Salicylates inhibit IκB-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3961-3969

  Pierce, Jacqueline W ^a   Read, Margaret A ^a   Ding, Han ^a   Luscinskas, Francis W ^a   Collins, Tucker ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERCELLULAR ADHESION MOLECULE 1; PROSTAGLANDIN SYNTHASE; SALICYLATE SODIUM; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKOCYTE ADHERENCE; LEUKOCYTE ADHERENCE INHIBITION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BASE SEQUENCE; CELL MOVEMENT; CELLS, CULTURED; DNA-BINDING PROTEINS; E-SELECTIN; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; MOLECULAR SEQUENCE DATA; NEUTROPHILS; NF-KAPPA B; PHOSPHORYLATION; SODIUM SALICYLATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029870463     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Springer, T. 1995. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol. 57:827.
2. Carlos, T M , and J M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood 84:2068.
3. Pober, J. S., and R. C. Cotran. 1990 Cytokines and endothelial biology. Physiol Rev. 70:427.
4. Wertheimer, S J., C. L Myers, R. W. Wallace, and T. P. Parks. 1992. Intercellular adhesion molecule-1 gene expression in human endothelial cells. J. Biol. Chem. 267:12030.
5. Lewis, H., W. Kaszubska, J. F. DeLamarter, and J. Whelan. 1994. Cooperativity between two NF-κB complexes mediated by high mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol. Cell. Biol. 14:5701.
6. Schindler, U., and V. R. Baichwal 1994. Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor α-induced expression. Mol. Cell. Biol. 14:5820.
7. Iademarco, M., J. McQuillan, G. Rosen, and D. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J Biol. Chem. 267:16323.
8. Read, M , M. Whitley, A. Williams, and T. Collins. 1994. NF-κB and IκB-α: an inducible regulatory system in endothelial activation. J. Exp. Med. 179:503.
9. Whitley, M., D. Thanos, M. Read, T. Maniatis, and T. Collins. 1994. A striking similarity in the organization of the E-selectin and β interferon gene promoters Mol Cell. Biol. 14:6464.
10. Neish, A , A. Williams, H. Palmer, M. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1583.
11. Hou, J., V. Baichwal, and Z. Cao. 1994 Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1 Proc. Natl. Acad. Sci. USA 91:11641.
12. Ledebur, H. C , and T. Park. 1995. Transcriptional regulation of the intercellular adhesion molecule 1 gene by inflammatory cytokines in human endothelial cells. J Biol Chem 270:933.
13. Grilli, M., J.-S. Chiu, and M. Lenardo. NF-κB and Rel, participants in a multiform transcriptional regulatory system. 1993. In International Review of Cyrology: A Survey of Cell Biology. K. Jeon, M. Freidlander, and J. Jarvik, eds. San Diego, Academic Press, Inc. Harcourt Brace Jovanovich, pp. 1-62.
14. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529
15. Siebenlist, U., G. Franzoso, and K Brown. 1994. Structure, regulation and function of NF-κB Annu. Rev. Cell. Biol. 10 405.
16. Beg, A, T. Finco, P. Nantermet, and A Baldwin. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB-α a mechanism for NF-κB activation. Mol. Cell Biol. 13:3301.
17. Brockman, J., D. Schierer, T. McKinsey, S. Hall, X. Qi, W. Lee, and D. Ballard. 1995. Coupling of a signal response domain in IκB-α to multiple pathways for NF-κB activation. Mol. Cell. Biol. 15:2809.
18. Brown, K., S. Park, T. Kanno, G Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific signal-induced phosphorylation. Science 267: 1485.
19. Chen, Z., J. Hagler, V. Palombella, F. Melandri, D. Scherer, D Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκB-α to the ubiquitin-proteasome pathway. Genes Dev. 9:586.
20. Henkel, T., T. Machleidt, I. Alkalay, M. Kronke, Y. Ben-Neriah, and P Baeuerle. 1993. Rapid proteolysis of IκB-α is necessary in the activation of transcription factor NF-κB. Nature 365:182.
21. Naumann, M., and C Scheidereit. 1994. Activation of NF-κB in vivo is regulated by multiple phosphorylations EMBO J. 13:4598.
22. Palombella, V., O. Rando, A Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773
23. Rice, N R., and M. K. Ernst 1993. In vivo control of NF-κB and activation by IκBα. EMBO J 12:4685.
24. Sun, S.-C., P Ganchi, D. Ballard, and W. Greene. 1993. NF-κB controls expression of inhibitor IκB-α: evidence for an inducible autoregulatory pathway. Science 259:1912.
25. Traencker, E, S Wilk, and P. Baeuerle. 1994. A proteosome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13:5433.
26. Read, M., A. Neish, F. Luscinskas, V. Palombella, T. Maniatis, and T. Collins. 1995. The proteosome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 2:493
27. Weissmann, G 1991. Aspirin. Sci Am. 264 84.
28. Kopp, E , and S Ghosh. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956.
29. Weber, C., W. Erl. A. Pietsch, and P. Weber. 1995. Aspirin inhibits nuclear factor κB mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 91:1914.
30. Gimbrone, M. A. 1976. Culture of vascular endothelium. In Progress in Hemostasis and Thrombosis. T. Spaet. ed. New York, Grune and Stratton, Inc, pp. 1-28.
31. Shen, J., F. W. Luscinskas, A Connolly, C. F. Dewey, and M. A Gimbrone. 1992. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells Am J. Physiol 262:C384.
32. + T-lymphocytes on TNF-α-activated vascular endothelium under flow. J. Exp. Med. 118:1179
33. Luscinskas, F. W., A. F. Brock, M. A. Arnaout, and M A. Gimbrone. 1989. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclcar leukocyte adhesion to cytokine-activated human vascular endothelium. J. Immunol. 142:2257.
34. Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705.
35. Mauxion, F., M. Pray, and R. Sen. 1990. Multiple nuclear factors interact with sequences within the JB2-CB2 intron of the murine T cell receptor β-chain gene. J. Immunol. 145:1577
36. Neish, A. M A. Read, D. Thanos, R Pine, T Mamatis, and T. Collins. 1995 Endothelial interferon regulatory factor 1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 15:2518.
37. Beg, A. A., and A. S. Baldwin. 1993. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2064.
38. Alkalay, I, A. Yaron, A. Hatzubai, S. Jung, A. Avraham, O. Gerlitz, I. Pashut-Lavon, and Y. Ben-Neriah. 1995. In vivo stimulation of IκB-α phosphorylation is not sufficient to activate NF-κB Mol. Cell. Biol. 15:1294.
39. Sluss, H., T. Barrett, B. Derijard, and R. Davis. 1994. Signal transduction by tumor necrosis factor mediated by JNK protein kinases Mol. Cell Biol. 14:8376.
40. Gupta, S., D. Cambell, B. Derijard, and R Davis. 1995. Transcription factor ATF-2 regulation by the JNK signal transduction pathway. Science 267 389.
41. Bevilacqua, M., S. Stengelin, M. A. Gimbrone, and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160.
42. Springer, T A. 1994 Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
43. Luscinskas, F. W , H. Ding, P Tan, D. Cumming, T. F. Tedder, and M. E Gerritsen. 1996 L- and P-selectins but not CD49d (VLA-4) integrins mediate monocyte initial attachment to TNF-α-activated vascular endothelium under flow in vitro J Immunol. In press.
44. Smith, C W., S. D. Marlin, R. Rothlein, C. Toman, and D. A. Anderson. 1989 Cooperative interaction of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest 83:2008.
45. Jones, D., L. McIntire, C. Smith, and L. Picker. 1994. A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions J. Clin. Invest. 94:2433.
46. Oppenheimer-Marks, N., L Davis, D. Tompkins Bogue, J. Ramberg, and P Lipsky. 1991 Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human lymphocytes. J. Immunol 147: 2913.
47. Kunsch, C., and C. A Rosen. 1993 NF-κB subunit-specific regulation of the interleukin-8 promoter. Mol. Cell. Biol. 13:6137.
48. Collins, T., M. A. Read, A Neish, M. Whitley, D. Thanos, and T Mamatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers FASEB 9.1.
49. Lewis, H., W. Kaszubska, J. F. DeLamarter, and J. Whelan. 1994. Cooperatively between two NF-κB complexes mediated by high mobility-group protein I(Y) is essential for cytokine-induced expression of the E-selectin promoter. Mol Cell. Biol. 14:5701
50. Cronstein, B., S. Kimmel, R Levin, F. Martiniuk, and G. Weissmann. 1992. A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 89:9991.
51. Famaey, J., and H Paulus 1992 Therapeutic Applications of NSAIDS Subpopulations and New Formulations. New York, Marcel Dekker.
52. Palmoski, M., and K. Brandt. 1985. Correction of data on salicylate and indomethacin concentrations in cartilage. Arthritis Rheum. 28:237
53. Pober, J , M. Slowik, L. De Luca, and A. Ritchie. 1993 Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. but not intercellular adhesion molecule-1. J. Immunol. 150:5114
54. Haynes, D., P. Wright, S. Gadd, M. Whitehouse, and B. Vernon-Roberts 1993 Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites? Agents Actions 39:49.
55. Asako, H. P. Kubes, J. Wallace, R. Wolf, and D. N. Granger. 1992. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 103:146.
56. Sagone, A., and R. Husney. 1987. Oxidation of salicylates by stimulated granulocytes: evidence that these drugs act as free radical scavengers in biological systems. J. Immunol. 138:2177.
57. Chen, Z., J. Malamy, J. Henning, U Conrath, P. Sanchezcasas, H Silva, J. Ricigliano, and D. Klessig. 1995. Induction, modification, and transduction of the salicylic acid signal in plant defense responses. Proc. Natl. Acad. Sci. USA 92:4134.
58. Collins, T. 1993. Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion. Lab. Invest. 68:499.
59. Finco, T., A. Beg, and A. Baldwin. 1994. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors Proc. Natl. Acad Sci. USA 91:11884
60. Baeuerle, P., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141
61. Weber, C., W. Erl, A. Pietsch, M. Strobel, H. Ziegler-Heitbrock, and P Weber. 1994. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-κB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler. Thromb 14:1665.
62. Marui, N., M. Offerman, R. Swerlick, C. Kunsch, C. Rosen, M. Ahmad, R. Alexander, and R. Medford. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated Through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92:1866.
63. fyn tyrosine kinases in human lymphocytes. Blood 82:1212.
64. Finco, T, and A Baldwin 1993. κB-site dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf 1. J Biol. Chem 268: 17676.
65. Machleidt, T., K. Wiegmann, T. Henkel, S. Schutze, P. Baeuerle, and M. Kronke 1994. Sphingomyelinase activates proteolytic IκB-α degradation in a cell-free system J. Biol. Chem. 269:13760.
66. Abramson, S., J. Leszenczynska-Piziak, R. Clancy, M Philips, and G. Weissman 1994. Inhibition of neutrophil function by aspirin-like drugs (NSAIDs) requirement for assembly of heterotrimeric G proteins in bilayer phospholipid. Biochem. Pharmacol. 47:563.
67. Frantz, B., and E. A O'Neill. 1995. The effect of sodium salicylate and aspirin on NF-κB Science 270 2017.
68. Peng, H., P. Libby, and J. Liao. 1995. Induction and stabilization of IκB-α by nitric oxide mediates inhibition of NF-κB. J. Biol Chem. 270:14214.
69. Ray, A, and K. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91:752.
70. Chen, C. C., C. L Rosenbloom, D. C. Anderson, and A. M. Manning. 1995. Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of IκB-α phosphorylation. J. Immunol. 155:3538.