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Volumn 43, Issue 21, 2000, Pages 4025-4040

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

(12) Liu, G a Link, J T a Pei, Z a Reilly, E B a Leitza, S a Nguyen, B a Marsh, K C a Okasinski, G F a Von Geldern, T W a Ormes, M b Fowler, K b Gallatin, M b

a ABBOTT LABORATORIES (United States)

b ELI LILLY AND COMPANY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOPROPYLPHENYL 2 NITRO 4 [[(4 ACETYLPIPERAZIN 1 YL)CARBONYL]ETHENYL]PHENYL SULFIDE; A 286982; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; RAT;

ANIMALS; B-LYMPHOCYTES; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL ADHESION; CELL LINE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 0034687234 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0002782 Document Type: Article

Times cited : (225)

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