Blockade of the integrin αLβ2 but not of integrins α4 and/or β7 significantly prolongs intestinal allograft survival in mice

Gut

Volumn 47, Issue 1, 2000, Pages 97-104

  Sarnacki, S ^a,b,c   Revillon Y ^a,b   Fischer, A ^a   Cerf Bensussan, N ^c   Auber, F ^b   Cretolle C ^b   Camby, C ^b   Cavazzana Calvo, M ^a   Muller W ^d   Wagner, N ^d   Brousse, N ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b Ecole de Chirurgie   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Calcineurin; Integrins; Mouse; Small bowel transplantation; Tolerance

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; TACROLIMUS; UNCLASSIFIED DRUG; ALPHA4 INTEGRIN; BETA INTEGRIN; BETA7 INTEGRIN; LEUKOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOPROPHYLAXIS; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE GRAFT; INTESTINE TRANSPLANTATION; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; TREATMENT OUTCOME; ANIMAL; C3H MOUSE; C57BL MOUSE; DRUG ANTAGONISM; FETAL TISSUE TRANSPLANTATION; IMMUNOLOGY; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; SMALL INTESTINE; TRANSPLANTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CALCINEURIN; FEMALE; FETAL TISSUE TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTEGRIN ALPHA4; INTEGRIN BETA CHAINS; INTEGRINS; INTESTINE, SMALL; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL;

EID: 0034223569     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.1.97     Document Type: Article

References (38)

1. Revillon Y, Jan D, Sarnacki S, Goulet O, Brousse N, Ricour C. Intestinal transpantation in the child: experimental and clinical studies. J Pcdiair Surg 1993;28:292-8.
2. Abu-EImag K, Todo S, Tzakis A, ei al. Three years clinical experience with intestinal transplantation. J Am Coll Surg 1994;179:385-400.
3. Langnas AN, Shaw BW jr, Antonson DL, el al. Preliminary experience with intestinal transplantation in infants and children. Pediatrics 1996;97:443-8.
4. Grant D. Current results of intestinal transplantation. Lanr1996;347:1801-2.
5. Grant D. Intestinal transplantation: 1997 report of the international registry. Transplantation 1999;67:1061-4.
6. Davignon D, Martz E, Reynolds T, Kurzinger K, Springer TA. Monoclonal antibody to a novel lymphocyte functionassociated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effect on other T and B function. J Immunol 1981;127:590-5.
7. Krensky AM, Sanchez-Madrid F, Robbins Z, Nagy JA, Springer TA, Burakoff SJ. The functional significance, distribution and structure of LFA-1, LFA-2 and LFA-3: cell surface antigens associated with CTL-target interactions. J /mraimo/1983:131:611-16.
8. Carlos TM, Harlan JM. Leucocyte-endothelial adhesion molecules. Blood 1994;84:2068-101.
9. Cavazzana-Calvo M, Sarnacki S, Haddad E, et al. Prevention of bone marrow and cardiac graft rejection in an H-2 haplotype disparate mouse combination by an antiLFA-1 antibody. Transplantation 1995;59:1576-82.
10. Fischer A, Cavazzana-Calvo M, Jabado N, Sarnacki S. Alonoclonal antibodies to adhesion molecules in bone marrow and organ transplantation. In: Chatenoud L, ed. Monoclonal antibodies in transplantation. Austin, TX, USA: RG Landes Company Publishers, 1995:137-45.
11. Hourmant M, Bedrossian J, Durand D, et al. A randomized multicenter trial comparing leucocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations. Transplantation 1996;62:1565-70.
12. Berlin C, Bargatze RF, Campbell JJ, et al. AIpha4 integrals mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995;SO:413-22.
13. Bargatze RF, Jutila MA, Butcher EC. Distinct roles of L-selectin and integrin alpha-4-beta-7 and LFA-1 in lymphocyte homing to Peyer's pâtch-HEV in situ: The multistep model confirmed and refined. Immunity 1995;3: 99-108.
14. Wagner N, Löhler J, Kunkel EJ, et al. Critical role for (37 integrins in formation of the gut-associated lymphoid tissue. Nature 1996;382:366-70.
15. Springer TA, Davignon D, Ho MK, Kürzingr K, Martz E, Sanchez-Madrid F. LFA-1 and Lyt-2,3, molecules associated with T-lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function. Immunol Rev 1982;68:171-95.
16. Berlin C, Berg EL, Briskin MJ, et al. u47 integrin mediates lymphocyte binding to the mucosal vascular adressin MAdCAM-1. Cell 1993;74:185-95.
17. Larsen CP, EKvood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996;381:434-8.
18. Lobb RR, Hemler ME. The pathophysiologic role of a4 integrins in vivo. J Clin Im-est 1994;94:1722-8.
19. Yang H, Issekutz TB, Wright JR Prolongation of rat islet allograft survival by treatment with monoclonal antibodies against VLA-4 and LFA-1. Transplantation 1995;60:71-6.
20. Isobe Ai, Susuki JI, Yagita H, et al. Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and very late antigen-4 monoclonal antibodies. J Immunol 1994;153:5811-18.
21. Bell RG, Issekutz T. Expression of protective intestinal immune response can be inhibited at three distinct sites by treatment with anti u4 integrin. J Immunol 1993;151:4790802.
22. Podolsky DK, Lobb R, Benjalin CD, Pepinsky B, Sehgal P, deBeaumont M. Attenuation of colitis in the cotton-top tamarin by anti u4 integrin monoclonal antibody. J Clin Invest 1993;92:372-80.
23. Hesterberg PE, Winsor-Hines D, Briskin MJ, et al. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin u47. Gastroenterology 1996;111:1373-80.
24. Tanaka T, Ohtsuka Y, Yagita H, Shiratori Y, Omata M, Okumura K. Involvement of al and ci4 integrins in gut mucosal injury of graft-versus-host disease. Int Immunol 1995;7:1183-9.
25. Ludviksson BR, Strober W, Nishikomori R, Hasan SK, Ehrhardt RO. Administration of mAb against alphaEbeta? prevents and ameliorates immunization-induced colitis in IL-2-/- mice. J Immunol 1999;162:4975-82.
26. Kato Y, Yamataka A, Yagita H, Okumura K, Fujiwara T, Miyano T. Specific acceptance of fetal bowel allograft in mice after combined treatment with anti-intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 antibodies. Ann Surg 1996;223:94-100.
27. Le-Mauff B, Hourmant M, Rougier JP, et ai. Effects of antiLFA-1 (CD 11 a) monoclonal antibodies in acute rejection in human kidney transplantation. Transplantation 1991;52: 291-6.
28. Oubenaissa A, Mouas C, Boyrgeois F, et al. Evidence for an involvement of the neutrophil integrin lymphocyte function-associated antigen-1 in early failure of heart transplants. Circulation 1996;94:254-9.
29. Hamann A, JablonskiAVestrich D, Duijvestijn A, et al. Evidence for an accessory role of LFA-1 in lymphocytehigh endothelium interaction during homing. J Immunol 1988;140:693-9.
30. Fromont G, Cerf-Bensussan N, Patey N, et al Small bowel transplantation in children: an immunohistochemical study of intestinal grafts. Gut 1995;37:783-90.
31. Van Seventer GA, Shimizu Y, Morgan KJ, et al. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T-cell receptor-mediated activation of resting cells. J Immunol 1990;144:4579-83.
32. Schmits R, Kündig TM, Baker DM, et al LFA-1 deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med 1996;183:1415-26.
33. Figdor CG, Van Kooyk, Keizer GD. On the mode of action of LFA-1. Immunol Today 1990;ll:277-9.
34. Bachmann MF, McKall-Faienza K, Schmits R, et al. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 1997;4:549-57.
35. Chan BM, Zheng H, Wang H, et al. Treatment of cardiac allografts with established leukocyte infiltration by modulation of alpha4 (CD49d) and leukocyte function-associated antigen-1 (CD11a/CD18) integrin function. Transplantation 1998;66:277-83.
36. Bashuda H, Seino K, Ra C, Yagita H, Okumura K. Lack of cognate help by CD4+ T cells and anergy of CD8+ T cells are the principal mechanisms for anti-leukocyte functionassociated antigen-l/intercellular adhesion molecule-linduced cardiac allograft tolerance. Transplantation 1997; 63:113-18.
37. Isobe M, Suzuki J, Yamazaki S, Sekiguchi M. Effects of exogenous IL-2 on tolerance induction by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. Transplant Proc 1996;28:1045-6.
38. Bemer V, Truffa-Bachi P. T cell activation by concanavalin A in the presence of cyclopsorin A: immunosuppressor withdrawal induces NFATp translocation and interIeukin-2 gene transcription. Eur J Immunol 1996;26: 1481-8.