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Volumn 32, Issue 2, 2002, Pages 67-112

In silico approaches to mechanistic and predictive toxicology: An introduction to bioinformatics for toxicologists

Author keywords

Bioinformatics; BLAST; Cluster analysis; Expressed sequence tags; In silico; Ligand docking; Microarray; Molecular modeling; Multiple sequence alignment; Position weight matrix; SAGE; Single nucleotide polymorphisms; Toxicogenomics

Indexed keywords

ANALYTIC METHOD; BIOINFORMATICS; DATA BASE; DNA DETERMINATION; DNA MICROARRAY; DNA SEQUENCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOME; GENOTYPE; HUMAN; MATHEMATICAL MODEL; NONHUMAN; NORTHERN BLOTTING; PREDICTION; PROGNOSIS; PROTEIN DOMAIN; REVIEW; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; TOXICOLOGY; VALIDATION PROCESS;

EID: 0036204734     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/20024091064183     Document Type: Review
Times cited : (37)

References (181)
  • 1
  • 21
    • 0030680966 scopus 로고    scopus 로고
    • IMAGE cDNA clones, UniGene clustering, and ACeDB: An integrated resource for expressed sequence information
    • (1997) Genome Res. , vol.7 , pp. 1027-1032
    • Miller, G.1    Fuchs, R.2    Lai, E.3
  • 33
    • 0025878149 scopus 로고
    • Amino acid substitution matrices from an information theoretic perspective
    • (1991) J. Mol. Biol. , vol.219 , pp. 555-565
    • Altschul, S.F.1
  • 40
    • 0032030839 scopus 로고    scopus 로고
    • Control of cell lineage-specific development and transcription by bHLH- PAS proteins
    • (1998) Genes Dev. , vol.12 , pp. 607-620
    • Crews, S.T.1
  • 45
    • 0034713994 scopus 로고    scopus 로고
    • Genomics. Rat genome off to an early start
    • (2000) Science , vol.289 , pp. 1267-1269
    • Pennisi, E.1
  • 47
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 49
  • 52
    • 0026527758 scopus 로고
    • Pattern-induced multisequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling
    • (1992) Protein Eng. , vol.5 , pp. 35-41
    • Smith, R.F.1    Smith, T.F.2
  • 68
  • 70
    • 0026754015 scopus 로고
    • Accurate modeling of protein conformation by automatic segment matching
    • (1992) J. Mol. Biol. , vol.226 , pp. 507-533
    • Levitt, M.1
  • 80
    • 0028158936 scopus 로고
    • Ligand docking to proteins with discrete side-chain flexibility
    • (1994) J. Mol. Biol. , vol.235 , pp. 345-356
    • Leach, A.R.1
  • 85
    • 0033976103 scopus 로고    scopus 로고
    • Differential binding affinities of PCBs, HO-PCBs, and aroclors with recombinant human, rainbow trout (Oncorhynchus mykiss), and green anole (Anolis carolinensis) estrogen receptors, using a semi-high throughput competitive binding assay
    • (2000) Toxicol. Sci. , vol.53 , pp. 326-339
    • Matthews, J.1    Zacharewski, T.2
  • 98
    • 0028978788 scopus 로고
    • Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds: Model validation and Ah receptor characterization
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 847-858
    • Waller, C.L.1    McKinney, J.D.2
  • 101
    • 0025572707 scopus 로고
    • Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection
    • (1990) Science , vol.250 , pp. 1104-1110
    • Blackwell, T.K.1    Weintraub, H.2
  • 104
    • 0023664018 scopus 로고
    • Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1353-1361
    • Cavener, D.R.1
  • 113
    • 0031772260 scopus 로고    scopus 로고
    • Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae
    • (1998) Mol. Cell Biol. , vol.18 , pp. 6560-6570
    • Karpichev, I.V.1    Small, G.M.2
  • 117
    • 0004052360 scopus 로고    scopus 로고
    • Xenoendocrine disrupters: Laboratory studies on male reproductive effects
    • (1998) Toxicol. Lett. , vol.102-103 , pp. 331-335
    • Gray Jr., L.E.1
  • 128
    • 0032748555 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
    • (1999) Clin. Genet. , vol.56 , pp. 247-258
    • Nebert, D.W.1
  • 137
    • 0033811486 scopus 로고    scopus 로고
    • Screening for single-nucleotide polymorphisms using branch migration inhibition in PCR-amplified DNA
    • (2000) Clin. Chem. , vol.46 , pp. 1464-1470
    • Lishanski, A.1
  • 140
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 141
    • 0033759620 scopus 로고    scopus 로고
    • Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants
    • (2000) Clin. Chem. Lab. Med. , vol.38 , pp. 857-861
    • Nebert, D.1
  • 143
    • 0033805156 scopus 로고    scopus 로고
    • Mammalian class theta GST and differential susceptibility to carcinogens: A review
    • (2000) Mutat. Res. , vol.463 , pp. 247-283
    • Landi, S.1
  • 152
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, K.J.1    Lindon, J.C.2    Holmes, E.3
  • 177
    • 0034623060 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor in human astrocytes by lead. Involvement of a protein kinase C/activator protein-1 complex-dependent and hypoxia-inducible factor 1-independent signaling pathway
    • (2000) J. Biol. Chem. , vol.275 , pp. 27874-27882
    • Hossain, M.A.1    Bouton, C.M.2    Pevsner, J.3    Laterra, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.