Xenoendocrine disrupters: Laboratory studies on male reproductive effects

Toxicology Letters

Volumn 102-103, Issue , 1998, Pages 331-335

  Gray Jr , Leon Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Antiandrogens; DDE; Dioxins; Estrogens; Phthalates; Procymidone; Reproduction; Vinclozolin

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; MYCOTOXIN; PESTICIDE; PHTHALIC ACID; PHYTOESTROGEN; POLYCHLORINATED BIPHENYL; PROCYMIDONE; TOXIC SUBSTANCE; VINCLOZOLIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BIRD; CONFERENCE PAPER; CRYPTORCHISM; DELAYED PUBERTY; FISH; GENE EXPRESSION; HUMAN; HYPOSPADIAS; MALE; MALE GENITAL SYSTEM; MAMMAL; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENTIATION; SEXUAL DYSFUNCTION; SPERMATOZOON COUNT; TESTIS CANCER; WILDLIFE;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; ESTROGENS; FETUS; GENITALIA, MALE; MALE; MICE; PESTICIDES; RATS; RECEPTORS, ARYL HYDROCARBON; SEX DIFFERENTIATION; SPERMATOZOA;

ALLIGATORINAE; AVES; BACULUM; LUTRINAE; PUMA CONCOLOR CORYI;

EID: 0004052360     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00327-0     Document Type: Conference Paper

References (24)

1. Gellert, R.J., Wilson, C., 1979. Reproductive function in rats exposed prenatally to pesticides and polychlorinated biphenyls (PCB). Environ. Res. 18, 437-443.
2. Gellert, R.J., Heinrichs, W.L., Swerdloff, R., 1974. Effects of neonatally-administered DDT homologs on reproductive function in male and female rats. Neuroendocrinology 16, 84-94.
3. Golub, M., Donald, J., Reyes, J., 1991. Reproductive toxicity of commercial PCB mixtures: LOAELS and NOAELS from animal studies. Environ. Health Perspect. 94, 245-253.
4. Gray, L.E., Jr., 1982. Neonatal chlordecone exposure alters behavioral sex differentiation in female hamsters. Neurotoxicology 3, 67-80.
5. Gray, L.E., Kelce, W.R., 1996. Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicol. Ind. Health 12, 515-531.
6. Gray, L.E., Osby, J.S., 1998. Effects of pesticides and toxic substances on behavioral and morphological reproductive development. Toxicol. Ind. Health 14, 159-184.
7. Gray, L.E., Jr., Ostby, J., Ferrell, J., et al., 1989. A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12, 92-108.
8. Gray, L.E., Ostby, J., Kelce, W.R., 1994. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rats. Toxicol. Appl. Pharmacol. 129, 46-52.
9. Gray, L.E., Kelce, W.R., Monosson, E., Ostby, J.S., Birnbaum, L.S., 1995. Exposure to TCDD during development permanently alters reproductive function in male LE rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131, 108-118.
10. Gray, L.E., Jr., Ostby, J., Kelce, W.R., 1997. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachloro-p-dioxin (TCDD) in male Long Evans hooded rat offspring. Toxicol. Appl. Pharmacol. 146, 11-20.
11. Gray, L.E., Ostby, J.S., Mychreest, E., Foster, P.M.D., Kelce, W.R., 1998. Dibutylphthalate induces antiandrogenic but not estrogenic in vivo effects in LE hooded rats. Toxicologist 42, 176.
12. Imperato-McGinley, J., Sanchez, R.S., Spencer, J.R., Yee, B., Vaughan, E.D., 1992. Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies. Endocrinology 131, 1149-1156.
13. Kelce, W.R., Stone, C.R., Laws, S.C., Gray, L.E., Kemppainen, J.A., Wilson, E.M., 1995. The persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375, 581-585.
14. McLachlan, J.A., 1981. Rodent models for perinatal exposure to diethylstilbestrol and their relation to human disease in the male. In: Herbst, A.L., Bern, H.A. (Eds.), Developmental Effects of Diethylstilbestrol in Pregnancy. Thieme-Stratton, New York, pp. 48-57.
15. Mylcreest, E., Cattley, R., Foster, P., 1998. Male reproductive tract malformations in rats following gestational and lactational exposure to DBP: An antiandrogenic mechanism. Toxicol. Sci. 43, 47-60.
16. Nagel, S., vom Saal, F., Thayer, K., Dhar, M., Boechler, M., Welshons, W., 1997. Relative binding affinity-serum modified access assay predicts the relative in vivo bioactivity of the xenoestrogen bisphenol A and octylphenol. Environ. Health Perspect. 105, 70-76.
17. Newbold, R., Bullock, B.C., McLachlan, J.A., 1987. Mullerian remnants of male mice exposed prenatally to diethylstilbestrol. Teratog. Carcinog. Mutag. 7, 377-389.
18. Schardein, J.L., 1993. Hormones and hormonal antagonists. In: Dekker, M. (Ed.), Chemically Induced Birth Defects. Marcel Dekker, New York, pp. 271-339.
19. Sharpe, R.M., Skakkebaek, N.M., 1993. Are estrogens involved with falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392-1395.
20. vom Saal, F., Timms, B., Montano, M., et al., 1997. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc. Natl. Acad. Sci. U.S.A. 94, 2056-2061.
21. van der Schoot, P., Baumgarten, R., 1990. Effects of treatment of male and female rats in infancy with mifepristone on reproductive function in adulthood. J. Reprod. Fertil. 90, 255.
22. Vannier, B., Raynaud, J.P., 1980. Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat. J. Reprod. Fertil. 59, 43-49.
23. Wilson, J.G., Wilson, H.C., 1943. Reproductive capacity in adult rats treated prepubertally with androgenic hormone. Endocrinology 33, 353-1350.
24. Wine, R., Ling-Hong, L., Barnes, L., Gulati, D., Chapin, R., 1997. Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ. Health Perspect. 105, 102-107.