Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

Medicinal Research Reviews

Volumn 22, Issue 2, 2002, Pages 146-167

  Yusuf Makagiansar, Helena ^a   Anderson, Meagan E ^a   Yakovleva, Tatyana V ^a   Murray, Joseph S ^a   Siahaan, Teruna J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Adhesion molecule peptides; Autoimmune diseases; ICAM 1; Inflammation; LFA 1; VCAM 1; VLA 4

Indexed keywords

ACECLOFENAC; ANTIINFLAMMATORY AGENT; BETA1 INTEGRIN; DICLOFENAC; GLUCOCORTICOID; INDOMETACIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MELOXICAM; METHOTREXATE; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE INHIBITOR; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEASOME INHIBITOR; SALICYLIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ASTHMA; AUTOIMMUNE DISEASE; CELL ADHESION; CELL KINETICS; CELL MIGRATION; CELLULAR DISTRIBUTION; EOSINOPHIL; EXTRAVASATION; GUINEA PIG; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INHIBITION KINETICS; LEUKOCYTE ACTIVATION; LYMPHOCYTE; MOLECULAR RECOGNITION; MONOCYTE; NONHUMAN; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS;

AUTOIMMUNE DISEASES; DRUG DESIGN; IMMUNE TOLERANCE; INFLAMMATION; INTEGRIN ALPHA4BETA1; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; NEOPLASMS; RECEPTORS, LYMPHOCYTE HOMING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0036174736     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/med.10001     Document Type: Review

References (162)

1. Immunobiology
2. Inhibition of ICAM-1/LFA-1 interactions for inducing immunotolerance
3. Cell adhesion molecules in the pathogenesis of and host defence against microbial infection
4. Dancing the immunological two-step
5. The anatomy of T-cell activation and tolerance
6. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production
7. Modulation of adhesion molecules in lymphocyte activation and cell-cell interaction
8. Pentoxifylline inhibits adhesion and activation of human T lymphocytes
9. Cell adhesion molecules-update
10. Leukocyte adhesion molecules
11. Cellular adhesion molecules: Regulation and functional significance in the pathogenesis of liver diseases
12. Use of adhesion molecules for gene delivery
13. Adhesion receptors in health and disease
14. Intercellular adhesion in vascular biology, thrombosis and cancer
15. Cell adhesion molecules in the kidney: From embryo to adult
16. The selectins and their ligands
17. Cadherins and catenins: Interactions and functions in embrionic development
18. Cell adhesion molecules and colon cancer
19. Cell adhesion molecules in the development and progression of malignant melanoma
20. 1 in mammalian cells
21. 2-integrin-dependent adhesion of human eosinophils to ICAM-1
22. 2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion
23. Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses
24. 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW blood group protein
25. 7 adhesion to epithelial (E)-cadherin
26. The role of the endothelium in inflammation and tumor metastasis
27. 2 integrin LFA-1 in multiple sclerosis lesions
28. The structure of the two amino-terminal domains of human intercellular adhesion molecule-1 suggests how it functions as a rhinovirus receptor
29. The leukocyte function-associated antigen-1 (LFA-1)-binding site on ICAM-3 comprises residues on both faces of the first immunoglobulin domain
30. Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1)
31. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response
32. VCAM-1/alpha 4-integrin adhesion pathway: Therapeutic target for allergic inflammatory disorders
33. 1 down-regulates inflammatory cytokine-induced VCAM-1 expression in cultured human glomerular endothelial cells
34. Erythroid cell adhesion molecules Lutheran and LW in health and disease
35. Integrin and neurocan binding to L1 involves distinct Ig domains
36. Elmer's glue, Elsie and you: Clinical applications of adhesion molecules
37. Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
38. Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
39. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
40. Lymphocyte homing and homeostasis
41. 1 + γδ T cell adherence and tissue retention
42. 4 integrins/VCAM-1 and LFA-1/ICAM-1 in the binding and transendothelial migration of T lymphocytes and T lymphoblasts across high endothelial venules
43. Human T lymphocytes bind to germinal centers of human tonsils via integrin alpha4/VCAM-1 and LFA-1/ICAM-1 and -2
44. 2 integrin-mediated adhesion to ICAM-1 in human T cells
45. 1-mediated function
46. Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis
47. Detection of a circulating form of vascular cell adhesion molecule-1: Raised levels in rheumatoid arthritis and systemic lupus erythematosus
48. Soluble VCAM-1 induces chemotaxis of Jurkat and synovial fluid T cells bearing high affinity very late antigen-4
49. Lymphocyte infiltration patterns in rat smallbowel transplants
50. Changes in phenotypically distinct mucosal macrophage populations may be a prerequisite for the development of inflammatory bowel disease
51. Regional specialization in the mucosal immune system: Primed cells do not always home along the same track
52. Brain microvascular endothelial cells and leukocytes derived from patients with multiple sclerosis exhibit increased adhesion capacity
53. Expression of functional ICAM-1 and VCAM-1 adhesion molecules by an immortalized epithelial cell clone derived from the small intestine
54. CD11a expression and soluble ICAM-1 levels in peripheral blood in high-risk and overt type 1 diabetes subjects
55. Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism
56. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma
57. Selective induction of intercellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells
58. Expression and modulation of adhesion molecules on human bronchial epithelial cells
59. Phenotyping and cytokine regulation of the BEAS-2B human bronchial epithelial cell: Demonstration of inducible expression of the adhesion molecules VCAM-1 and ICAM-1
60. Adhesion molecules and rejection of renal allografts
61. Glomerular vascular cell adhesion molecule-1 expression in renal vasculitis
62. T lymphocyte adhesion mechanisms within inflamed human kidney: Studies with a Stamper-Woodruff assay
63. Rhinovirus infections: Induction and modulation of airways inflammation in asthma
64. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure
65. Interaction between virion-bound host intercellular adhesion molecule-1 and the high-affinity state of lymphocyte function-associated antigen-1 on target cells renders R5 and X4 isolates of human immunodeficiency virus type 1 more refractory to neutralization
66. Role of the leukocyte function antigen-1 conformational state in the process of human immunodeficiency virus type 1-mediated syncytium formation and virus infection
67. Rotavirus contains integrin ligand sequences and a disintegrinlike domain that are implicated in virus entry into cells
68. Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma
69. Enhancement of lymphokine-activated killer cell cytotoxicity implicated in the increased expression of surface adhesion molecules on tumor cells treated with anticancer agents
70. Decreased expression of ICAM-1 and its induction by tumor necrosis factor on breast-cancer cells in vitro
71. 4-integrins for distinct steps of lymphoma metastasis
72. Prevention of bone marrow and cardiac graft rejection in an H-2 haplotype disparate mouse combination by an anti-LFA-1 antibody
73. A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations
74. Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies
75. 2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice
76. 4 integrins in the lung
77. 1 integrin
78. Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the α4 integrin
79. The immunological synapse: A molecular machine controlling T cell activation
80. 2 integrin lymphocyte function-associated antigen-1 regulates aviditydependent inside-out signaling
81. H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells
82. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
83. Molecular regulation of the interaction between leukocyte function-associated antigen-1 and soluble ICAM-1 by divalent metal cations
84. The I domain of integrin leukocyte function-associated antigen-1 is involved in a conformational change leading to high affinity binding to ligand intercellular adhesion molecule 1 (ICAM-1)
85. Affinity and kinetic analysis of the molecular interaction of ICAM-1 and leukocyte function-associated antigen-1
86. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a betapropeller domain
87. Integrin LFA-1 alpha subunit contains an ICAM-1 binding site in domains V and VI
88. Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function
89. How LFA-1 binds to different ligands
90. A meric crystal structure for the N-terminal two domain of intercellular adhesion molecule-1
91. Intestinal inflammation in adhesion molecule-deficient mice: An assessment of P-selectin alone and in combination with ICAM-1 or E-selectin
92. Lymphocyte function-association antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-1) and the integrin binding surface in the ICAM subfamily
93. The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand binding site in the first domain
94. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface
95. 4 subunit of the integrin VLA-4: Distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin
96. Alternative splicing of human VCAM-1 in activated vascular endothelium
97. Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1
98. 1)
99. 1
100. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus
101. The I domain of integrin LFA-1 interacts with ICAM-1 domain 1 at residue Glu-34 but not Gln-73
102. 1
103. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
104. 1 function by RGD peptide homologues
105. 1 through chemical cross-linking
106. Peptide recognition motifs involved in the binding of integrins to their ligands
107. Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2
108. The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): A cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction
109. Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4
110. 1 peptide antagonists as potential anti-inflammatory agents
111. 4 integrins
112. Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1
113. 4 epitopes
114. 1 (VLA-4, CD49d/CD29)
115. 4-integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity
116. 4 integrin is required for cell adhesion
117. A novel region of the alpha4 integrin subunit with a modulatory role in VLA-4-mediated cell adhesion to fibronectin
118. 5 subunits
119. 5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion
120. 2-integrins
121. 2-Integrin blockade driven by E-selectin promoter prevents neutrophil sequestration and lung injury in mice
122. N-acyl phenylalanine analogues as potent small molecule VLA-4 antagonists
123. N-benzylpyroglutamyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists
124. Inhibition of homotypic adhesion of T-cells: Secondary structure of an ICAM-1-derived cyclic peptide
125. Binding and internalization of an ACAM-1 peptide by the surface receptors of T cells
126. 2+ binding cyclic peptide derived from the α-subunit of LFA-1: Inhibitor of ICAM-1/LFA-1-mediated T-cell adhesion
127. Comparison of solution conformations of a cell-adhesive peptide LBE and its reverse sequence EBL
128. Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture
129. Linear and cyclic LFA-1 and ICAM-1 peptides inhibit T cell adhesion and function
130. Inhibition of intercellular adhesion molecule 1-dependent biological activities by a synthetic peptide analog
131. Synthetic peptide analogs of intercellular adhesion molecule 1 (ICAM-1) inhibit HIV-1 replication in MT-2 cells
132. Binding and internalization of an LFA-1-derived cyclic peptide by ICAM receptors on activated lymphocyte: A potential ligand for drug targeting to ICAM-1 expressing cells
133. Inhibition of the adherence of T-lymphocytes to epithelial cells by a cyclic peptide derived from inserted domain of lymphocyte function-associated antigen-1
134. ICAM-2 peptides mediate lymphocyte adhesion by binding to CD11a/CD18 and CD49d/CD29 integrins
135. 1 that inhibit allergic airway responses
136. 1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo (MePHE-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation
137. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions
138. Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients:I, Treatment with connecting segment-1 peptides prevents acure rejection by suppressing intragraft mononuclear cell accumulation, endothelial activation, and cytocine expression
139. Blockade of very late antigen-4 integrin binding to fibronectin in allograft recipients. II. Treatment with connecting segment-1 peptides prevents chronic rejection by attenuating arteriosclerotic development and suppressing intragraft T cell and macrophage activation
140. Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds
141. Anti-inflammatory effects of glucocorticoids in brain cells, independent of NF-κ B
142. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
143. Salicylates inhibit adhesion and transmigration of T lymphocytes by preventing integrin activation induced by contact with endothelial cells
144. Prevention of cytokine-induced changes in leukocyte adhesion receptors by nonsteroidal antiinflammatory drugs from the oxicam family
145. Interference of nonsteroidal antiinflammatory drugs with very late activation antigen 4/ vascular cells adhesion molecule 1-mediated lymphocyte-endothelial cell adhesion
146. Inhibition of NF-κ B by sodium salicylate and aspirin
147. Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration
148. Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis
149. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers
150. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1
151. Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells
152. Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions
153. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain
154. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. I. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
155. Cutting edge: A small molecule antagonist of LFA-1-mediated cell adhesion
156. Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells
157. Nuclear factor kappa-B dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium
158. Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1
159. Organ targeting in vivo using phage display peptide libraries
160. Peptides which bind to E-selectin and block neutrophil adhesion