Identification, by cDNA microarray, of A-raf and proliferating cell nuclear antigen as genes induced in rat lung by exposure to diesel exhaust

Research Communications in Molecular Pathology and Pharmacology

Volumn 105, Issue 1-2, 1999, Pages 77-86

  Sato, Hiromi ^a,b   Sagai, Masaru ^c   Suzuki, Kazuo T ^b   Aoki, Yasunobu ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c AOMORI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; EXHAUST GAS; GENE INDUCTION; LUNG CANCER; NONHUMAN; NORTHERN BLOTTING; ONCOGENE; PRIORITY JOURNAL; RAT;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; LUNG; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RATS, INBRED F344; VEHICLE EMISSIONS;

EID: 0033506257     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bond, J.A., Mauderly, J.L. and Wolff, R.K. (1990). Concentration and time-dependent formation of DNA adducts in lungs of rats exposed to diesel exhaust. Toxicology 60: 127-135.
2. Chalifour, L.E., Fahmy, R., Holder, E.L. and Hutchinson, E.W. (1994). A method for analysis of gene expression patterns. Anal. Biochem. 216: 299-304.
3. Chomczynski, P. and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
4. Daum, G., Eisenmann-Tappe, I., Fries, H.W., Troppmair, J. and Rapp, U.R. (1994). The ins and outs of Raf kinases. Trends Biochem. Sci. 19: 474-480.
5. Dent, P., Haser, W., Haystead, T.A., Vincent, L.A., Robert, T.M. and Sturgill, T.W. (1992). Activation of mitogen-activated protein kinase by v-Raf in NIH 3T3 cells and in vitro. Science 4: 1404-1407.
6. Gallagher, J., Heinrich, U., George, M., Hendee, L., Phillips, D.H. and Lewtas, J. (1994). Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles. Carcinogenesis 15: 1291-1299.
7. Heller, R.A., Schena, M., Chai, A., Shalon, D., Bedilion, T., Gilmore, J., Woolley, D.E. and Davis, R. W. (1997). Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc. Natl. Acad. Sci. USA. 94: 2150-2155.
8. Howe, L.R., Leevers, S.J., Gomez, N., Nakielny, S., Cohen, P. and Marshall, C.J. (1992). Activation of the MAP kinase pathway by the protein kinase raf. Cell 71: 335-342.
9. IARC Monographs on the Elevation and Carcinogenic Risks to Humans. (1989). Diesel and Gasoline Engine Exhausts and some Nitroarenes, Vol. 46. IARC, Lyon.
10. Ichinose, T., Yamanushi, T., Seto, H. and Sagai, M. (1997a). Oxygen radicals in lung carcinogenesis accompanying phagocytosis of diesel exhaust particles. Int. J. Oncol. 11:571-575.
11. Ichinose, T., Yajima, Y., Nagashima, M., Takenoshita, S., Nagamachi, Y.and Sagai, M. (1997b). Lung carcinogenesis and formation of 8-hydroxydeoxyguanosine in mice by diesel exhaust particles. Carcinogenesis 18: 185-192.
12. Innis, M.A., Gelfand, G.H., Sininsky, J.J. and White, T.J. (1990). PCR Protocols: A Guide to Methods and Applications. Academic Press Inc, San Diego.
13. Iwai, K., Udagawa, T., Yamagishi, M. and Yamada, H. (1986). Long-term inhalation studies of diesel exhaust on F344 SPF rats. Incidence of lung cancer and lymphoma. Dev. Toxicol. Environ. Sci. 13: 349-360.
14. Iwai, K., Higuchi, K., Udagawa, T., Ohtomo, K. and Kawabata, Y. (1997). Lung tumor induced by long-term inhalation or intratracheal instillation of diesel exhaust particles. Exp. Toxic. Pathol. 49: 393-401.
15. Kasai, H. and Nishimura, S. (1991). Formation of 8-hydroxyguanosine in DNA by oxygen radicals and its biological significance. In Sies, H. (ed), Oxidative Stress, Oxidant and Antioxidants, Academic Press Ltd., London, pp. 99-116.
16. Mauderly, J.L., Jones, R.K., Griffith, W.C., Henderson, R.F. and McClellan, R.O. (1987). Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. Appl. Toxicol. 9: 208-221.
17. Nagashima, M., Kasai, H., Yokota, J., Nagamachi, Y., Ichinose, T. and Sagai, M. (1995). Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process. Carcinogenesis 16: 1441-1445.
18. Nikula, K.J., Snipes, M.B., Barr, E.B., Griffith, W.C., Henderson, R.F. and Mauderly, J.L. (1995). Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. Appl. Toxicol. 25: 80-94.
19. Rittinghausen, S., Mohr, U. and Dungworth, D.L. (1997). Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles. Exp. Toxicol. Pathol. 49: 433-446.
20. Sagai, M., Saito, H., Ichinose, T., Kodama, M. and Mori, Y. (1993). Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Rad. Biol. Med. 14: 37-47.
21. Sagai, M., Furuyama, A. and Ichinose, T. (1996). Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic. Biol. Med. 21: 199-209.
22. Smith, M.L., Chen, I.T., Zhan, Q., Bae, I., Chen, C.Y., Gilmer, T.M., Kastan, M.B., O'Connor, P.M. and Fornace, A.J. Jr. (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376-1380.
23. Swafford, D.S., Nikula, K.J., Mitchell, C.E. and Belinsky, S.A. (1995). Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black. Carcinogenesis 16: 1215-1221.
24. Westerholm, R. and Egeback K.E. (1994). Exhaust emissions from light-and heavy-duty vehicles: chemical composition, impact of exhaust after treatment, and fuel parameters. Environ. Health Perspect. 102 Suppl 4: 13-23.