Cellular adhesion molecules: Regulation and functional significance in the pathogenesis of liver diseases

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 3 36-3, 1997, Pages

  Jaeschke, Hartmut ^a  

^a PFIZER INC   (United States)

Author keywords

Chemokines; Complement; Cytokines; Immunoglobulin gene superfamily; Integrins; Kupffer cells; Liver inflammation; Lymphocytes; Neutrophils; Pit cells; Selectins; Stellate cells

Indexed keywords

CELL ADHESION MOLECULE; INTEGRIN; SELECTIN;

BILIARY CIRRHOSIS; HEPATITIS; HUMAN; KUPFFER CELL; LIVER DISEASE; LIVER INJURY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SCLEROSING CHOLANGITIS; STELLATE CELL;

EID: 0030760637     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.3.g602     Document Type: Review

References (131)

1. Adams, D. H. Lymphocyte-endothelial cell interactions in hepatic inflammation. Hepatogastroenterology 43: 32-43, 1996.
2. Adams, D. H., P. Burra, S. G. Hubscher, E. Elias, and W. Newman. Endothelial activation and circulating vascular adhesion molecules in alcoholic liver disease. Hepatology 19: 588-594, 1994.
3. Adams, D. H., S. G. Hubscher, N. C. Fisher, A. Williams, and M. Robinson. Expression of E-selectin and E-selectin ligands in human liver inflammation. Hepatology 24: 533-538, 1994.
4. Adams, D. H., S. G. Hubscher, J. Shaw, G. D. Johnson, C. Babbs, R. Rothlein, and J. M. Neuberger. Increased expression of intercellular adhesion molecule-1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 14: 426-431, 1991.
5. Arthur, M. J. P., P. Kowalski-Saunders, and R. Wright. Corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident Kupffer cells in the rat. Gastroenterology 91: 174-181, 1986.
6. Bacchi, C. E., C. L. Marsh, J. D. Perkins, R. L. Carithers, Jr., J. P. McVicar, K. L. Hudkins, C. D. Benjamin, J. M. Harlan, R. Lobb, and C. E. Alpers. Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection. Am. J. Pathol. 142: 579-591, 1993.
7. Bainton, D. F., L. J. Miller, T. K. Kishimoto, and T. A. Springer. Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils. J. Exp. Med. 166: 1641-1653, 1987.
8. Bauer, C., S. Siaplaouras, H. R. Soule, M. Moyle, and I. Marzi. A natural glycoprotein inhibitor (NIP) of CD11b/CD18 reduces leukocyte adhesion in the liver after hemorrhagic shock. Shock 4: 187-192, 1995.
9. Bauer, M., J. X. Zhang, I. Bauer, and M. G. Clemens. Endothelin-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G143-G149, 1994.
10. Bautista, A. P. Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology 25: 335-342, 1997.
11. Bautista, A. P., A. Schuler, Z. Spolarics, and J. J. Spitzer. Tumor necrosis factor-α stimulates superoxide anion generation by perfused rat liver and Kupffer cells. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G891-G895, 1991.
12. Bautista, A. P., and J. J. Spitzer. Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. Free Radic. Res. Commun. 17: 195-209, 1992.
13. Bautista, A. P., Z. Spolarics, H. Jaeschke, C. W. Smith, and J. J. Spitzer. Anti-neutrophil monoclonal antibody (1F12) alters superoxide anion release by neutrophils and Kupffer cells. J. Leukoc. Biol. 55: 328-335, 1994.
14. Bioulac-Sage, P., J. Kuiper, T. J. C. Van Berkel, and C. Balabaud. Lymphocyte and macrophage populations in the liver. Hepatogastroenterology 43: 4-14, 1996.
15. Broome, U., D. Hauzenberger, and J. Klominek. Adhesion molecules in primary biliary cirrhosis and primary sclerosing cholangitis. Hepatogastroenterology 43: 1109-1112, 1996.
16. Chosay, J. G., N. A. Essani, C. J. Dunn, and H. Jaeschke. Neutrophil margination and extravasation in sinusoids and venules of the liver during endotoxin-induced injury. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G1195-G1200, 1997.
17. Chosay, J. G., M. A. Fisher, C. J. Dunn, K. A. Ready, A. Farhood, and H. Jaeschke. Platelet endothelial cell adhesion molecule-1 (PECAM-1) expression in a murine model of endotoxin-induced liver injury (Abstract). Hepatology. In press.
18. Colletti, L. M., S. L. Kunkel, M. Green, M. D. Burdick, and R. M. Strieter. Hepatic inflammation following 70% hepatectomy may be related to upregulation of epithelial neutrophil activating protein-78. Shock 6: 397-402, 1996.
19. Colletti, L. M., S. L. Kunkel, A. Walz, M. D. Burdick, R. G. Kunkel, C. A. Wilke, and R. M. Strieter. The role of cytokine networks in the local liver injury following hepatic ischemia/ reperfusion in the rat. Hepatology 23: 506-514, 1996.
20. Collins, T., M. A. Read, A. S. Neish, M. Z. Whitley, D. Thanos, and T. Maniatis. Transcriptional regulation of endothelial cell adhesion molecules: NF-κ and cytokine-inducible enhancers. FASEB J. 9: 899-909, 1995.
21. Cywes, R., M. A. Packham, L. Tietze, J. R. Sanabria, P. R. C. Harvey, M. J. Phillips, and S. M. Strasberg. Role of platelets in hepatic allograft preservation injury in the rat. Hepatology 18: 635-647, 1993.
22. Detmers, P. A., S. K. Lo, E. Olsen-Egbert, A. Walz, M. Baggiolini, and Z. A. Cohn. Neutrophil-activating protein-1/ interleukin-8 stimulates the binding activity of the leukocyte adhesion receptor CD11/CD18 on human neutrophils. J. Exp. Med. 171: 1155-1162, 1990.
23. Dohi, F., T. Goya, and M. Torisu. Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis. Hepatology 17: 1086-1094, 1993.
24. Entman, M. L., K. Youker, T. Shoji, G. Kukielka, S. B. Shappell, A. A. Taylor, and C. W. Smith. Neutrophil-induced oxidative injury of cardiac myocytes; a compartmented system requiring CD11b/CD18-ICAM-1 adherence. J. Clin. Invest. 90: 1335-1345, 1992.
25. Essani, N. A., M. L. Bajt, S. L. Vonderfecht, A. Farhood, and H. Jaeschke. Transcriptional activation of vascular cell adhesion molecule-1 (VCAM-1) gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Immunol. 158: 5941-5948, 1997.
26. Essani, N. A., M. A. Fisher, A. Farhood, A. M. Manning, C. W. Smith, and H. Jaeschke. Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) mRNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 21: 1632-1639, 1995.
27. Essani, N. A., M. A. Fisher, and H. Jaeschke. Inhibition of NF-κB activation by dimethyl sulfoxide correlates with suppression of TNF-α formation, reduced ICAM-1 gene transcription and protection against endotoxin-induced liver injury. Shock 7: 90-96, 1997.
28. Essani, N. A., M. A. Fisher, C. A. Simmons, J. L. Hoover, A. Farhood, and H. Jaeschke. Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Leukocyte Biol. In press.
29. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia. Biochem. Biophys. Res. Commun. 211: 74-82, 1995.
30. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. Endotoxin-induced activation of the nuclear transcription factor κB in hepatocytes, Kupffer cells and endothelial cells in vivo. J. Immunol. 156: 2956-2963, 1996.
31. Farhood, A., G. M. McGuire, A. M. Manning, M. Miyasaka, C. W. Smith, and H. Jaeschke. Intercellular adhesion molecule-1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J. Leukoc. Biol. 57: 368-374, 1995.
32. Ferluga, J., and A. C. Allison. Role of mononuclear infiltrating cells in pathogenesis of hepatitis. Lancet 2: 610-611, 1978.
33. Fisher, M. A., R. R. Eversole, L. J. Beuving, and H. Jaeschke. Sinusoidal endothelial cell and parenchymal cell injury during endotoxemia and hepatic ischemia-reperfusion: protection by the 21-aminosteroid tirilazad mesylate. Int. Hepatol. Commun. 6: 121-129, 1997.
34. Fisher, N., S. Afford, and D. H. Adams. Adhesion molecules and alcoholic liver disease. Hepatogastroenterology 43: 1113-1116, 1996.
35. Furie, M. B., and G. J. Randolph. Chemokines and tissue injury. Am. J. Pathol. 146: 1287-1301, 1995.
36. Garcia-Criado, F. J., L. H. Toledo-Pereyra, F. Lopez-Neblina, M. L. Phillips, A. Paez-Rollys, and K. Misawa. Role of P-selectin in total hepatic ischemia and reperfusion. Am. Coll. Surg. 181: 327-334, 1995.
37. Gibbs, A. A. L., M. R. Weiser, L. Kobzik, C. R. Valeri, D. Shepro, and H. B. Hechtman. P-selectin mediates intestinal ischemic injury by enhancing complement deposition. Surgery 119: 652-656, 1996.
38. Granger, D. N., and P. Kubes. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J. Leukoc. Biol. 55: 662-675, 1994.
39. Harihara, Y., H. Sakamoto, K. Sanjo, O. Otsubo, G. Watanabe, and Y. Idezuki. Prolongation of hepatic allograft survival with antibodies to ICAM-1 and LFA-1. Transplant. Proc. 26: 2258, 1994.
40. Hellerbrand, C., S. C. Wang, H. Tsukamoto, D. A. Brenner, and R. A. Rippe. Expression of intercellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 24: 670-676, 1996.
41. Hewett, J. A., A. E. Schultze, S. Vancise, and R. A. Roth. Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab. Invest. 66: 347-361, 1992.
42. Hill, J., T. Lindsay, J. Rusche, R. Valeri, D. Shepro, and H. B. Hechtman. A Mac-1 antibody reduces liver and lung injury but not neutrophil sequestration after intestinal ischemia-reperfusion. Surgery 112: 166-172, 1992.
43. Horie, Y., R. Wolf, M. Miyasaka, D. C. Anderson, and D. N. Granger. Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia-reperfusion in rats. Gastroenterology 111: 666-673, 1996.
44. Isobe, M., J. Suzuki, H. Yagita, K. Okumura, and M. Sekiguchi. Effect of anti-VCAM-1 and VLA-4 monoclonal antibodies on cardiac allograft survival and response to soluble antigens in mice. Transplant. Proc. 26: 867-868, 1994.
45. Jaeschke, H., A. P. Bautista, Z. Spolarics, and J. J. Spitzer. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic. Res. Commun. 15: 277-284, 1991.
46. Jaeschke, H., A. P. Bautista, Z. Spolarics, and J. J. Spitzer. Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats. J. Leukoc. Biol. 52: 377-382, 1992.
47. Jaeschke, H., N. A. Essani, A. Farhood, and C. W. Smith. Mechanisms of inflammatory liver injury during ischemia-reperfusion and endotoxemia. In: Cells of the Hepatic Sinusoid, edited by E. Wisse, D. L. Knook, and C. Balabaud. Leiden, The Netherlands: Kupffer Cell Foundation. In press.
48. Jaeschke, H., N. A. Essani, M. A. Fisher, S. L. Vonderfecht, A. Farhood, and C. W. Smith. Release of soluble intercellular adhesion molecule-1 (sICAM-1) into bile and blood in murine endotoxin shock. Hepatology 23: 530-536, 1996.
49. Jaeschke, H., and A. Farhood. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver in vivo. Am. J. Physiol. 260 (Gastrointest. Liver Physiol. 23): G355-G362, 1991.
50. Jaeschke, H., A. Farhood, A. P. Bautista, Z. Spolarics, and J. J. Spitzer. Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G801-G809, 1993.
51. Jaeschke, H., A. Farhood, A. P. Bautista, Z. Spolarics, J. J. Spitzer, and C. W. Smith. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology 17: 915-923, 1993.
52. 2 integrins and intercellular adhesion molecule-1. Shock 6: 351-356, 1996.
53. Jaeschke, H., A. Farhood, and C. W. Smith. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 4: 3355-3359, 1990.
54. Jaeschke, H., A. Farhood, and C. W. Smith. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G1051-G1056, 1991.
55. Jaeschke, H., A. Farhood, and C. W. Smith. Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats. Hepatology 19: 973-979, 1994.
56. Jaeschke, H., M. A. Fisher, J. A. Lawson, and A. Farhood. Parenchymal cell apoptosis and neutrophil-induced liver injury in murine endotoxin shock (Abstract). Hepatology. In press.
57. Jaeschke, H., M. A. Fisher, J. A. Lawson, A. Farhood, and D. A. Jones. Caspase (ICE-protease) activation and parenchymal cell apoptosis in murine endotoxin shock (Abstract). Hepatology. In press.
58. Kawano, K., J. L. Bowers, M. P. Bree, and M. E. Clouse. Contribution of leukocytes to hepatic graft injury following cold preservation and transplantation (Abstract). Hepatology 20: 141A, 1994.
59. Keelan, E. T. M., S. T. Licence, A. M. Peters, R. M. Binns, and D. O. Haskard. Characterization of E-selectin expression in vivo with use of a radiolabeled monoclonal antibody. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H279-H290, 1994.
60. Keizer, G. D., W. Visser, M. Vliem, and C. G. Figdor. A monoclonal antibody (NK1-L16) directed against a unique epitope on the α-chain of human lymphocyte function-associated antigen-1 induces homotypic cell-cell interactions. J. Immunol. 140: 1393-1400, 1988.
61. Kimura, T., K. Suzuki, S. Inada, A. Hayashi, M. Isobe, Y. Matsuzaki, N. Tanaka, T. Osuga, and M. Fujiwara. Monoclonal antibody against lymphocyte function-associated antigen-1 inhibits the formation of primary biliary cirrhosis-like lessions induced by murine graft-versus-host reaction. Hepatology 24: 888-894, 1996.
62. Kishimoto, T. K., and D. C. Anderson. The role of integrins in inflammation. In: Inflammation. Basic Principles and Clinical Correlates, edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 353-406.
63. Kishimoto, T. K., M. A. Jutila, E. L. Berg, and E. C. Butcher. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238-1241, 1989.
64. Kishimoto, T. K., and R. Rothlein. Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites. Adv. Pharmacol. 25: 117-169, 1994.
65. Kvale, D., and P. Brandtzaeg. Immune modulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human hepatocytic cell lines. J. Hepatol. 17: 347-352, 1993.
66. Laskin, D. L. Sinusoidal lining cells and hepatotoxicity. Toxicol. Pathol. 24: 112-118, 1996.
67. Liu, P., G. M. McGuire, M. A. Fisher, A. Farhood, C. W. Smith, and H. Jaeschke. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 3: 56-62, 1995.
68. Liu, P., S. L. Vonderfecht, M. A. Fisher, G. M. McGuire, and H. Jaeschke. Priming of phagocytes for reactive oxygen production during hepatic ischemia and reperfusion increases the susceptibility for endotoxin-induced liver injury. Circ. Shock 43: 9-17, 1994.
69. Lou, D., K. Vanderkerken, L. Bouwens, P. J. K. Kuppen, M. Baekeland, C. Seynaeve, and E. Wisse. The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver. Hepatology 24: 1475-1480, 1996.
70. Maher, J. J., M. K. Scott, J. M. Saito, and M. C. Burton. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology 25: 624-630, 1997.
71. Maroushek-Boury, N. M., and C. J. Czuprynski. Listeria monocytogenes infection increases neutrophil adhesion and damage to a murine hepatocyte cell line in vitro. Immunol. Lett. 46: 111-116, 1995.
72. McCuskey, R. S., J. Nishida, H. Euchi, D. McDonnell, G. L. Baker, W. Ekataksin, M. A. Krasovich, V. Rudi, H. K. Seitz, B. Urbaschek, and R. Urbaschek. Role of endotoxin in the hepatic microvascular response to ethanol. J. Gastroenterol. Hepatol. 10, Suppl.: S18-S23, 1995.
73. McCuskey, R. S., R. Urbaschek, and B. Urbaschek. The microcirculation during endotoxemia. Cardiovasc. Res. 32: 752-763, 1996.
74. McEver, R. P., K. L. Moore, and R. D. Cummings. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J. Biol. Chem. 270: 11025-11028, 1995.
75. McNab, G., S. C. Afford, D. Neil, K. Yoong, C. Morland, and D. H. Adams. Lymphocytes use distinct pathways to bind to human hepatic sinusoidal endothelium in vitro (Abstract). Hepatology 24: 331A, 1996.
76. Meyer, D. M., M. L. Dustin, and C. P. Carron. Characterization of intercellular adhesion molecule-1 ectodomain (sICAM-1) as an inhibitor of lymphocyte function-associated molecule-1 interaction with ICAM-1. J. Immunol. 155: 3578-3584, 1995.
77. Mickelson, J. K., G. Kukielka, J. S. Bravenec, E. Mainolfi, R. Rothlein, H. K. Hawkins, J. H. Kelly, and C. W. Smith. Differential expression and release of CD54 induced by cytokines. Hepatology 22: 866-875, 1995.
78. Miller, L. J., R. Scharting, and T. A. Springer. Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation. J. Immunol. 137: 2891-2900, 1986.
79. Mochida, S., A. Ohno, M. Arai, and K. Fujiwara. Role of adhesion between activated macrophages and endothelial cells in the development of two types of massive necrosis in rats. J. Gastroenterol. Hepatol. 10: S38-S42, 1995.
80. Mochida, S., A. Ohno, M. Arai, T. Tamatani, M. Miyasaka, and K. Fujiwara. Role of adhesion molecules in the development of massive hepatic necrosis in rats. Hepatology 23: 320-328, 1996.
81. Morita, M., Y. Watanabe, and T. Akaike. Inflammatory cytokines up-regulate intercellular adhesion molecule-1 expression on primary cultured mouse hepatocytes and T-lymphocyte adhesion. Hepatology 19: 426-431, 1994.
82. Nagendra, A. R., J. K. Mickelson, and C. W. Smith. CD18 integrin and intercellular adhesion molecule-1 (CD54)-dependent neutrophil adhesion to cytokine-stimulated human hepatocytes. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G408-G416, 1997.
83. Nathan, C. F., S. Srimal, C. Farber, E. Sanchez, L. Kabbash, A. Asch, J. Gailit, and S. D. Wright. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J. Cell Biol. 109: 1341-1349, 1987.
84. Neuberger, J. Liver allograft rejection - current concepts on diagnosis and treatment. J. Hepatol. 23, Suppl. 1: 54-61, 1995.
85. Nishida, J., R. S. McCuskey, D. McDonnell, and E. S. Fox. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1135-G1141, 1994.
86. Nishimura, Y., Y. Takei, S. Kawano, M. Goto, K. Nagano, S. Tsuji, H. Nagai, A. Ohmae, H. Fusamoto, and T. Kamada. The F(ab′)2 fragment of an anti-ICAM-1 monoclonal antibody attenuates liver injury after orthotopic liver transplantation. Transplantation 61: 99-104, 1996.
87. Ohira, H., T. Ueno, S. Shakado, M. Sakamoto, T. Torimura, S. Inuzuka, M. Sata, and K. Tanikawa. Cultured rat hepatic sinusoidal endothelial cells express intercellular adhesion molecule-1 (ICAM-1) by tumor necrosis factor-α or interleukin-1α stimulation. J. Hepatol. 20: 729-734, 1994.
88. Ohira, H., T. Ueno, T. Torimura, K. Tanikawa, and R. Kasukawa. Leukocyte adhesion molecules in the liver and plasma cytokine levels in endotoxin-induced rat liver injury. Scand. J. Gastroenterol. 30: 1027-1035, 1995.
89. Ohki, E., S. Kato, Y. Horie, T. Mizukami, H. Tamai, H. Yokoyama, D. Ito, M. Fukuda, H. Suzuki, I. Kurose, and H. Ishii. Chronic ethanol consumption enhances endotoxin induced hepatic sinusoidal leukocyte adhesion. Alcohol Clin. Exp. Res. 20, Suppl.: 350A-355A, 1996.
90. Öhlinger, W., H. P. Dinges, K. Zatloukal, S. Mair, F. Gollowitsch, and H. Denk. Immunohistochemical detection of tumor necrosis factor-α, other cytokines and adhesion molecules in human livers with alcoholic hepatitis. Virchows Arch. 423: 169-176, 1993.
91. Ohtsuka, M., M. Miyazaki, Y. Hondo, and N. Nakajima. Neutrophil-mediated sinusoidal endothelial cell injury after extensive hepatectomy in cholestatic rats. Hepatology 25: 636-641, 1997.
92. Pearson, J. M., A. E. Schultze, P. A. Jean, and R. A. Roth. Platelet participation in liver injury from Gram-negative bacterial lipopolysaccharide in the rat. Shock 4: 178-186, 1995.
93. Redl, H., H. P. Dinges, W. A. Buurman, C. J. Van Der Linden, J. S. Pober, R. S. Cotran, and G. Schlag. Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am. J. Pathol. 139: 461-466, 1991.
94. Riekmann, P., U. Michel, M. Albrecht, W. Brück, L. Wöckel, and K. Felgenhauer. Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells. J. Neuroimmunol. 60: 9-15, 1995.
95. Rothlein, R., E. A. Mainolfi, M. Czajkowski, and S. D. Marlin. A form of circulating ICAM-1 in human serum. J. Immunol. 147: 3788-3793, 1991.
96. Ruoslahti, E. Integrins. J. Clin. Invest. 87: 1-5, 1991.
97. Sakamoto, S., T. Okanoue, K. Nishioji, Y. Nakagawa, and K. Kashima. Dynamic analysis of the interaction between lymphocytes and sinusoidal endothelial cells in vitro (Abstract). Hepatology 24: 330A, 1996.
98. Sakata, H., B. Jiand, M. Kusano, T. Furune, S. Kasai, and M. Mito. Effects of monoclonal antibodies to ICAM-1 and LFA-1 on allogeneic hepatocytes transplanted into rat spleen. Int. Hepatol. Commun. 3: 15-19, 1995.
99. Schlayer, H. J., H. Laaff, T. Peters, M. Woort-Menker, H. C. Estler, U. Karck, H. E. Schaefer, and K. Decker. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J. Hepatol. 7: 239-249, 1988.
100. Scoazec, J. Y., F. Durand, C. Degott, D. Delautier, J. Bernuau, J. Belghiti, J. P. Benhamou, and G. Feldmann. Expression of cytokine-dependent adhesion molecules in postreperfusion biopsy specimens of liver allograft. Gastroenterology 107: 1094-1102, 1994.
101. Scoazec, J. Y., and G. Feldmann. In situ immunophenotyping study of endothelial cells of the human hepatic sinusoid: results and functional implications. Hepatology 14: 789-797, 1991.
102. Serizawa, A., S. Nakamura, S. Suzuki, S. Baba, and M. Nakano. Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. Hepatology 23: 1656-1663, 1996.
103. Shappell, S. B., C. Toman, D. C. Anderson, A. A. Taylor, M. L. Entman, and C. W. Smith. Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J. Immunol. 144: 2702-2711, 1990.
104. Shi, J., H. Fujieda, Y. Kokubo, and K. Wake. Apoptosis of neutrophils and their elimination by Kupffer cells in rat liver. Hepatology 24: 1256-1263, 1996.
105. 1) integrin receptors on T cells. Nature 345: 250-253, 1990.
106. Shiratori, Y., Y. Hikiba, E. Mawet, Y. Niwa, M. Matsumura, N. Kato, S. Shiina, M. Tada, Y. Komatsu, T. Kawabe, H. Yoshida, K. Okano, and M. Omata. Modulation of KC/gro protein (interleukin-8 related protein in rodents) release from hepatocytes by biologically active mediators. Biochem. Biophys. Res. Commun. 203: 1398-1403, 1994.
107. Simonet, W. S., T. M. Hughes, H. Q. Nguyen, L. D. Trebasky, D. M. Danilenko, and E. S. Medlock. Long-term impaired neutrophil migration in mice overexpressing human interleukin-8. J. Clin. Invest. 94: 1310-1319, 1994.
108. Simpson, K. J., and P. C. Hayes. Soluble adhesion molecules in immune mediated liver disease. Gut 36: 806-808, 1995.
109. Smith, C. W. Transendothelial migration. In: Adhesion. Its Role in Inflammatory Disease, edited by J. M. Harlan and D. Y. Liu. New York: Freeman, 1992, p. 85-115.
110. Spitzer, J. A., P. Zhang, and A. M. S. Mayer. Functional characterization of peripheral circulating and liver recruited neutrophils in endotoxic rats. J. Leukoc. Biol. 56: 166-173, 1994.
111. Steinhoff, G., and M. Brandt. Adhesion molecules in liver transplantation. Hepatogastroenterology 43: 1117-1123, 1996.
112. Strassman, G., T. A. Springer, and D. O. Adams. Studies on antigens associated with the activation of murine mononuclear phagocytes: kinetics of and requirements for induction of lymphocyte function-associated antigen (LFA-1) in vitro. J. Immunol. 135: 147-151, 1985.
113. Tanaka, Y., K. Kobayashi, A. Takahashi, I. Arai, S. Higuchi, S. Otomo, S. Habu, and T. Nishimura. Inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1. J. Immunol. 151: 5088-5095, 1993.
114. Tanaka, Y., A. Takahashi, K. Kobayashi, I. Arai, S. Higuchi, S. Otomo, K. Watanabe, S. Habu, and T. Nishimura. Establishment of a T cell-dependent nude mouse liver injury model induced by Propionebacterium acnes and LPS. J. Immunol. Methods 182: 21-28, 1995.
115. Thornton, A. J., R. M. Strieter, I. Lindley, M. Baggiolini, and S. L. Kunkel. Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J. Immunol. 144: 2609-2613, 1990.
116. Van Oosten, M., E. Van De Bilt, H. E. De Vries, T. J. C. Van Berkel, and J. Kuiper. Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. Hepatology 22: 1538-1546, 1995.
117. Vollmar, B., J. Glasz, M. D. Menger, and K. Messmer. Leukocytes contribute to hepatic ischemia-reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery 117: 195-200, 1995.
118. Vollmar, B., M. D. Menger, J. Glasz, R. Leiderer, and K. Messmer. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G786-G793, 1994.
119. Vollmar, B., S. Richter, and M. D. Menger. Leukocyte stasis in hepatic sinusoids. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G798-G803, 1996.
120. Vollmar, B., A. Senkel, and M. D. Menger. In vivo evidence that intercellular adhesion molecule-1 does not mediate endotoxin-induced hepatic leukocyte-endothelial cell interaction. J. Hepatol. 23: 613-616, 1995.
121. Volpes, R., J. J. Van den Oord, and V. J. Desmet. Immunohistochemical study of adhesion molecules in liver inflammation. Hepatology 12: 59-65, 1990.
122. Volpes, R., J. J. Van den Oord, and V. J. Desmet. Memory T cells represent the predominant lymphocyte subset in acute and chronic liver inflammation. Hepatology 13: 826-829, 1991.
123. Volpes, R., J. J. Van den Oord, and V. J. Desmet. Vascular adhesion molecules in acute and chronic liver inflammation. Hepatology 15: 269-275, 1992.
124. Wakelin, M. W., M. J. Sanz, S. M. Albelda, S. W. Larkin, N. Boughton-Smith, T. J. Williams, and S. Nourshargh. An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J. Exp. Med. 184: 229-239, 1996.
125. Wisse, E. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J. Ultrastruct. Res. 38: 528-562, 1972.
126. Witthaut, R., A. Farhood, C. W. Smith, and H. Jaeschke. Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) upregulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukoc. Biol. 55: 105-111, 1994.
127. Worthen, G. S., B. Schwab, E. L. Elson, and G. P. Downey. Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science 245: 183-186, 1989.
128. Zhang, J. X., D. V. Jones, and M. G. Clemens. Effect of activation on neutrophil-induced hepatic microvascular injury in isolated rat liver. Shock 1: 273-278, 1994.
129. Zhang, P., M. Xie, and J. A. Spitzer. Hepatic neutrophil sequestration in early sepsis: enhanced expression of adhesion molecules and phagocytic activity. Shock 2: 133-140, 1994.
130. Zhang, P., M. Xie, J. Zagorski, and J. A. Spitzer. Attenuation of hepatic neutrophil sequestration by anti-CINC antibody in endotoxic rats. Shock 4: 262-268, 1995.
131. Zimmerman, G. A., and T. M. McIntyre. Neutrophil adherence to human endothelium in vitro occurs by CD18 glycoprotein-dependent and -independent mechanisms. J. Clin. Invest. 81: 531-537, 1988.