Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-κB

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 2113-2119

  Bourke, Emer ^a   Moynagh, Paul N ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTOMA; BRAIN CELL; CELL ADHESION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG EFFECT; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; STEROID THERAPY;

ANTI-INFLAMMATORY AGENTS; ASTROCYTOMA; BRAIN; DEXAMETHASONE; GENES, REPORTER; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; INTERLEUKIN-8; NEUROBLASTOMA; NF-KAPPA B; TUMOR CELLS, CULTURED; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033567085     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Cupps, T. R., and A. S. Fauci. 1982. Corticosteroid-mediated immunoregulation in man. Immunol. Rev. 65:133.
2. Lee, S. W., A. P. Tsou, H. Chan, J. Thomas, K. Petrie, E. M. Eugui, and A. C. Allison. 1988. Glucocorticoids selectivley inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA. Proc. Natl. Acad. Sci. USA 85:1204.
3. Arya, S. K., F. Wong-Stahl, and R. C. Gallo. 1984. Dexamethasone-mediated inhibition of human T cell growth factor and γ-interferon messenger RNA. J. Immunol. 133:273.
4. Beutler, B., N. Krochin, I. W. Milsark, C. Leudke, and A. Cerami. 1986. Control of cachectin (tumor necrosis factor) synthesis: mechanism of endotoxin resistance. Science 232:977.
5. Peppel, K., J. M. Vinci, and C. Baglioni. 1991. The AU-rich sequences in the 3′ untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J. Exp. Med. 173:349.
6. Mukaida, N., C. C. O. Zachariae, G. L. Gusella, and K. Matsushima. 1991. Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or tumor necrosis. J. Immunol. 146:1212.
7. Dumont, A., S. P. Hehner, M. L. Schmitz, J. A. Gustafsson, J. Liden, S. Okret, P. T. Van Der Saag, S. Wissink, B. Van Der Burg, P. Herrlich, G. Haegeman, K. De Bosscher, and W. Fiers. 1998. Cross-talk between steroids and NF-κB: what language? Trends Biochem. Sci. 23:233.
8. Narayanan, R., K. A. Higgins, J. R. Perez, T. A. Coleman, and C. A. Rosen. 1993. Evidence for differential functions of the p50 and p65 subunits of NF-κB with a cell adhesion model. Mol. Cell Biol. 13:3802.
9. Baeuerle, P. A., and D. Baltimore. 1988. 1κB: a specific inhibitor of the NF-κB transcription factor. Science 242:540.
10. Ganchi, P. A., S. C. Sun, W. C. Greene, and D. W. Ballard. 1992. 1κB/MAD-3 masks the nuclear localization signal of NF-κB p65 and requires the transactivation domain to inhibit NF-κB p65 DNA binding. Mol. Cell Biol. 3:1339.
11. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
12. Whiteside, S. T., J. Epinat, N. R. Rice, and A. Israel. 1997. A new member of the IκB protein family, IκB∈, inhibits RelA (p65)-mediated NF-κB transcription. EMBO J. 16:1413.
13. Beg, A. A., T. S. Finco, P. V. Nantermet, and A. S. Baldwin. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB: a mechanism for NF-κB activation. MoI. Cell Biol. 13:3301.
14. Henkel, T., T. Machleidt, I. Alkalay, M. Kronke, Y. Ben-Yeriah, and P. A. Baeuerle. 1993. Rapid proteolytic degradation of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365:182.
15. Baeuerle, P. A. 1991. The inducible transcription factor NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63.
16. Scheinman, R. I., P. C. Cogwell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283.
17. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286.
18. Moynagh, P. N., D. C. Williams, and L. A. J. O'Neill. 1994. Activation of NF-κB and induction of VCAM-1 and ICAM-1 expression in human glial cells by IL-1. J. Immunol. 153:2681.
19. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. In Molecular Cloning: A Laboratory Manual. N. Ford, C. Nolan, and M. Ferguson, eds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, p.5.68.
20. Scheinman, R. I., A. Gualberto, C. M. Jewell, J. A. Cidlowski, and A. S. Baldwin, Jr. 1995. Characterisation of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell Biol. 15:943.
21. Liden, J., F. Delaunay, I. Rafter, J. Gustafsson, and S. Okret. 1997. A new function for the C-terminal zinc finger of the glucocorticoid receptor: repression of RelA transactivation. J. Biol. Chem, 272:21467.
22. Ray, K. P., S. Farrow, M. Daky, F. Talabot, and N. Searle. 1997. Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor α, and inhibition by glucocorticoids. Biochem. J. 328:707.
23. De Bosscher, K., M. Lienhard Schmitz, W. Vanden Berghe, S. Plaisance, W. Fiers, and G. Haegeman. 1997. Glucocorticoid-mediated repression of nuclear factor-κB dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 94:13504.
24. Cybulsky, M. I., J. W. U. Fries, A. J. Williams, P. Sultan, R. Eddy, M. Byers, T. Shows, M. A. Gimbrone, and T. Collins. 1991. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc. Natl. Acad. Sci. USA 88:7859.
25. Voraberger, G., R. Schafer, and C. Stratowa. 1991. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatoryregion. J. Immunol. 147:2777.
26. Mukaida, N., M. Shiroo, and K. Matsushima. 1989. Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J. Immunol. 143: 1366.
27. Ledebur, H.C., and T. P. Parks. 1995. Transcriptional regulation of the intercellular adhesion moelcule-1 gene by inflammatory cytokines in human endothelial cells: essential roles of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:933.
28. Harant, H., R. de Martin, P. J. Andrew, E. Foglar, C. Dittrich, and I. J. D. Lindley. 1996. Synergisitc activation of interleukin-8 gene transcription by all-trans-retinoic acid and tumour necrosis factor-α involves the transcription factor NF-κB. J. Biol. Chem. 271:26954.
29. Unlap, M. T., and R. S. Jope. 1997. Dexamethasone attenuates NF-κB DNA binding activity without inducing IκB levels in rat brain in vivo. Mol. Brain Res. 45:83.
30. Wissink, S., E. C. van Heerde, M. L. Schmitz, E. Kalkhoven, B. van der Burg, P. A. Baeuerle, and P. T. van der Saag. 1997. Distinct domains of the RelA NF-κB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J. Biol. Chem. 272:22278.
31. Heck, S., K. Bender, M. Kullmann, M. Gottlicher, P. Herrlich, and A. C. B. Cato. 1997. IκBα-independent downregulation of NF-κB activity by glucocorticoid receptor. EMBO J. 16:4698.
32. Wang, Y., J. J. Zhang, W. Dai, K. Y. Lei, and J. W. Pike. 1997. Dexamethasone potently enhances phorbol ester-induced IL-1β gene expression and nuclear factor NF-κB activation. J. Immunol. 159:534.