Functional role of transmembrane helix 7 in the activation of the heptahelical lutropin receptor

Molecular Endocrinology

Volumn 14, Issue 4, 2000, Pages 459-471

  Angelova, Krassimira ^a   Narayan, Prema ^a   Paul Simon, J ^a   Puett, David ^a  

^a University of Georgia   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHORIONIC GONADOTROPIN; CYCLIC AMP; LUTEINIZING HORMONE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; DISSOCIATION CONSTANT; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

ANIMALIA;

EID: 0034465518     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.4.0439     Document Type: Article

References (39)

1. The luteinizing hormone receptor
2. The lutropin/choriogonadotropin receptor. 4 Years later
3. Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity
4. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity
5. Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity
6. Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site
7. Lutropin/beta-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface
8. Disorders of Sexual Differentiation
9. i proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C
10. Activation of membrane receptors
11. A model of the lutropin/choriogonadotropin receptor: Insights into the structural and functional effects of constitutively activating mutations
12. Structural basis of G protein-coupled receptor function
13. Three-dimensional models of gonado-thyrotropin hormone receptor transmembrane domain
14. 383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production
15. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors
16. Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig cell hypoplasia
17. Identification of amino acid residues in transmembrane helices VI and VII of the lutropin/choriogonadotropin receptor involved in signaling
18. 578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor
19. Roles of transmembrane prolines and proline-induced kinks of the lutropin/choriogonadotropin receptor
20. Activating and inactivating mutations in LH receptors
21. Disorders caused by mutations of the lutropin/choriogonadotropin receptor gene
22. Molecular genetic, biomedical, and clinical implications of gonadotropin receptor mutations
23. Molecular pathophysiology and clinical manifestations of gonadotropin receptor defects
24. 583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling
25. Exoloop 3 of the luteinizing hormone/choriogonadotropin receptor
26. Testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene
27. A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: Correlation between receptor activity and phenotype
28. A homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptor
29. Evidence that interhelical hydrogen bonding between Asp 578, Asn 619 helps maintain the inactive conformation of the human lutropin receptor (LHR)
30. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty
31. Somatic and germline mutations of the TSH receptor gene in thyroid diseases
32. X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases
33. Surface of bacteriorhodopsin revealed by high-resolution electron crystallography
34. Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution
35. Diversity and selectivity of receptor-G protein interaction
36. The biologic action of single-chain gonadotropin is not dependent on the individual disulfide bonds of the β subunit
37. Mutations that induce constitutive activation and mutation that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the lutropin/choriogonadotropin receptor
38. Evidence that constitutively active luteinizing hormone/human chorionic gonadotropin receptors are rapidly internalized
39. 383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production