N-Acyl phenylalanine analogues as potent small molecule VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 8, 2000, Pages 725-727

  Chen, Li ^a   Tilley, Jefferson W ^a   Huang, Tai Nan ^a   Miklowski, Dorota ^a   Trilles, Richard ^a   Guthrie, Robert W ^a   Luk, Kin ^a   Hanglow, Angela ^a   Rowan, Karen ^a   Schwinge, Virginia ^a   Wolitzky, Barry ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; GLUTAMIC ACID DERIVATIVE; N ACYLPHENYLALANINE DERIVATIVE; N BENZYLPYROGLUTAMYL DERIVATIVE; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CHEMICAL MODIFICATION; DRUG STRUCTURE; HUMAN; INHIBITION KINETICS; PARTIAL DRUG SYNTHESIS; PROTEIN INTERACTION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ACYLATION; INTEGRIN ALPHA4BETA1; INTEGRINS; PHENYLALANINE; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034678645     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00088-3     Document Type: Article

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