Pentoxifylline inhibits adhesion and activation of human T lymphocytes

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 65-72

  González Amaro, Roberto ^a   Portales Pérez, Diana ^a   Baranda, Lourdes ^a   Redondo, Juan M ^c   Martínez Martínez, Sara ^c   Yáñez Mó, María ^c   García Vicuńa, Rosario ^c   Cabañas, Carlos ^b   Sánchez Madrid, Francisco ^c,d  

^a UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2 RECEPTOR; PENTOXIFYLLINE; PHORBOL ESTER; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CALCIUM CELL LEVEL; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; DNA CONTENT; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE ACTIVATION; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

CELL ADHESION; CELL AGGREGATION; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; PENTOXIFYLLINE; T-LYMPHOCYTES;

EID: 0031803274     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Ward, A., and S. P. Clissold. 1987. Pentoxifylline. Drugs 34:50.
2. Schwarz, A., C. Krone, F. Trauntinger, Y. Aragane, P. Neuner, T. A. Lager, and T. Schwarz. 1993. Pentoxifylline suppresses irritant and contact hypersensitivity reactions. J. Invest. Dermatol. 101:549.
3. Nataf, S., J. P. Louboutin, D. Chabannes, J. R. Feve, and J. Y. Muller. 1993. Pentoxifylline inhibits experimental allergic encephalomyelitis. Acta Neurol. Scand. 88:97.
4. Bianco, J. A., F. R. Applebaum, J. Nemunaitis, J. Almgren, F. Andrews, P. Kettner, A. Shields, and J. W. Singer. 1991. Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood 78:1205.
5. Neuner, P., G. Klosner, M. Schauer, M. Pourmojib, W. Macheiner, C. Grunwald, R. Knobler, A. Schwarz, T. A. Luger, and T. Schwarz. 1994. Pentoxifylline in vivo down-regulates the release of IL-1β, IL-6, IL-8 and tumor necrosis factor-α by human peripheral blood mononuclear cells. Immunology 83:262.
6. Zabel, P., D. T. Wolter, N. M. Schonharting, and U. F. Schade. 1989. Oxipentofylline in endotoxaemia. Lancet ii:1474.
7. Kovach N. L., C. G. Lindgren, A. Fefer, J. A. Thompson, T. Yednock, and J. M. Harlan. 1994. Pentoxifylline inhibits integrin-mediated adherence of interleukin-2-activated human peripheral blood lymphocytes to human umbilical vein endothelial cells, matrix components, and cultured tumor cells. Blood 84:2234.
8. Weiss, J. M., W. Vanscheidt, K. A. Pilarski, A. Weyl, M. Peschen, E. Schopf, D. Vestweber, and J. C. Simon. 1995. Pentoxifylline inhibits tumor necrosis factor-α (TNF-α)-induced T-lymphoma cell adhesion to endothelioma cells. J. Invest. Dermatol. 104:824.
9. Springer, T. A. 1994. Traffic signal for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
10. Postigo, A. A., R. Garcia-Vicuna, A. Laffón, and F. Sánchez-Madrid. 1993. The role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Autoimmunity 15:1.
11. Butcher, E. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033.
12. Carlos, T. M., and J. M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood 84:2068.
13. Acevedo, A., M. A. del Pozo, A. G. Arroyo, P. Sánchez-Mateos, R. González-Amaro, and F. Sánchez-Madrid. 1993. Distribution of ICAM-3 bearing cells in normal human tissues: expression of a novel counter-receptor for LFA-1 in epidermal Langerhans cells. Am. J. Pathol. 143:774.
14. Hernández-Caselles, T., G. Rubio, M. R. Campanero, M. A. del Pozo, M. Muro, F. Sánchez-Madrid, and P. Aparicio. 1993. ICAM-3, the third LFA-1 counterreceptor, is a co-stimulatory molecule for both resting and activated T lymphocytes. Eur. J. Immunol. 23:2799.
15. Sánchez-Madrid, F., and A. L. Corbi. 1992. Leukocyte integrins: structure, function and regulation of their activity. Semin. Cell. Biol. 3:199.
16. Masumoto, A., and M. E. Hemler. 1993. Multiple activation states of VLA-4: mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J. Biol. Chem. 268:228.
17. Ginsberg, M. H., M. A. Schwartz, and M. D. Schaller. 1995. Integrins: emerging paradigms and signal transduction. Annu. Rev. Cell Dev. Biol. 11:549.
18. Sánchez-Mateos, P., C. Cabanas, and F. Sánchez-Madrid. 1996. Regulation of integrin function. Semin. Cancer Biol. 7:99.
19. 2 integrin "activation" epitopes during T cell responses in secondary lymphoid tissue. Eur. J. Immunol. 23:2751.
20. 1 chain. J. Biol. Chem. 127:11067.
21. Arroyo, A. G., R. García-Vicuña, M. Marazuela, T. A. Yednock, R. GonzálezAmaro, and F. Sánchez-Madrid. 1995. Expression and functional significance of an activation-dependent epitope of beta-1 integrins in chronic inflammatory diseases. Eur. J. Immunol. 25:1720.
22. 1 subunit. Eur. J. Immunol. 22:3111.
23. Campanero, M. R., R. Pulido, J. L. Alonso, J. P. Pivel, F. X. Pimentel-Muños, M. Fresno, and F. Sánchez-Madrid. 1991. Down-regulation by tumor necrosis factor alpha of neutrophil surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism. Eur. J. Immunol. 21:3045.
24. Campanero, M. R., M. A. del Pozo, A. G. Arroyo, P. Sánchez-Mateos, T. Hernández-Caselles, A. Craig, R. Pulido, and F. Sánchez-Madrid. 1993. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J. Cell Biol. 123:1007.
25. Melero, I., M. A. Balboa, J. L. Alonso, E. Yagüe, J. P. Pivel, F. Sánchez-Madrid, and M. López-Botet. 1993. Signaling through the LFA-1 leucocyte integrin actively regulates intercellular adhesion and tumor necrosis factor-α production in natural killer cells. Eur. J. Immunol. 23:1859.
26. Cebrian, M., E. Yagüe, M. Rincón, M. López-Botet, M. O. de Landázuri, and F. Sánchez-Madrid. 1988. Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J. Exp. Med. 168:1621.
27. Hemler, M. E., F. Sánchez-Madrid, T. J. Flotte, A. M. Krensky, S. J. Burakoff, A. K. Bhan, T. A. Springer, and J. L. Strominger. 1984. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting and T cell lines. J. Immunol. 132:3011.
28. Berendt, A. R., A. McDowall, A. G. Craig, P. A. Bates, M. J. E. Sternberg, K. Marsh, C. I. Newbold, and N. Hogg. 1992. The binding site on ICAM-1 for Plasmodium falciparum infected erythrocytes overlaps, but is distinct from the LFA-1 binding site. Cell 14:9.
29. + exchanger activity in cells from bone marrow transplantation recipients. J. Immunol. 143:3653.
30. 2+ during activation of lymphocytes from patients with systemic lupus erythematosus. Lupus 6:48.
31. Berlin, C., R. F. Bargatze, J. J. Campbell, V. H. van Adrian, N. C. Szabo, S. R. Hasslen, R. D. Nelson, E. L. Berg, S. L. Erlandsen, and E. C. Butcher. 1995. Alpha-4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413.
32. 1 integrin. Nature 356:63.
33. Axelsson, B., R. Youseffi-Etermad, S. Hammarström, and P. Perlmann. 1988. Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43. J. Immunol. 141:2912.
34. Taniguchi, T., and Y. Minami. 1993. The IL-2/IL-2 receptor system: a current overview. Cell 73:5.
35. Schlossman, S. F., L. Boumsell, W. Gilks, J. M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. L. Silverstein, T. A. Springer, T. F. Tedder, and R. F. Todd. 1994. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press, Oxford.
36. Gillies, R. J., R. Martínez-Zaguilán, E. P. Peterson, and R. Perona. 1992. Role of intracellular pH in mammalian cell proliferation. Cell. Physiol. Biochem. 2:159.
37. Busa, W. B. 1986. Mechanisms and consequences of pH-mediated cell regulation. Annu. Rev. Physiol. 48:389.
38. + exchanger in a leukemic T cell line. J. Biol. Chem. 260:14053.
39. Cebrián, M., J. M. Redondo, A. López-Rivas, G. Rodríguez-Tarduchy, M. O. de Landazuri, and F. Sánchez-Madrid. 1989. Expression and function of AIM, an activation inducer molecule of human lymphocytes is dependent on the activation of protein kinase C. Eur. J. Immunol. 19:809.
40. Wang, W., W. F. Tam, C. C. W. Hughes, S. Rath, and R. Sen. 1997. c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Immunity 6:165.
41. Rao, K. M., M. S. Currie, S. S. McCachren, and H. J. Cohen. 1991. Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. Cell. Immunol. 135:314.
42. Rames, A., J. M. Poirier, F. LeCoz, M. Midavaine, B. Lecocq, J. D. Grange, R. Poupon, G. Cheymol, and P. Jaillon. 1990. Pharmacokinetics of intravenous and oral pentoxifylline in healthy volunteers and in cirrhotic patients. Clin. Pharmacol. Ther. 47:354.