulation of the arrestin-clathrin interaction in cells
32. The slow rate of internalization of deglycosylated hCG is not due to its inability to stimulate cAMP accumulation
33. Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration
34. Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation, and internalization of the follitropin receptor
35. A one-step procedure for biotinylation and chemical cross-linking of lymphocyte surface and intracellular membrane-associated molecules
36. Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein
37. Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA
38. Variant forms of the pig lutropin/choriogonadotropin receptor
39. Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor
40. Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization
41. Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
42. Cloning and sequencing of human LH/hCG receptor cDNA
43. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
44. Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity
45. β-adrenergic receptor kinase: Primary structure delineates a multigene family
46. High-efficiency transformation of mammalian cells by plasmid DNA
47. The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis
48. A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor
49. A polyclonal antibody to a synthetic peptide derived from the rat FSH receptor reveals the recombinant receptor as a 74 kDa protein
50. Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells